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The pathophysiology of osteoarthritis

https://doi.org/10.1007/bf03327357
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-4644(19990915)74:4<576::aid-jcb7>3.0.co;2-nopenalex-snapshot
Bcl-2 regulates chondrocyte morphology and aggrecan gene expression independent of caspase activation and full apoptosis
inferredcites →https://doi.org/10.1002/1529-0131(199802)41:2<263::aid-art10>3.0.co;2-5openalex-snapshot
Presence of cartilage-derived morphogenetic proteins in articular cartilage and enhancement of matrix replacement in vitro
inferredcites →https://doi.org/10.1002/1529-0131(199907)42:7<1528::aid-anr28>3.0.co;2-9openalex-snapshot
Apoptotic chondrocyte death in rheumatoid arthritis
inferredcites →https://doi.org/10.1002/1529-0131(200009)43:9<2091::aid-anr21>3.0.co;2-copenalex-snapshot
Mechanotransduction via integrins and interleukin‐4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes
inferredcites →https://doi.org/10.1002/art.10554openalex-snapshot
Apoptosis and cellular vitality: Issues in osteoarthritic cartilage degeneration
inferredcites →https://doi.org/10.1002/art.1780331113openalex-snapshot
Interleukin‐1‐induced interleukin‐6 is required for the inhibition of proteoglycan synthesis by interleukin‐1 in human articular cartilage
inferredcites →https://doi.org/10.1002/art.1780350507openalex-snapshot
The interleukin‐1 receptor in normal and osteoarthritic human articular chondrocytes. Identification as the type I receptor and analysis of binding kinetics and biologic function
inferredcites →https://doi.org/10.1002/art.1780361209openalex-snapshot
Generalized osteoarthritis associated with increased insulin‐like growth factor types i and ii and transforming growth factor β in cortical bone from the iliac crest. possible mechanism of increased bone density and protection against osteoporosis
inferredcites →https://doi.org/10.1002/art.1780370215openalex-snapshot
Human Osteoarthritic Chondrocytes Possess an Increased Number of Insulin‐Like Growth Factor 1 Binding Sites but are Unresponsive to its Stimulation
inferredcites →https://doi.org/10.1002/art.1780370314openalex-snapshot
Transforming Growth Factor β1 Regulates Tissue Inhibitor of Metalloproteinases—1 Expression in Differentiated Human Articular Chondrocytes
inferredcites →https://doi.org/10.1002/art.1780370414openalex-snapshot
Integrin expression by human articular chondrocytes
inferredcites →https://doi.org/10.1002/art.1780380204openalex-snapshot
Role of interleukin‐1, tumor necrosis factor α, and interleukin‐6 in cartilage proteoglycan metabolism and destruction effect of in situ blocking in murine antigen‐ and zymosan‐induced arthritis
inferredcites →https://doi.org/10.1002/art.1780380514openalex-snapshot
Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage
inferredcites →https://doi.org/10.1002/art.1780390914openalex-snapshot
Chondroprotective effect of intraarticular injections of interleukin‐1 receptor antagonist in experimental osteoarthritis. Suppression of collagenase‐1 expression
inferredcites →https://doi.org/10.1002/art.1780400209openalex-snapshot
Role of interleukin‐4 and interleukin‐10 in murine collagen‐induced arthritis. Protective effect of interleukin‐4 and interleukin‐10 treatment on cartilage destruction
inferredcites →https://doi.org/10.1002/art.1780400609openalex-snapshot
Interleukin‐17 up‐regulation of nitric oxide production in human osteoarthritis cartilage
inferredcites →https://doi.org/10.1002/art.1780401004openalex-snapshot
FAS/FAS ligand expression and induction of apoptosis in chondrocytes
inferredcites →https://doi.org/10.1002/j.1460-2075.1992.tb05036.xopenalex-snapshot
Expression of prepro‐enkephalin in human articular chondrocytes is linked to cell proliferation.
inferredcites →https://doi.org/10.1002/jcp.1041500222openalex-snapshot
Differential regulation of the expression of transforming growth factor‐β mRNAs by growth factors and retinoic acid in chicken embryo chondrocytes, myocytes, and fibroblasts
inferredcites →https://doi.org/10.1002/jor.1100070505openalex-snapshot
Cellular turnover at the chondro‐osseous junction of growth plate cartilage: Analysis by serial sections at the light microscopical level
inferredcites →https://doi.org/10.1002/jor.1100140614openalex-snapshot
Recombinant human bone morphogenetic protein‐2 maintains the articular chondrocyte phenotype in long‐term culture
inferredcites →https://doi.org/10.1006/excr.1993.1087openalex-snapshot
β1 Integrins Mediate Chondrocyte Interaction with Type I Collagen, Type II Collagen, and Fibronectin
inferredcites →https://doi.org/10.1006/excr.1993.1189openalex-snapshot
Localization of β1-Integrins in Human Cartilage and Their Role in Chondrocyte Adhesion to Collagen and Fibronectin
inferredcites →https://doi.org/10.1006/excr.1995.1084openalex-snapshot
Expression of β1 Integrins by Cultured Articular Chondrocytes and in Osteoarthritic Cartilage
inferredcites →https://doi.org/10.1007/978-1-4615-4857-7_62openalex-snapshot
Chondrocytes-ECM Interactions in Human Osteoarthritis
inferredcites →https://doi.org/10.1007/bf01452253openalex-snapshot
Chondrocyte phenotyping in human osteoarthritis
inferredcites →https://doi.org/10.1007/s004410051318openalex-snapshot
β1-Integrins in the cartilage matrix
inferredcites →https://doi.org/10.1007/s100510170359openalex-snapshot
Delocalization effects and charge reorganizations induced by repulsive interactions in strongly disordered chains
inferredcites →https://doi.org/10.1016/0002-9343(86)90075-6openalex-snapshot
Pathogenesis of osteoarthritis
inferredcites →https://doi.org/10.1016/0167-5699(92)90116-oopenalex-snapshot
Two TNF receptors
inferredcites →https://doi.org/10.1016/0306-9877(93)90046-sopenalex-snapshot
A metabolite of substance P, SP7–11 is involved in the pathogenesis of inflammatory joint disease
inferredcites →https://doi.org/10.1016/0945-053x(94)90029-9openalex-snapshot
Changes in the expression of decorin and biglycan in human articular cartilage with age and regulation by TGF-β
inferredcites →https://doi.org/10.1016/0955-0674(92)90100-qopenalex-snapshot
Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information
inferredcites →https://doi.org/10.1016/s0014-5793(99)00897-2openalex-snapshot
Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinases
inferredcites →https://doi.org/10.1016/s0021-9258(18)52202-xopenalex-snapshot
Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA)
inferredcites →https://doi.org/10.1016/s0021-9258(18)53806-0openalex-snapshot
Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors.
