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Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/archneur.58.3.512openalex-snapshot
How Amyotrophic Lateral Sclerosis Got Its Name
inferredcites →https://doi.org/10.1002/14651858.cd001447openalex-snapshot
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
inferredcites →https://doi.org/10.1002/14651858.cd001447.pub2openalex-snapshot
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
inferredcites →https://doi.org/10.1002/14651858.cd001447.pub3openalex-snapshot
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)
inferredcites →https://doi.org/10.1002/eji.201142048openalex-snapshot
The need for littermate controls
inferredcites →https://doi.org/10.1016/0022-510x(94)90191-0openalex-snapshot
El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1016/j.brainres.2013.10.013openalex-snapshot
C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS
inferredcites →https://doi.org/10.1016/j.jns.2005.02.006openalex-snapshot
Background and gender effects on survival in the TgN(SOD1-G93A)1Gur mouse model of ALS
inferredcites →https://doi.org/10.1016/j.jns.2010.10.011openalex-snapshot
Gender-based effect of statins on functional decline in amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1016/j.nbd.2006.12.015openalex-snapshot
Lost in translation: Treatment trials in the SOD1 mouse and in human ALS
inferredcites →https://doi.org/10.1016/j.neuint.2015.07.024openalex-snapshot
Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress
inferredcites →https://doi.org/10.1016/j.neuron.2013.12.009openalex-snapshot
Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration
inferredcites →https://doi.org/10.1016/j.neuron.2016.04.006openalex-snapshot
Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs
inferredcites →https://doi.org/10.1016/j.stemcr.2017.09.021openalex-snapshot
Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons
inferredcites →https://doi.org/10.1016/j.tips.2006.03.009openalex-snapshot
Targets in ALS: designing multidrug therapies
inferredcites →https://doi.org/10.1016/s0022-510x(99)00210-5openalex-snapshot
The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function
inferredcites →https://doi.org/10.1016/s0031-6997(24)01340-1openalex-snapshot
Role of Pharmacokinetics and Metabolism in Drug Discovery and Development
inferredcites →https://doi.org/10.1016/s0140-6736(96)91680-3openalex-snapshot
Dose-ranging study of riluzole in amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1016/s1474-4422(14)70129-2openalex-snapshot
Clinical trials in amyotrophic lateral sclerosis: why so many negative trials and how can trials be improved?
inferredcites →https://doi.org/10.1016/s1474-4422(17)30115-1openalex-snapshot
Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial
inferredcites →https://doi.org/10.1016/s1474-4422(17)30289-2openalex-snapshot
Edaravone for treatment of early-stage ALS
inferredcites →https://doi.org/10.1016/s1474-4422(18)30054-1openalex-snapshot
Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
inferredcites →https://doi.org/10.1016/s1474-4422(18)30089-9openalex-snapshot
Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model
inferredcites →https://doi.org/10.1016/s1474-4422(18)30111-xopenalex-snapshot
What if you knew the prognosis of your patients with ALS?
inferredcites →https://doi.org/10.1021/jp110400topenalex-snapshot
OH Radical Scavenging Activity of Edaravone: Mechanism and Kinetics
inferredcites →https://doi.org/10.1038/507423aopenalex-snapshot
Preclinical research: Make mouse studies work
inferredcites →https://doi.org/10.1038/nrn1870openalex-snapshot
Astrocyte dysfunction in neurological disorders: a molecular perspective
inferredcites →https://doi.org/10.1038/nrneurol.2011.147openalex-snapshot
How can we improve clinical trials in amyotrophic lateral sclerosis?
inferredcites →https://doi.org/10.1038/psp.2013.41openalex-snapshot
Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development
inferredcites →https://doi.org/10.1038/s41598-017-00993-0openalex-snapshot
Endothelial and Astrocytic Support by Human Bone Marrow Stem Cell Grafts into Symptomatic ALS Mice towards Blood-Spinal Cord Barrier Repair
inferredcites →https://doi.org/10.1056/nejm199403033300901openalex-snapshot
A Controlled Trial of Riluzole in Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.1080/13510002.1996.11747069openalex-snapshot
Antioxidant activity of 3-methyl-1-phenyl-2-pyrazolin-5-one
inferredcites →https://doi.org/10.1080/14656566.2017.1319937openalex-snapshot
Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1080/14660820410019602openalex-snapshot
Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials
inferredcites →https://doi.org/10.1080/17482960802195913openalex-snapshot
Scrutinizing enrollment in ALS clinical trials: Room for improvement?
