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Aurantio‐obtusin improves obesity and insulin resistance induced by high‐fat diet in obese mice

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/pca.1331openalex-snapshot
Simultaneous Determination of Eight Anthraquinones in Semen Cassiae by HPLC‐DAD
inferredcites →https://doi.org/10.1016/0300-9084(91)90078-fopenalex-snapshot
New insights into the mitochondrial carnitine palmitoyltransferase enzyme system
inferredcites →https://doi.org/10.1016/j.bbadis.2017.08.012openalex-snapshot
Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3 T3-L1 adipocytes
inferredcites →https://doi.org/10.1016/j.bbagen.2012.10.016openalex-snapshot
Insulin sensitization via partial agonism of PPARγ and glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway by embelin in type 2 diabetic rats
inferredcites →https://doi.org/10.1016/j.bbi.2013.10.004openalex-snapshot
Glucocorticoid inhibition of leptin- and lipopolysaccharide-induced interleukin-6 production in obesity
inferredcites →https://doi.org/10.1016/j.bbrc.2016.04.066openalex-snapshot
Prolonged exposure to insulin with insufficient glucose leads to impaired Glut4 translocation
inferredcites →https://doi.org/10.1016/j.cell.2015.01.012openalex-snapshot
Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes
inferredcites →https://doi.org/10.1016/j.cmet.2011.10.011openalex-snapshot
The Inflammasome Puts Obesity in the Danger Zone
inferredcites →https://doi.org/10.1016/j.cmet.2012.03.004openalex-snapshot
The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
inferredcites →https://doi.org/10.1016/j.cmet.2012.04.001openalex-snapshot
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
inferredcites →https://doi.org/10.1016/j.cmet.2016.04.022openalex-snapshot
Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production
inferredcites →https://doi.org/10.1016/j.cyto.2012.06.018openalex-snapshot
Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes
inferredcites →https://doi.org/10.1016/j.foodchem.2012.09.017openalex-snapshot
Reduction of lipid accumulation in white adipose tissues by Cassia tora (Leguminosae) seed extract is associated with AMPK activation
inferredcites →https://doi.org/10.1016/j.jep.2012.06.050openalex-snapshot
MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model
inferredcites →https://doi.org/10.1016/j.nutres.2018.04.020openalex-snapshot
Vernonia cinerea water extract improves insulin resistance in high-fat diet–induced obese mice
inferredcites →https://doi.org/10.1016/j.phymed.2018.03.004openalex-snapshot
Determination of quality markers of Xuezhiling tablet for hyperlipidemia treatment
inferredcites →https://doi.org/10.1016/j.tem.2011.10.004openalex-snapshot
SREBPs: metabolic integrators in physiology and metabolism
inferredcites →https://doi.org/10.1016/s0031-9422(98)00325-2openalex-snapshot
Anthraquinones from hairy root cultures of Cassia obtusifolia
inferredcites →https://doi.org/10.1021/jf049379popenalex-snapshot
Anthraquinones Isolated from Cassia tora (Leguminosae) Seed Show an Antifungal Property against Phytopathogenic Fungi
inferredcites →https://doi.org/10.1038/nature05482openalex-snapshot
Mechanisms linking obesity to insulin resistance and type 2 diabetes
inferredcites →https://doi.org/10.1038/nm.4350openalex-snapshot
Insulin action and resistance in obesity and type 2 diabetes
inferredcites →https://doi.org/10.1038/nm1185openalex-snapshot
IKK-β links inflammation to obesity-induced insulin resistance
inferredcites →https://doi.org/10.1038/sj.ijo.0802641openalex-snapshot
Conjugated linoleic acid and obesity control: efficacy and mechanisms
inferredcites →https://doi.org/10.1056/nejmoa0706628openalex-snapshot
Effects of Torcetrapib in Patients at High Risk for Coronary Events
inferredcites →https://doi.org/10.1073/pnas.0306743102openalex-snapshot
Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
inferredcites →https://doi.org/10.1079/bjn20041213openalex-snapshot
Adipokines: inflammation and the pleiotropic role of white adipose tissue
inferredcites →https://doi.org/10.1097/mol.0b013e3282ff5e55openalex-snapshot
Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1097/mol.0b013e32832b2024openalex-snapshot
Dissecting the role of insulin resistance in the metabolic syndrome
inferredcites →https://doi.org/10.1101/gad.14.11.1293openalex-snapshot
Transcriptional regulation of adipogenesis
inferredcites →https://doi.org/10.1136/jim-2017-000535openalex-snapshot
Adipose Tissue Inflammation in Insulin Resistance: Review of Mechanisms Mediating Anti-Inflammatory Effects of Omega-3 Polyunsaturated Fatty Acids
inferredcites →https://doi.org/10.1155/2010/612089openalex-snapshot
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
inferredcites →https://doi.org/10.1155/2014/653017openalex-snapshot
PPARs Integrate the Mammalian Clock and Energy Metabolism
inferredcites →https://doi.org/10.1155/2014/832606openalex-snapshot
PPARs and Metabolic Syndrome
inferredcites →https://doi.org/10.1161/atvbaha.117.310587openalex-snapshot
High-Density Lipoprotein Cholesterol and Mortality
inferredcites →https://doi.org/10.1161/atvbaha.118.310727openalex-snapshot
Is It Time for New Thinking About High-Density Lipoprotein?
inferredcites →https://doi.org/10.1172/jci14120openalex-snapshot
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
inferredcites →https://doi.org/10.1172/jci26498openalex-snapshot
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
inferredcites →https://doi.org/10.1172/jci29126openalex-snapshot
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
inferredcites →https://doi.org/10.1177/0960327114561663openalex-snapshot
Glucose uptake through translocation and activation of GLUT4 in PI3K/Akt signaling pathway by asiatic acid in diabetic rats
inferredcites →https://doi.org/10.1194/jlr.m400373-jlr200openalex-snapshot
Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation
inferredcites →https://doi.org/10.1210/er.2003-0011openalex-snapshot
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes
inferredcites →https://doi.org/10.1371/journal.pone.0116540openalex-snapshot
Obesity Increases Airway Hyperresponsiveness via the TNF-α Pathway and Treating Obesity Induces Recovery
inferredcites →https://doi.org/10.18388/abp.2012_2149openalex-snapshot
Protective effects of cassia seed ethanol extract against carbon tetrachloride-induced liver injury in mice.
inferredcites →https://doi.org/10.19540/j.cnki.cjcmm.20161222.054openalex-snapshot
[Pathogenesis and treatment of insulin resistance in chronic kidney disease and interventional effects of Chinese herbal medicine].
inferredcites →https://doi.org/10.2337/db14-1708openalex-snapshot
GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice
inferredcites →https://doi.org/10.2337/diabetes.51.3.797openalex-snapshot
The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes
inferredcites →https://doi.org/10.3389/fendo.2019.00531openalex-snapshot
17β-Estradiol Regulates Glucose Metabolism and Insulin Secretion in Rat Islet β Cells Through GPER and Akt/mTOR/GLUT2 Pathway
inferredcites →https://doi.org/10.3390/molecules23123093openalex-snapshot
Anti-Inflammatory Effects of Aurantio-Obtusin from Seed of Cassia obtusifolia L. through Modulation of the NF-κB Pathway

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4622518openalex-extracted
Circulating Exosome-Mediated AMPKα–SIRT1 Pathway Regulates Lipid Metabolism Disorders in Dairy Cows with Subclinical Ketosis
inferred← citeshttps://doi.org/10.1002/efd2.70035openalex-snapshot
The Effect of a Novel Functional Solid Drink on Obesity Management and Its Underlying Mechanisms
inferred← citeshttps://doi.org/10.1002/jsfa.14295openalex-snapshot