inferredcites →https://doi.org/10.1016/s0065-2776(08)60535-0openalex-snapshot
Interleukin-1 Receptor Antagonist
inferredcites →https://doi.org/10.1016/s0736-0266(01)00073-0openalex-snapshot
The involvement of β1 integrin in the modulation by collagen of chondrocyte‐response to transforming growth factor‐β1
inferredcites →https://doi.org/10.1016/s0889-857x(21)00216-7openalex-snapshot
SENSORY NEUROPEPTIDES AND RHEUMATIC DISEASES
inferredcites →https://doi.org/10.1016/s0945-053x(99)00027-xopenalex-snapshot
β1-Integrin–collagen interaction reduces chondrocyte apoptosis
inferredcites →https://doi.org/10.1016/s8756-3282(97)00253-6openalex-snapshot
Subchondral Bone Failure in an Equine Model of Overload Arthrosis
inferredcites →https://doi.org/10.1038/346281a0openalex-snapshot
Negative regulation of transforming growth factor-β by the proteoglycan decorin
inferredcites →https://doi.org/10.1038/346425a0openalex-snapshot
Adhesion receptors of the immune system
inferredcites →https://doi.org/10.1038/372786a0openalex-snapshot
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
inferredcites →https://doi.org/10.1042/0264-6021:3420615openalex-snapshot
Signal transduction by β1 integrin receptors in human chondrocytes in vitro: collaboration with the insulin-like growth factor-I receptor
inferredcites →https://doi.org/10.1046/j.1471-4159.1995.65062484.xopenalex-snapshot
Nerve Growth Factor Regulates Transforming Growth Factor‐β1 Gene Expression by Both Transcriptional and Posttranscriptional Mechanisms in PC12 Cells
inferredcites →https://doi.org/10.1053/joca.1998.0110openalex-snapshot
Intra-articular injection of collagenase induces experimental osteoarthritis in mature rabbits
inferredcites →https://doi.org/10.1053/joca.1998.0129openalex-snapshot
Differential effects of local application of BMP-2 or TGF-β1 on both articular cartilage composition and osteophyte formation
inferredcites →https://doi.org/10.1083/jcb.153.1.35openalex-snapshot
TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage
inferredcites →https://doi.org/10.1093/rheumatology/31.4.231openalex-snapshot
INTEGRIN EXPRESSION BY HUMAN ARTICULAR CHONDROCYTES
inferredcites →https://doi.org/10.1093/rheumatology/36.6.651openalex-snapshot
Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis
inferredcites →https://doi.org/10.1093/rheumatology/41.12.1413openalex-snapshot
Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes
inferredcites →https://doi.org/10.1097/00001756-199009000-00003openalex-snapshot
Transforming growth factor-β1 stimulates expression of nerve growth factor in the rat CNS
inferredcites →https://doi.org/10.1097/00002281-199805000-00018openalex-snapshot
The role of nitric oxide in articular cartilage breakdown in osteoarthritis
inferredcites →https://doi.org/10.1111/1523-1747.ep12340768openalex-snapshot
Autocrine Nerve Growth Factor Protects Human Keratinocytes from Apoptosis Through its High Affinity Receptor (TRK): A Role for BCL-2
inferredcites →https://doi.org/10.1111/j.1749-6632.1987.tb35781.xopenalex-snapshot
Effects of Nerve Growth Factor on the Expression of Interleukin‐2 Receptors on Cultured Human Lymphocytes
inferredcites →https://doi.org/10.1136/ard.54.1.25openalex-snapshot
Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis.
inferredcites →https://doi.org/10.1136/ard.56.9.542openalex-snapshot
Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific
inferredcites →https://doi.org/10.1136/ard.57.5.303openalex-snapshot
Expression of α and β subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral heads
inferredcites →https://doi.org/10.1152/ajpcell.1995.268.4.c936openalex-snapshot
Nerve growth factor stimulates rapid metabolic responses in PC12 cells
inferredcites →https://doi.org/10.1172/jci115964openalex-snapshot
Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis.
inferredcites →https://doi.org/10.1172/jci116547openalex-snapshot
Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1.
inferredcites →https://doi.org/10.1172/jci867openalex-snapshot
Abnormal cancellous bone collagen metabolism in osteoarthritis.
inferredcites →https://doi.org/10.1177/44.2.8609369openalex-snapshot
Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage.
inferredcites →https://doi.org/10.1210/en.130.5.2811openalex-snapshot
Mitogenic action of gastrin-releasing polypeptide on isolated epiphyseal growth plate chondrocytes from the ovine fetus
inferredcites →https://doi.org/10.3109/17453679509157647openalex-snapshot
Cartilage-derived morphogenetic proteins Key regulators in chondrocyte differentiation?

