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STAT3 Phosphorylation at Tyrosine 705 and Serine 727 Differentially Regulates Mouse ESC Fates

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jnr.21119openalex-snapshot
Injury‐induced Janus kinase/protein kinase C‐dependent phosphorylation of growth‐associated protein 43 and signal transducer and activator of transcription 3 for neurite growth in dorsal root ganglion
inferredcites →https://doi.org/10.1002/mc.21949openalex-snapshot
Serine 727 phosphorylation of STAT3: An early change in mouse hepatocarcinogenesis induced by neonatal treatment with diethylnitrosamine
inferredcites →https://doi.org/10.1002/stem.1252openalex-snapshot
TGF-β-Superfamily Signaling Regulates Embryonic Stem Cell Heterogeneity: Self-Renewal as a Dynamic and Regulated Equilibrium
inferredcites →https://doi.org/10.1006/dbio.1999.9265openalex-snapshot
Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells
inferredcites →https://doi.org/10.1007/0-306-46832-8_16openalex-snapshot
The Role of Stat3 in Apoptosis and Mammary Gland Involution
inferredcites →https://doi.org/10.1016/j.bbrc.2010.03.092openalex-snapshot
Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells
inferredcites →https://doi.org/10.1016/j.canlet.2006.10.017openalex-snapshot
STAT3 as a central mediator of neoplastic cellular transformation
inferredcites →https://doi.org/10.1016/j.cell.2006.07.025openalex-snapshot
A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules
inferredcites →https://doi.org/10.1016/j.cell.2010.09.010openalex-snapshot
A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs
inferredcites →https://doi.org/10.1016/j.stem.2010.06.022openalex-snapshot
Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency
inferredcites →https://doi.org/10.1016/s0076-6879(03)65023-8openalex-snapshot
Defined Conditions for Neural Commitment and Differentiation
inferredcites →https://doi.org/10.1016/s0092-8674(00)81959-5openalex-snapshot
Stat3 as an Oncogene
inferredcites →https://doi.org/10.1016/s0962-8924(02)02352-8openalex-snapshot
Signalling, cell cycle and pluripotency in embryonic stem cells
inferredcites →https://doi.org/10.1021/bi052490jopenalex-snapshot
Phosphorylation of STAT3 Serine-727 by Cyclin-Dependent Kinase 1 Is Critical for Nocodazole-Induced Mitotic Arrest
inferredcites →https://doi.org/10.1038/jid.2012.45openalex-snapshot
Role and Regulation of STAT3 Phosphorylation at Ser727 in Melanocytes and Melanoma Cells
inferredcites →https://doi.org/10.1038/nature06403openalex-snapshot
Nanog safeguards pluripotency and mediates germline development
inferredcites →https://doi.org/10.1038/nature06968openalex-snapshot
The ground state of embryonic stem cell self-renewal
inferredcites →https://doi.org/10.1038/nature09726openalex-snapshot
Intrinsic transition of embryonic stem-cell differentiation into neural progenitors
inferredcites →https://doi.org/10.1038/ncomms1822openalex-snapshot
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency
inferredcites →https://doi.org/10.1038/nprot.2011.338openalex-snapshot
Generating gene knockout rats by homologous recombination in embryonic stem cells
inferredcites →https://doi.org/10.1038/sj.onc.1203476openalex-snapshot
The role of STATs in transcriptional control and their impact on cellular function
inferredcites →https://doi.org/10.1038/sj.onc.1203481openalex-snapshot
Serine phosphorylation of STATs
inferredcites →https://doi.org/10.1073/pnas.94.8.3801openalex-snapshot
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality
inferredcites →https://doi.org/10.1073/pnas.96.6.2846openalex-snapshot
Essential role of STAT3 for embryonic stem cell pluripotency
inferredcites →https://doi.org/10.1074/jbc.271.22.13221openalex-snapshot
STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription
inferredcites →https://doi.org/10.1089/scd.2007.0098openalex-snapshot
Regulation of Sox2 by STAT3 Initiates Commitment to the Neural Precursor Cell Fate
inferredcites →https://doi.org/10.1093/emboj/17.4.1006openalex-snapshot
IL‐10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3‐dependent and ‐independent pathways
inferredcites →https://doi.org/10.1093/nar/gks1300openalex-snapshot