inferredcites →https://doi.org/10.1080/21678421.2017.1361442openalex-snapshot
Post-hoc analysis of MCI186-17, the extension study to MCI186-16, the confirmatory double-blind, parallel-group, placebo-controlled study of edaravone in amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1080/21678421.2017.1362000openalex-snapshot
Exploratory double-blind, parallel-group, placebo-controlled extension study of edaravone (MCI-186) in amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1093/hmg/ddt202openalex-snapshot
PGC-1 is a male-specific disease modifier of human and experimental amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1111/b.9780631215356.2005.xopenalex-snapshot
The Blackwell Companion to Hinduism
inferredcites →https://doi.org/10.1124/mol.108.050831openalex-snapshot
Cu/Zn Superoxide Dismutase Typical for Familial Amyotrophic Lateral Sclerosis Increases the Vulnerability of Mitochondria and Perturbs Ca2+ Homeostasis in SOD1G93A Mice
inferredcites →https://doi.org/10.1186/1471-2202-10-64openalex-snapshot
Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease
inferredcites →https://doi.org/10.1186/1471-2202-14-37openalex-snapshot
Improving basic and translational science by accounting for litter-to-litter variation in animal models
inferredcites →https://doi.org/10.1186/2052-8426-2-26openalex-snapshot
Selective vulnerability of motoneuron and perturbed mitochondrial calcium homeostasis in amyotrophic lateral sclerosis: implications for motoneurons specific calcium dysregulation
inferredcites →https://doi.org/10.1212/wnl.0b013e31822dc7a5openalex-snapshot
Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1371/journal.pbio.1000412openalex-snapshot
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
inferredcites →https://doi.org/10.14573/altex.2007.4.320openalex-snapshot
Animal experiments scrutinised: systematic reviews demonstrate poor human clinical and toxicological utility
inferredcites →https://doi.org/10.1503/cmaj.081879openalex-snapshot
Legumes, lemons and streptomycin: A short history of the clinical trial
inferredcites →https://doi.org/10.1523/jneurosci.1457-16.2016openalex-snapshot
Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy
inferredcites →https://doi.org/10.15585/mmwr.mm6707a3openalex-snapshot
Prevalence of Amyotrophic Lateral Sclerosis — United States, 2014
inferredcites →https://doi.org/10.15585/mmwr.ss6508a1openalex-snapshot
Prevalence of Amyotrophic Lateral Sclerosis — United States, 2012–2013
inferredcites →https://doi.org/10.3109/21678421.2014.959024openalex-snapshot
Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients
inferredcites →https://doi.org/10.3389/978-2-88945-146-3openalex-snapshot
The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments
inferredcites →https://doi.org/10.3389/fncel.2013.00199openalex-snapshot
Calcium, mitochondria, and the pathogenesis of ALS: the good, the bad, and the ugly
inferredcites →https://doi.org/10.3389/fncel.2016.00219openalex-snapshot
Promise and Pitfalls of Mitochondrial Replacement for Prevention and Cure of Heritable Neurodegenerative Diseases Caused by Deleterious Mutations in Mitochondrial DNA
inferredcites →https://doi.org/10.3389/fncel.2016.00295openalex-snapshot
Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca2+ Signaling in Amyotrophic Lateral Sclerosis
inferredcites →https://doi.org/10.4103/0976-500x.72351openalex-snapshot
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
inferredcites →https://doi.org/10.4103/1673-5374.206635openalex-snapshot
Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease
inferredcites →https://doi.org/10.5040/9798400667251openalex-snapshot
Encyclopedia of Human Genetics and Disease
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/acn3.51174openalex-snapshot
Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis
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inferred← citeshttps://doi.org/10.1002/ana.26259openalex-snapshot
Promise of Nucleic Acid Therapeutics for Amyotrophic Lateral Sclerosis
inferred← citeshttps://doi.org/10.1002/ana.26285openalex-snapshot
Adaptive Platform Trials to Transform Amyotrophic Lateral Sclerosis Therapy Development
inferred← citeshttps://doi.org/10.1002/cbic.202400224openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/cmdc.202300705openalex-snapshot
Current Small Molecule–Based Medicinal Chemistry Approaches for Neurodegeneration Therapeutics
inferred← citeshttps://doi.org/10.1002/ctm2.657openalex-snapshot
A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1002/jcb.29533openalex-snapshot
The new role of riluzole in the treatment of pancreatic cancer through the apoptosis and autophagy pathways