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/14651858.cd006402openalex-snapshot
Homeopathy for osteoarthritis
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TRPV1 Agonist Approaches for Pain Management
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Infrared Microscopy and Imaging of Hard and Soft Tissues
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Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome
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Probing Multicellular Tissue Fusion of Cocultured Spheroids—A 3D‐Bioassembly Model
inferred← citeshttps://doi.org/10.1002/advs.202412010openalex-snapshot
Microphysiological System‐Generated Physiological Shear Forces Reduce TNF‐α‐Mediated Cartilage Damage in a 3D Model of Arthritis
inferred← citeshttps://doi.org/10.1002/art.21771openalex-snapshot
Intraarticular induction of interleukin‐1β expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain
inferred← citeshttps://doi.org/10.1002/art.22836openalex-snapshot
Inverse relationship between matrix remodeling and lipid metabolism during osteoarthritis progression in the STR/ORT mouse
inferred← citeshttps://doi.org/10.1002/art.24258openalex-snapshot
Prostaglandin E2and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis
inferred← citeshttps://doi.org/10.1002/art.27733openalex-snapshot
Insulin‐like growth factor 1 synergizes with bone morphogenetic protein 7–mediated anabolism in bovine intervertebral disc cells
inferred← citeshttps://doi.org/10.1002/art.30279openalex-snapshot
Tumor necrosis factor α–mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
inferred← citeshttps://doi.org/10.1002/art.33407openalex-snapshot
75‐kd sirtuin 1 blocks tumor necrosis factor α–mediated apoptosis in human osteoarthritic chondrocytes
inferred← citeshttps://doi.org/10.1002/art.37799openalex-snapshot
Matrix‐assisted laser desorption ionization–imaging mass spectrometry: A new methodology to study human osteoarthritic cartilage
inferred← citeshttps://doi.org/10.1002/art.41738openalex-snapshot
Genetic and Epigenetic Interplay Within a COLGALT2 Enhancer Associated With Osteoarthritis
inferred← citeshttps://doi.org/10.1002/cpz1.596openalex-snapshot
Animal Models of Osteoarthritis Part 1–Preclinical Small Animal Models: Challenges and Opportunities for Drug Development
inferred← citeshttps://doi.org/10.1002/hsr2.70829openalex-snapshot
Burden of Osteoarthritis in Iran: A National and Subnational Perspective, 1990−2019 Global Burden of Disease Study
inferred← citeshttps://doi.org/10.1002/jcp.24946openalex-snapshot
RETRACTED: Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis‐Like Changes in Knee Joint
inferred← citeshttps://doi.org/10.1002/micr.20889openalex-snapshot
Make no bones about it (regulation and control): NGF versus TGF‐beta and BMP
inferred← citeshttps://doi.org/10.1002/mrd.21157openalex-snapshot
Dynamic interactions between cells and their extracellular matrix mediate embryonic development
inferred← citeshttps://doi.org/10.1002/path.2097openalex-snapshot
Morphology, mechanisms and pathology of musculoskeletal ageing
inferred← citeshttps://doi.org/10.1007/11946465_41openalex-snapshot
A Decision Support System for the Automatic Assessment of Hip Osteoarthritis Severity by Hip Joint Space Contour Spectral Analysis
inferred← citeshttps://doi.org/10.1007/978-1-4899-7606-2_15openalex-snapshot
Potential Mechanisms of PTA: Cell Death
inferred← citeshttps://doi.org/10.1007/978-1-84628-701-5_7openalex-snapshot
Chondrocyte Hypertrophy and Apoptosis at the Cartilage-Bone Interface
inferred← citeshttps://doi.org/10.1007/978-3-030-50413-7_1openalex-snapshot
The Role of TGF-β in Post-traumatic Osteoarthritis
inferred← citeshttps://doi.org/10.1007/978-3-319-25787-7_13openalex-snapshot
Arthritides in the Elderly
inferred← citeshttps://doi.org/10.1007/bf02913099openalex-snapshot
Tumor necrosis factor alpha (TNF-α) and estrogen hormone in osteoarthritic female patients
inferred← citeshttps://doi.org/10.1007/bf03327355openalex-snapshot
Aging and osteoarthritis
inferred← citeshttps://doi.org/10.1007/s00011-014-0794-5openalex-snapshot
Anti-inflammatory and chondroprotective effects of atorvastatin in a cartilage explant model of osteoarthritis
inferred← citeshttps://doi.org/10.1007/s00296-009-0864-0openalex-snapshot
Inflammatory response in patients with active and inactive osteoarthritis
inferred← citeshttps://doi.org/10.1007/s00418-005-0011-2openalex-snapshot
Temporospatial expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in mouse antigen-induced arthritis
inferred← citeshttps://doi.org/10.1007/s10067-006-0365-4openalex-snapshot
Age-related decrease in the activity of collagenase in the femoral head in patients with hip osteoarthritis
inferred← citeshttps://doi.org/10.1007/s10067-006-0472-2openalex-snapshot
Age-related decrease in the activity of collagenase in the femoral head in patients with hip osteoarthritis
inferred← citeshttps://doi.org/10.1007/s10195-012-0200-4openalex-snapshot
Pravastatin suppresses matrix metalloproteinase expression and activity in human articular chondrocytes stimulated by interleukin-1β
inferred← citeshttps://doi.org/10.1007/s10237-005-0012-zopenalex-snapshot
An Introductory Review of Cell Mechanobiology
inferred← citeshttps://doi.org/10.1007/s10334-014-0457-0openalex-snapshot
Characterization of metabolites determined by means of 1H HR MAS NMR in intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1007/s11596-022-2627-zopenalex-snapshot
GW842166X Alleviates Osteoarthritis by Repressing LPS-mediated Chondrocyte Catabolism in Mice
inferred← citeshttps://doi.org/10.1007/s11916-011-0225-zopenalex-snapshot
Effects of Exercise and Physical Activity on Knee Osteoarthritis
inferred← citeshttps://doi.org/10.1007/s11926-016-0591-yopenalex-snapshot
