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Harnessing monocyte‐derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cne.21252openalex-snapshotMacrophage depletion in the murine olfactory epithelium leads to increased neuronal death and decreased neurogenesis
inferredcites →https://doi.org/10.1002/glia.20616openalex-snapshotIn vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia
inferredcites →https://doi.org/10.1002/stem.659openalex-snapshotCombined Effects of Hematopoietic Progenitor Cell Mobilization from Bone Marrow by Granulocyte Colony Stimulating Factor and AMD3100 and Chemotaxis into the Brain Using Stromal Cell‐Derived Factor‐1α in an Alzheimer's Disease Mouse Model
inferredcites →https://doi.org/10.1006/exnr.1999.7118openalex-snapshotDepletion of Hematogenous Macrophages Promotes Partial Hindlimb Recovery and Neuroanatomical Repair after Experimental Spinal Cord Injury
inferredcites →https://doi.org/10.1016/j.jneuroim.2004.08.011openalex-snapshotMinocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination
inferredcites →https://doi.org/10.1016/j.nbd.2006.12.013openalex-snapshotTherapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS
inferredcites →https://doi.org/10.1038/nm1474openalex-snapshotLEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
inferredcites →https://doi.org/10.1038/nm1555openalex-snapshotCcr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
inferredcites →https://doi.org/10.1038/nn.2432openalex-snapshotFormation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
inferredcites →https://doi.org/10.1038/nn.2887openalex-snapshotInfiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
inferredcites →https://doi.org/10.1038/nn1629openalex-snapshotImmune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
inferredcites →https://doi.org/10.1038/nn1701openalex-snapshotOncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
inferredcites →https://doi.org/10.1038/nn1997openalex-snapshotMicroglia: active sensor and versatile effector cells in the normal and pathologic brain
inferredcites →https://doi.org/10.1038/sc.2012.39openalex-snapshotAutologous incubated macrophage therapy in acute, complete spinal cord injury: results of the phase 2 randomized controlled multicenter trial
inferredcites →https://doi.org/10.1073/pnas.0408258102openalex-snapshotDirected migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway
inferredcites →https://doi.org/10.1073/pnas.0604681103openalex-snapshotGlatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
inferredcites →https://doi.org/10.1073/pnas.0812183106openalex-snapshotGlatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis
inferredcites →https://doi.org/10.1084/jem.193.6.713openalex-snapshotAbsence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis
inferredcites →https://doi.org/10.1084/jem.20101202openalex-snapshotNeuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages
inferredcites →https://doi.org/10.1093/brain/awr339openalex-snapshotTransplanted neural stem/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord
inferredcites →https://doi.org/10.1093/jnen/60.7.676openalex-snapshotBone Marrow Chimeric Rats Reveal the Unique Distribution of Resident and Recruited Macrophages in the Contused Rat Spinal Cord
inferredcites →https://doi.org/10.1096/fj.09-141754openalex-snapshotMassive gliosis induced by interleukin‐6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
inferredcites →https://doi.org/10.1172/jci26836openalex-snapshotInduction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis
inferredcites →https://doi.org/10.1172/jci31450openalex-snapshotSustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
inferredcites →https://doi.org/10.1172/jci37914openalex-snapshotAdult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis
inferredcites →https://doi.org/10.1172/jci59145openalex-snapshotInflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosis
inferredcites →https://doi.org/10.1177/1352458510379243openalex-snapshotAltered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
inferredcites →https://doi.org/10.1186/1742-2094-2-23openalex-snapshotEarly correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice
inferredcites →https://doi.org/10.1189/jlb.68.3.413openalex-snapshotMononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia
inferredcites →https://doi.org/10.1371/journal.pone.0019439openalex-snapshotHIV-1-Infected and Immune-Activated Macrophages Induce Astrocytic Differentiation of Human Cortical Neural Progenitor Cells via the STAT3 Pathway
inferredcites →https://doi.org/10.1371/journal.pone.0026921openalex-snapshotExcess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis
inferredcites →https://doi.org/10.1523/jneurosci.1418-07.2007openalex-snapshotChronic Interleukin-1β Expression in Mouse Brain Leads to Leukocyte Infiltration and Neutrophil-Independent Blood–Brain Barrier Permeability without Overt Neurodegeneration
inferredcites →https://doi.org/10.1634/stemcells.2006-0807openalex-snapshotComplete Spinal Cord Injury Treatment Using Autologous Bone Marrow Cell Transplantation and Bone Marrow Stimulation with Granulocyte Macrophage-Colony Stimulating Factor: Phase I/II Clinical Trial
inferredcites →https://doi.org/10.3109/17482960902803432openalex-snapshotGlatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial
inferredcites →https://doi.org/10.4049/jimmunol.0804247openalex-snapshotSialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression
inferredcites →https://doi.org/10.4049/jimmunol.1103608openalex-snapshotActivation of Invariant NKT Cells in Early Phase of Experimental Autoimmune Encephalomyelitis Results in Differentiation of Ly6Chi Inflammatory Monocyte to M2 Macrophages and Improved Outcome
inferredcites →https://doi.org/10.4049/jimmunol.161.7.3767openalex-snapshotImmune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4652512openalex-extractedIntegrating Mendelian Randomization and Single-Cell Analysis to Elucidate the Role of Intermediate Monocytes in Multiple Sclerosis
inferred← citeshttps://doi.org/10.1002/glia.22796openalex-snapshotCSF ‐1‐activated macrophages are target‐directed and essential mediators of schwann cell dedifferentiation and dysfunction in C x32‐deficient mice
inferred← citeshttps://doi.org/10.1002/glia.23041openalex-snapshotIL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury
inferred← citeshttps://doi.org/10.1002/jnr.23309openalex-snapshotIntravenous infusion of nerve growth factor‐secreting monocytes supports the survival of cholinergic neurons in the nucleus basalis of meynert in hypercholesterolemia brown‐norway rats
inferred← citeshttps://doi.org/10.1002/mabi.201500150openalex-snapshotFluorescent Phosphorus Dendrimer as a Spectral Nanosensor for Macrophage Polarization and Fate Tracking in Spinal Cord Injury
inferred← citeshttps://doi.org/10.1002/sctm.19-0327openalex-snapshotIntranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/term.2188openalex-snapshotImmune remodelling of stromal cell grafts in the central nervous system: therapeutic inflammation or (harmless) side-effect?
inferred← citeshttps://doi.org/10.1007/s12035-014-8934-zopenalex-snapshotMyeloid-Specific Blockade of Notch Signaling by RBP-J Knockout Attenuates Spinal Cord Injury Accompanied by Compromised Inflammation Response in Mice
inferred← citeshttps://doi.org/10.1007/s12035-016-9723-7openalex-snapshotLentiviral-Mediated Netrin-1 Overexpression Improves Motor and Sensory Functions in SCT Rats Associated with SYP and GAP-43 Expressions
inferred← citeshttps://doi.org/10.1007/s13311-013-0254-xopenalex-snapshotProgrammed Death 1 Deficiency Induces the Polarization of Macrophages/Microglia to the M1 Phenotype After Spinal Cord Injury in Mice
inferred← citeshttps://doi.org/10.1016/j.bbi.2014.10.015openalex-snapshotAlterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10
inferred← citeshttps://doi.org/10.1016/j.bbi.2021.10.007openalex-snapshotAntibiotic-induced gut dysbiosis leads to activation of microglia and impairment of cholinergic gamma oscillations in the hippocampus
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.06.018openalex-snapshotROS-responsive biomimetic nanosystem camouflaged by hybrid membranes of platelet-exosomes engineered with neuronal targeting peptide for TBI therapy
inferred← citeshttps://doi.org/10.1016/j.jcyt.2020.03.002openalex-snapshotTransplantation of activated olfactory ensheathing cells by curcumin strengthens regeneration and recovery of function after spinal cord injury in rats
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2014.09.014openalex-snapshotRNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course
inferred← citeshttps://doi.org/10.1021/nn4036014openalex-snapshotSelective Nanovector Mediated Treatment of Activated Proinflammatory Microglia/Macrophages in Spinal Cord Injury
inferred← citeshttps://doi.org/10.1038/ncomms15062openalex-snapshotLow-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior
inferred← citeshttps://doi.org/10.1038/s41598-021-91698-yopenalex-snapshotCystine–glutamate antiporter deletion accelerates motor recovery and improves histological outcomes following spinal cord injury in mice
inferred← citeshttps://doi.org/10.1089/neu.2021.0464openalex-snapshotExosome-Shuttled miR-672-5p from Anti-Inflammatory Microglia Repair Traumatic Spinal Cord Injury by Inhibiting AIM2/ASC/Caspase-1 Signaling Pathway Mediated Neuronal Pyroptosis
