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Bromelain: biochemistry, pharmacology and medical use

https://doi.org/10.1007/pl00000936
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.2910600324openalex-snapshot
The effect of platelets on invasiveness and protease production of human mammary tumor cells
inferredcites →https://doi.org/10.1007/978-3-642-79511-4_10openalex-snapshot
Bioavailability of Therapeutically Used Hydrolytic Enzymes
inferredcites →https://doi.org/10.1007/978-3-642-79511-4_6openalex-snapshot
Intestinal Absorption of Undegraded Bromelain in Humans
inferredcites →https://doi.org/10.1007/bf00391501openalex-snapshot
Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity
inferredcites →https://doi.org/10.1007/bf01902843openalex-snapshot
Isolation and partial characterization of basic proteinases from stem bromelain
inferredcites →https://doi.org/10.1016/0014-5793(94)00860-4openalex-snapshot
Bromelain protease F9 reduces the CD44 mediated adhesion of human peripheral blood lymphocytes to human umbilical vein endothelial cells
inferredcites →https://doi.org/10.1016/0049-3848(79)90121-xopenalex-snapshot
Bromelain, a thilprotease from pineapple stem, depletes high molecular weight kininogen by activation of Hageman factor (factor XII)
inferredcites →https://doi.org/10.1016/0076-6879(94)44040-9openalex-snapshot
[38] Pineapple cysteine endopeptidases
inferredcites →https://doi.org/10.1016/0378-8741(88)90127-4openalex-snapshot
Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update
inferredcites →https://doi.org/10.1016/s0046-8177(87)80010-2openalex-snapshot
Thrombosis and cancer
inferredcites →https://doi.org/10.1016/s0140-6736(97)10018-6openalex-snapshot
Venous thromboembolism and cancer
inferredcites →https://doi.org/10.1016/s0167-5699(96)30065-0openalex-snapshot
Oral cytokine administration
inferredcites →https://doi.org/10.1016/s0196-0644(87)80759-xopenalex-snapshot
Enzymatic frostbite eschar debridement by bromelain
inferredcites →https://doi.org/10.1021/bi952754+openalex-snapshot
Solution Structure of Bromelain Inhibitor VI from Pineapple Stem: Structural Similarity with Bowman−Birk Trypsin/Chymotrypsin Inhibitor from Soybean,
inferredcites →https://doi.org/10.1023/a:1015899011324openalex-snapshot
Inactivation kinetics of enzyme pharmaceuticals in aqueous solution.
inferredcites →https://doi.org/10.1023/a:1022507316434openalex-snapshot
Isolation and Characterization of Two Forms of an Acidic Bromelain Stem Proteinase
inferredcites →https://doi.org/10.1038/383489a0openalex-snapshot
Mechanosensors in plants
inferredcites →https://doi.org/10.1042/bj3010727openalex-snapshot
Purification and characterization of multiple forms of the pineapple-stem-derived cysteine proteinases ananain and comosain
inferredcites →https://doi.org/10.1042/bj3270199openalex-snapshot
Complete amino acid sequence of ananain and a comparison with stem bromelain and other plant cysteine proteases
inferredcites →https://doi.org/10.1055/s-2006-960949openalex-snapshot
On the Pharmacology of Bromelain: An Update with Special Regard to Animal Studies on Dose-Dependent Effects
inferredcites →https://doi.org/10.1055/s-2006-962475openalex-snapshot
Bromelain Induces the Differentiation of Leukemic Cellsin Vitro: An Explanation for its Cytostatic Effects?