The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis
inferred← citeshttps://doi.org/10.1016/b978-0-323-02948-3.00022-5openalex-snapshot
Impaired joint mobility
inferred← citeshttps://doi.org/10.1016/b978-0-323-89843-0.00019-2openalex-snapshot
Exercise for the management of osteoarthritis
inferred← citeshttps://doi.org/10.1016/b978-0-443-13683-2.00019-0openalex-snapshot
Chronobiology and clock genes in bone and mineral metabolism
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Connective Tissues and Aging
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Mechanics of the cell: Interaction mechanisms and mechanobiological models
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Matrix Metalloproteinases and Synovial Joint Pathology
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Modeling IL-1 induced degradation of articular cartilage
inferred← citeshttps://doi.org/10.1016/j.arrct.2023.100256openalex-snapshot
Bilateral Suprascapular Nerve Cryoneurolysis for Pain Associated With Glenohumeral Osteoarthritis: A Case Report
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Evidence for a protective role for adiponectin in osteoarthritis
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Inflammatory osteoarthritis of the hand
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2021.04.031openalex-snapshot
Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2006.11.043openalex-snapshot
FT-IR imaging of native and tissue-engineered bone and cartilage
inferred← citeshttps://doi.org/10.1016/j.bioorg.2010.11.002openalex-snapshot
Heteroarylimino-4-thiazolidinones as inhibitors of cartilage degradation
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.07.161openalex-snapshot
Caffeic acid protects against IL-1β-induced inflammatory responses and cartilage degradation in articular chondrocytes
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Synthesis and SAR of α-sulfonylcarboxylic acids as potent matrix metalloproteinase inhibitors
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Possible chondroprotective effect of canakinumab: An in vitro study on human osteoarthritic chondrocytes
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Circulating cytokines levels and osteoarthritis: A Mendelian randomization study
inferred← citeshttps://doi.org/10.1016/j.ejphar.2026.178563openalex-snapshot
PEGylated cerium oxide nanoparticles alleviate osteoarthritis progression by inhibiting chondrocyte ferroptosis and maintaining cartilage homeostasis
inferred← citeshttps://doi.org/10.1016/j.exger.2018.07.007openalex-snapshot
Reactive oxygen species and NADPH oxidase 4 involvement in osteoarthritis
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Effect of type II diabetes-induced osteoarthritis on articular cartilage aging in rats: A study in vivo and in vitro
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Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis
inferred← citeshttps://doi.org/10.1016/j.gene.2013.04.003openalex-snapshot
Lactoferricin enhances BMP7-stimulated anabolic pathways in intervertebral disc cells
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Sugar-coated bullets: Unveiling the enigmatic mystery ‘sweet arsenal’ in osteoarthritis
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Yin-Yang regulation of prostaglandins and nitric oxide by PGD2 in human arthritis: Reversal by celecoxib
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.108563openalex-snapshot
Shikonin, a promising therapeutic drug for osteoarthritis that acts via autophagy activation
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.111755openalex-snapshot
SIRT3 alleviates high glucose-induced chondrocyte injury through the promotion of autophagy and suppression of apoptosis in osteoarthritis progression
inferred← citeshttps://doi.org/10.1016/j.isci.2024.110130openalex-snapshot
Identification of osteoblastic autophagy-related genes for predicting diagnostic markers in osteoarthritis
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Reduction in knee adduction moment via non-invasive biomechanical training: A longitudinal gait analysis study
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Effect of Phellodendron amurense in protecting human osteoarthritic cartilage and chondrocytes
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Regulation of matrix metalloproteinase expression by dynamic tensile strain in rat fibrochondrocytes
inferred← citeshttps://doi.org/10.1016/j.joca.2006.04.012openalex-snapshot
Changes in immunolocalisation of β-dystroglycan and specific degradative enzymes in the osteoarthritic synovium
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Membrane type-1 matrix metalloproteinase is induced following cyclic compression of in vitro grown bovine chondrocytes
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Characterization of degenerative human facet joints and facet joint capsular tissues
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Evaluating the efficacy of intra-articular polydioxanone (PDO) injections as a novel viscosupplement in osteoarthritis treatment
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The matrix metalloproteinases as pharmacological target in osteoarthritis: Statins may be of therapeutic benefit
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Extracorporeal shockwave therapy promotes chondrogenesis in cartilage tissue engineering: A hypothesis based on previous evidence
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Relationship between growth factors and its implication in the pathogenesis of leprosy
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Bimodal effect of humic acids on the LPS-induced TNF-α release from differentiated U937 cells