Distinct transcriptional regulatory modules underlie STAT3’s cell type-independent and cell type-specific functions
inferredcites →https://doi.org/10.1101/gad.12.13.2048openalex-snapshot
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
inferredcites →https://doi.org/10.1101/gad.13.19.2604openalex-snapshot
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3
inferredcites →https://doi.org/10.1101/gad.1606508openalex-snapshot
Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
inferredcites →https://doi.org/10.1111/j.1749-6632.2009.04911.xopenalex-snapshot
Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer
inferredcites →https://doi.org/10.1128/mcb.00508-06openalex-snapshot
The Grb2/Mek Pathway Represses Nanog in Murine Embryonic Stem Cells
inferredcites →https://doi.org/10.1128/mcb.00838-12openalex-snapshot
Role of Krüppel-Like Factor 4 in Neurogenesis and Radial Neuronal Migration in the Developing Cerebral Cortex
inferredcites →https://doi.org/10.1158/0008-5472.can-08-1125openalex-snapshot
Activation of Signal Transducer and Activator of Transcription 3 through a Phosphomimetic Serine 727 Promotes Prostate Tumorigenesis Independent of Tyrosine 705 Phosphorylation
inferredcites →https://doi.org/10.1182/blood-2009-10-230060openalex-snapshot
STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells
inferredcites →https://doi.org/10.1242/dev.01670openalex-snapshot
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
inferredcites →https://doi.org/10.1242/dev.02858openalex-snapshot
A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
inferredcites →https://doi.org/10.1242/dev.02880openalex-snapshot
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
inferredcites →https://doi.org/10.1242/jcs.02744openalex-snapshot
The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation
inferredcites →https://doi.org/10.1371/journal.pone.0003932openalex-snapshot
Stat3 and c-Myc Genome-Wide Promoter Occupancy in Embryonic Stem Cells
inferredcites →https://doi.org/10.1634/stemcells.2007-0126openalex-snapshot
A Heterogeneous Expression Pattern for Nanog in Embryonic Stem Cells
inferredcites →https://doi.org/10.1634/stemcells.22-3-243openalex-snapshot
Electroporation of Murine Embryonic Stem Cells: A Step‐by‐Step Guide

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4750446openalex-extracted
STAT3 Signalling Drives Tissue Expansion During Postimplantation Mouse Development
inferred← citeshttps://doi.org/10.1002/1873-3468.13112openalex-snapshot
Modulation of STAT3 phosphorylation by PTPN2 inhibits naïve pluripotency of embryonic stem cells
inferred← citeshttps://doi.org/10.1002/adma.202007209openalex-snapshot
Nanoparticle‐Assembled Vacuolated Coacervates Control Macromolecule Spatiotemporal Distribution to Provide a Stable Segregated Cell Microenvironment
inferred← citeshttps://doi.org/10.1002/advs.76860openalex-snapshot
Hypomethylation of GNA15 Promotes Pancreatic Ductal Adenocarcinoma Progression and Macrophage M2 Polarization via STAT3‐CXCL8 Axis
inferred← citeshttps://doi.org/10.1002/bdr2.1666openalex-snapshot
Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD‐1 mouse embryos with neural tube defects
inferred← citeshttps://doi.org/10.1002/biof.1614openalex-snapshot
Retracted: JMJD6‐STAT3 Y705ph axis promotes autophagy in osteosarcoma cancer cells by regulating ATG
inferred← citeshttps://doi.org/10.1002/cyto.b.22194openalex-snapshot
Multiparameter quantitative analyses of diagnostic cells in brain tissues from tuberous sclerosis complex
inferred← citeshttps://doi.org/10.1002/jcp.27241openalex-snapshot
Stat3 activation is critical for pluripotency maintenance
inferred← citeshttps://doi.org/10.1002/jcp.30133openalex-snapshot
Signal transducer and activator of transcription 3 mediates apoptosis inhibition through reducing mitochondrial ROS and activating Bcl‐2 in gemcitabine‐resistant lung cancer A549 cells
inferred← citeshttps://doi.org/10.1002/jcp.30229openalex-snapshot
LDL cholesterol promotes the proliferation of prostate and pancreatic cancer cells by activating the STAT3 pathway
inferred← citeshttps://doi.org/10.1002/stem.1942openalex-snapshot
Ciliary Neurotrophic Factor Promotes the Activation of Corneal Epithelial Stem/Progenitor Cells and Accelerates Corneal Epithelial Wound Healing