inferred← citeshttps://doi.org/10.1093/brain/awv289openalex-snapshotRetinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination
inferred← citeshttps://doi.org/10.1093/brain/aww017openalex-snapshotEarly and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging
inferred← citeshttps://doi.org/10.1111/cns.14903openalex-snapshotFucoidan improving spinal cord injury recovery: Modulating microenvironment and promoting remyelination
inferred← citeshttps://doi.org/10.1111/imm.12156openalex-snapshotThe impact of neuroimmune changes on development of amyloid pathology; relevance to A lzheimer's disease
inferred← citeshttps://doi.org/10.1111/pim.12173openalex-snapshotPersistence of Toxoplasma gondii in the central nervous system: a fine‐tuned balance between the parasite, the brain and the immune system
inferred← citeshttps://doi.org/10.1111/sji.12162openalex-snapshotAn optimized Protocol for Human M2 Macrophages using M‐ CSF and IL ‐4/ IL ‐10/ TGF ‐β Yields a Dominant Immunosuppressive Phenotype
inferred← citeshttps://doi.org/10.1167/iovs.13-12237openalex-snapshotCD11b+GR1+ Myeloid Cells Secrete NGF and Promote Trigeminal Ganglion Neurite Growth: Implications for Corneal Nerve Regeneration
inferred← citeshttps://doi.org/10.1177/2055217315583385openalex-snapshotSafety, tolerability and pharmacodynamics of a novel immunomodulator, MIS416, in patients with chronic progressive multiple sclerosis
inferred← citeshttps://doi.org/10.1186/s12951-024-02529-xopenalex-snapshotHigh-density lipoprotein mimetic nano-therapeutics targeting monocytes and macrophages for improved cardiovascular care: a comprehensive review
inferred← citeshttps://doi.org/10.1186/s12974-016-0756-7openalex-snapshotIntracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model
inferred← citeshttps://doi.org/10.1186/s12974-018-1212-7openalex-snapshotTargeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke
inferred← citeshttps://doi.org/10.1242/dmm.014886openalex-snapshotIntravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation
inferred← citeshttps://doi.org/10.1523/jneurosci.3644-14.2015openalex-snapshotImmunization with a Myelin-Derived Antigen Activates the Brain's Choroid Plexus for Recruitment of Immunoregulatory Cells to the CNS and Attenuates Disease Progression in a Mouse Model of ALS
inferred← citeshttps://doi.org/10.18002/10612/6774openalex-snapshotEdad y respuesta a las proteínas mal plegadas en el accidente cerebro vascular. El efecto de la edad = Age and unfolded protein response enhancement in stroke-induced inflammation
inferred← citeshttps://doi.org/10.2217/rme.13.73openalex-snapshotDissecting the Damaging Versus Regenerative Roles of CNS Macrophages: Implications for the Use of Immunomodulatory Therapeutics
inferred← citeshttps://doi.org/10.3389/fncel.2018.00507openalex-snapshotTransplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery
inferred← citeshttps://doi.org/10.3389/fpubh.2021.664748openalex-snapshotMultifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy
inferred← citeshttps://doi.org/10.3390/ijms24065176openalex-snapshotMycobacterium vaccae NCTC 11659, a Soil-Derived Bacterium with Stress Resilience Properties, Modulates the Proinflammatory Effects of LPS in Macrophages
inferred← citeshttps://doi.org/10.3390/ijms241310971openalex-snapshotCo-Administration of Resolvin D1 and Peripheral Nerve-Derived Stem Cell Spheroids as a Therapeutic Strategy in a Rat Model of Spinal Cord Injury
inferred← citeshttps://doi.org/10.3390/jpm12111817openalex-snapshotImmunosenescence and Aging: Neuroinflammation Is a Prominent Feature of Alzheimer’s Disease and Is a Likely Contributor to Neurodegenerative Disease Pathogenesis
inferred← citeshttps://doi.org/10.4049/jimmunol.1900844openalex-snapshotA 20-Year Journey from Axonal Injury to Neurodegenerative Diseases and the Prospect of Immunotherapy for Combating Alzheimer’s Disease
inferred← citeshttps://doi.org/10.4103/1673-5374.235302openalex-snapshotLocal inhibition of matrix metalloproteinases reduced M2 macrophage activity and impeded recovery in spinal cord transected rats after treatment with fibroblast growth factor-1 and nerve grafts
inferred← citeshttps://doi.org/10.6084/m9.figshare.12211940openalex-snapshotAdditional file 1 of LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3
inferred← citeshttps://doi.org/10.6084/m9.figshare.12211949openalex-snapshotAdditional file 2 of LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3
inferred← citeshttps://doi.org/10.6084/m9.figshare.12211955openalex-snapshotAdditional file 3 of LncGBP9/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1/STAT6 and SOCS3
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