inferred← citeshttps://doi.org/10.1002/jcp.31187openalex-snapshot
The role of DNA damage in neural stem cells ageing
inferred← citeshttps://doi.org/10.1002/jdn.10101openalex-snapshot
Stem cell in neurodegenerative disorders; an emerging strategy
inferred← citeshttps://doi.org/10.1002/lio2.859openalex-snapshot
ALS patients in otorhinolaryngology: A retrospective study
inferred← citeshttps://doi.org/10.1002/med.21725openalex-snapshot
In a search for efficient treatment for amyotrophic lateral sclerosis: Old drugs for new approaches
inferred← citeshttps://doi.org/10.1002/mef2.70026openalex-snapshot
Mitochondrial Dysfunction in Aging: Future Therapies and Precision Medicine Approaches
inferred← citeshttps://doi.org/10.1002/psp4.12852openalex-snapshot
Hallmarks of neurodegenerative disease: A systems pharmacology perspective
inferred← citeshttps://doi.org/10.1002/smll.201907308openalex-snapshot
Redox‐Responsive Nanobiomaterials‐Based Therapeutics for Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1002/smll.202304082openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/430_2025_93openalex-snapshot
Environmentally Friendly Organic Synthesis Using Bismuth(III) Compounds: A Mini Review
inferred← citeshttps://doi.org/10.1007/978-3-030-71519-9_34-1openalex-snapshot
Neurotrophic Therapy for ALS/MND
inferred← citeshttps://doi.org/10.1007/978-3-031-15080-7_34openalex-snapshot
Neurotrophic Therapy for ALS/MND
inferred← citeshttps://doi.org/10.1007/978-981-16-8158-5_14openalex-snapshot
Nanoceuticals as Theranostics Against Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1007/978-981-96-6202-9_1openalex-snapshot
Neurodegenerative Disorder: An Overview
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Advantages and Disadvantages of Current Therapeutics and Phytochemicals for Age-Related Brain Disorders
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inferred← citeshttps://doi.org/10.1007/s00415-021-10862-6openalex-snapshot
Influence of a clinical trial in the decision-making processes of patients with amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1007/s00415-022-11555-4openalex-snapshot
Physical activity as risk factor in amyotrophic lateral sclerosis: a systematic review and meta-analysis
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The safety and effectiveness of high-calorie therapy for treating amyotrophic lateral sclerosis: a systematic review and meta-analysis
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Impact of Limb Phenotype on Tongue Denervation Atrophy, Dysphagia Penetrance, and Survival Time in a Mouse Model of ALS
inferred← citeshttps://doi.org/10.1007/s10072-022-06518-6openalex-snapshot
The level of homocysteine in amyotrophic lateral sclerosis: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1007/s10072-025-08154-2openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10571-020-00993-1openalex-snapshot
Nerve Growth Factor is a Potential Treated Target in Tg(SOD1*G93A)1Gur Mice
inferred← citeshttps://doi.org/10.1007/s11011-023-01334-zopenalex-snapshot
Development of novel treatments for amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1007/s11030-024-10940-7openalex-snapshot
Recent developments in the design of functional derivatives of edaravone and exploration of their antioxidant activities
inferred← citeshttps://doi.org/10.1007/s11064-023-03973-1openalex-snapshot
Edaravone Dexborneol Alleviates Neuroinflammation by Reducing Neuroglial Cell Proliferation and Suppresses Neuronal Apoptosis/Autophagy in Vascular Dementia Rats
inferred← citeshttps://doi.org/10.1007/s11064-023-04085-6openalex-snapshot
The Role of IL-6 in Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.1007/s11094-024-03134-wopenalex-snapshot
Synthesis of New Conjugates of Edaravone and 1-Aminoadamantanes and Their Interaction with NMDA Receptors in Rats
inferred← citeshttps://doi.org/10.1007/s11172-021-3113-7openalex-snapshot
2-Propargylamino-6-(trifluoromethoxy)benzo[d]thiazoles in an alkyne-azide click reaction with pharmacologically active fragments
inferred← citeshttps://doi.org/10.1007/s11172-021-3176-5openalex-snapshot
Fluorinated γ-carbolines as a promising class of neuroprotective drugs
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Molecular design of multitarget neuroprotective agents 5. Modification with pharmacologically active fragments of 4,4- and 1,4-dipropargyl-5-methyl-2-phenylpyrazol-3-one
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New 1,1-dibenzyl-3-(1-benzyl-1H-pyrazol-4-yl)-2-methylisothioureas: synthesis and evaluation of antioxidant activity