inferred← citeshttps://doi.org/10.1007/s00018-015-1833-2openalex-snapshot
Molecular basis of embryonic stem cell self-renewal: from signaling pathways to pluripotency network
inferred← citeshttps://doi.org/10.1007/s00018-019-03072-xopenalex-snapshot
A role for polycystin-1 and polycystin-2 in neural progenitor cell differentiation
inferred← citeshttps://doi.org/10.1007/s00018-020-03616-6openalex-snapshot
The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis
inferred← citeshttps://doi.org/10.1007/s10495-016-1231-8openalex-snapshot
Sodium orthovanadate suppresses palmitate-induced cardiomyocyte apoptosis by regulation of the JAK2/STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1007/s10495-016-1289-3openalex-snapshot
Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks
inferred← citeshttps://doi.org/10.1007/s11427-019-1753-3openalex-snapshot
Sodium cantharidinate, a novel anti-pancreatic cancer agent that activates functional p53
inferred← citeshttps://doi.org/10.1007/s12031-016-0820-xopenalex-snapshot
Stat3 Controls Maturation and Terminal Differentiation in Mouse Hippocampal Neurons
inferred← citeshttps://doi.org/10.1007/s12975-020-00860-7openalex-snapshot
Folic Acid Deficiency Enhances the Tyr705 and Ser727 Phosphorylation of Mitochondrial STAT3 in In Vivo and In Vitro Models of Ischemic Stroke
inferred← citeshttps://doi.org/10.1007/s13205-024-03981-0openalex-snapshot
Exploring the therapeutic effect of Pen Yan Kang Fu Decoction on SPID rats based on LIF/JAK2/STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.addr.2022.114586openalex-snapshot
Functional antibody delivery: Advances in cellular manipulation
inferred← citeshttps://doi.org/10.1016/j.arr.2026.103095openalex-snapshot
The STAT3 paradox in aging: Molecular mechanisms and targeted therapeutic strategies
inferred← citeshttps://doi.org/10.1016/j.bbagen.2018.12.001openalex-snapshot
TRIM8-driven transcriptomic profile of neural stem cells identified glioma-related nodal genes and pathways
inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119595openalex-snapshot
Elucidating the molecular mechanisms underlying the therapeutic effects of 6-shogaol on Parkinson’s disease
inferred← citeshttps://doi.org/10.1016/j.bpj.2017.10.033openalex-snapshot
Network Features and Dynamical Landscape of Naive and Primed Pluripotency
inferred← citeshttps://doi.org/10.1016/j.canlet.2026.218362openalex-snapshot
MUC15 loss promotes perineural invasion in pancreatic cancer by activating the IGF1R/STAT3/NGF pathway
inferred← citeshttps://doi.org/10.1016/j.ccell.2026.01.005openalex-snapshot
Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma
inferred← citeshttps://doi.org/10.1016/j.cell.2015.09.004openalex-snapshot
Molecular Identity of Human Outer Radial Glia during Cortical Development
inferred← citeshttps://doi.org/10.1016/j.cell.2020.06.034openalex-snapshot
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
inferred← citeshttps://doi.org/10.1016/j.cellsig.2019.109447openalex-snapshot
TCDD-mediated suppression of naïve human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by interferon-γ
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115506openalex-snapshot
STAT3 signaling enhances tissue expansion during postimplantation mouse development
inferred← citeshttps://doi.org/10.1016/j.devcel.2024.09.003openalex-snapshot
An ILK/STAT3 pathway controls glioblastoma stem cell plasticity
inferred← citeshttps://doi.org/10.1016/j.drup.2022.100903openalex-snapshot
A highly potent small-molecule antagonist of exportin-1 selectively eliminates CD44+CD24- enriched breast cancer stem-like cells
inferred← citeshttps://doi.org/10.1016/j.fct.2022.112850openalex-snapshot
Heteronemin and tetrac derivatives suppress non-small cell lung cancer growth via ERK1/2 inhibition
inferred← citeshttps://doi.org/10.1016/j.gde.2015.06.002openalex-snapshot
New insights into the conserved mechanism of pluripotency maintenance
inferred← citeshttps://doi.org/10.1016/j.jare.2026.10.016openalex-snapshot
TERT is a therapeutic target for tertiary stroke prevention
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101161openalex-snapshot