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Intervertebral Disk Repair by Protein, Gene, or Cell Injection: A Framework for Rehabilitation‐Focused Biologics in the Spine
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The High Clinical Burden of Erosive Hand Osteoarthritis is Associated with Clinical Findings, Pain, and Radiographic Severity
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The High Clinical Burden of Erosive Hand Osteoarthritis is Associated with Clinical Findings, Pain, and Radiographic Severity
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Osteoarthritis: An Overview of the Disease and Its Treatment Strategies
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Nerve Growth Factor in Rheumatic Diseases
inferred← citeshttps://doi.org/10.1016/j.tox.2026.154403openalex-snapshot
PFHxS exposure causes osteoarthritis through the innate immune signaling pathway mediated by lipid peroxidation
inferred← citeshttps://doi.org/10.1016/j.ultrasmedbio.2014.03.002openalex-snapshot
Effects of Low-Intensity Pulsed Ultrasound on Integrin-FAK-PI3K/Akt Mechanochemical Transduction in Rabbit Osteoarthritis Chondrocytes
inferred← citeshttps://doi.org/10.1038/s41598-020-72227-9openalex-snapshot
Nociceptive mechanisms driving pain in a post-traumatic osteoarthritis mouse model
inferred← citeshttps://doi.org/10.1038/s41598-020-78757-6openalex-snapshot
Characterization of regional meniscal cell and chondrocyte phenotypes and chondrogenic differentiation with histological analysis in osteoarthritic donor-matched tissues
inferred← citeshttps://doi.org/10.1039/c4md00556bopenalex-snapshot
Evaluation of the anti-inflammatory/chondroprotective activity of aldose reductase inhibitors in human chondrocyte cultures
inferred← citeshttps://doi.org/10.1073/pnas.0510645103openalex-snapshot
Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade
inferred← citeshttps://doi.org/10.1073/pnas.2116855119openalex-snapshot
Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction
inferred← citeshttps://doi.org/10.1074/jbc.m609040200openalex-snapshot
Basic Fibroblast Growth Factor Stimulates Matrix Metalloproteinase-13 via the Molecular Cross-talk between the Mitogen-activated Protein Kinases and Protein Kinase Cδ Pathways in Human Adult Articular Chondrocytes
inferred← citeshttps://doi.org/10.1080/10408360591001886openalex-snapshot
New Biochemical Insights into the Pathogenesis of Osteoarthritis and the Role of Laboratory Investigations in Clinical Assessment
inferred← citeshttps://doi.org/10.1089/dna.2005.24.446openalex-snapshot
Wnt Influence on Chondrocyte Differentiation and Cartilage Function
inferred← citeshttps://doi.org/10.1093/ecam/neh117openalex-snapshot
Biological Basis for the Use of Botanicals in Osteoarthritis and Rheumatoid Arthritis: A Review
inferred← citeshttps://doi.org/10.1093/rheumatology/kel419openalex-snapshot
Interleukin-1 induced activation of nuclear factor- b can be inhibited by novel pharmacological agents in osteoarthritis
inferred← citeshttps://doi.org/10.1093/rheumatology/kem323openalex-snapshot
17 -Oestradiol up-regulates the expression of a functional UDP-glucose dehydrogenase in articular chondrocytes: comparison with effects of cytokines and growth factors
inferred← citeshttps://doi.org/10.1096/fj.05-4504comopenalex-snapshot
Matrix metalloproteinase 2 and tissue inhibitors of metalloproteinases regulate human aortic smooth muscle cell migration during in vitro aging
inferred← citeshttps://doi.org/10.1097/brs.0b013e3181883883openalex-snapshot
The Action of Resveratrol, a Phytoestrogen Found in Grapes, on the Intervertebral Disc
inferred← citeshttps://doi.org/10.1101/2023.03.28.533768openalex-snapshot
Biochemical reactions between intra-articular tissues and joint instability in a rat model of osteoarthritis
inferred← citeshttps://doi.org/10.1117/1.1854131openalex-snapshot
Fourier transform infrared imaging spectroscopy analysis of collagenase-induced cartilage degradation
inferred← citeshttps://doi.org/10.1136/annrheumdis-2020-217072openalex-snapshot
Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence
inferred← citeshttps://doi.org/10.1136/ard.2004.029140openalex-snapshot
Increased pentosidine, an advanced glycation end product, in serum and synovial fluid from patients with knee osteoarthritis and its relation with cartilage oligomeric matrix protein
inferred← citeshttps://doi.org/10.1136/bmjopen-2020-048298openalex-snapshot
Relative effectiveness of non-surgical interventions for pain management in knee osteoarthritis: a protocol for a component network meta-analysis of randomised controlled trials
inferred← citeshttps://doi.org/10.1152/ajpcell.00529.2005openalex-snapshot
Dynamic biophysical strain modulates proinflammatory gene induction in meniscal fibrochondrocytes
inferred← citeshttps://doi.org/10.11606/d.10.2013.tde-06122013-142533openalex-snapshot
Avaliação dos efeitos da utilização de plasma autólogo condicionado em articulações sinoviais hígidas de equinos
inferred← citeshttps://doi.org/10.11606/d.10.2016.tde-19082015-151340openalex-snapshot
Estudo in vitro do potencial de diferenciação condrogênico e osteogênico de células mesenquimais obtidas de líquido e membrana sinovial de equinos
inferred← citeshttps://doi.org/10.11606/t.10.2014.tde-13112014-143630openalex-snapshot
Desenvolvimento de protocolo de avaliação, por determinação de escore, das alterações encontradas nas doenças articulares em equinos e sua correlação com evolução após tratamento
inferred← citeshttps://doi.org/10.1177/0006355x2006043003004029openalex-snapshot
Human chondrocytes and mesenchymal stem cells grown onto engineered scaffold
inferred← citeshttps://doi.org/10.1177/10225536221147213openalex-snapshot
Expression and diagnostic significance of integrin beta-2 in synovial fluid of patients with osteoarthritis