Investigating the separation and purification of flavonoids extracted from foxtail millet, with an in‐depth study on its functions in alleviating metabolic syndrome through suppressing lipid absorption
inferred← citeshttps://doi.org/10.1007/s10528-023-10471-0openalex-snapshot
Aurantio-obtusin Alleviates Dry Eye Disease by Targeting NF-κB/NLRP3 Signaling in Rodent Models
inferred← citeshttps://doi.org/10.1007/s12672-025-01784-0openalex-snapshot
Exploring the mechanism of rosmarinic acid in the treatment of lung adenocarcinoma based on bioinformatics methods and experimental validation
inferred← citeshttps://doi.org/10.1016/b978-0-443-24126-0.00007-xopenalex-snapshot
Quinones: A promising remedy for respiratory health
inferred← citeshttps://doi.org/10.1016/j.envint.2025.109554openalex-snapshot
Deriving a Health-Based Guidance Value for 9,10-Anthraquinone via integrating PBTK modeling-based reverse dosimetry and In Vitro bioassays
inferred← citeshttps://doi.org/10.1016/j.jep.2026.121426openalex-snapshot
The anti-obesity potential of Cassiae Semen: A review based on ethnopharmacology and modern pharmacology
inferred← citeshttps://doi.org/10.1016/j.jep.2026.121970openalex-snapshot
Aurantio-obtusin ameliorates prediabetes in a gut microbiota-dependent manner via regulating LPS-TLR4 axis and Akt/GLUT4 signaling
inferred← citeshttps://doi.org/10.1016/j.sajb.2024.07.067openalex-snapshot
Exploring the therapeutic potential of Cassia species on metabolic syndrome: A comprehensive review
inferred← citeshttps://doi.org/10.1038/s41401-023-01089-4openalex-snapshot
Aurantio-obtusin ameliorates obesity by activating PPARα-dependent mitochondrial thermogenesis in brown adipose tissues
inferred← citeshttps://doi.org/10.1080/14756366.2024.2398561openalex-snapshot
Discovery of natural anthraquinones as potent inhibitors against pancreatic lipase: structure-activity relationships and inhibitory mechanism
inferred← citeshttps://doi.org/10.1186/s40364-025-00855-2openalex-snapshot
Novel therapeutic strategies for targeting fatty acid oxidation in cancer
inferred← citeshttps://doi.org/10.26599/fmh.2024.9420003openalex-snapshot
The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms
inferred← citeshttps://doi.org/10.26599/fmh.2026.9420096openalex-snapshot
Lipid-clearing tea aqueous extract alleviates dyslipidaemia in vivo and in vitro by activating the AMPK pathway
inferred← citeshttps://doi.org/10.3389/fphar.2021.826628openalex-snapshot
Aurantio-Obtusin Attenuates Non-Alcoholic Fatty Liver Disease Through AMPK-Mediated Autophagy and Fatty Acid Oxidation Pathways
inferred← citeshttps://doi.org/10.3389/fphar.2023.1275430openalex-snapshot
Role of anthraquinones in combating insulin resistance
inferred← citeshttps://doi.org/10.3390/foods15050806openalex-snapshot
Preventive and Ameliorative Effects of Alanine Supplementation on High-Fat Diet–Induced Obesity and Metabolic Dysfunction via the Gut–Liver–Adipose Axis in C57BL/6J Mice
inferred← citeshttps://doi.org/10.3390/medicina58040472openalex-snapshot
Recent Advances in the Treatment of Insulin Resistance Targeting Molecular and Metabolic Pathways: Fighting a Losing Battle?
inferred← citeshttps://doi.org/10.3390/molecules28145525openalex-snapshot
Natural Drugs: A New Direction for the Prevention and Treatment of Diabetes
inferred← citeshttps://doi.org/10.38212/2224-6614.3417openalex-snapshot
Systems pharmacology dissection of the mechanisms and therapeutic potential of Cassiae semen for hepatoprotection and brightening eyes
inferred← citeshttps://doi.org/10.3892/etm.2023.12079openalex-snapshot
Pharmacological properties and underlying mechanisms of aurantio‑obtusin (Review)
inferred← citeshttps://doi.org/10.4196/kjpp.2024.28.1.11openalex-snapshot
Aurantio-obtusin exerts an anti-inflammatory effect on acute kidney injury by inhibiting NF-κB pathway
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