Dynamic interplay of two molecular switches enabled by the MEK1/2–ERK1/2 and IL-6–STAT3 signaling axes controls epithelial cell migration in response to growth factors
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101335openalex-snapshot
The KRAS-regulated kinome identifies WEE1 and ERK coinhibition as a potential therapeutic strategy in KRAS-mutant pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.jgg.2024.05.003openalex-snapshot
GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.mrrev.2025.108553openalex-snapshot
Rett syndrome: Pathogenicity and regulation of MECP2 (human) and Mecp2 (mouse) genes and their protein products through various molecular mechanisms
inferred← citeshttps://doi.org/10.1016/j.nano.2020.102315openalex-snapshot
Demonstration of intracellular trafficking, cytosolic bioavailability, and target manipulation of an antibody delivery platform
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2021.07.031openalex-snapshot
Signal Transducer and Activator of Transcription 3 Activation in Hippocampal Neural Stem Cells and Cognitive Deficits in Mice Following Short-term Cuprizone Exposure
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2023.06.004openalex-snapshot
miR-146a-5p Modulates Adult Hippocampal Neurogenesis Deficits Through Klf4/p-Stat3 Signaling in APP/PS1 Mice
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.105414openalex-snapshot
Resistin induces cardiac fibroblast-myofibroblast differentiation through JAK/STAT3 and JNK/c-Jun signaling
inferred← citeshttps://doi.org/10.1016/j.phymed.2017.08.006openalex-snapshot
Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid
inferred← citeshttps://doi.org/10.1016/j.phymed.2021.153574openalex-snapshot
Blockage of the JAK/STAT3 signaling pathway in multiple myeloma by leelamine
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155563openalex-snapshot
Epigallocatechin gallate suppresses mitotic clonal expansion and adipogenic differentiation of preadipocytes through impeding JAK2/STAT3-mediated transcriptional cascades
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155698openalex-snapshot
Atractylenolide-I Alleviates Hyperglycemia-Induced Heart Developmental Malformations through Direct and Indirect Modulation of the STAT3 Pathway
inferred← citeshttps://doi.org/10.1016/j.xinn.2026.101359openalex-snapshot
PROTAC-mediated regulation of programmed cell death: From molecular mechanisms to therapeutic breakthroughs
inferred← citeshttps://doi.org/10.1021/acs.jafc.1c02565openalex-snapshot
Chrysin Inhibits Pseudo-allergic Reaction by Suppressing Mitochondrial STAT3 Activation via MAS-Related GPR Family Member X2
inferred← citeshttps://doi.org/10.1038/cddis.2016.201openalex-snapshot
Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model
inferred← citeshttps://doi.org/10.1038/cmi.2017.128openalex-snapshot
The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection
inferred← citeshttps://doi.org/10.1038/ncomms13594openalex-snapshot
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog
inferred← citeshttps://doi.org/10.1038/onc.2014.175openalex-snapshot
RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch
inferred← citeshttps://doi.org/10.1038/s41388-020-01566-8openalex-snapshot
STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis
inferred← citeshttps://doi.org/10.1038/s41388-020-1194-7openalex-snapshot
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis
inferred← citeshttps://doi.org/10.1038/s41388-021-01931-1openalex-snapshot
HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer
inferred← citeshttps://doi.org/10.1038/s41401-021-00718-0openalex-snapshot
The novel STAT3 inhibitor WZ-2-033 causes regression of human triple-negative breast cancer and gastric cancer xenografts
inferred← citeshttps://doi.org/10.1038/s41420-018-0084-zopenalex-snapshot
Two novel SHP-1 agonists, SC-43 and SC-78, are more potent than regorafenib in suppressing the in vitro stemness of human colorectal cancer cells
inferred← citeshttps://doi.org/10.1038/s41420-023-01507-wopenalex-snapshot
STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia
inferred← citeshttps://doi.org/10.1038/s41467-017-01236-6openalex-snapshot
Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
inferred← citeshttps://doi.org/10.1038/s41580-020-0255-7openalex-snapshot
