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Coagulation and fibrinolysis abnormalities in obesity

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Reciprocal regulation of tissue‐type and urokinase‐type plasminogen activators in the differentiation of murine preadipocyte line 3T3‐L1 and the hormonal regulation of fibrinolytic factors in the mature adipocytes

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Insulin Continues to Induce Plasminogen Activator Inhibitor 1 Gene Expression in Insulin-Resistant Mice and Adipocytes

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Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss

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Stimulation in vivo of expression of intra-abdominal adipose tissue plasminogen activator inhibitor Type I by proinsulin

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Influence of free testosterone on antigen levels of plasminogen activator inhibitor-1 in premonopausal women with central obesity

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Lower androgenicity is associated with higher plasma levels of prothrombotic factors irrespective of age, obesity, body fat distribution, and related metabolic parameters in men

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Plasma plasminogen activator inhibitor-I is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women

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Factor VII, Tissue Factor Pathway Inhibitor, and Monocyte Tissue Factor in Diabetes Mellitus: Influence of Type of Diabetes, Obesity Index, and Age

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Dietary treatment of thrombogenic disorders related tothe metabolic syndrome

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Thrombophilia in Patients with Hypertriglyceridemia

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Leptin Does Not Play a Major Role in Platelet Aggregation in Obesity and Leptin Deficiency

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Increase in both pro-thrombotic and anti-thrombotic factors in obese premenopausal women: relationship with body fat distribution

inferredcites →https://doi.org/10.1038/sj.ijo.0801087openalex-snapshot

Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 gene during very low calorie diet in obese subjects

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Effects of short-term energy restriction and physical training on haemostatic risk factors for coronary heart disease in obese children and adolescents

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The effect of fish oil on hypertension, plasma lipids and hemostasis in hypertensive, obese, dyslipidemic patients with and without diabetes mellitus

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Influence of t-PA and u-PA on Adipose Tissue Development in a Murine Model of Diet-Induced Obesity

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Activated Protein C Resistance and the FV:R506Q Mutation in a Random Population Sample

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A Family History of Type 2 Diabetes Is Associated with Lower Sensitivity to Activated Protein C in Overweight and Obese Premenopausal Women

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Fat Cell Function and Fibrinolysis

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Regulation of Plasminogen Activitor Inhibitor-1 in Human Adipose Tissue: Interaction Between Cytokines, Cortisol and Estrogen

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Clustering of Procoagulation, Inflammation, and Fibrinolysis Variables with Metabolic Factors in Insulin Resistance Syndrome

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Correlation between cholesterol, soluble P-selectin, and D-dimer in obese children and adolescents

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The Fat Mouse: A Powerful Genetic Model to Study Hemostatic Gene Expression in Obesity/NIDDM

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Effect of Leptin in Platelet and Endothelial Cells: Obesity and Arterial Thrombosis

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The Prothrombotic Effects of Leptin

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Activation of Tissue Factor–Induced Coagulation and Endothelial Cell Dysfunction in Non–Insulin-Dependent Diabetic Patients With Microalbuminuria

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Visceral Fat Accumulation and Its Relation to Plasma Hemostatic Factors in Healthy Men

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Moderate Genetic Influences on Plasma Levels of Plasminogen Activator Inhibitor-1 and Evidence of Genetic and Environmental Influences Shared by Plasminogen Activator Inhibitor-1, Triglycerides, and Body Mass Index

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Influence of PAI-1 on Adipose Tissue Growth and Metabolic Parameters in a Murine Model of Diet-Induced Obesity

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Angiotensin II and Its Metabolites Stimulate PAI-1 Protein Release From Human Adipocytes in Primary Culture

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Inhibition of Platelet-Collagen Interaction

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Hormonal Control of Plasminogen Activator Inhibitor-1 Gene Expression and Production in Human Adipose Tissue: Stimulation by Glucocorticoids and Inhibition by Catecholamines1

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Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects.

