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Investigation of potential toxic components based on the identification of Genkwa Flos chemical constituents and their metabolites by high‐performance liquid chromatography coupled with a Q Exactive high‐resolution benchtop quadrupole Orbitrap mass spectrometer
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jssc.201000054openalex-snapshot
A simple and efficient protocol for large‐scale preparation of three flavonoids from the flower of Daphne genkwa by combination of macroporous resin and counter‐current chromatography
inferredcites →https://doi.org/10.1002/jssc.201201116openalex-snapshot
Plasma pharmacochemistry combined with microdialysis to screen potential bioactive components and their metabolites in A nemarrhena asphodeloides saponin extract using ultrahigh‐performance liquid chromatography/quadrupole‐time‐of‐flight mass spectrometry
inferredcites →https://doi.org/10.1002/jssc.201300794openalex-snapshot
Rapid identification and comparative analysis of the chemical constituents and metabolites of P hellodendri amurensis cortex and Z hibai dihuang pill by ultra‐performance liquid chromatography with quadrupole TOF ‐ MS
inferredcites →https://doi.org/10.1002/jssc.201600954openalex-snapshot
Metabolic mapping of Schisandra sphenanthera extract and its active lignans using a metabolomic approach based on ultra high performance liquid chromatography with high‐resolution mass spectrometry
inferredcites →https://doi.org/10.1002/jssc.201700236openalex-snapshot
Identification and analysis of chemical constituents and rat serum metabolites in Suan‐Zao‐Ren granule using ultra high performance liquid chromatography quadrupole time‐of‐flight mass spectrometry combined with multiple data processing approaches
inferredcites →https://doi.org/10.1002/ptr.4748openalex-snapshot
Metabonomic Study of Genkwa Flos–induced Hepatotoxicity and Effect of Herb‐Processing Procedure on Toxicity
inferredcites →https://doi.org/10.1016/j.aca.2014.10.037openalex-snapshot
Quantitative performance of liquid chromatography coupled to Q-Exactive high resolution mass spectrometry (HRMS) for the analysis of tetracyclines in a complex matrix
inferredcites →https://doi.org/10.1016/j.bmc.2004.10.054openalex-snapshot
Novel diterpenoids with potent inhibitory activity against endothelium cell HMEC and cytotoxic activities from a well-known TCM plant Daphne genkwa
inferredcites →https://doi.org/10.1016/j.jchromb.2014.07.032openalex-snapshot
Simultaneous identification, confirmation and quantitation of illegal adulterated antidiabetics in herbal medicines and dietary supplements using high-resolution benchtop quadrupole-Orbitrap mass spectrometry
inferredcites →https://doi.org/10.1016/j.jchromb.2015.08.024openalex-snapshot
Yuanhuapine-induced intestinal and hepatotoxicity were correlated with disturbance of amino acids, lipids, carbohydrate metabolism and gut microflora function: A rat urine metabonomic study
inferredcites →https://doi.org/10.1016/j.jchromb.2016.01.008openalex-snapshot
An optimized method for neurotransmitters and their metabolites analysis in mouse hypothalamus by high performance liquid chromatography–Q Exactive hybrid quadrupole-orbitrap high-resolution accurate mass spectrometry
inferredcites →https://doi.org/10.1016/j.jchromb.2017.07.021openalex-snapshot
Systematic screening and characterization of multiple constituents in Guizhi Fuling capsule and metabolic profiling of bioactive components in rats using ultra-high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry
inferredcites →https://doi.org/10.1016/j.jep.2014.10.055openalex-snapshot
Evaluation of the indicative roles of seven potential biomarkers on hepato-nephrotoxicity induced by Genkwa Flos
inferredcites →https://doi.org/10.1016/j.jpba.2006.01.014openalex-snapshot
Live cell extraction and HPLC–MS analysis for predicting bioactive components of traditional Chinese medicines
inferredcites →https://doi.org/10.1016/j.jpba.2013.06.011openalex-snapshot
Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry
inferredcites →https://doi.org/10.1016/j.jpba.2014.09.005openalex-snapshot
The development and validation of a rapid method for the determination of antimicrobial agent residues in milk and meat using ultra performance liquid chromatography coupled to quadrupole – Orbitrap mass spectrometry
inferredcites →https://doi.org/10.1016/j.jpba.2015.04.023openalex-snapshot