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The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice
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Cyclophosphamide: a Therapeutic Option for Amyotrophic Lateral Sclerosis
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Drug Combination to Slow Down the Progression of Amyotrophic Lateral Sclerosis
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Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research
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The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis
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P2RX7 Dynamics in CNS Disorders: Molecular Insights and Therapeutic Perspectives
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Computational insight into in silico analysis and molecular dynamics simulation of the dimer interface residues of ALS-linked hSOD1 forms in apo/holo states: a combined experimental and bioinformatic perspective
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Amyotrophic Lateral Sclerosis as an Adverse Drug Reaction: A Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System
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The Role of Gut Microbiota-derived Short Chain Fatty Acids in Amyotrophic Lateral Sclerosis
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Comparison of Demographics: National Amyotrophic Lateral Sclerosis Registry and Clinical Trials Data
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A novel treatment for Parkinson's disease and ALS: Combined cell and gene therapies
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New opportunities for treatment of neurodegenerative disease through the modulation of TDP-43
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Neuroprotective effects of flavonoids
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An overview of neurodegenerative diseases
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Dysregulated mitochondrial Ca2+ and ROS signaling in skeletal muscle of ALS mouse model
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Multi-scale neural homeostasis mechanisms: Insights into neurodegenerative diseases and therapeutic approaches, including exercise
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Drug discovery and amyotrophic lateral sclerosis: Emerging challenges and therapeutic opportunities
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Leading individual features of antioxidant systematically classified by the ORAC assay and its single electron transfer and hydrogen atom transfer reactivities; analyzing ALS therapeutic drug Edaravone
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Regulation of ferroptosis in colorectal cancer through therapeutic modulation and miRNA targeting
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Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis
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Quercetin activates the Sestrin2/AMPK/SIRT1 axis to improve amyotrophic lateral sclerosis
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Identification of Riluzole derivatives as novel calmodulin inhibitors with neuroprotective activity by a joint synthesis, biosensor, and computational guided strategy
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117588openalex-snapshot
L-NRB alleviates amyotrophic lateral sclerosis by regulating P11-Htr4 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119761openalex-snapshot
FUS-driven zebrafish model of ALS identifies tribenzylamine as a candidate modulator of ALS-associated pathology
inferred← citeshttps://doi.org/10.1016/j.bmc.2026.118703openalex-snapshot
PROTACs for central nervous system disorders: challenges and opportunities
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Cell therapy in ALS: An update on preclinical and clinical studies
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Domain Contrast Network for cross-muscle ALS disease identification with EMG signal
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Neuromuscular Weakness in Intensive Care
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Targeting calciumopathy for neuroprotection: focus on calcium channels Cav1, Orai1 and P2X7
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Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.clinph.2022.02.020openalex-snapshot
The landscape of neurophysiological outcome measures in ALS interventional trials: A systematic review
inferred← citeshttps://doi.org/10.1016/j.compmedimag.2023.102279openalex-snapshot