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Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity.

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High levels of circulating proinflammatory cytokines and leptin in urban, but not rural, Indians. A potential explanation for increased risk of diabetes and coronary heart disease.

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Health consequences of visceral obesity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Effect of Low- Power Laser Therapy with Aerobic Exercise on Anthropometric Measures and Selected Coagulation Biomarkers in Obese Older Adults: Randomized Controlled Trial

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References

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Adipose Tissue and Overweight

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Management of Venous Thromboembolism in the Critically Ill Obese Patient

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Fibrinogen kinetics and protein turnover in obese non‐diabetic males: effects of insulin

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Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study

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Life‐threatening spontaneous uterine rupture in a non‐gravid, unscarred uterus of a nulliparous woman: A case report

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Plasma marker proteins associated with the progression of lung cancer in obese mice fed a high‐fat diet

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Vicious Link of Obesity with Cardiometabolic and Renal Diseases

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Obesity and COVID19

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Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome

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Clinical markers of the hypercoagulable state by rotational thrombelastometry in obese patients submitted to bariatric surgery

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Bariatric surgery in morbidly obese individuals affects plasma levels of protein C and thrombomodulin

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Global Research Hotspots and Trends in Obesity-Related Venous Thromboembolism (2000–2025): a Bibliometric Analysis

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Study of Prothrombotic Changes in Metabolic Syndrome

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The Acute Effects of Postprandial Hypertriglyceridemia on Coagulation Parameters in Normal and Overweight Individuals

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Impact of body mass index on outcomes after primary angioplasty in acute myocardial infarction

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Hematopoietic Tissue Factor–Protease-Activated Receptor 2 Signaling Promotes Hepatic Inflammation and Contributes to Pathways of Gluconeogenesis and Steatosis in Obese Mice

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Impact of body mass index on In-Hospital outcomes following percutaneous coronary intervention (report from the New York State Angioplasty Registry)11*This study was performed with the permission of the New York State Department of Health, which retains ownership of the registry.

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Haemostatic alterations in overweight children: Associations between metabolic syndrome, thrombin generation, and fibrinogen levels

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Obesity-Related Traits Partially Mediate the Impact of Obstructive Sleep Apnea on the risk of Venous Thromboembolism

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Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance

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sP-selectin plasma levels in obesity: Association with insulin resistance and related metabolic and prothrombotic factors

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Circulating procoagulant microparticles in obesity

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Tissue Factor Pathway–Driven Initial Thrombin Generation is Associated with Hypercoagulability in Obesity

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Significant associations between hemostatic/fibrinolytic systems and accumulation of cardiovascular risk factors in Japanese elementary schoolchildren

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Mice with diet-induced obesity demonstrate a relative prothrombotic factor profile and a thicker aorta with reduced ex-vivo function

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Hypercoagulable state in C ushing's syndrome is reversible following remission

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Inflammatory and haemostatic markers in idiopathic intracranial hypertension

inferred← citeshttps://doi.org/10.1111/j.1474-9726.2010.00608.xopenalex-snapshot

Fat tissue, aging, and cellular senescence

inferred← citeshttps://doi.org/10.1111/j.1538-7836.2006.02038.xopenalex-snapshot

Thrombin generation in severely obese children

inferred← citeshttps://doi.org/10.1111/j.1753-4887.1956.tb01403.xopenalex-snapshot

OBESITY AND CORONARY ARTERY DISEASE

inferred← citeshttps://doi.org/10.1111/jth.13369openalex-snapshot

C‐reactive protein, obesity, and the risk of arterial and venous thrombosis

inferred← citeshttps://doi.org/10.1111/jvim.12159openalex-snapshot

Assessment of Coagulation and Potential Biochemical Markers for Hypercoagulability in Canine Hyperadrenocorticism

inferred← citeshttps://doi.org/10.1155/2015/291209openalex-snapshot

Tissue Factor Expression in Obese Type 2 Diabetic Subjects and Its Regulation by Antidiabetic Agents

inferred← citeshttps://doi.org/10.1160/th11-01-0030openalex-snapshot

Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients

inferred← citeshttps://doi.org/10.1160/th14-02-0156openalex-snapshot

Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events

inferred← citeshttps://doi.org/10.11606/t.5.2014.tde-25022015-083517openalex-snapshot