inferred← citeshttps://doi.org/10.1177/10538127261477951openalex-snapshot
Temporal effects of Palmitoylethanolamide (PEA) in modulating knee osteoarthritis symptoms: A randomized, double-blind, placebo-controlled trial
inferred← citeshttps://doi.org/10.1177/1759720x13508508openalex-snapshot
Clinical experience with duloxetine in the management of chronic musculoskeletal pain. A focus on osteoarthritis of the knee
inferred← citeshttps://doi.org/10.1177/1947603514553095openalex-snapshot
Effects of Adipokines and Insulin on Intracellular pH, Calcium Concentration, and Responses to Hypo-Osmolarity in Human Articular Chondrocytes from Healthy and Osteoarthritic Cartilage
inferred← citeshttps://doi.org/10.1177/2040622312454157openalex-snapshot
Prospects for treating osteoarthritis: enzyme–protein interactions regulating matrix metalloproteinase activity
inferred← citeshttps://doi.org/10.1186/1471-2474-9-16openalex-snapshot
Extracorporeal shock waves down-regulate the expression of interleukin-10 and tumor necrosis factor-alpha in osteoarthritic chondrocytes
inferred← citeshttps://doi.org/10.1186/ar2407openalex-snapshot
Action of fibroblast growth factor-2 on the intervertebral disc
inferred← citeshttps://doi.org/10.1186/ar3273openalex-snapshot
Chemerin/ChemR23 pathway: a system beyond chemokines
inferred← citeshttps://doi.org/10.1186/ar4037openalex-snapshot
Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development
inferred← citeshttps://doi.org/10.1186/s12967-025-07022-zopenalex-snapshot
Serum TSP-1 is a useful biomarker in severity assessment and the diagnosis of osteoarthritis
inferred← citeshttps://doi.org/10.1186/s13075-015-0586-5openalex-snapshot
Detecting cathepsin activity in human osteoarthritis via activity-based probes
inferred← citeshttps://doi.org/10.1186/s13075-024-03342-5openalex-snapshot
Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
inferred← citeshttps://doi.org/10.1186/s40001-023-01034-5openalex-snapshot
RETRACTED ARTICLE: Emerging role of mesenchymal stem/stromal cells (MSCs) and MSCs-derived exosomes in bone- and joint-associated musculoskeletal disorders: a new frontier
inferred← citeshttps://doi.org/10.1203/01.pdr.0000156510.96253.5aopenalex-snapshot
Joint and Bone Disease in Mucopolysaccharidoses VI and VII: Identification of New Therapeutic Targets and BioMarkers Using Animal Models
inferred← citeshttps://doi.org/10.1258/ebm.2012.011278openalex-snapshot
Expression of the H- and L-subunits of ferritin in bone marrow macrophages of patients with osteoarthritis
inferred← citeshttps://doi.org/10.12659/msm.892409openalex-snapshot
Serum and Synovial Fluid Levels of CCL18 are Correlated with Radiographic Grading of Knee Osteoarthritis
inferred← citeshttps://doi.org/10.12680/balneo.2022.564openalex-snapshot
Cellular and Molecular Homeostatic Microenvironmental imbalances in Osteoarthritis and Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.1364/boe.485082openalex-snapshot
Nanosensitive optical coherence tomography for detecting structural changes in stem cells
inferred← citeshttps://doi.org/10.1517/13543776.2014.937424openalex-snapshot
Matrix metalloproteinase inhibitors: a patent review (2011 – 2013)
inferred← citeshttps://doi.org/10.1517/21678707.2014.978856openalex-snapshot
The cellular microenvironment: a new target in the search for cellular and molecular treatment for Dupuytren’s disease
inferred← citeshttps://doi.org/10.15212/bioi-2021-0025openalex-snapshot
The Roles of Long Non-coding RNAs in Osteogenic Differentiation and Bone Diseases
inferred← citeshttps://doi.org/10.16965/ijpr.2017.240openalex-snapshot
EFFECT OF AGE, CARTILAGE HEALTH AND PAIN ON THE ISOMETRIC STRENGTH OF KNEE MUSCULATURE: A CROSS-SECTIONAL STUDY
inferred← citeshttps://doi.org/10.17582/journal.aavs/2021/9.1.26.34openalex-snapshot
Synergistic Effect of Nanocurcumin and Platelet Rich Plasma on Resolving Experimentally Induced Osteoarthritis in Albino Rats
inferred← citeshttps://doi.org/10.17832/isc.2012.22.2.1openalex-snapshot
Advances in Prevention and Diagnosis of Osteoarthritis
inferred← citeshttps://doi.org/10.18311/ijmds/2020/24871openalex-snapshot
Oxaceprol Monotherapy versus Oxaceprol and Glucosamine Combination Therapy for Knee Osteoarthritis
inferred← citeshttps://doi.org/10.18325/jkmr.2015.25.2.015openalex-snapshot
Effects of Bujasasim-tang Ethanol Extract on Oxidative Stress, Inflammation and Osteoarthritic Rat Model
inferred← citeshttps://doi.org/10.18410/jebmh/2016/285openalex-snapshot
ROLE OF TUMOUR NECROSIS FACTOR ALPHA (TNF-α) AND INTERLEUKIN-6 (IL-6) IN POSTMENOPAUSAL OSTEOARTHRITIC FEMALE PATIENTS
inferred← citeshttps://doi.org/10.2147/btat.s44217openalex-snapshot
Phytothermotherapy in osteoarthritis: new evidence for an old therapy
inferred← citeshttps://doi.org/10.2147/dddt.s244462openalex-snapshot
Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
inferred← citeshttps://doi.org/10.2147/jir.s82320openalex-snapshot
The macrophages in rheumatic diseases
inferred← citeshttps://doi.org/10.2147/jpr.s186413openalex-snapshot
Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats
inferred← citeshttps://doi.org/10.2147/jpr.s421689openalex-snapshot
A Secondary Analysis: Comparison of Experimental Pain and Psychological Impact in Individuals with Carpometacarpal and Knee Osteoarthritis
inferred← citeshttps://doi.org/10.2165/00063030-200519060-00003openalex-snapshot
Novel Biological Approaches to the Intra-Articular Treatment of Osteoarthritis
inferred← citeshttps://doi.org/10.2174/1381612825666190708184745openalex-snapshot
Targeting Polymeric Nanobiomaterials as a Platform for Cartilage Tissue Engineering
inferred← citeshttps://doi.org/10.2174/157339708785133460openalex-snapshot
Does Osteoblast to Adipocyte Differentiation Play a Role in Osteoarthritis?