ERK signalling: a master regulator of cell behaviour, life and fate
inferred← citeshttps://doi.org/10.1038/s41598-017-03351-2openalex-snapshot
Inhibiting STAT3 signaling is involved in the anti-melanoma effects of a herbal formula comprising Sophorae Flos and Lonicerae Japonicae Flos
inferred← citeshttps://doi.org/10.1038/s41598-017-16611-yopenalex-snapshot
OCT4 supports extended LIF-independent self-renewal and maintenance of transcriptional and epigenetic networks in embryonic stem cells
inferred← citeshttps://doi.org/10.1038/s41598-020-59346-zopenalex-snapshot
The ELISA Detectability and Potency of Pegfilgrastim Decrease in Physiological Conditions: Key Roles for Aggregation and Individual Variability
inferred← citeshttps://doi.org/10.1038/s41598-023-46628-5openalex-snapshot
STAT3 phosphorylation at serine 727 activates specific genetic programs and promotes clear cell renal cell carcinoma (ccRCC) aggressiveness
inferred← citeshttps://doi.org/10.1038/s41598-024-53549-4openalex-snapshot
Molecular crosstalk between MUC1 and STAT3 influences the anti-proliferative effect of Napabucasin in epithelial cancers
inferred← citeshttps://doi.org/10.1038/s44320-026-00240-7openalex-snapshot
Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays
inferred← citeshttps://doi.org/10.1055/s-0036-1584198openalex-snapshot
STAT3 Inhibition as a Therapeutic Strategy for Chordoma
inferred← citeshttps://doi.org/10.1080/08820139.2025.2450239openalex-snapshot
Timosaponin A-III Alleviates Asthma-Induced Airway Inflammation, Th17 Cell Differentiation, and STAT3/RORγt Pathway
inferred← citeshttps://doi.org/10.1080/15384101.2016.1188230openalex-snapshot
Multipotent neurogenic fate of mesenchymal stem cell is determined by Cdk4-mediated hypophosphorylation of Smad-STAT3
inferred← citeshttps://doi.org/10.1080/21623996.2015.1086520openalex-snapshot
LIF signal in mouse embryonic stem cells
inferred← citeshttps://doi.org/10.1089/cell.2019.0080openalex-snapshot
Advances in Isolation and Culture of Chicken Embryonic Stem Cells In Vitro
inferred← citeshttps://doi.org/10.1089/jir.2020.0111openalex-snapshot
Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells
inferred← citeshttps://doi.org/10.1089/scd.2022.0283openalex-snapshot
Deletion of p66Shc Dysregulates ERK and STAT3 Activity in Mouse Embryonic Stem Cells, Enhancing Their Naive-Like Self-Renewal in the Presence of Leukemia Inhibitory Factor
inferred← citeshttps://doi.org/10.1093/infdis/jiw511openalex-snapshot
Selective Destruction of Interleukin 23–Induced Expansion of a Major Antigen–Specific γδ T-Cell Subset in Patients With Tuberculosis
inferred← citeshttps://doi.org/10.1095/biolreprod.115.134254openalex-snapshot
Signal Inhibition Reveals JAK/STAT3 Pathway as Critical for Bovine Inner Cell Mass Development1
inferred← citeshttps://doi.org/10.1097/shk.0000000000002105openalex-snapshot
SEX-DEPENDENT EFFECTS OF ADIPOCYTE STAT3 INHIBITION ON THE INFLAMMATORY RESPONSE DURING SEVERE SEPSIS
inferred← citeshttps://doi.org/10.1101/2020.07.17.208264openalex-snapshot
Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells
inferred← citeshttps://doi.org/10.1101/2021.04.27.441678openalex-snapshot
Defining the KRAS-regulated kinome in KRAS-mutant pancreatic cancer
inferred← citeshttps://doi.org/10.1101/2021.11.22.469156openalex-snapshot
Simultaneous assessment of eight phosphorylated STAT residues in T-cells by flow cytometry.
inferred← citeshttps://doi.org/10.1101/2022.03.08.483469openalex-snapshot
Distinct phospho-variants of STAT3 regulate naïve pluripotency and developmental pace in vivo
inferred← citeshttps://doi.org/10.1101/2022.12.21.521494openalex-snapshot
Sex-biased Yap1 oncogene function
inferred← citeshttps://doi.org/10.1101/2023.06.22.546177openalex-snapshot
Overexpression of MUC1 influences the anti-proliferative effect of STAT3-inhibitor Napabucasin in epithelial cancers
inferred← citeshttps://doi.org/10.1101/2023.07.19.549653openalex-snapshot
A novel ILK/STAT3 pathway controls plasticity in a neural stem cell model of glioblastoma
inferred← citeshttps://doi.org/10.1101/2024.10.11.617785openalex-snapshot
STAT3 signalling enhances tissue expansion during postimplantation mouse development