inferredcites →https://doi.org/10.1055/s-2007-1002578openalex-snapshot
Platelets and Cancer Metastasis: More Than an Epiphenomenon
inferredcites →https://doi.org/10.1056/nejm199804233381701openalex-snapshot
The Risk of a Diagnosis of Cancer after Primary Deep Venous Thrombosis or Pulmonary Embolism
inferredcites →https://doi.org/10.1089/cbr.1995.10.147openalex-snapshot
Stimulation of Reactive Oxygen Species Production and Cytotoxicity in Human Neutrophils in vitro and after Oral Administration of a Polyenzyme Preparation
inferredcites →https://doi.org/10.1097/00001622-199701000-00017openalex-snapshot
CD44 as a marker in human cancers
inferredcites →https://doi.org/10.1111/j.1526-4610.1967.hed0701013.xopenalex-snapshot
A DOUBLE‐BLIND CLINICAL EVALUATION OF BROMELAINS IN THE TREATMENT OF ACUTE SINUSITIS
inferredcites →https://doi.org/10.1159/000164070openalex-snapshot
Selective Modulation of Cell Adhesion Molecules on Lymphocytes by Bromelain Protease 5
inferredcites →https://doi.org/10.1159/000215780openalex-snapshot
Platelet Contribution to the Formation of Metastatic Foci: The Role of Cancer Cell-Induced Platelet Activation
inferredcites →https://doi.org/10.1159/000226875openalex-snapshot
Induction of Tumor Necrosis Factor in Human Peripheral-Blood Mononuclear Cells by Proteolytic Enzymes
inferredcites →https://doi.org/10.1159/000227219openalex-snapshot
Cytokine Synthesis in Human Peripheral Blood Mononuclear Cells after Oral Administration of Polyenzyme Preparations
inferredcites →https://doi.org/10.1182/blood.v63.1.55.55openalex-snapshot
Potential role of platelets in the pathogenesis of tumor metastasis
inferredcites →https://doi.org/10.1515/bchm3.1992.373.2.459openalex-snapshot
Characterization and Structure of Pineapple Stem Inhibitor of Cysteine Proteinases
inferredcites →https://doi.org/10.3892/ijo.11.2.243openalex-snapshot
Bromelain proteases suppress growth, invasion and lung metastasis of B16F10 mouse melanoma cells
inferredcites →https://doi.org/10.3892/ijo.5.2.197openalex-snapshot
BROMELAIN PROTEINASE-F9 AUGMENTS HUMAN LYMPHOCYTE-MEDIATED GROWTH-INHIBITION OF VARIOUS TUMOR-CELLS IN-VITRO
inferredcites →https://doi.org/10.4049/jimmunol.149.12.3809openalex-snapshot
Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation
inferredcites →https://doi.org/10.4049/jimmunol.163.5.2568openalex-snapshot
Bromelain, from Pineapple Stems, Proteolytically Blocks Activation of Extracellular Regulated Kinase-2 in T Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Phytochemicals and Health Applications of Dried Passion and Pineapple Fruits
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Pineapples ( Ananas comosus )
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inferred← citeshttps://doi.org/10.1002/9781405181099.k0504openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/bab.1121openalex-snapshot
Polymer‐based alternative method to extract bromelain from pineapple peel waste
inferred← citeshttps://doi.org/10.1002/biof.121openalex-snapshot
Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells
inferred← citeshttps://doi.org/10.1002/btpr.1639openalex-snapshot
Pineapple stem bromelain immobilized on different supports: Catalytic properties in model wine
inferred← citeshttps://doi.org/10.1002/btpr.2098openalex-snapshot
Application of an aqueous two‐phase micellar system to extract bromelain from pineapple ( A nanas comosus ) peel waste and analysis of bromelain stability in cosmetic formulations
inferred← citeshttps://doi.org/10.1002/btpr.2190openalex-snapshot
Stability, purification, and applications of bromelain: A review
inferred← citeshttps://doi.org/10.1002/btpr.2405openalex-snapshot
Heterologous expression of the plant cysteine protease bromelain and its inhibitor in Pichia pastoris
inferred← citeshttps://doi.org/10.1002/ciuz.202400040openalex-snapshot
Ist doch nicht die Möglichkeit! Wackelpeter Ananas!