inferred← citeshttps://doi.org/10.2174/157340613804488378openalex-snapshot
5-Arylidene-4-Thiazolidinone Derivatives Active as Antidegenerative Agents on Human Chondrocyte Cultures
inferred← citeshttps://doi.org/10.2217/ijr.10.3openalex-snapshot
Joint aging and chondrocyte cell death
inferred← citeshttps://doi.org/10.2217/rme-2022-0110openalex-snapshot
An Observational Study Evaluating the Efficacy of Microfragmented Adipose Tissue in the Treatment of Osteoarthritis
inferred← citeshttps://doi.org/10.22203/ecm.v037a04openalex-snapshot
Therapeutic efficacy of intra-articular delivery of encapsulated human mesenchymal stem cells on early stage osteoarthritis
inferred← citeshttps://doi.org/10.22271/ortho.2019.v5.i4c.1656openalex-snapshot
The study on prevalence and management of osteoarthritis in South India
inferred← citeshttps://doi.org/10.2298/ns20140129filipovicopenalex-snapshot
Glukozamin sulfat u lecenju osteoartroze kolena
inferred← citeshttps://doi.org/10.2460/ajvr.82.11.912openalex-snapshot
Pharmacokinetics of grapiprant administered to red-tailed hawks (Buteo jamaicensis) after food was withheld for 24 hours
inferred← citeshttps://doi.org/10.26855/ijfsa.2021.12.014openalex-snapshot
Osteoarthritis in Dogs—Effect of Diet
inferred← citeshttps://doi.org/10.2741/1817openalex-snapshot
Matrix Metalloproteinases: Role In Arthritis
inferred← citeshttps://doi.org/10.2741/361openalex-snapshot
Osteoarthritis: genetic factors, animal models, mechanisms, and therapies
inferred← citeshttps://doi.org/10.2741/4105openalex-snapshot
Towards elucidating the role of SirT1 in osteoarthritis
inferred← citeshttps://doi.org/10.3109/08923973.2014.972414openalex-snapshot
Acetylated derivative of glaucine inhibits joint inflammation in collagenase-induced arthritis
inferred← citeshttps://doi.org/10.3109/1354750x.2011.634028openalex-snapshot
Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis
inferred← citeshttps://doi.org/10.3109/1354750x.2014.955884openalex-snapshot
Chopping off the chondrocyte proteome
inferred← citeshttps://doi.org/10.32469/10355/78600openalex-snapshot
Characterization of the relationship between radiographic grading and biomarkers in patients with knee osteoarthritis
inferred← citeshttps://doi.org/10.33564/ijeast.2020.v05i04.053openalex-snapshot
LIVE BETTER ADDING AVOCADO FRUIT TO YOUR DAILY DIET
inferred← citeshttps://doi.org/10.3389/fmed.2021.727700openalex-snapshot
Editorial: Inflammation and Biomarkers in Osteoarthritis
inferred← citeshttps://doi.org/10.3389/fvets.2020.00570openalex-snapshot
Intra-articular Administration of Allogeneic Adipose Derived MSCs Reduces Pain and Lameness in Dogs With Hip Osteoarthritis: A Double Blinded, Randomized, Placebo Controlled Pilot Study
inferred← citeshttps://doi.org/10.3390/antiox9040348openalex-snapshot
Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview
inferred← citeshttps://doi.org/10.3390/ijms19030674openalex-snapshot
Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis
inferred← citeshttps://doi.org/10.3390/jcm14217573openalex-snapshot
The Effect of IL-17A and Combined Mechanical Injury on Meniscal Tissue Integrity In Vitro
inferred← citeshttps://doi.org/10.3390/jfmk2030027openalex-snapshot
A Role for Soluble IL-6 Receptor in Osteoarthritis
inferred← citeshttps://doi.org/10.3390/polym15051172openalex-snapshot
MMP-2 Silencing through siRNA Loaded Positively-Charged Nanoparticles (AcPEI-NPs) Counteracts Chondrocyte De-Differentiation
inferred← citeshttps://doi.org/10.36106/ijsr/4924280openalex-snapshot
ROLE OF PREGABALIN IN POSTOPERATIVE PAIN MANAGEMENT IN PATIENTS UNDERGOING TOTAL KNEE ARTHROPLASTY
inferred← citeshttps://doi.org/10.36837/chapman.000208openalex-snapshot
Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.3746/jkfn.2013.42.8.1183openalex-snapshot
Effects of Oyster Shell Extract on Papain-induced Osteoarthritis in C57BL/6J Mice
inferred← citeshttps://doi.org/10.3892/etm.2017.4636openalex-snapshot
Expression of synovial fluid biomarkers in patients with knee osteoarthritis and meniscus injury
inferred← citeshttps://doi.org/10.3892/etm.2022.11459openalex-snapshot
Protective role of Achyranthes bidentata polysaccharides against chondrocyte extracellular matrix degeneration through lncRNA GAS5 in osteoarthritis
inferred← citeshttps://doi.org/10.3892/ijmm.2014.1743openalex-snapshot
MicroRNAs play a role in chondrogenesis and osteoarthritis (Review)
