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Genetic risk and age in Parkinson's disease: Continuum not stratum

https://doi.org/10.1002/mds.26192
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/mds.23469openalex-snapshot
The motor phenotype of Parkinson's disease in relation to age at onset
inferredcites →https://doi.org/10.1002/mds.25132openalex-snapshot
Systematic Review and UK‐Based Study of PARK2 (parkin), PINK1, PARK7 (DJ‐1) and LRRK2 in early‐onset Parkinson's disease
inferredcites →https://doi.org/10.1016/s0140-6736(10)61267-6openalex-snapshot
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses
inferredcites →https://doi.org/10.1016/s0140-6736(10)62345-8openalex-snapshot
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
inferredcites →https://doi.org/10.1038/ng.3043openalex-snapshot
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
inferredcites →https://doi.org/10.1038/ng.487openalex-snapshot
Genome-wide association study reveals genetic risk underlying Parkinson's disease
inferredcites →https://doi.org/10.1093/hmg/ddp059openalex-snapshot
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1101/cshperspect.a008870openalex-snapshot
Clinical Approach to Parkinson's Disease: Features, Diagnosis, and Principles of Management
inferredcites →https://doi.org/10.1371/journal.pgen.1002548openalex-snapshot
Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database
inferredcites →https://doi.org/10.1371/journal.pone.0041859openalex-snapshot
Genome Wide Assessment of Young Onset Parkinson’s Disease from Finland

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Mechanism-Free Repurposing of Drugs For C9orf72-related ALS/FTD Using Large-Scale Genomic Data
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Mechanism-Free Repurposing of Drugs For C9orf72-Related ALS/FTD Using Large-Scale Genomic Data
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Association of Polygenic Risk Score With Cognitive Decline and Motor Progression in Parkinson Disease
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Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
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Genetic risk loci for Parkinson's disease: Moving from state to trait?
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Cumulative genetic risk and age at onset in Parkinson's disease
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A cumulative genetic risk score predicts progression in P arkinson's disease
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Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy
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Cognitive changes in prodromal Parkinson's disease: A review
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Polygenic load: Earlier disease onset but similar longitudinal progression in Parkinson's disease
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A paradoxical relationship between family history, onset age, and genetic risk in Parkinson's disease
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The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
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Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms
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Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score
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Genetic Modifiers of Age at Onset for Parkinson's Disease in Asians: A Genome‐Wide Association Study
inferred← citeshttps://doi.org/10.1002/mds.28808openalex-snapshot
Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score
inferred← citeshttps://doi.org/10.1002/mds.28974openalex-snapshot
Erratum to “Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Approach”
inferred← citeshttps://doi.org/10.1002/mds.70053openalex-snapshot
Reply to: “Early Indian Age at Onset of Parkinson's: A Case for a Gene‐Environment Lens”
inferred← citeshttps://doi.org/10.1002/mgg3.267openalex-snapshot
A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
inferred← citeshttps://doi.org/10.1007/978-3-319-95360-1_29openalex-snapshot
Genetic Factors Influencing the Development and Treatment of Cognitive Impairment and Psychosis in Parkinson’s Disease
inferred← citeshttps://doi.org/10.1007/s00441-018-2817-yopenalex-snapshot
Genetic risk factors in Parkinson’s disease
inferred← citeshttps://doi.org/10.1007/s00702-016-1526-5openalex-snapshot
Association of three candidate genetic variants in RAB7L1/NUCKS1, MCCC1 and STK39 with sporadic Parkinson’s disease in Han Chinese
inferred← citeshttps://doi.org/10.1007/s10654-017-0229-zopenalex-snapshot
Agricultural activities and the incidence of Parkinson’s disease in the general French population
inferred← citeshttps://doi.org/10.1016/b978-0-12-803783-6.00001-8openalex-snapshot
The Neurogenetics of Parkinson’s Disease and Putative Links to Other Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101648openalex-snapshot
What have we learned from genome-wide association studies (GWAS) in Parkinson's disease?
inferred← citeshttps://doi.org/10.1016/j.envres.2021.111161openalex-snapshot
Pesticides expenditures by farming type and incidence of Parkinson disease in farmers: A French nationwide study
inferred← citeshttps://doi.org/10.1016/j.mayocp.2017.03.014openalex-snapshot
Parkinson Disease and Melanoma
inferred← citeshttps://doi.org/10.1016/j.mcp.2016.11.001openalex-snapshot
Genetics of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.mcp.2019.101471openalex-snapshot
WITHDRAWN: Genetics of Parkinson’s disease
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2016.06.001openalex-snapshot
Genome-wide assessment of Parkinson's disease in a Southern Spanish population
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2018.09.022openalex-snapshot
No evidence for DNM3 as genetic modifier of age at onset in idiopathic Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2018.10.030openalex-snapshot
Genetic variants of PARK genes in Korean patients with early-onset Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.neurol.2015.09.012openalex-snapshot
Epidemiology of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2025.12.012openalex-snapshot
Genetic predispositions and nutritional strategies: a review of nutrigenomics in Parkinson’s disease
inferred← citeshttps://doi.org/10.1016/j.parkreldis.2022.11.017openalex-snapshot
Early onset of Parkinson's disease in India: Complicating the conundrum
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Progress in Polygenic Composite Scores in Alzheimer’s and Other Complex Diseases
inferred← citeshttps://doi.org/10.1016/j.xgen.2024.100679openalex-snapshot
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data
inferred← citeshttps://doi.org/10.1016/s1474-4422(16)30243-5openalex-snapshot
Modifiers of LRRK2 parkinsonism: new therapeutic targets
inferred← citeshttps://doi.org/10.1016/s1474-4422(19)30320-5openalex-snapshot
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
inferred← citeshttps://doi.org/10.1037/met0000175openalex-snapshot
Alternating optimization for G × E modelling with weighted genetic and environmental scores: Examples from the MAVAN study.
