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Microtubule‐targeting agents for cancer treatment: Seven binding sites and three strategies
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inferredcites →https://doi.org/10.1016/j.bbrc.2009.08.009openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.bbrc.2019.02.064openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.bbrc.2021.05.071openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.bioorg.2022.105848openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.bioorg.2022.105915openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.bmcl.2019.05.042openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ddtec.2019.01.002openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.devcel.2018.08.014openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ejmech.2011.02.011openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ejmech.2014.09.051openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ejmech.2019.111583openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.isci.2020.101511openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.jacep.2023.02.003openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.jmb.2016.06.023openalex-snapshot
Pironetin Binds Covalently to αCys316 and Perturbs a Major Loop and Helix of α-Tubulin to Inhibit Microtubule Formation
inferredcites →https://doi.org/10.1016/j.jmb.2017.01.001openalex-snapshot
Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures
inferredcites →https://doi.org/10.1016/j.kjms.2015.12.006openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.molmed.2007.07.001openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.semarthrit.2015.06.013openalex-snapshot
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Microtubule and tubulin binding and regulation of microtubule dynamics by the antibody drug conjugate (ADC) payload, monomethyl auristatin E (MMAE): Mechanistic insights into MMAE ADC peripheral neuropathy
inferredcites →https://doi.org/10.1016/j.tcb.2015.08.009openalex-snapshot
Regulation of Microtubule Growth and Catastrophe: Unifying Theory and Experiment
inferredcites →https://doi.org/10.1016/j.tcb.2018.05.001openalex-snapshot
Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton
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Microtubule-Associated Proteins: Structuring the Cytoskeleton
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Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond
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inferredcites →https://doi.org/10.1021/acs.orglett.5b02262openalex-snapshot
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inferredcites →https://doi.org/10.1021/acsmedchemlett.6b00195openalex-snapshot
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inferredcites →https://doi.org/10.1021/bi00031a014openalex-snapshot
Kinetic Stabilization of Microtubule Dynamics at Steady State in Vitro by Substoichiometric Concentrations of Tubulin-Colchicine Complex
inferredcites →https://doi.org/10.1021/bi00514a041openalex-snapshot
Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins
inferredcites →https://doi.org/10.1021/ja00738a045openalex-snapshot
Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
inferredcites →https://doi.org/10.1021/ja00759a054openalex-snapshot
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In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and SBTub2M
inferredcites →https://doi.org/10.1021/jo00250a053openalex-snapshot
Laulimalides. New potent cytotoxic macrolides from a marine sponge and a nudibranch predator
inferredcites →https://doi.org/10.1021/jo991296yopenalex-snapshot
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inferredcites →https://doi.org/10.1023/a:1006075007857openalex-snapshot
Inhibition of apoptotic signaling pathways in cancer cells as a mechanism of chemotherapy resistance
inferredcites →https://doi.org/10.1038/34465openalex-snapshot
Structure of the αβ tubulin dimer by electron crystallography
inferredcites →https://doi.org/10.1038/embor.2008.171openalex-snapshot
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inferredcites →https://doi.org/10.1038/jid.2008.37openalex-snapshot
Microtubule-Targeted Drugs Inhibit VEGF Receptor-2 Expression by both Transcriptional and Post-Transcriptional Mechanisms
inferredcites →https://doi.org/10.1038/nature02393openalex-snapshot
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inferredcites →https://doi.org/10.1038/nature03566openalex-snapshot
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inferredcites →https://doi.org/10.1038/ncomms12103openalex-snapshot
Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule
inferredcites →https://doi.org/10.1038/ncomms15286openalex-snapshot
Kinesin-5-independent mitotic spindle assembly requires the antiparallel microtubule crosslinker Ase1 in fission yeast
inferredcites →https://doi.org/10.1038/nrc1317openalex-snapshot
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inferredcites →https://doi.org/10.1038/nrd3253openalex-snapshot
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inferredcites →https://doi.org/10.1038/s41388-020-1336-yopenalex-snapshot
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inferredcites →https://doi.org/10.1038/s41392-022-00947-7openalex-snapshot
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inferredcites →https://doi.org/10.1038/s41392-022-00966-4openalex-snapshot
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inferredcites →https://doi.org/10.1038/s41467-020-18389-6openalex-snapshot
Photoswitchable paclitaxel-based microtubule stabilisers allow optical control over the microtubule cytoskeleton
inferredcites →https://doi.org/10.1038/s41571-023-00736-3openalex-snapshot
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inferredcites →https://doi.org/10.1038/s41573-021-00371-6openalex-snapshot
PROTAC targeted protein degraders: the past is prologue
inferredcites →https://doi.org/10.1038/s41580-018-0009-yopenalex-snapshot
Microtubule dynamics: an interplay of biochemistry and mechanics
inferredcites →https://doi.org/10.1038/s41580-020-0214-3openalex-snapshot
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inferredcites →https://doi.org/10.1038/s41580-021-00399-xopenalex-snapshot
Regulation of microtubule dynamics, mechanics and function through the growing tip
inferredcites →https://doi.org/10.1039/c5ob02005kopenalex-snapshot