inferred← citeshttps://doi.org/10.1002/cre2.651openalex-snapshot
Effect of Er:YAG, Co2 lasers, papain, and bromelain enzymes dentin treatment on shear bond strength of composite resin
inferred← citeshttps://doi.org/10.1002/fsn3.70162openalex-snapshot
The Effects of Bromelain Supplementation on Clinical Outcomes, Inflammatory and Oxidative Stress Biomarkers in Patients With Traumatic Brain Injury: A Randomized, Double‐Blind Placebo‐Controlled Clinical Trial
inferred← citeshttps://doi.org/10.1002/fsn3.999openalex-snapshot
The potential use of bromelain as a natural oral medicine having anticarcinogenic activities
inferred← citeshttps://doi.org/10.1002/ijc.28380openalex-snapshot
A formulation for in situ lysis of mucin secreted in pseudomyxoma peritonei
inferred← citeshttps://doi.org/10.1002/jcb.26173openalex-snapshot
Destabilization of Human Insulin Fibrils by Peptides of Fruit Bromelain Derived From Ananas comosus (Pineapple)
inferred← citeshttps://doi.org/10.1002/jsfa.8561openalex-snapshot
Chemical profile of pineapple cv. Vitória in different maturation stages using electrospray ionization mass spectrometry
inferred← citeshttps://doi.org/10.1002/mc.20769openalex-snapshot
Bromelain inhibits nuclear factor kappa‐B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis
inferred← citeshttps://doi.org/10.1002/mnfr.201300345openalex-snapshot
The chemopreventive action of bromelain, from pineapple stem ( A nanas comosus L .), on colon carcinogenesis is related to antiproliferative and proapoptotic effects
inferred← citeshttps://doi.org/10.1002/mrd.22801openalex-snapshot
Validation of a laboratory-developed test of human sperm capacitation
inferred← citeshttps://doi.org/10.1002/ptr.4678openalex-snapshot
Placebo‐controlled Randomized Clinical Trial on the Immunomodulating Activities of Low‐ and High‐Dose Bromelain after Oral Administration – New Evidence on the Antiinflammatory Mode of Action of Bromelain
inferred← citeshttps://doi.org/10.1002/ptr.5707openalex-snapshot
Perioperative Bromelain Therapy after Wisdom Teeth Extraction – A Randomized, Placebo‐Controlled, Double‐Blinded, Three‐Armed, Cross‐Over Dose‐Finding Study
inferred← citeshttps://doi.org/10.1002/ptr.6102openalex-snapshot
Natural actives for wound healing: A review
inferred← citeshttps://doi.org/10.1002/ptr.6244openalex-snapshot
Is bromelain effective in controlling the inflammatory parameters of pain, edema, and trismus after lower third molar surgery? A systematic review and meta‐analysis
inferred← citeshttps://doi.org/10.1002/slct.201600524openalex-snapshot
Comprehensive Evaluation of Biomolecular Interactions between Protein and Amino Acid Based‐Ionic Liquids: A Comparable Study between [Bmim][Br] and [Bmim][Gly] Ionic Liquids
inferred← citeshttps://doi.org/10.1007/3-211-26646-1_43openalex-snapshot
Phytotherapie
inferred← citeshttps://doi.org/10.1007/978-0-387-73062-2_9openalex-snapshot
Complementary and Alternative Medicine in Rhinology
inferred← citeshttps://doi.org/10.1007/978-3-030-59295-0_10openalex-snapshot
Herbal Substances that Affect Hemostasis
inferred← citeshttps://doi.org/10.1007/978-3-032-03503-5_12openalex-snapshot
Health Endorsing Perspectives of Herbal Plants
inferred← citeshttps://doi.org/10.1007/978-3-211-88900-8_13openalex-snapshot
Hämatologie, Onkologie und Gerinnungsstörungen
inferred← citeshttps://doi.org/10.1007/978-3-319-12397-4_10openalex-snapshot
Case Study: Recombinant Bromelain Selection
inferred← citeshttps://doi.org/10.1007/978-3-319-12397-4_9openalex-snapshot
Economic and Environmental Evaluation of Recombinant Enzyme Production
inferred← citeshttps://doi.org/10.1007/978-3-319-28570-2_3openalex-snapshot
Bromelain
