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Systems approaches and algorithms for discovery of combinatorial therapies
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1 of the 71 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1038/nm1491 (notice 2011-01-07).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/anie.200603675openalex-snapshot
Combinatorial and High‐Throughput Materials Science
inferredcites →https://doi.org/10.1002/bies.20170openalex-snapshot
Distributed robustness versus redundancy as causes of mutational robustness
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Gene duplications, robustness and evolutionary innovations
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Metabolic analysis of adaptive evolution for in silico‐designed lactate‐producing strains
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From Bench to Bedside with Targeted Therapies
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Closed-loop insulin delivery—the path to physiological glucose control
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A mathematical model of combination therapy using the EGFR signaling network
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Robustness of Cellular Functions
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Multi-target therapeutics: when the whole is greater than the sum of the parts
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A note on a method for determining advantageous properties of an anti-arrhythmic drug based on a mathematical model of cardiac cells
inferredcites →https://doi.org/10.1016/s0021-9517(02)00036-2openalex-snapshot
Catalyst design: knowledge extraction from high-throughput experimentation
inferredcites →https://doi.org/10.1016/s0031-6997(25)06847-4openalex-snapshot
The search for synergy: a critical review from a response surface perspective.
inferredcites →https://doi.org/10.1021/ja970389zopenalex-snapshot
A Combinatorial Approach for Polymer Design
inferredcites →https://doi.org/10.1023/a:1027325400459openalex-snapshot
Experiment planning for combinatorial materials discovery
inferredcites →https://doi.org/10.1038/22055openalex-snapshot
Determining computational complexity from characteristic ‘phase transitions’
inferredcites →https://doi.org/10.1038/46995openalex-snapshot
The inverse band-structure problem of finding an atomic configuration with given electronic properties
inferredcites →https://doi.org/10.1038/msb.2008.51openalex-snapshot
High‐order combination effects and biological robustness
inferredcites →https://doi.org/10.1038/msb.2008.53openalex-snapshot
Models from experiments: combinatorial drug perturbations of cancer cells
inferredcites →https://doi.org/10.1038/msb.2008.60openalex-snapshot
Finding multiple target optimal intervention in disease‐related molecular network
inferredcites →https://doi.org/10.1038/msb4100116openalex-snapshot
Chemical combination effects predict connectivity in biological systems
inferredcites →https://doi.org/10.1038/msb4100179openalex-snapshot
Towards a theory of biological robustness
inferredcites →https://doi.org/10.1038/msb4100180openalex-snapshot
Network‐based classification of breast cancer metastasis
inferredcites →https://doi.org/10.1038/nbt981openalex-snapshot
Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells
inferredcites →https://doi.org/10.1038/nchembio.118openalex-snapshot
Network pharmacology: the next paradigm in drug discovery
inferredcites →https://doi.org/10.1038/nm1491openalex-snapshot
Genomic signatures to guide the use of chemotherapeutics
inferredcites →https://doi.org/10.1038/nrd1799openalex-snapshot
Computer-based de novo design of drug-like molecules
inferredcites →https://doi.org/10.1038/nrd2089openalex-snapshot
Strategies for optimizing combinations of molecularly targeted anticancer agents
inferredcites →https://doi.org/10.1038/nrd2381openalex-snapshot
Proteins, drug targets and the mechanisms they control: the simple truth about complex networks
inferredcites →https://doi.org/10.1039/b808649dopenalex-snapshot
Advances in combinatorial and high-throughput screening of biofunctional polymers for gene delivery, tissue engineering and anti-fouling coatings
inferredcites →https://doi.org/10.1039/b815225jopenalex-snapshot
Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs
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Rational Design of Cancer-Drug Combinations
inferredcites →https://doi.org/10.1056/nejme0809343openalex-snapshot
Targeted Therapy for Advanced Colorectal Cancer — More Is Not Always Better
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Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer
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Options for Slowing the Growth of Health Care Costs
inferredcites →https://doi.org/10.1063/1.2987711openalex-snapshot
Exploring chemical space with discrete, gradient, and hybrid optimization methods
inferredcites →https://doi.org/10.1073/pnas.0800823105openalex-snapshot
Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm
inferredcites →https://doi.org/10.1073/pnas.0803571105openalex-snapshot
Cascading failure and robustness in metabolic networks
inferredcites →https://doi.org/10.1073/pnas.0806077105openalex-snapshot
Information flow and optimization in transcriptional regulation
inferredcites →https://doi.org/10.1073/pnas.1337088100openalex-snapshot
Systematic discovery of multicomponent therapeutics
inferredcites →https://doi.org/10.1089/cmb.2009.0007openalex-snapshot
Maximal Information Transfer and Behavior Diversity in Random Threshold Networks
inferredcites →https://doi.org/10.1093/bioinformatics/18.suppl_1.s233openalex-snapshot
Discovering regulatory and signalling circuits in molecular interaction networks
inferredcites →https://doi.org/10.1093/comjnl/7.4.308openalex-snapshot
A Simplex Method for Function Minimization
inferredcites →https://doi.org/10.1097/med.0b013e3282f7960bopenalex-snapshot
Sensor-augmented pump therapy in type 1 diabetes
inferredcites →https://doi.org/10.1103/physreve.60.1412openalex-snapshot
Highly optimized tolerance: A mechanism for power laws in designed systems
inferredcites →https://doi.org/10.1103/physreve.71.051909openalex-snapshot
Multiple weak hits confuse complex systems: A transcriptional regulatory network as an example
inferredcites →https://doi.org/10.1103/physrevlett.84.2529openalex-snapshot
Highly Optimized Tolerance: Robustness and Design in Complex Systems
inferredcites →https://doi.org/10.1103/physrevlett.88.255506openalex-snapshot
Combined Electronic Structure and Evolutionary Search Approach to Materials Design
inferredcites →https://doi.org/10.1103/revmodphys.77.783openalex-snapshot
Feedback for physicists: A tutorial essay on control
inferredcites →https://doi.org/10.1109/9.718605openalex-snapshot