inferred← citeshttps://doi.org/10.1038/s41467-021-26280-1openalex-snapshot
Finding genetically-supported drug targets for Parkinson’s disease using Mendelian randomization of the druggable genome
inferred← citeshttps://doi.org/10.1038/s41531-019-0080-xopenalex-snapshot
Mitochondria function associated genes contribute to Parkinson’s Disease risk and later age at onset
inferred← citeshttps://doi.org/10.1038/s41531-023-00623-9openalex-snapshot
Risk factors associated with age at onset of Parkinson’s disease in the UK Biobank
inferred← citeshttps://doi.org/10.1038/s41582-020-0343-5openalex-snapshot
Pathogenetic insights into young-onset Parkinson disease
inferred← citeshttps://doi.org/10.1042/ns20220040openalex-snapshot
Modeling Parkinson’s disease in LRRK2 rodents
inferred← citeshttps://doi.org/10.1093/brain/awae073openalex-snapshot
Genetic analysis and natural history of Parkinson’s disease due to the LRRK2 G2019S variant
inferred← citeshttps://doi.org/10.1093/brain/awz350openalex-snapshot
Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia
inferred← citeshttps://doi.org/10.1093/hmg/ddw206openalex-snapshot
Identification of genetic modifiers of age-at-onset for familial Parkinson’s disease
inferred← citeshttps://doi.org/10.1101/2020.07.24.208975openalex-snapshot
Finding drug targeting mechanisms with genetic evidence for Parkinson’s disease
inferred← citeshttps://doi.org/10.1101/2020.11.23.20235671openalex-snapshot
DEFINING CANDIDATE PARKINSON’S DISEASE GENES THROUGH THE ANALYSIS OF GENOME-WIDE HOMOZYGOSITY
inferred← citeshttps://doi.org/10.1101/2023.11.28.23299090openalex-snapshot
Insights into Ancestral Diversity in Parkinson’s Disease Risk: A Comparative Assessment of Polygenic Risk Scores
inferred← citeshttps://doi.org/10.1101/475111openalex-snapshot
Genetic variation within genes associated with mitochondrial function is significantly associated with later age at onset of Parkinson disease and contributes to disease risk
inferred← citeshttps://doi.org/10.1136/jmedgenet-2019-106283openalex-snapshot
Genetic variability and potential effects on clinical trial outcomes: perspectives in Parkinson’s disease
inferred← citeshttps://doi.org/10.1136/jnnp-2015-312283openalex-snapshot
Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis
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Patient narratives of hope in stem cell technologies: Trust in biomedicine and the body’s natural ability to heal itself
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Plasticity-related gene 3 ( LPPR1 ) and age at diagnosis of Parkinson disease
inferred← citeshttps://doi.org/10.1212/nxg.0000000000000348openalex-snapshot
Genetic risk of Parkinson disease and progression:
inferred← citeshttps://doi.org/10.1212/nxg.0000000000000557openalex-snapshot
Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes
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The impact of age on genetic risk for common diseases
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Current Therapeutic Strategies of Parkinson's Disease
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The Search for Environmental Causes of Parkinson’s Disease: Moving Forward
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Age at Onset of Parkinson’s Disease Among Ashkenazi Jewish Patients: Contribution of Environmental Factors, LRRK2 p.G2019S and GBA p.N370S Mutations
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Ten Years of the International Parkinson Disease Genomics Consortium: Progress and Next Steps
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Early-Onset Parkinson’s Disease: Creating the Right Environment for a Genetic Disorder
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Polygenic risk scores: An overview from bench to bedside for personalised medicine
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Pathological Role of Natural Killer Cells in Parkinson's Disease: A Systematic Review
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Global trends of early-onset Parkinson’s disease from 1990 to 2021, and projections until to 2030: a systematic analysis of the global burden of disease study 2021
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Characterizing the Expression Patterns of Parkinson’s Disease Associated Genes
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Gene4PD: A Comprehensive Genetic Database of Parkinson’s Disease
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Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead
inferred← citeshttps://doi.org/10.3390/genes11010097openalex-snapshot
Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis
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Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease
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Alternating optimization for GxE modelling with weighted genetic and environmental scores: examples from the MAVAN study
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