inferred← citeshttps://doi.org/10.1007/978-3-319-28570-2_5openalex-snapshot
A Novel Approach to Peritoneal Dissemination of Mucin-Expressing Malignancies of Gastrointestinal Origin
inferred← citeshttps://doi.org/10.1007/978-3-642-12819-6_16openalex-snapshot
Komplementäre Verfahren in der Schmerztherapie
inferred← citeshttps://doi.org/10.1007/978-3-642-20447-0_2openalex-snapshot
Ananas
inferred← citeshttps://doi.org/10.1007/978-3-642-36202-6_261-1openalex-snapshot
Micropropagation and Phytochemical Characteristics of Fruits From Regenerated Plants of the Two Main Genotypes of Pineapple (Ananas comosus L. Merr.) Grown in Côte d’Ivoire
inferred← citeshttps://doi.org/10.1007/978-3-642-37605-4_16openalex-snapshot
Komplementäre Verfahren in der Schmerztherapie
inferred← citeshttps://doi.org/10.1007/978-3-642-54670-9_16-1openalex-snapshot
Komplementäre Verfahren in der Schmerztherapie
inferred← citeshttps://doi.org/10.1007/978-3-642-54670-9_16-2openalex-snapshot
Komplementäre Verfahren in der Schmerztherapie
inferred← citeshttps://doi.org/10.1007/978-3-642-55528-2_23openalex-snapshot
Plants and the Cutaneous System
inferred← citeshttps://doi.org/10.1007/978-3-662-57487-4_16openalex-snapshot
Komplementäre Verfahren in der Schmerztherapie
inferred← citeshttps://doi.org/10.1007/978-90-481-8661-7_83openalex-snapshot
Ananas comosus
inferred← citeshttps://doi.org/10.1007/978-94-017-8953-0_18openalex-snapshot
Systemic Enzyme Therapy: Fact or Fiction? A Review with Focus on Bromelains, Proteolytic Enzymes from the Pineapple Plant
inferred← citeshttps://doi.org/10.1007/978-981-10-2513-6_14openalex-snapshot
Plant Latex Proteases: Natural Wound Healers
inferred← citeshttps://doi.org/10.1007/978-981-13-1933-4_3openalex-snapshot
Food Enzymes in Pharmaceutical Industry: Perspectives and Limitations
inferred← citeshttps://doi.org/10.1007/978-981-15-2063-1_6openalex-snapshot
Medicinal Properties of Fruit and Vegetable Peels
inferred← citeshttps://doi.org/10.1007/978-981-15-7285-2_19openalex-snapshot
Pineapple
inferred← citeshttps://doi.org/10.1007/978-981-16-9527-8_9openalex-snapshot
Vegetable and Fruit Wastes: Utilization in Novel Industrial Applications
inferred← citeshttps://doi.org/10.1007/978-981-92-1007-7_20openalex-snapshot
Waste Management in Horticulture: A Remunerative Approach
inferred← citeshttps://doi.org/10.1007/978-981-97-1837-5_5openalex-snapshot
Bioeconomy for Sustainable Biomaterials and Bioproducts Development
inferred← citeshttps://doi.org/10.1007/s00105-003-0582-6openalex-snapshot
Konditionierung chronischer Wunden mittels proteolytischer Enzyme
inferred← citeshttps://doi.org/10.1007/s00210-013-0890-zopenalex-snapshot
Bromelain down-regulates myofibroblast differentiation in an in vitro wound healing assay
inferred← citeshttps://doi.org/10.1007/s00449-012-0774-5openalex-snapshot
Bromelain purification through unconventional aqueous two-phase system (PEG/ammonium sulphate)
inferred← citeshttps://doi.org/10.1007/s00726-008-0223-6openalex-snapshot
Papaya latex enzymes capable of detoxification of gliadin
inferred← citeshttps://doi.org/10.1007/s00784-018-2690-9openalex-snapshot
Efficacy of a drug composed of herbal extracts on postoperative discomfort after surgical removal of impacted mandibular third molar: a randomized, triple-blind, controlled clinical trial
inferred← citeshttps://doi.org/10.1007/s00894-020-04398-1openalex-snapshot
Comparative modelling studies of fruit bromelain using molecular dynamics simulation
inferred← citeshttps://doi.org/10.1007/s10006-020-00854-7openalex-snapshot
The effects of systemic proteolytic enzyme therapy on pain and swelling in third molar surgery equal to diclofenac therapy: a prospective randomized double blinded clinical trial