SF2Former: Amyotrophic lateral sclerosis identification from multi-center MRI data using spatial and frequency fusion transformer
inferred← citeshttps://doi.org/10.1016/j.drudis.2025.104499openalex-snapshot
From matrix factorization to graph neural networks: Advances in computational drug repositioning
inferred← citeshttps://doi.org/10.1016/j.dscb.2022.100052openalex-snapshot
The effect of Riluzole on neurological outcomes, blood-brain barrier, brain water and neuroinflammation in traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.ebiom.2020.102980openalex-snapshot
Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114742openalex-snapshot
A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116496openalex-snapshot
Current therapy in amyotrophic lateral sclerosis (ALS): A review on past and future therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.117213openalex-snapshot
Design, synthesis and evaluation of pyrimidine derivatives as sedative-hypnotic agents
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.177187openalex-snapshot
Therapeutic targeting of the oxidative stress generated by pathological molecular pathways in the neurodegenerative diseases, ALS and Huntington's
inferred← citeshttps://doi.org/10.1016/j.exer.2025.110440openalex-snapshot
The effects of pigment epithelium-derived factor and associated peptides on the differentiation of retinal ganglion cells from human-induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.07.029openalex-snapshot
Cysteine 343 in the substrate binding domain is the primary S-Nitrosylated site in protein disulfide isomerase
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2024.03.016openalex-snapshot
Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2024.03.019openalex-snapshot
Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27944openalex-snapshot
Treatment gaps in the care of amyotrophic lateral sclerosis in the Philippines: A scoping review
inferred← citeshttps://doi.org/10.1016/j.ica.2021.120610openalex-snapshot
Arene-ruthenium(II) complexes with pyrazole-based ligands bearing a pyridine moiety: Synthesis, structure, DFT calculations, and cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.128308openalex-snapshot
Advances in microfluidic chips targeting toxic aggregation proteins for neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.injury.2019.12.030openalex-snapshot
Riluzole protects against skeletal muscle ischaemia-reperfusion injury in a porcine model
inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.06.001openalex-snapshot
Intranasal administration of edaravone nanoparticles improves its stability and brain bioavailability
inferred← citeshttps://doi.org/10.1016/j.jhsa.2023.03.023openalex-snapshot
Misdiagnosis in Amyotrophic Lateral Sclerosis
inferred← citeshttps://doi.org/10.1016/j.jics.2025.102113openalex-snapshot
Innovative valorization of ceramic waste by transforming it into high-performance heterogeneous catalysts for green and efficient benzothiazole derivatives synthesis
inferred← citeshttps://doi.org/10.1016/j.jocn.2024.02.011openalex-snapshot
Prognostic value of geriatric nutritional risk index in patients with amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.jot.2025.04.008openalex-snapshot
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function
inferred← citeshttps://doi.org/10.1016/j.lanwpc.2025.101684openalex-snapshot
Pan-Asian consortium for treatment and research in ALS (PACTALS) guidelines for management of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.120156openalex-snapshot
The panoramic view of amyotrophic lateral sclerosis: A fatal intricate neurological disorder
inferred← citeshttps://doi.org/10.1016/j.mcpro.2025.101017openalex-snapshot
Driving Therapeutic Innovation in Neurodegenerative Disease With Hydrogen Deuterium eXchange Mass Spectrometry
inferred← citeshttps://doi.org/10.1016/j.mgene.2021.100979openalex-snapshot
No association between GSTM1 and GSTT1 deletion polymorphisms and Amyotrophic Lateral Sclerosis: a genetic study in Brazilian patients
inferred← citeshttps://doi.org/10.1016/j.microc.2025.116220openalex-snapshot
The interplay of oxidative stress and neurodegeneration: Nanoantioxidants as a novel therapeutic approach
inferred← citeshttps://doi.org/10.1016/j.microc.2026.118421openalex-snapshot
A novel copper oxide–MWCNTs nanocomposite graphite sensor: the first synergistic and eco-friendly potentiometric platform for edaravone monitoring in human plasma
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101536openalex-snapshot
Pharmacological inhibition of ALCAT1 mitigates amyotrophic lateral sclerosis by attenuating SOD1 protein aggregation