Impacto da pressão arterial sobre os marcadores metabólicos, inflamatórios e hemodinâmicos em pacientes com síndrome metabólica

inferred← citeshttps://doi.org/10.1161/01.atv.0000191656.71812.7copenalex-snapshot

Diabetes, the Metabolic Syndrome, and Angiographic Progression of Coronary Arterial Disease in Postmenopausal Women

inferred← citeshttps://doi.org/10.1161/01.res.0000163635.62927.34openalex-snapshot

Adipose Tissue, Inflammation, and Cardiovascular Disease

inferred← citeshttps://doi.org/10.1161/atvbaha.107.148221openalex-snapshot

Links Between Adipose Tissue and Thrombosis in the Mouse

inferred← citeshttps://doi.org/10.1161/atvbaha.123.318286openalex-snapshot

Clot or Not? Reviewing the Reciprocal Regulation Between Lipids and Blood Clotting

inferred← citeshttps://doi.org/10.1161/circulationaha.105.169404openalex-snapshot

Diagnosis and Management of the Metabolic Syndrome

inferred← citeshttps://doi.org/10.1161/jaha.119.012860openalex-snapshot

Association of Body Mass Index and Extreme Obesity With Long‐Term Outcomes Following Percutaneous Coronary Intervention

inferred← citeshttps://doi.org/10.1172/jci19246openalex-snapshot

Obesity is associated with macrophage accumulation in adipose tissue

inferred← citeshttps://doi.org/10.1177/0192623318803557openalex-snapshot

The Effect of Diet-induced Obesity on Toxicological Parameters in the Polygenic Sprague-Dawley Rat Model

inferred← citeshttps://doi.org/10.1177/107602960501100308openalex-snapshot

Hemostatic Status and Fibrinolytic Response Potential at Different Phases of the Menstrual Cycle

inferred← citeshttps://doi.org/10.1177/1076029606291403openalex-snapshot

Decrements in the Thrombin Activatable Fibrinolysis Inhibitor (TAFI) Levels in Association with Orlistat Treatment in Obesity

inferred← citeshttps://doi.org/10.1182/blood-2003-08-2860openalex-snapshot

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma

inferred← citeshttps://doi.org/10.1182/blood-2013-05-427708openalex-snapshot

Inflammation, obesity, and thrombosis

inferred← citeshttps://doi.org/10.1186/s12944-025-02700-9openalex-snapshot

Association between serum triglyceride levels and venous thrombosis risk in older Chinese patients with fractures: a retrospective cross-sectional study

inferred← citeshttps://doi.org/10.1186/s12959-024-00641-4openalex-snapshot

Coagulation dysfunction events associated with echinocandins: a real-world study from FDA adverse event reporting system (FAERS) database

inferred← citeshttps://doi.org/10.1186/s12974-026-03774-7openalex-snapshot

Obesity supersizes macrophage and neutrophil activation after stroke while lipid droplets play a protective role

inferred← citeshttps://doi.org/10.1186/s12979-020-00212-xopenalex-snapshot

Obesity and COVID-19: what makes obese host so vulnerable?