Pharmacokinetic profile and metabolite identification of yuanhuapine, a bioactive component in Daphne genkwa by ultra-high performance liquid chromatography coupled with tandem mass spectrometry
inferredcites →https://doi.org/10.1016/j.mayocp.2013.09.016openalex-snapshot
Drug-Induced Liver Injury
inferredcites →https://doi.org/10.1016/j.phymed.2013.06.012openalex-snapshot
Toxicity of daphnane-type diterpenoids from Genkwa Flos and their pharmacokinetic profile in rat
inferredcites →https://doi.org/10.1039/c5ra14678jopenalex-snapshot
Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer
inferredcites →https://doi.org/10.1080/00498254.2016.1275064openalex-snapshot
Consequences of daily corticosteroid dosing with or without pre-treatment with quinidine on thein vivocytochrome P450 2D (CYP2D) enzyme in rats: effect on O-demethylation activity of dextromethorphan and expression levels of CYP2D1 mRNA
inferredcites →https://doi.org/10.1080/00498254.2018.1427905openalex-snapshot
Investigation of the mechanisms of Genkwa Flos hepatotoxicity by a cell metabolomics strategy combined with serum pharmacology in HL-7702 liver cells
inferredcites →https://doi.org/10.1111/apt.12798openalex-snapshot
Review article: herbal hepatotoxicity – an update on traditional Chinese medicine preparations
inferredcites →https://doi.org/10.1155/2013/459390openalex-snapshot
In VitroScreening for Antihepatic Steatosis Active Components within Coptidis Rhizoma Alkaloids Extract Using Liver Cell Extraction with HPLC Analysis and a Free Fatty Acid-Induced Hepatic Steatosis HepG2 Cell Assay
inferredcites →https://doi.org/10.1155/2014/170959openalex-snapshot
Investigation of the Chemical Changes from Crude and Processed Paeoniae Radix Alba‐Atractylodis Macrocephalae Rhizoma Herbal Pair Extracts by Using Q Exactive High‐Performance Benchtop Quadrupole‐Orbitrap LC‐MS/MS
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Chemical Constituents and Their Chemotaxonomic Significance from the Aerial Parts of Scutellaria Barbata D. Don
inferred← citeshttps://doi.org/10.1002/jsfa.11239openalex-snapshot
LC‐ESI / HRMS analysis of glucosinolates, oxylipins and phenols in Italian rocket salad ( Diplotaxis erucoides subsp. erucoides (L.) DC .) and evaluation of its healthy potential
inferred← citeshttps://doi.org/10.1002/jssc.202200319openalex-snapshot
Comprehensive analysis of dihydromyricetin metabolites in rats using ultra‐high‐performance liquid chromatography coupled with high‐resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.foodchem.2020.126165openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.foodchem.2024.139319openalex-snapshot
Comment on the “Does saponin in quinoa really embody the source of its bitterness?”
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e25091openalex-snapshot
The modern scientific mystery of traditional Chinese medicine processing——take some common traditional Chinese medicine as examples
inferred← citeshttps://doi.org/10.1016/j.jchromb.2021.122793openalex-snapshot
Characterization of chemical constituents and metabolites in rat plasma after oral administration of San Miao Wan by ultra-high performance liquid chromatography tandem Q-Exactive Orbitrap mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117594openalex-snapshot
Research progress on the toxicity of toxic Traditional Herbals from Thymelaeaceae
inferred← citeshttps://doi.org/10.1016/j.jep.2024.117914openalex-snapshot
Bioactivity, phytochemistry studies and subacute in vivo toxicity of ethanolic leaf extract of white mulberry (Morus alba linn.) in female mice
inferred← citeshttps://doi.org/10.1038/s41598-021-91341-wopenalex-snapshot
Analytical quality by design methodology for botanical raw material analysis: a case study of flavonoids in Genkwa Flos
inferred← citeshttps://doi.org/10.3389/fphar.2020.00048openalex-snapshot
Bioactivity, Compounds Isolated, Chemical Qualitative, and Quantitative Analysis of Cymbaria daurica Extracts
inferred← citeshttps://doi.org/10.3390/ijms19092745openalex-snapshot
Molecular Mechanisms Involved in Oxidative Stress-Associated Liver Injury Induced by Chinese Herbal Medicine: An Experimental Evidence-Based Literature Review and Network Pharmacology Study
inferred← citeshttps://doi.org/10.3390/md21110574openalex-snapshot
Metabolic Profiling, Antiviral Activity and the Microbiome of Some Mauritian Soft Corals
inferred← citeshttps://doi.org/10.51847/l9zhhu5tvgopenalex-snapshot
The Modern Scientific Enigma of Processing in Traditional Chinese Medicine: Illustrated with Common Examples
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