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.137413openalex-snapshot
Synthesis and characterization of fullerene modified with copper nanoparticles catalyzed C H bond activation as a sustainable and green catalyst for electro synthesis of benzothiazole derivatives
inferred← citeshttps://doi.org/10.1016/j.mtadv.2026.100787openalex-snapshot
A carrier-free nanodrug based on the self-assembly of hydroxysafflor yellow A and ethyl ferulate for cerebral ischemia-reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.mtbio.2026.103259openalex-snapshot
Edaravone-based precision antioxidative therapy alleviates intervertebral disc degeneration via the Nrf2/Aldh3a1 axis
inferred← citeshttps://doi.org/10.1016/j.nbd.2019.104532openalex-snapshot
Modified age-dependent expression of NaV1.6 in an ALS model correlates with motor cortex excitability alterations
inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105315openalex-snapshot
ALS-causing SOD1 mutants regulate occludin phosphorylation/ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis
inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105480openalex-snapshot
Prolonged NCX activation prevents SOD1 accumulation, reduces neuroinflammation, ameliorates motor behavior and prolongs survival in a ALS mouse model
inferred← citeshttps://doi.org/10.1016/j.nbd.2021.105538openalex-snapshot
CXCR2 increases in ALS cortical neurons and its inhibition prevents motor neuron degeneration in vitro and improves neuromuscular function in SOD1G93A mice
inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105749openalex-snapshot
Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy
inferred← citeshttps://doi.org/10.1016/j.nbd.2024.106435openalex-snapshot
Communication defects with astroglia contribute to early impairments in the motor cortex plasticity of SOD1G93A mice
inferred← citeshttps://doi.org/10.1016/j.nbd.2024.106534openalex-snapshot
FUDNC1-dependent mitophagy ameliorate motor neuron death in an amyotrophic lateral sclerosis mouse model
inferred← citeshttps://doi.org/10.1016/j.nbd.2025.106987openalex-snapshot
TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.nbd.2026.107396openalex-snapshot
Elucidation of the influence of the CaV2.2 calcium channel on ALS disease progression in the SOD1*G93A mouse model
inferred← citeshttps://doi.org/10.1016/j.neuarg.2024.03.003openalex-snapshot
Disautonomía cardíaca parasimpática en pacientes con esclerosis lateral amiotrófica
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2023.105138openalex-snapshot
Swimming against ALS: How to model disease in zebrafish for pathophysiological and behavioral studies
inferred← citeshttps://doi.org/10.1016/j.neures.2026.105119openalex-snapshot
Anti-LAG-3 antibody treatment initiated after symptom onset extends survival in ALS model mice
inferred← citeshttps://doi.org/10.1016/j.neuro.2020.09.003openalex-snapshot
Amyotrophic lateral sclerosis and lead: A systematic update
inferred← citeshttps://doi.org/10.1016/j.neurol.2022.11.010openalex-snapshot
Retinal vessels as a window on amyotrophic lateral sclerosis pathophysiology: A systematic review
inferred← citeshttps://doi.org/10.1016/j.neurop.2021.11.005openalex-snapshot
Cell therapy as a treatment strategy in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2020.07.047openalex-snapshot
Genetic Inactivation of Cholinergic C Bouton Output Improves Motor Performance but not Survival in a Mouse Model of Amyotrophic Lateral Sclerosis
inferred← citeshttps://doi.org/10.1016/j.nrl.2022.07.003openalex-snapshot
A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients
inferred← citeshttps://doi.org/10.1016/j.nrleng.2022.07.003openalex-snapshot
A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients
inferred← citeshttps://doi.org/10.1016/j.pharmr.2025.100053openalex-snapshot
Activating autophagy to eliminate toxic protein aggregates with small molecules in neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.pharmr.2025.100101openalex-snapshot
Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action
inferred← citeshttps://doi.org/10.1016/j.phrs.2019.03.002openalex-snapshot
Novel function of VEGF-B as an antioxidant and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2024.102587openalex-snapshot
The multifaceted role of the CXC chemokines and receptors signaling axes in ALS pathophysiology
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2025.102734openalex-snapshot
Current amyloid inhibitors: Therapeutic applications and nanomaterial-based innovations
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2026.102891openalex-snapshot
ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – A new pharmacological target for Glu-related neurotoxicity
inferred← citeshttps://doi.org/10.1016/j.preme.2025.100022openalex-snapshot
Nanomedicines for the treatment of ischemic stroke: An overview of recent advances
inferred← citeshttps://doi.org/10.1016/j.sbi.2020.12.002openalex-snapshot
SOD1 oligomers in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.semcdb.2019.04.014openalex-snapshot
Functional microglia neurotransmitters in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1016/j.stem.2023.04.017openalex-snapshot
Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery
inferred← citeshttps://doi.org/10.1016/j.stemcr.2022.05.019openalex-snapshot
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1021/acs.biochem.1c00133openalex-snapshot
A pH Switch Controls Zinc Binding in Tomato Copper–Zinc Superoxide Dismutase
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.4c03109openalex-snapshot
Tandem Deacetalization–Knoevenagel Condensation Reactions for the Synthesis of Benzylidene Malononitrile Using Ruthenium(II) Cymene Complexes
inferred← citeshttps://doi.org/10.1021/acscatal.2c01924openalex-snapshot
Design and Application of Chiral Bifunctional 4-Pyrrolidinopyridines: Powerful Catalysts for Asymmetric Cycloaddition of Allylic N-Ylide
inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00717openalex-snapshot
Edaravone Improves Motor Dysfunction Following Brachial Plexus Avulsion Injury in Rats
inferred← citeshttps://doi.org/10.1021/acsnano.1c07205openalex-snapshot
Bioactive Nanoenzyme Reverses Oxidative Damage and Endoplasmic Reticulum Stress in Neurons under Ischemic Stroke
inferred← citeshttps://doi.org/10.1038/s41392-025-02179-xopenalex-snapshot
Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery
inferred← citeshttps://doi.org/10.1038/s41392-025-02549-5openalex-snapshot
p53: from understanding its structure to advances in therapeutic targeting
inferred← citeshttps://doi.org/10.1038/s41420-025-02302-5openalex-snapshot
Rapid iPSC-derived neuromuscular junction model uncovers motor neuron dominance in amyotrophic lateral sclerosis cytopathy
inferred← citeshttps://doi.org/10.1038/s41591-022-01956-3openalex-snapshot
Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial
inferred← citeshttps://doi.org/10.1038/s41598-020-69845-8openalex-snapshot
The alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patients
inferred← citeshttps://doi.org/10.1038/s41598-022-09332-4openalex-snapshot
NU-9 improves health of hSOD1G93A mouse upper motor neurons in vitro, especially in combination with riluzole or edaravone
inferred← citeshttps://doi.org/10.1038/s41598-022-15701-wopenalex-snapshot
SOD1 gains pro-oxidant activity upon aberrant oligomerization: change in enzymatic activity by intramolecular disulfide bond cleavage
inferred← citeshttps://doi.org/10.1038/s41598-023-47935-7openalex-snapshot
Accurate personalized survival prediction for amyotrophic lateral sclerosis patients
inferred← citeshttps://doi.org/10.1038/s42256-026-01263-3openalex-snapshot
A dexterous soft hand exoskeleton restores intentional grasping in individuals with severe hand impairment
inferred← citeshttps://doi.org/10.1039/d0md00328jopenalex-snapshot
Chemical modulation of Kv7 potassium channels
inferred← citeshttps://doi.org/10.1039/d4ra04281fopenalex-snapshot
Chemical composition and toxicity studies on Lantana camara L. flower essential oil and its in silico binding and pharmacokinetics to superoxide dismutase 1 for amyotrophic lateral sclerosis (ALS) therapy
inferred← citeshttps://doi.org/10.1039/d6nr00300aopenalex-snapshot
Targeting lipid nanoparticle mediated co-delivery of edaravone and kaempferol for amyotrophic lateral sclerosis therapy
inferred← citeshttps://doi.org/10.1080/01616412.2025.2553147openalex-snapshot
Impacts of oral supplementation of vitamin B12 and plasma levels of homocysteine on progression and survival in a Chinese ALS cohort
inferred← citeshttps://doi.org/10.1080/13543784.2023.2252738openalex-snapshot
CNM-Au8: an experimental agent for the treatment of amyotrophic lateral sclerosis (ALS)
inferred← citeshttps://doi.org/10.1080/14656566.2020.1746270openalex-snapshot
Advances in disease-modifying pharmacotherapies for the treatment of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1080/14740338.2025.2470874openalex-snapshot
Safety of edaravone in real-world use: analysis based on FDA adverse event reporting system
inferred← citeshttps://doi.org/10.1080/17460441.2026.2619067openalex-snapshot
The preclinical discovery and development of edaravone for the treatment of amyotrophic lateral sclerosis: what lessons have we learnt?