inferred← citeshttps://doi.org/10.1201/9780203508756-19openalex-snapshot

Weight Loss and Associated Diseases

inferred← citeshttps://doi.org/10.1201/9780203508756.ch9openalex-snapshot

Weight Loss and Associated Diseases

inferred← citeshttps://doi.org/10.1201/9781420006568.ch5openalex-snapshot

The Multifactorial Model of Cardiovascular Pathology

inferred← citeshttps://doi.org/10.1210/clinem/dgab124openalex-snapshot

Lifestyle Intervention Improves Prothrombotic Coagulation Profile in Individuals at High Risk for Type 2 Diabetes

inferred← citeshttps://doi.org/10.1210/jc.2004-0372openalex-snapshot

Obesity, Metabolic Syndrome, and Cardiovascular Disease

inferred← citeshttps://doi.org/10.1253/circj.72.521openalex-snapshot

Impact of Body Mass Index on In-Hospital Outcomes After Percutaneous Coronary Intervention for ST Segment Elevation Acute Myocardial Infarction

inferred← citeshttps://doi.org/10.1308/205016815814954911openalex-snapshot

Managing Bariatric Patients in Dentistry

inferred← citeshttps://doi.org/10.1345/aph.1r720openalex-snapshot

Dabigatran: Is There a Role for Coagulation Assays in Guiding Therapy?

inferred← citeshttps://doi.org/10.1371/journal.pone.0168878openalex-snapshot

Weight Change and Risk of Venous Thromboembolism: The Tromsø Study

inferred← citeshttps://doi.org/10.1385/1-59259-865-x:119openalex-snapshot

Medical Consequences of Obesity and Benefits of Weight Loss

inferred← citeshttps://doi.org/10.1515/cclm.2007.020openalex-snapshot

Evaluation of pre-analytical, demographic, behavioural and metabolic variables on fibrinolysis and haemostasis activation markers utilised to assess hypercoagulability

inferred← citeshttps://doi.org/10.1530/ec-21-0490openalex-snapshot

Reduced fibrin clot lysis in Klinefelter syndrome associated with hypogonadism

inferred← citeshttps://doi.org/10.15407/ubj95.04.003openalex-snapshot

Characterization of the blood coagulation system in morbidly obese patients

inferred← citeshttps://doi.org/10.1542/peds.2004-0289openalex-snapshot

Obesity and Renal Transplant Outcome: A Report of the North American Pediatric Renal Transplant Cooperative Study

inferred← citeshttps://doi.org/10.1576/toag.11.1.25.27465openalex-snapshot

Obesity: impact on obstetric practice and outcome

inferred← citeshttps://doi.org/10.1586/14779072.4.4.487openalex-snapshot

Stroke prevention in diabetes and obesity

inferred← citeshttps://doi.org/10.1586/eem.10.68openalex-snapshot

The Nε-(carboxymethyl)lysine–RAGE axis: putative implications for the pathogenesis of obesity-related complications

inferred← citeshttps://doi.org/10.1590/s0104-42302010000100026openalex-snapshot

Adipose tissue, inflammation and cardiovascular disease

inferred← citeshttps://doi.org/10.1590/s1807-59322006000500010openalex-snapshot

RELATIONSHIP BETWEEN ADIPOKINES, INFLAMMATION, AND VASCULAR REACTIVITY IN LEAN CONTROLS AND OBESE SUBJECTS WITH METABOLIC SYNDROME

inferred← citeshttps://doi.org/10.1677/joe.0.1810001openalex-snapshot

Leptin and hyperleptinemia - from friend to foe for cardiovascular function

inferred← citeshttps://doi.org/10.17116/repro201622140-43openalex-snapshot

Oral contraception influence on early metabolic syndrome

inferred← citeshttps://doi.org/10.17219/acem/44361openalex-snapshot

Determinants of Elevated Levels of Natural Anticoagulants in Healthy Subjects

inferred← citeshttps://doi.org/10.18705/1607-419x-2020-26-4-440-446openalex-snapshot

Obesity and COVID-19

inferred← citeshttps://doi.org/10.2147/jir.s556871openalex-snapshot

P-Selectin and Platelet–Monocyte Interaction in Inflammation: Mechanisms, Hypothesis, and Open Questions

inferred← citeshttps://doi.org/10.21518/2079-701x-2022-16-6-264-272openalex-snapshot

