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Antiplatelet effect of ginkgo diterpene lactone meglumine injection in acute ischemic stroke: A randomized, double‐blind, placebo‐controlled clinical trial

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1 of the 47 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1155/2020/6685740 (notice 2024-03-20).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2022.3337openalex-snapshot
Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer
inferredcites →https://doi.org/10.1002/14651858.cd000029.pub4openalex-snapshot
Oral antiplatelet therapy for acute ischaemic stroke
inferredcites →https://doi.org/10.1002/ptr.7544openalex-snapshot
Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta‐analysis of the clinical trials
inferredcites →https://doi.org/10.1007/s12192-019-00977-1openalex-snapshot
Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo
inferredcites →https://doi.org/10.1007/s12975-021-00949-7openalex-snapshot
High On-Treatment Platelet Reactivity as Predictor of Long-term Clinical Outcomes in Stroke Patients with Antiplatelet Agents
inferredcites →https://doi.org/10.1016/j.biopha.2020.110908openalex-snapshot
Therapeutic promises of ginkgolide A: A literature-based review
inferredcites →https://doi.org/10.1016/j.biopha.2020.111165openalex-snapshot
Combination of Panax notoginseng saponins and aspirin potentiates platelet inhibition with alleviated gastric injury via modulating arachidonic acid metabolism
inferredcites →https://doi.org/10.1016/j.biopha.2022.113299openalex-snapshot
Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient
inferredcites →https://doi.org/10.1016/j.blre.2020.100694openalex-snapshot
Platelet activation and prothrombotic mediators at the nexus of inflammation and atherosclerosis: Potential role of antiplatelet agents
inferredcites →https://doi.org/10.1016/j.cell.2022.04.004openalex-snapshot
Atherosclerosis: Recent developments
inferredcites →https://doi.org/10.1016/j.gene.2018.02.022openalex-snapshot
PXR polymorphisms have impact on the clinical efficacy of clopidogrel in patients undergoing percutaneous coronary intervention
inferredcites →https://doi.org/10.1016/j.jacc.2019.06.039openalex-snapshot
Antithrombotic Therapy to Prevent Recurrent Strokes in Ischemic Cerebrovascular Disease
inferredcites →https://doi.org/10.1016/j.jep.2019.112365openalex-snapshot
Ginkgo diterpene lactones inhibit cerebral ischemia/reperfusion induced inflammatory response in astrocytes via TLR4/NF-κB pathway in rats
inferredcites →https://doi.org/10.1016/j.jep.2020.112964openalex-snapshot
Chip-based serum proteomics approach to reveal the potential protein markers in the sub-acute stroke patients receiving the treatment of Ginkgo Diterpene Lactone Meglumine Injection
inferredcites →https://doi.org/10.1016/j.jpba.2016.04.035openalex-snapshot
Pharmacokinetics and tissue distribution of ginkgolide A, ginkgolide B, and ginkgolide K after intravenous infusion of ginkgo diterpene lactones in a rat model
inferredcites →https://doi.org/10.1016/j.jpba.2017.04.031openalex-snapshot
Exploring the neuroprotective effects of ginkgolides injection in a rodent model of cerebral ischemia–reperfusion injury by GC–MS based metabolomic profiling
inferredcites →https://doi.org/10.1016/j.pharmthera.2019.107393openalex-snapshot
Progress in the development of antiplatelet agents: Focus on the targeted molecular pathway from bench to clinic
inferredcites →https://doi.org/10.1016/j.phymed.2004.02.002openalex-snapshot
Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts
inferredcites →https://doi.org/10.1016/j.phytochem.2022.113355openalex-snapshot
Discovery of unreported ginkgolides of anti-PAF activity using characteristic ion and neutral loss recognition strategy in Ginkgo biloba L
inferredcites →https://doi.org/10.1016/s0140-6736(87)90066-3openalex-snapshot
EFFECT OF A GINKGOLIDE MIXTURE (BN 52063) IN ANTAGONISING SKIN AND PLATELET RESPONSES TO PLATELET ACTIVATING FACTOR IN MAN
inferredcites →https://doi.org/10.1016/s1474-4422(21)00252-0openalex-snapshot
Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
inferredcites →https://doi.org/10.1038/aps.2017.149openalex-snapshot
Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling
inferredcites →https://doi.org/10.1056/nejmoa1813046openalex-snapshot
Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke
inferredcites →https://doi.org/10.1056/nejmoa2118191openalex-snapshot
Endovascular Therapy for Acute Stroke with a Large Ischemic Region
inferredcites →https://doi.org/10.1080/j157v04n04_02openalex-snapshot
The Ingestion of Ginkgo biloba Extract (EGb 761) Inhibits Arachidonic Acid-Mediated Platelet Aggregation and Thromboxane B2 Production in Healthy Volunteers
inferredcites →https://doi.org/10.1111/cns.12577openalex-snapshot
Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice
inferredcites →https://doi.org/10.1111/cns.13742openalex-snapshot
Effect of Ginkgolide in Ischemic Stroke patients with large Artery Atherosclerosis: Results from a randomized trial
inferredcites →https://doi.org/10.1124/pr.117.014530openalex-snapshot
Platelet Signaling and Disease: Targeted Therapy for Thrombosis and Other Related Diseases
inferredcites →https://doi.org/10.1136/svn-2021-001166openalex-snapshot
Contemporary antiplatelet therapy for secondary stroke prevention: a narrative review of current literature and guidelines
inferredcites →https://doi.org/10.1142/s0192415x22500665openalex-snapshot
Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway
inferredcites →https://doi.org/10.1152/physrev.2000.80.4.1669openalex-snapshot
Role of Platelet-Activating Factor in Cardiovascular Pathophysiology
inferredcites →https://doi.org/10.1155/2017/3504950openalex-snapshot
Adequate Platelet Function Inhibition Confirmed by Two Inductive Agents Predicts Lower Recurrence of Ischemic Stroke/Transient Ischemic Attack
inferredcites →https://doi.org/10.1155/2020/6685740openalex-snapshot
[Retracted] The Relationship between the Mean Platelet Volume and Carotid Atherosclerosis and Prognosis in Patients with Acute Cerebral Infarction
inferredcites →https://doi.org/10.1155/2021/6687386openalex-snapshot
Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications
inferredcites →https://doi.org/10.1161/01.str.0000116105.26237.ecopenalex-snapshot
Association of Mean Platelet Volume With Risk of Stroke Among 3134 Individuals With History of Cerebrovascular Disease
inferredcites →https://doi.org/10.1161/01.str.0000130512.81212.a2openalex-snapshot
Is Elevated Mean Platelet Volume Associated With a Worse Outcome in Patients With Acute Ischemic Cerebrovascular Events?
inferredcites →https://doi.org/10.1161/circulationaha.116.025250openalex-snapshot
Prevalence, Incidence, and Mortality of Stroke in China
inferredcites →https://doi.org/10.1182/blood-2016-07-692673openalex-snapshot
Platelets and von Willebrand factor in atherogenesis
inferredcites →https://doi.org/10.1300/j157v04n04_02openalex-snapshot
The Ingestion of Ginkgo biloba Extract (EGb 761) Inhibits Arachidonic Acid-Mediated Platelet Aggregation and Thromboxane B2 Production in Healthy Volunteers
inferredcites →https://doi.org/10.2147/dddt.s318515openalex-snapshot
The Synergistic Effect of Ginkgo biloba Extract 50 and Aspirin Against Platelet Aggregation
inferredcites →https://doi.org/10.3109/09537104.2013.865835openalex-snapshot
Comparison between a new platelet count drop method PL-11, light transmission aggregometry, VerifyNow aspirin system and thromboelastography for monitoring short-term aspirin effects in healthy individuals
inferredcites →https://doi.org/10.3174/ajnr.a5853openalex-snapshot
Standards of Practice in Acute Ischemic Stroke Intervention: International Recommendations
inferredcites →https://doi.org/10.3389/fendo.2021.624132openalex-snapshot
New Insights Into the Pathologic Roles of the Platelet-Activating Factor System
inferredcites →https://doi.org/10.3389/fphar.2022.821937openalex-snapshot
The Efficacy and Safety of Ginkgo Terpene Lactone Preparations in the Treatment of Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
inferredcites →https://doi.org/10.3390/ijms21030866openalex-snapshot
Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis
inferredcites →https://doi.org/10.3390/nu10050604openalex-snapshot
Inflammation, not Cholesterol, Is a Cause of Chronic Disease