inferred← citeshttps://doi.org/10.1101/2025.01.31.25321508openalex-snapshot
Sam68 Exacerbates Pathological Cardiac Hypertrophy by Suppressing Cardiomyocyte Glucose Oxidation
inferred← citeshttps://doi.org/10.1111/cbdd.13666openalex-snapshot
SANTAMARINE: Mechanistic studies on multiple diseases
inferred← citeshttps://doi.org/10.1111/cbdd.13778openalex-snapshot
Alantolactone induces apoptosis in THP‐1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway
inferred← citeshttps://doi.org/10.1111/cbdd.13818openalex-snapshot
Molecular mechanisms of anticancer activities of polyphyllin VII
inferred← citeshttps://doi.org/10.1111/cpr.12771openalex-snapshot
Interleukin‐11 regulates the fate of adipose‐derived mesenchymal stem cells via STAT3 signalling pathways
inferred← citeshttps://doi.org/10.1111/jcmm.13314openalex-snapshot
The classic signalling and trans‐signalling of interleukin‐6 are both injurious in podocyte under high glucose exposure
inferred← citeshttps://doi.org/10.1111/jnc.13870openalex-snapshot
Interleukin‐6‐mediated signaling in adrenal medullary chromaffin cells
inferred← citeshttps://doi.org/10.1111/jnc.15531openalex-snapshot
Zinc induces reactive astrogliosis through ERK‐dependent activation of Stat3 and promotes synaptic degeneration
inferred← citeshttps://doi.org/10.11164/jjsps.43.3_466_2openalex-snapshot
P-060A 生体部分肝移植術を施行した先天性肝線維症の3例(臓器移植, 第44回日本小児外科学会学術集会)
inferred← citeshttps://doi.org/10.1155/2018/8632950openalex-snapshot
STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation
inferred← citeshttps://doi.org/10.1155/2020/1308526openalex-snapshot
Cytokines Induce Monkey Neural Stem Cell Differentiation through Notch Signaling
inferred← citeshttps://doi.org/10.1158/1535-7163.c.6541920openalex-snapshot
Data from A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis
inferred← citeshttps://doi.org/10.1158/1535-7163.c.6541920.v1openalex-snapshot
Data from A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-20-0037openalex-snapshot
A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis
inferred← citeshttps://doi.org/10.11606/t.42.2021.tde-15082022-173310openalex-snapshot
Influência das vias de sinalização de STAT3 e STAT6 em células dendríticas convencionais do tipo 1 e 2 na instrução da polarização da resposta de células T auxiliares.
inferred← citeshttps://doi.org/10.1161/circulationaha.121.055727openalex-snapshot
DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics
inferred← citeshttps://doi.org/10.1161/circulationaha.125.077533openalex-snapshot
Sam68 Exacerbates Pathologic Cardiac Hypertrophy by Suppressing Cardiomyocyte Glucose Oxidation
inferred← citeshttps://doi.org/10.1165/rcmb.2018-0201ocopenalex-snapshot
IL-17A–Producing γδT Cells Inhibit the Formation of Malignant Pleural Effusions
inferred← citeshttps://doi.org/10.1172/jci135937openalex-snapshot
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3
inferred← citeshttps://doi.org/10.1182/blood.2022016033openalex-snapshot
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia
inferred← citeshttps://doi.org/10.1186/s11658-018-0078-0openalex-snapshot
STAT3, stem cells, cancer stem cells and p63
inferred← citeshttps://doi.org/10.1186/s12974-016-0753-xopenalex-snapshot
In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response
inferred← citeshttps://doi.org/10.1186/s12974-025-03591-4openalex-snapshot
STAT3 S727 phosphorylation drives pathogenic Th17 differentiation and neuroinflammation in autoimmune disease
inferred← citeshttps://doi.org/10.1186/s40478-023-01557-2openalex-snapshot
IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma
inferred← citeshttps://doi.org/10.1242/bio.059650openalex-snapshot
Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro
inferred← citeshttps://doi.org/10.1242/bio.20149514openalex-snapshot
Stat3 signaling regulates embryonic stem cell fate in a dose-dependent manner
inferred← citeshttps://doi.org/10.1242/dev.199477openalex-snapshot
Y705 and S727 are required for the mitochondrial import and transcriptional activities of STAT3, and for regulation of stem cell proliferation
inferred← citeshttps://doi.org/10.1242/dev.201704openalex-snapshot
Signalling pathway crosstalk stimulated by L-proline drives mouse embryonic stem cells to primitive-ectoderm-like cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0148994openalex-snapshot