Pathophysiological disorders in iron metabolism in the development of obesity and metabolic syndrome

inferred← citeshttps://doi.org/10.21608/ejhm.2006.18024openalex-snapshot

Leptin Level and Plasma Prothrombotic Factors in Obese Subjects

inferred← citeshttps://doi.org/10.2169/internalmedicine.47.0787openalex-snapshot

Metformin and Parameters of Physical Health

inferred← citeshttps://doi.org/10.21767/1989-5216.1000284openalex-snapshot

Weight Loss vs. Heart Disease: Weight Loss is Determined by Caloric Intake. Heart Disease is Determined by Dietary Inflammatory Components. True Quantification of Coronary Artery Disease Measured by AI Using FMTVDM©℗

inferred← citeshttps://doi.org/10.2217/clp.12.13openalex-snapshot

The metabolic syndrome and dyslipidemia in primary and secondary prevention: examining the implications of recent trials

inferred← citeshttps://doi.org/10.2459/jcm.0b013e3282eee9a8openalex-snapshot

The role of adiposity as a determinant of an inflammatory milieu

inferred← citeshttps://doi.org/10.24875/rme.21000041openalex-snapshot

Marcadores e índices inflamatorios en diferentes fenotipos metabólicos

inferred← citeshttps://doi.org/10.29333/ejgm/82456openalex-snapshot

RELATIONSHIP BETWEEN VON WILLEBRAND FACTOR ACTIVITY AND THERAPEUTIC SUCCESS OF THROMBOLYTIC THERAPY IN PATIENTS WITH MYOCARDIAL INFARCTION

inferred← citeshttps://doi.org/10.31038/edmj.2020423openalex-snapshot

When two pandemics meet

inferred← citeshttps://doi.org/10.31080/asps.2019.03.0309openalex-snapshot

The Weight, Inflammation, Diet and Heart (WIDtH) Study Looking at Potential Primary Prevention of Coronary Artery Disease

inferred← citeshttps://doi.org/10.3109/9781420018905.009openalex-snapshot

Risk Assessment and Treatment Standards of Obesity and Overweight in Relation to Cardiovascular Disease

inferred← citeshttps://doi.org/10.32007/jfacmedbagdad.591162openalex-snapshot

The relationship between obesity and plasma level of factor V and fibrinogen

inferred← citeshttps://doi.org/10.32007/med.1936/jfacmedbagdad.v59i1.11openalex-snapshot

The relationship between obesity and plasma level of factor V and fibrinogen

inferred← citeshttps://doi.org/10.33805/2690-2613.105openalex-snapshot

Cardiovascular Outcomes of Diet Counseling

inferred← citeshttps://doi.org/10.3389/fcell.2022.840866openalex-snapshot

Associations of Visceral Adipose Tissue, Circulating Protein Biomarkers, and Risk of Cardiovascular Diseases: A Mendelian Randomization Analysis

inferred← citeshttps://doi.org/10.3389/fcvm.2022.897733openalex-snapshot

Increased BMI and Blood Lipids Are Associated With a Hypercoagulable State in the Moli-sani Cohort

inferred← citeshttps://doi.org/10.3389/fendo.2026.1781048openalex-snapshot

Incidence and risk factors of tocilizumab-induced hypofibrinogenemia in patients with thyroid eye disease: a single-center retrospective study

inferred← citeshttps://doi.org/10.3390/cancers14071679openalex-snapshot

Thromboinflammatory Processes at the Nexus of Metabolic Dysfunction and Prostate Cancer: The Emerging Role of Periprostatic Adipose Tissue

inferred← citeshttps://doi.org/10.3390/geriatrics7060127openalex-snapshot

Higher Hospital Frailty Risk Score Is an Independent Predictor of In-Hospital Mortality in Hospitalized Older Adults with Obstructive Sleep Apnea