inferred← citeshttps://doi.org/10.1007/s10039-013-1938-5openalex-snapshot
Konservative Behandlung von Muskelverletzungen
inferred← citeshttps://doi.org/10.1007/s10068-011-0168-5openalex-snapshot
Aqueous two-phase extraction of bromelain from pineapple peels (‘Phu Lae’ cultv.) and its biochemical properties
inferred← citeshttps://doi.org/10.1007/s10267-011-0179-3openalex-snapshot
Purification and characterization of a fibrinolytic protease from Aspergillus oryzae KSK-3
inferred← citeshttps://doi.org/10.1007/s10295-008-0516-5openalex-snapshot
Purification and characterization of a novel fibrinolytic protease from Fusarium sp. CPCC 480097
inferred← citeshttps://doi.org/10.1007/s10528-017-9803-zopenalex-snapshot
Genetic Diversity in Various Accessions of Pineapple [Ananas comosus (L.) Merr.] Using ISSR and SSR Markers
inferred← citeshttps://doi.org/10.1007/s10570-017-1307-9openalex-snapshot
Gauze-reinforced electrospun regenerated cellulose ultrafine fibers for immobilizing bromelain
inferred← citeshttps://doi.org/10.1007/s10658-012-0165-4openalex-snapshot
Enhancement of resistance to soft rot (Pectobacterium carotovorum subsp. carotovorum) in transgenic Brassica rapa
inferred← citeshttps://doi.org/10.1007/s10722-011-9763-9openalex-snapshot
Genetic variation of the Ananas genus with ornamental potential
inferred← citeshttps://doi.org/10.1007/s10856-025-06915-1openalex-snapshot
Bromelain-functionalized omega-3 nanocarriers for targeted icariin delivery: a multifunctional shield for cardiac repair in doxorubicin-induced injury
inferred← citeshttps://doi.org/10.1007/s10989-015-9462-zopenalex-snapshot
In Vitro Antiproliferative Activity of Fresh Pineapple Juices on Ovarian and Colon Cancer Cell Lines
inferred← citeshttps://doi.org/10.1007/s11250-008-9213-7openalex-snapshot
Effect of bromelain on milk yield, milk composition and mammary health in dairy goats
inferred← citeshttps://doi.org/10.1007/s11250-019-02195-4openalex-snapshot
Effects of concentrate levels and pineapple stem on growth performance, carcass and meat quality of dairy steers
inferred← citeshttps://doi.org/10.1007/s11515-018-1479-1openalex-snapshot
Invulnerability of bromelain against oxidative degeneration and cholinergic deficits imposed by dichlorvos in mice brains
inferred← citeshttps://doi.org/10.1007/s11696-017-0341-2openalex-snapshot
The evidence of proteases in sprouted seeds and their application for animal protein digestion
inferred← citeshttps://doi.org/10.1007/s11947-010-0431-4openalex-snapshot
Native and Biotechnologically Engineered Plant Proteases with Industrial Applications
inferred← citeshttps://doi.org/10.1007/s11947-014-1380-0openalex-snapshot
Effect of pH on Enzyme Inactivation Kinetics in High-Pressure Processed Pineapple (Ananas comosus L.) Puree Using Response Surface Methodology
inferred← citeshttps://doi.org/10.1007/s11947-015-1663-0openalex-snapshot
Changes in Quality Attributes During Storage of High-Pressure and Thermally Processed Pineapple Puree
inferred← citeshttps://doi.org/10.1007/s11947-020-02460-7openalex-snapshot
Effect of Pulsed Light Treatment on Natural Microbiota, Enzyme Activity, and Phytochemical Composition of Pineapple (Ananas comosus [L.] Merr.) juice
inferred← citeshttps://doi.org/10.1007/s11947-020-02520-yopenalex-snapshot
Non-thermal Processing of Pineapple (Ananas comosus [L.] Merr.) Juice Using Continuous Pressure Change Technology (PCT): Effects on Physical Traits, Microbial Loads, Enzyme Activities, and Phytochemical Composition
inferred← citeshttps://doi.org/10.1007/s12010-012-0026-9openalex-snapshot