Zinc Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling
inferred← citeshttps://doi.org/10.1371/journal.ppat.1011169openalex-snapshot
Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation
inferred← citeshttps://doi.org/10.1530/jme-21-0213openalex-snapshot
Glucocorticoids inhibit the maturation of committed osteoblasts via SOX2
inferred← citeshttps://doi.org/10.15761/imm.1000268openalex-snapshot
Approaching non-canonical STAT3 signaling to redefine cancer therapeutic strategy
inferred← citeshttps://doi.org/10.1586/17474086.2015.971005openalex-snapshot
STAT3 as a possible therapeutic target in human malignancies: lessons from acute myeloid leukemia
inferred← citeshttps://doi.org/10.18632/aging.204333openalex-snapshot
SENP3 affects the expression of PYCR1 to promote bladder cancer proliferation and EMT transformation by deSUMOylation of STAT3
inferred← citeshttps://doi.org/10.18632/oncotarget.15013openalex-snapshot
The interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets
inferred← citeshttps://doi.org/10.18632/oncotarget.3056openalex-snapshot
Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation
inferred← citeshttps://doi.org/10.18632/oncotarget.3991openalex-snapshot
Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells
inferred← citeshttps://doi.org/10.18632/oncotarget.9039openalex-snapshot
BIS-mediated STAT3 stabilization regulates glioblastoma stem cell-like phenotypes
inferred← citeshttps://doi.org/10.19080/gjpps.2021.09.555759openalex-snapshot
Rotundic Acid Promotes Angiogenesis Potentially by Activating the STAT3 -JAK Signaling Pathway
inferred← citeshttps://doi.org/10.21203/rs.3.rs-875422/v1openalex-snapshot
SENP3 Promotes Bladder Cancer Proliferation and EMT Transformation by Affecting the Expression of PYCR1 via DeSUMOylation of STAT3
inferred← citeshttps://doi.org/10.2147/ott.s287354openalex-snapshot
Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
inferred← citeshttps://doi.org/10.2174/0115665232336447241010094744openalex-snapshot
Probing the Depths of Molecular Complexity: STAT3 as a Key Architect in Colorectal Cancer Pathogenesis
inferred← citeshttps://doi.org/10.2174/0118715206349131241121091834openalex-snapshot
Schisanhenol Inhibits the Proliferation of Hepatocellular Carcinoma Cells by Targeting Programmed Cell Death-ligand 1 via the STAT3 Pathways
inferred← citeshttps://doi.org/10.2174/1568026619666190620145052openalex-snapshot
STAT3: A Potential Drug Target for Tumor and Inflammation
inferred← citeshttps://doi.org/10.2174/1574888x09666140616130217openalex-snapshot
Protein Kinases and Associated Pathways in Pluripotent State and Lineage Differentiation
inferred← citeshttps://doi.org/10.3389/fcell.2025.1566482openalex-snapshot
IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression
inferred← citeshttps://doi.org/10.3389/fcvm.2022.807298openalex-snapshot
Bilateral Superior Cervical Sympathectomy Activates Signal Transducer and Activator of Transcription 3 Signal to Alleviate Myocardial Ischemia-Reperfusion Injury
inferred← citeshttps://doi.org/10.3389/fgene.2022.933534openalex-snapshot
Double cytoplast embryonic cloning improves in vitro but not in vivo development from mitotic pluripotent cells in cattle
inferred← citeshttps://doi.org/10.3389/fgene.2026.1857225openalex-snapshot
SOCS3 deficiency drives the primed to naive pluripotency transition by sustaining STAT3 activation
inferred← citeshttps://doi.org/10.3389/fimmu.2022.899413openalex-snapshot
Nanovesicles From Lactobacillus johnsonii N6.2 Reduce Apoptosis in Human Beta Cells by Promoting AHR Translocation and IL10 Secretion
inferred← citeshttps://doi.org/10.3389/fphar.2022.944089openalex-snapshot
Insights Into the Properties, Biological Functions, and Regulation of USP21
inferred← citeshttps://doi.org/10.3389/pore.2022.1610592openalex-snapshot
Stat3 Tyrosine 705 and Serine 727 Phosphorylation Associate With Clinicopathological Characteristics and Distinct Tumor Cell Phenotypes in Triple-Negative Breast Cancer
inferred← citeshttps://doi.org/10.3390/biomedicines9080956openalex-snapshot
The Roles of Post-Translational Modifications in STAT3 Biological Activities and Functions