inferred← citeshttps://doi.org/10.3892/mmr.2013.1729openalex-snapshot
Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes
inferred← citeshttps://doi.org/10.3892/mmr.2015.3939openalex-snapshot
Quantitative analysis of the mRNA expression levels of BCL2 and BAX genes in human osteoarthritis and normal articular cartilage: An investigation into their differential expression
inferred← citeshttps://doi.org/10.3892/mmr.2016.5981openalex-snapshot
Effects of miR-145 on the inhibition of chondrocyte proliferation and fibrosis by targeting TNFRSF11B in human osteoarthritis
inferred← citeshttps://doi.org/10.3892/mmr.2017.8209openalex-snapshot
Influence of protein kinase RIPK4 expression on the apoptosis and proliferation of chondrocytes in osteoarthritis
inferred← citeshttps://doi.org/10.3923/ijp.2016.440.450openalex-snapshot
Myricetin Exerts Anti-osteoarthritic Effects in IL-1β Stimulated SW1353 Cells via Regulating Matrix Metalloproteinases and Modulating JNK/P38MAPK/Ap-1/c-Fos and JAK/STAT Signalling
inferred← citeshttps://doi.org/10.4081/reumatismo.2013.97openalex-snapshot
Bradykinin and its role in osteoarthritis
inferred← citeshttps://doi.org/10.4236/jbise.2016.97027openalex-snapshot
Inhibition of Osteoarthritis in Rats by Electroporation with Interleukin-1 Receptor Antagonist
inferred← citeshttps://doi.org/10.4274/tod.galenos.2024.29974openalex-snapshot
Bilateral Shoulder Osteoarthritis After COVID-19 in a Patient with Hereditary Spastic Paraplegia: A Case Report
inferred← citeshttps://doi.org/10.4414/smw.2010.13098openalex-snapshot
New horizons in osteoarthritis
inferred← citeshttps://doi.org/10.47749/t/unicamp.2009.439192openalex-snapshot
Participação do HIF-1'alfa' na expressão de colageno tipo II e agrecano na cartilagem articular mediada pela IL-1'beta' e TNF'alfa'
inferred← citeshttps://doi.org/10.5204/thesis.eprints.103634openalex-snapshot
Role of hypercholesterolemia in osteoarthritis development
inferred← citeshttps://doi.org/10.52711/0974-360x.2023.00057openalex-snapshot
Association between Sodium Intake and Biopsychosocial Factors with Knee Joint Pain in Osteoarthritis patient
inferred← citeshttps://doi.org/10.52965/001c.25549openalex-snapshot
A Comprehensive Review of Viscosupplementation in Osteoarthritis of the Knee
inferred← citeshttps://doi.org/10.55905/oelv21n6-110openalex-snapshot
Clinical measures and gait parameters in individuals with knee Osteoarthritis: a comparison between men and women
inferred← citeshttps://doi.org/10.56808/2985-1130.2689openalex-snapshot
The Use of Omega-3 Concentrate to Relieve Coxofemoral Osteoarthritic Pain in Dogs
inferred← citeshttps://doi.org/10.56808/2985-1130.2739openalex-snapshot
Ameliorative Effects of Omega-3 Concentrate in Managing Coxofemoral Osteoarthritic Pain in Dogs
inferred← citeshttps://doi.org/10.5772/26805openalex-snapshot
Biochemical Mediators Involved in Cartilage Degradation and the Induction of Pain in Osteoarthritis
inferred← citeshttps://doi.org/10.58837/chula.the.2017.352openalex-snapshot
Characterization of t cell secreted cytokines and cytotoxic mediators profiling in knee osteoarthritis patients
inferred← citeshttps://doi.org/10.6061/clinics/2012(01)06openalex-snapshot
Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes
inferred← citeshttps://doi.org/10.6084/m9.figshare.26725292openalex-snapshot
Additional file 1 of Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1
inferred← citeshttps://doi.org/10.70675/336e1eabz92c2z463cza33cz5d08cd35f9abopenalex-snapshot
Evaluation d'outils pour l'étude de l'arthrose à l'échelle protéique, cellulaire et animale
inferred← citeshttps://doi.org/10.70675/f4162315z2c94z404ezb198zaaa068d79125openalex-snapshot
Lin28a induit la reprogrammation du métabolisme énergétique des chondrocytes pour régénérer le cartilage
inferred← citeshttps://doi.org/10.7916/d8709j98openalex-snapshot
Investigations of Articular Cartilage Delamination Wear and a Novel Laser Treatment Strategy to Increase Wear Resistance
inferred← citeshttps://doi.org/10.7916/d8vh74xcopenalex-snapshot
Regulation of Chondrogenesis in Human Mesenchymal Stem Cells by Cartilage Extracellular Matrix and Therapeutic Applications
inferred← citeshttps://doi.org/10.9790/3013-037109-12openalex-snapshot
Effects of D-002 on Formaldehyde-Induced Osteoarthritis in Rats
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