inferred← citeshttps://doi.org/10.3390/ijms19010267openalex-snapshot

Mechanical Activation of Adipose Tissue and Derived Mesenchymal Stem Cells: Novel Anti-Inflammatory Properties

inferred← citeshttps://doi.org/10.3390/ijms21155529openalex-snapshot

Iron Metabolism in Obesity and Metabolic Syndrome

inferred← citeshttps://doi.org/10.3390/jcm15197500openalex-snapshot

From Adipose Tissue Dysfunction to Venous Thromboembolism

inferred← citeshttps://doi.org/10.3390/medicina59020228openalex-snapshot

Body Mass Index and Waist Circumference as Determinants of Hemostatic Factors in Participants of a Population-Based Study

inferred← citeshttps://doi.org/10.3390/metabo16080517openalex-snapshot

BMI-Stratified Physiological Responses to a 12-Week Mat Pilates Intervention on Body Composition, Cardiometabolic Risk Factors, and Autonomic Function in Middle-Aged Women: An Exploratory Secondary Analysis

inferred← citeshttps://doi.org/10.3390/nu17162656openalex-snapshot

Vegan and Plant-Based Diets in the Management of Metabolic Syndrome: A Narrative Review from Anti-Inflammatory and Antithrombotic Perspectives

inferred← citeshttps://doi.org/10.3390/scipharm90010006openalex-snapshot

Dehydroepiandrosterone (DHEA) Improves the Metabolic and Haemostatic Disturbances in Rats with Male Hypogonadism

inferred← citeshttps://doi.org/10.34019/ufjf/di/2021/00460openalex-snapshot

Efeito de exossomos do tecido adiposo de camundongos obesos na polarização de macrófagos

inferred← citeshttps://doi.org/10.4038/sljog.v35i1.6002openalex-snapshot

Obesity in pregnancy – The bigger issues

inferred← citeshttps://doi.org/10.4067/s0717-95022019000200647openalex-snapshot

Pre-Diabetes Induces Ultrastructural Alterations in the Large Blood Vessel Aorta in Rats

inferred← citeshttps://doi.org/10.4081/monaldi.2006.518openalex-snapshot

Cardiovascular complications of obesity

inferred← citeshttps://doi.org/10.4330/wjc.v7.i10.603openalex-snapshot

“Obesity paradox” in coronary artery disease

inferred← citeshttps://doi.org/10.46743/1540-580x/2016.1561openalex-snapshot

Evaluation of Current Heparin Weight Based Protocol in Obese Patients

inferred← citeshttps://doi.org/10.5633/amm.2018.0410openalex-snapshot

THE INFLUENCE OF METABOLIC SYNDROME ON T HE QUALITY OF LIFE IN PATIENTS WITH ACU TE MYOCARDIAL INFARCTION WITH ST SEGMENT ELEVATION

inferred← citeshttps://doi.org/10.5742/mejn2021.9378016openalex-snapshot

NURSES’ PERCEPTION OF ORGANIZATIONAL SUPPORT DURING COVID-19 PANDEMIC

inferred← citeshttps://doi.org/10.5742/mejn2021.9378017openalex-snapshot

OBESITY MAY ACTUALLY BE A PRECIRRHOTIC CONDITION IN ADULTS

inferred← citeshttps://doi.org/10.5742/mejn2021.9378018openalex-snapshot

EFFECT OF REGULAR EXERCISE DURING PREGNANCY ON DURATION OF LABOR: A SYSTEMATIC REVIEW AND META-ANALYSIS

inferred← citeshttps://doi.org/10.5772/32058openalex-snapshot

Risk Factors of Deep Vein Thrombosis

inferred← citeshttps://doi.org/10.5772/65977openalex-snapshot

Obesity and Coronary Artery Disease

inferred← citeshttps://doi.org/10.6064/2012/525374openalex-snapshot

The Prothrombotic Tendency in Metabolic Syndrome: Focus on the Potential Mechanisms Involved in Impaired Haemostasis and Fibrinolytic Balance

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