Application of Enzymatic Method in the Extraction and Transformation of Natural Botanical Active Ingredients
inferred← citeshttps://doi.org/10.1007/s12010-012-9753-1openalex-snapshot
Bromelain Enzyme from Pineapple: In Vitro Activity Study under Different Micropropagation Conditions
inferred← citeshttps://doi.org/10.1007/s12010-014-1462-5openalex-snapshot
Exploring a New Serine Protease from Cucumis sativus L
inferred← citeshttps://doi.org/10.1007/s12010-015-1917-3openalex-snapshot
A Comprehensive Review on l-Asparaginase and Its Applications
inferred← citeshttps://doi.org/10.1007/s12010-018-2725-3openalex-snapshot
Structural Properties of Macrodontain I, a Cysteine Protease from Pseudananas macrodontes (Morr.) Harms (Bromeliaceae)
inferred← citeshttps://doi.org/10.1007/s12011-020-02278-6openalex-snapshot
Ameliorative Effect of Ananas comosus on Cobalt Chloride-Induced Hypoxia in Caco2 cells via HIF-1α, GLUT 1, VEGF, ANG and FGF
inferred← citeshttps://doi.org/10.1007/s12033-010-9273-6openalex-snapshot
Efficient DNA Extraction from Nail Clippings Using the Protease Solution from Cucumis melo
inferred← citeshttps://doi.org/10.1007/s12033-013-9692-2openalex-snapshot
Functional Characterization of Recombinant Bromelain of Ananas comosus Expressed in a Prokaryotic System
inferred← citeshttps://doi.org/10.1007/s12221-012-0282-xopenalex-snapshot
Optimization of enzymatic treatment of polyamide fabrics by bromelain
inferred← citeshttps://doi.org/10.1007/s12221-020-1247-0openalex-snapshot
Bromelain Immobilized onto Diamine-functionalized Electrospun Polyvinyl Chloride Fibers as a Durable Heterogeneous Catalyst
inferred← citeshttps://doi.org/10.1007/s12223-021-00906-9openalex-snapshot
Protein extract of Bromelia karatas L. rich in cysteine proteases (ananain- and bromelain-like) has antibacterial activity against foodborne pathogens Listeria monocytogenes and Salmonella Typhimurium
inferred← citeshttps://doi.org/10.1007/s12602-020-09714-yopenalex-snapshot
Enhancement of the Anti-inflammatory Effect of Bromelain by Its Immobilization on Probiotic Spore of Bacillus cereus
inferred← citeshttps://doi.org/10.1007/s12649-019-00651-8openalex-snapshot
Effect of Maltodextrin Content and Inlet Temperature on the Powder Qualities of Spray-Dried Pineapple (Ananas comosus) Waste Extract
inferred← citeshttps://doi.org/10.1007/s13197-014-1639-5openalex-snapshot
Kinetics studies with fruit bromelain (Ananas comosus) in the presence of cysteine and divalent ions
inferred← citeshttps://doi.org/10.1007/s13197-015-1812-5openalex-snapshot
Characteristic properties of crude pineapple waste extract for bromelain purification by membrane processing
inferred← citeshttps://doi.org/10.1007/s13197-021-05271-6openalex-snapshot
Pineapple processing waste (PPW): bioactive compounds, their extraction, and utilisation: a review
inferred← citeshttps://doi.org/10.1007/s13233-023-00119-8openalex-snapshot
Bromelain-loaded polyvinyl alcohol–activated charcoal-based film for wound dressing applications
inferred← citeshttps://doi.org/10.1007/s13596-021-00563-wopenalex-snapshot
A phytopharmacological review on Ananas comosus
inferred← citeshttps://doi.org/10.1007/s13596-022-00638-2openalex-snapshot
Bromelain mediates apoptosis in HeLa cells via ROS-independent pathway
inferred← citeshttps://doi.org/10.1007/s40005-022-00605-8openalex-snapshot
Digestive enzyme supplementation in prescription drugs, over-the-counter drugs, and enzyme foods
inferred← citeshttps://doi.org/10.1007/s40199-025-00585-8openalex-snapshot
Harnessing therapeutic potential of bromelain and its nanoformulations: sojourn of pineapple from food to nanomedicine
inferred← citeshttps://doi.org/10.1007/s42452-020-2100-1openalex-snapshot