inferredcites →https://doi.org/10.5414/cp202911openalex-snapshot
Association between platelet function and recurrent ischemic vascular events after TIA and minor stroke

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4524574openalex-extracted
A Network Meta-Analysis of the Efficacy and Safety of Chinese Patent Medicines for Cerebral Small Vessel Disease with Cognitive Impairment
inferred← citeshttps://doi.org/10.1002/ptr.8472openalex-snapshot
Systematic Review and Network Meta‐Analysis of the Effects of Plant Extracts on Cognitive Function and Quality of Life in Stroke Patients
inferred← citeshttps://doi.org/10.1016/j.jep.2024.118297openalex-snapshot
Efficacy and safety of Ginkgo biloba extract in the treatment of unstable angina pectoris: A systematic review and network meta-analysis
inferred← citeshttps://doi.org/10.1016/j.jep.2025.119416openalex-snapshot
Ginkgo diterpene lactone meglumine for functional recovery in patients with acute ischemic stroke: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.jep.2026.121703openalex-snapshot
Advanced extraction to targeted delivery: A holistic review of technological innovations and therapeutic mechanisms of Ginkgo biloba extract
inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.102733openalex-snapshot
A novel dual-action drug TJ94 facilitated by lipid nanocrystal formulations targeting neuroprotection and antithrombosis in ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.prmcm.2023.100242openalex-snapshot
Comparative efficacy and safety of ginkgo biloba related agents in patients with acute ischemic stroke: A Bayesian network meta-analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.1038/s41401-026-01898-3openalex-snapshot
Ginkgo biloba L. in preventing cardiovascular disease: pharmacological effects, mechanism of action, and therapeutic potential
inferred← citeshttps://doi.org/10.1097/st9.0000000000000070openalex-snapshot
Drug innovation via integration of traditional Chinese and Western medicine
inferred← citeshttps://doi.org/10.1101/2025.07.05.25330942openalex-snapshot
Effects of Ginkgo diterpene lactone meglumine on cognition and neurological function in stroke patients: a systematic evaluation and meta-analysis
inferred← citeshttps://doi.org/10.1142/s0192415x24500435openalex-snapshot
Comprehensive Exploration of the Neuroprotective Mechanisms of Ginkgo biloba Leaves in Treating Neurological Disorders
inferred← citeshttps://doi.org/10.1177/09731296251313639openalex-snapshot
Mechanism of Ginkgo Diterpene Lactone Meglumine Injection Promoting Angiogenesis and Improving Cerebral Perfusion in Cerebral Infarction Rats
inferred← citeshttps://doi.org/10.1515/med-2024-0908openalex-snapshot
Effectiveness of ginkgo diterpene lactone meglumine on cognitive function in patients with acute ischemic stroke
inferred← citeshttps://doi.org/10.3389/fphar.2024.1475021openalex-snapshot
Efficacy analysis of neuroprotective drugs in patients with acute ischemic stroke based on network meta-analysis
inferred← citeshttps://doi.org/10.3389/fphar.2025.1554207openalex-snapshot
The efficacy and safety of ginkgo terpene lactone preparations combined with antiplatelet aents in the treatment of ischemic stroke: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.3389/fphar.2025.1707717openalex-snapshot
Effectiveness of diterpene ginkgolides meglumine injection after endovascular therapy for cardioembolic stroke: a randomized controlled trial
inferred← citeshttps://doi.org/10.36468/pharmaceutical-sciences.1270openalex-snapshot
Exploring the Impact of Ginkgo Diterpenoid Lactones on Cognitive Impairment in Cerebrovascular Disease-affected Rats
inferred← citeshttps://doi.org/10.4314/tjpr.v23i2.24openalex-snapshot
Efficacy and safety of combining ginkgolide diterpene glucosamine injection with dual antibodies in elderly patients with acute ischemic stroke
inferred← citeshttps://doi.org/10.62641/aep.v53i1.1676openalex-snapshot
Repetitive Transcranial Magnetic Stimulation Combined with Ginkgo Diterpene Lactone Meglumine Injection Recover Cognitive and Neurological Functions of Patients with Acute Ischemic Stroke
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