Photoswitchable anticancer activity via trans–cis isomerization of a combretastatin A-4 analog
inferredcites →https://doi.org/10.1039/d1cb00011jopenalex-snapshot
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inferredcites →https://doi.org/10.1056/nejmoa1209124openalex-snapshot
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inferredcites →https://doi.org/10.1056/nejmoa1814017openalex-snapshot
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inferredcites →https://doi.org/10.1056/nejmoa2112435openalex-snapshot
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inferredcites →https://doi.org/10.1056/nejmoa2206125openalex-snapshot
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inferredcites →https://doi.org/10.1073/pnas.1408124111openalex-snapshot
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
inferredcites →https://doi.org/10.1073/pnas.1416418112openalex-snapshot
Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins
inferredcites →https://doi.org/10.1073/pnas.2001546117openalex-snapshot
Dynamic and asymmetric fluctuations in the microtubule wall captured by high-resolution cryoelectron microscopy
inferredcites →https://doi.org/10.1073/pnas.2021847118openalex-snapshot
Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site
inferredcites →https://doi.org/10.1073/pnas.2114994119openalex-snapshot
Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules
inferredcites →https://doi.org/10.1073/pnas.94.18.9679openalex-snapshot
p53-independent apoptosis induced by paclitaxel through an indirect mechanism
inferredcites →https://doi.org/10.1073/pnas.95.16.9313openalex-snapshot
Antiproliferative mechanism of action of cryptophycin-52: Kinetic stabilization of microtubule dynamics by high-affinity binding to microtubule ends
inferredcites →https://doi.org/10.1074/jbc.273.9.4928openalex-snapshot
Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways
inferredcites →https://doi.org/10.1074/jbc.m113.496844openalex-snapshot
Growth Arrest by the Antitumor Steroidal Lactone Withaferin A in Human Breast Cancer Cells Is Associated with Down-regulation and Covalent Binding at Cysteine 303 of β-Tubulin
inferredcites →https://doi.org/10.1074/jbc.m901789200openalex-snapshot
Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by Proteasomes
inferredcites →https://doi.org/10.1074/jbc.ra118.006325openalex-snapshot
Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation
inferredcites →https://doi.org/10.1074/jbc.ra119.010732openalex-snapshot
Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity
inferredcites →https://doi.org/10.1080/02652048.2023.2188943openalex-snapshot
Co-delivery of paclitaxel and etoposide prodrug by human serum albumin and PLGA nanoparticles: synergistic cytotoxicity in brain tumour cells
inferredcites →https://doi.org/10.1080/07391102.2020.1745689openalex-snapshot
Exploring the interaction of Peloruside-A with drug resistant αβII and αβIII tubulin isotypes in human ovarian carcinoma using a molecular modeling approach
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Vinflunine for the treatment of breast cancer
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Strategies for the drug discovery and development of taxane anticancer therapeutics
inferredcites →https://doi.org/10.1083/jcb.59.2.267openalex-snapshot
MICROTUBULES: EVIDENCE FOR 13 PROTOFILAMENTS
inferredcites →https://doi.org/10.1093/abt/tbz009openalex-snapshot
Dual-mechanistic antibody-drug conjugate via site-specific selenocysteine/cysteine conjugation
inferredcites →https://doi.org/10.1093/annonc/mdw424openalex-snapshot
Antibody drug conjugates: lessons from 20 years of clinical experience
inferredcites →https://doi.org/10.1097/cad.0000000000000464openalex-snapshot
Potential anticancer role of colchicine-based derivatives
inferredcites →https://doi.org/10.1101/cshperspect.a022608openalex-snapshot
Microtubules and Microtubule-Associated Proteins
inferredcites →https://doi.org/10.1101/gad.196147.112openalex-snapshot
Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells
inferredcites →https://doi.org/10.1111/bcp.13126openalex-snapshot
Microtubule destabilising agents: far more than just antimitotic anticancer drugs
inferredcites →https://doi.org/10.1111/boc.201300054openalex-snapshot
Mechanism and regulation of kinesin‐5, an essential motor for the mitotic spindle
inferredcites →https://doi.org/10.1111/febs.13555openalex-snapshot
Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery
inferredcites →https://doi.org/10.1124/mol.106.027847openalex-snapshot
Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly
inferredcites →https://doi.org/10.1126/sciadv.abg4168openalex-snapshot
Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect
inferredcites →https://doi.org/10.1126/science.1230582openalex-snapshot
Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
inferredcites →https://doi.org/10.1136/ard.13.3.190openalex-snapshot
History of the Use of Colchicum and related Medicaments in Gout
inferredcites →https://doi.org/10.1155/2018/8956072openalex-snapshot
Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma
inferredcites →https://doi.org/10.1155/2022/1623181openalex-snapshot
Microtubule Organization Is Essential for Maintaining Cellular Morphology and Function
inferredcites →https://doi.org/10.1158/0008-5472.can-04-0771openalex-snapshot
Peloruside A Does Not Bind to the Taxoid Site on β-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines
inferredcites →https://doi.org/10.1158/0008-5472.can-12-3256openalex-snapshot
Cytotoxic Activity of Tivantinib (ARQ 197) Is Not Due Solely to c-MET Inhibition
inferredcites →https://doi.org/10.1158/0008-5472.can-15-1313openalex-snapshot
Enfortumab Vedotin Antibody–Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-0488openalex-snapshot
Brentuximab Vedotin (SGN-35)
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0614openalex-snapshot
βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0791openalex-snapshot
Targeting Microtubules by Natural Agents for Cancer Therapy
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Regulation of Class II β-Tubulin Expression by Tumor Suppressor p53 Protein in Mouse Melanoma Cells in Response toVincaAlkaloid
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Colchicine in Cardiovascular Disease: In-Depth Review.
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Microtubules: Evolving roles and critical cellular interactions
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