Model-free control of nonlinear stochastic systems with discrete-time measurements
inferredcites →https://doi.org/10.1109/acc.1997.609707openalex-snapshot
SPSA/SIMMOD optimization of air traffic delay cost
inferredcites →https://doi.org/10.1109/tac.2008.917738openalex-snapshot
Global Random Optimization by Simultaneous Perturbation Stochastic Approximation
inferredcites →https://doi.org/10.1109/tcst.2005.863660openalex-snapshot
Extremum seeking methods for optimization of variable cam timing engine operation
inferredcites →https://doi.org/10.1126/science.1093649openalex-snapshot
Quantum Optimally Controlled Transition Landscapes
inferredcites →https://doi.org/10.1126/science.1116598openalex-snapshot
A Systems Model of Signaling Identifies a Molecular Basis Set for Cytokine-Induced Apoptosis
inferredcites →https://doi.org/10.1126/science.1132939openalex-snapshot
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
inferredcites →https://doi.org/10.1126/science.1145803openalex-snapshot
Self-Organization, Embodiment, and Biologically Inspired Robotics
inferredcites →https://doi.org/10.1126/science.268.5218.1738openalex-snapshot
A Combinatorial Approach to Materials Discovery
inferredcites →https://doi.org/10.1128/aac.46.9.2982-2989.2002openalex-snapshot
In Vitro Interaction of Flucytosine Combined with Amphotericin B or Fluconazole against Thirty-Five Yeast Isolates Determined by both the Fractional Inhibitory Concentration Index and the Response Surface Approach
inferredcites →https://doi.org/10.1146/annurev.matsci.38.060407.130217openalex-snapshot
Combinatorial Materials Sciences: Experimental Strategies for Accelerated Knowledge Discovery
inferredcites →https://doi.org/10.1161/01.res.68.6.1501openalex-snapshot
A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction.
inferredcites →https://doi.org/10.1186/1750-1172-3-11openalex-snapshot
Adaptive design methods in clinical trials – a review
inferredcites →https://doi.org/10.1196/annals.1339.024openalex-snapshot
Preclinical Modeling of Combination Treatments: Fantasy or Requirement?
inferredcites →https://doi.org/10.1371/journal.pcbi.1000249openalex-snapshot
Search Algorithms as a Framework for the Optimization of Drug Combinations
inferredcites →https://doi.org/10.1371/journal.pone.0000547openalex-snapshot
Selective Control of the Apoptosis Signaling Network in Heterogeneous Cell Populations
inferredcites →https://doi.org/10.26144/yqez-2q90openalex-snapshot
An Overview of the Simultaneous Perturbation Method for Efficient Optimization
inferredcites →https://doi.org/10.3949/ccjm.71.7.551openalex-snapshot
The promise of targeted therapy: cancer drugs become more specific.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks
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Molecular combination networks in medicinal plants: understanding synergy by network pharmacology in Indian traditional medicine
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Synergistic effects of α-Mangostin and sorafenib in hepatocellular carcinoma: New insights into α-mangostin cytotoxicity
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Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines – Lessons for design of combination targeted therapy
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Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning
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Consequential drug combinations for tuberculosis treatments
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Construction of a Waddington-like landscape model that can guide clinical exploration of p53-dynamics-activating parameters in the face of divergent p53 dynamics
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A hybrid deep forest-based method for predicting synergistic drug combinations
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Compromise design for combination experiment of two drugs
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Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives
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Vitamin E-based prodrug self-delivery for nanoformulated irinotecan with synergistic antitumor therapeutics
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A rapid way of formulation development revealing potential synergic effects on numerous antimicrobial combinations against foodborne pathogens
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A Stacked Ensemble Approach For Enhancing Anti Cancer Drug Synergy Prediction
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Climate-resilient retrofitting for Australian homes: A parametric analysis of future performance and overheating risk
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Modeling Tumor Clonal Evolution for Drug Combinations Design
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A combination of metabolic strategies plus cardiopulmonary bypass improves short-term resuscitation from prolonged lethal cardiac arrest
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MMSyn: A New Multimodal Deep Learning Framework for Enhanced Prediction of Synergistic Drug Combinations
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DrugSK: A Stacked Ensemble Learning Framework for Predicting Drug Combinations of Multiple Diseases
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Systems Biology Brings New Dimensions for Structure-Based Drug Design
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Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing
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Metabolomic high-content nuclear magnetic resonance-based drug screening of a kinase inhibitor library
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Optimization of drug combinations using Feedback System Control
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Uncovering expression signatures of synergistic drug responses via ensembles of explainable machine-learning models
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Systematic chemical-genetic and chemical-chemical interaction datasets for prediction of compound synergism
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Enhancing drug synergy in malignant diseases with deep architecture optimization algorithms
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Role of Artificial Intelligence and Machine Learning in Drug Discovery and Drug Repurposing
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Additional file 1 of DFFNDDS: prediction of synergistic drug combinations with dual feature fusion networks
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Acute Antihyperglycaemic Effect of The Combination of Metformin and Ethanol Seed Extract of Moringa oleifera Lam. In Rats
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