inferred← citeshttps://doi.org/10.3390/cancers10110427openalex-snapshot
Ophiopogonin D, a Steroidal Glycoside Abrogates STAT3 Signaling Cascade and Exhibits Anti-Cancer Activity by Causing GSH/GSSG Imbalance in Lung Carcinoma
inferred← citeshttps://doi.org/10.3390/cells12020294openalex-snapshot
Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions
inferred← citeshttps://doi.org/10.3390/cells9030568openalex-snapshot
Administration of Steamed and Freeze-Dried Mature Silkworm Larval Powder Prevents Hepatic Fibrosis and Hepatocellular Carcinogenesis by Blocking TGF-β/STAT3 Signaling Cascades in Rats
inferred← citeshttps://doi.org/10.3390/cells9102202openalex-snapshot
Perspectives Regarding the Intersections between STAT3 and Oxidative Metabolism in Cancer
inferred← citeshttps://doi.org/10.3390/ijms22189981openalex-snapshot
Nitro-Oleic Acid Inhibits Stemness Maintenance and Enhances Neural Differentiation of Mouse Embryonic Stem Cells via STAT3 Signaling
inferred← citeshttps://doi.org/10.3390/ijms23105549openalex-snapshot
ASC-J9 Blocks Cell Proliferation and Extracellular Matrix Production of Keloid Fibroblasts through Inhibiting STAT3 Signaling
inferred← citeshttps://doi.org/10.3390/ijms23105553openalex-snapshot
β-Elemene Attenuates Renal Fibrosis in the Unilateral Ureteral Obstruction Model by Inhibition of STAT3 and Smad3 Signaling via Suppressing MyD88 Expression
inferred← citeshttps://doi.org/10.3390/ijms26146936openalex-snapshot
The Role of Protein Kinases in the Suppressive Phenotype of Myeloid-Derived Suppressor Cells
inferred← citeshttps://doi.org/10.3390/jpm11060542openalex-snapshot
A Proteomic Atlas of Lineage and Cancer-Polarized Expression Modules in Myeloid Cells Modeling Immunosuppressive Tumor-Infiltrating Subsets
inferred← citeshttps://doi.org/10.3892/ol.2018.8129openalex-snapshot
EGFR-TKI resistance and MAP17 are associated with cancer stem cell like properties
inferred← citeshttps://doi.org/10.3892/or.2018.6198openalex-snapshot
Combination of gemcitabine and erlotinib inhibits recurrent pancreatic cancer growth in mice via the JAK-STAT pathway
inferred← citeshttps://doi.org/10.4049/jimmunol.1601712openalex-snapshot
Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3
inferred← citeshttps://doi.org/10.4049/jimmunol.1801142openalex-snapshot
Mechanism for IL-15–Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins
inferred← citeshttps://doi.org/10.5483/bmbrep.2015.48.12.215openalex-snapshot
Stem cell maintenance by manipulating signaling pathways: past, current and future
inferred← citeshttps://doi.org/10.6084/m9.figshare.22618022openalex-snapshot
Additional file 1 of IGFBP2 promotes proliferation and cell migration through STAT3 signaling in Sonic hedgehog medulloblastoma
inferred← citeshttps://doi.org/10.64898/2025.12.15.694447openalex-snapshot
Molecular Mechanisms Underlying the Regulation of VCAM-1 Expression by the Short-Chain Fatty Acid Butyrate
inferred← citeshttps://doi.org/10.64898/2026.01.05.697632openalex-snapshot
Systematic comparison of estimates of transcription factor activity by ATAC-seq and multiplexed reporter assays
inferred← citeshttps://doi.org/10.70675/05f4f7dbz61a7z4676za4a0za42de848cbcdopenalex-snapshot
Regulation of heterochromatin by a pluripotency-associated long non coding RNA in mouse embryonic stem cells and in oocytes : implications for early embryogenesis
inferred← citeshttps://doi.org/10.70675/6694a20az0df0z414bz9bbez1b753d188739openalex-snapshot
Déchiffrer le réseau moléculaire contrôlant la pluripotence du porc
inferred← citeshttps://doi.org/10.70675/f62c21aczd212z4aadza443z0544a76e6c43openalex-snapshot
The Role of Gp130 signaling in initiation of naïve Reprogramming of hPSCs
inferred← citeshttps://doi.org/10.7150/ijbs.11595openalex-snapshot
Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells
inferred← citeshttps://doi.org/10.7150/ijbs.63125openalex-snapshot
Discovery and Validation of Nitroxoline as a Novel STAT3 Inhibitor in Drug-resistant Urothelial Bladder Cancer
inferred← citeshttps://doi.org/10.7150/ijbs.96400openalex-snapshot
Tail Fin Regeneration in Zebrafish: The Role of Non-canonical Crosstalk Between STAT3 and Vitamin D Pathway
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