inferred← citeshttps://doi.org/10.1080/17582024.2024.2344396openalex-snapshot
Bone marrow mesenchymal stem cell-derived extracellular vesicle infusion for amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1080/21678421.2020.1771734openalex-snapshot
Real-world evidence of riluzole effectiveness in treating amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1080/21678421.2021.1936063openalex-snapshot
Tailoring patients’ enrollment in ALS clinical trials: the effect of disease duration and vital capacity cutoffs
inferred← citeshttps://doi.org/10.1080/21678421.2023.2278503openalex-snapshot
Amyotrophic lateral sclerosis: exploring pathophysiology in the context of treatment
inferred← citeshttps://doi.org/10.1080/21678421.2024.2447922openalex-snapshot
Association of UNC13A with increased amyotrophic lateral sclerosis risk, bulbar onset, and lower motor neuron involvement in a Norwegian ALS cohort
inferred← citeshttps://doi.org/10.1083/jcb.202002179openalex-snapshot
Mitochondria as intracellular signaling platforms in health and disease
inferred← citeshttps://doi.org/10.1089/ten.tec.2020.0337openalex-snapshot
Advances in Central Nervous System Organoids: A Focus on Organoid-Based Models for Motor Neuron Disease
inferred← citeshttps://doi.org/10.1093/bfgp/elac017openalex-snapshot
Multiomics technologies: role in disease biomarker discoveries and therapeutics
inferred← citeshttps://doi.org/10.1093/brain/awac306openalex-snapshot
Maiden voyage: induced pluripotent stem cell-based drug screening for amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1093/hmg/ddaa140openalex-snapshot
Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models
inferred← citeshttps://doi.org/10.1093/hmg/ddac116openalex-snapshot
Genetic and pharmacological PARP inhibition reduces axonal degeneration in C. elegans models of ALS
inferred← citeshttps://doi.org/10.1093/med/9780197537855.003.0025openalex-snapshot
Amyotrophic Lateral Sclerosis and Neurologic Disease
inferred← citeshttps://doi.org/10.1093/nar/gkae473openalex-snapshot
Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD
inferred← citeshttps://doi.org/10.1093/oxfordhb/9780190686307.013.25openalex-snapshot
RNA-Binding Proteins and Translation in Neurodegenerative Disease
inferred← citeshttps://doi.org/10.1093/stcltm/szad095openalex-snapshot
Optimal Therapeutic Strategy of Bone Marrow-Originated Autologous Mesenchymal Stromal/Stem Cells for ALS
inferred← citeshttps://doi.org/10.1097/md.0000000000021933openalex-snapshot
The efficacy and safety of Chinese herbal compound combined with western medicine for amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1097/md.0000000000026751openalex-snapshot
Relationship between statins and the risk of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1097/md.0000000000031446openalex-snapshot
Herbal medicine and acupuncture relieved progressive bulbar palsy for more than 3 years: A case report
inferred← citeshttps://doi.org/10.1097/shk.0000000000002374openalex-snapshot
INFLUENCES OF HEAT STRESS ON GLUTAMATE TRANSMISSION-DEPENDENT EXPRESSION LEVELS OF IL-1β and IL-18 IN BV-2 MICROGLIAL CELLS
inferred← citeshttps://doi.org/10.1101/2022.11.02.514252openalex-snapshot
Pharmacological Modulation of Autophagy Prevents Mutant SOD1 G93A Induced Neurotoxicity in Experimental Models of Amyotrophic Lateral Sclerosis (ALS)
inferred← citeshttps://doi.org/10.1101/2025.01.22.634350openalex-snapshot
AAV-Delivered Anti-PC-OxPL Antibody Fragments: A Novel Therapeutic Approach to Target ALS
inferred← citeshttps://doi.org/10.1101/2025.03.06.641147openalex-snapshot
Artificial intelligence-augmented drug discovery identifies gefitinib as a potential treatment for ALS
inferred← citeshttps://doi.org/10.1107/s2059798323003649openalex-snapshot
Structure-based discovery of an antipsychotic drug, paliperidone, as a modulator of human superoxide dismutase 1: a potential therapeutic target in amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1109/itme60234.2023.00117openalex-snapshot
Research hotspots analysis of Edaravone by PubMed
inferred← citeshttps://doi.org/10.1111/ane.13698openalex-snapshot
Blood biomarkers in ALS : challenges, applications and novel frontiers
inferred← citeshttps://doi.org/10.1111/bph.15221openalex-snapshot
Protein kinase inhibitors for amyotrophic lateral sclerosis therapy
inferred← citeshttps://doi.org/10.1111/cns.13637openalex-snapshot
A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice
inferred← citeshttps://doi.org/10.1111/jnc.15289openalex-snapshot
Neuromuscular junction‐on‐a‐chip: ALS disease modeling and read‐out development in microfluidic devices
inferred← citeshttps://doi.org/10.1111/jnc.16005openalex-snapshot
Induced pluripotent stem cells‐based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1111/jnc.70146openalex-snapshot
Astrocytes Contribute to Motor Neuron Degeneration in ALS via the TRAIL ‐ DR5 Signaling Pathway
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