Fibers of cellulose sugarcane bagasse with bromelain enzyme immobilized to application in dressing
inferred← citeshttps://doi.org/10.1016/b978-0-08-100596-5.22466-9openalex-snapshot
Proteases as Digestive Aids
inferred← citeshttps://doi.org/10.1016/b978-0-12-374628-3.00010-4openalex-snapshot
The Antibacterial Properties of Dietary Fruit
inferred← citeshttps://doi.org/10.1016/b978-0-12-382219-2.00423-3openalex-snapshot
Stem Bromelain
inferred← citeshttps://doi.org/10.1016/b978-0-12-384947-2.00547-xopenalex-snapshot
Pineapple
inferred← citeshttps://doi.org/10.1016/b978-0-12-812491-8.00050-3openalex-snapshot
Pineapple (Ananas comosus)
inferred← citeshttps://doi.org/10.1016/b978-0-12-816200-2.00003-7openalex-snapshot
Metal nanoparticles-based colorimetric methods for drug analyses
inferred← citeshttps://doi.org/10.1016/b978-0-12-816992-6.00004-8openalex-snapshot
Natural anti-inflammatory agents for the management of osteoarthritis
inferred← citeshttps://doi.org/10.1016/b978-0-323-43044-9.00059-5openalex-snapshot
Bromelain
inferred← citeshttps://doi.org/10.1016/b978-0-323-99856-7.00022-7openalex-snapshot
Chemical functionalization and characterization of silk fibroin materials
inferred← citeshttps://doi.org/10.1016/b978-0-443-40344-6.00275-1openalex-snapshot
Tropical Fruits: Types, Composition, Dietary Importance and Health Benefits
inferred← citeshttps://doi.org/10.1016/b978-1-4377-2333-5.00071-7openalex-snapshot
Bromelain
inferred← citeshttps://doi.org/10.1016/b978-3-437-15290-0.00031-5openalex-snapshot
Damm-, Scheiden- bzw. Zervixriss
inferred← citeshttps://doi.org/10.1016/b978-3-437-55134-5.00002-8openalex-snapshot
Diagnostische und therapeutische Verfahren in der Naturheilkunde
inferred← citeshttps://doi.org/10.1016/b978-3-437-55143-7.00002-2openalex-snapshot
Diagnostische und therapeutische Verfahren in der Naturheilkunde
inferred← citeshttps://doi.org/10.1016/b978-343755132-1.10002-3openalex-snapshot
Diagnostische und therapeutische Verfahren in der Naturheilkunde
inferred← citeshttps://doi.org/10.1016/j.abb.2010.05.005openalex-snapshot
Specific molten globule conformation of stem bromelain at alkaline pH
inferred← citeshttps://doi.org/10.1016/j.abb.2013.10.015openalex-snapshot
Concentration-dependent antagonistic persuasion of SDS and naphthalene derivatives on the fibrillation of stem bromelain
inferred← citeshttps://doi.org/10.1016/j.adoms.2021.100112openalex-snapshot
Comparison of efficacy and safety of bromelain with diclofenac sodium in the management of postoperative pain and swelling following mandibular third molar surgery
inferred← citeshttps://doi.org/10.1016/j.adoms.2023.100449openalex-snapshot
Effectiveness of oral bromelain on third molar surgery patients: A systematic review of systematic reviews
inferred← citeshttps://doi.org/10.1016/j.afres.2024.100491openalex-snapshot
Cysteine proteases from plants: Utilization in foods and nutraceuticals and characterization approaches for quality management
inferred← citeshttps://doi.org/10.1016/j.apcbee.2012.11.022openalex-snapshot
Physico-Chemical Properties of Pineapple Crown Extract Variety N36 and Bromelain Activity in Different Forms
inferred← citeshttps://doi.org/10.1016/j.bbapap.2008.12.019openalex-snapshot
Resistance of bromelain to SDS binding
inferred← citeshttps://doi.org/10.1016/j.bej.2010.08.012openalex-snapshot
Two phase partitioning and collagen hydrolysis of bromelain from pineapple peel Nang Lae cultivar
inferred← citeshttps://doi.org/10.1016/j.bioadv.2026.214731openalex-snapshot
In vitro and ex vivo evaluation of a papain-loaded mucoadhesive buccal patch with potential antifibrotic and anticancer activity
inferred← citeshttps://doi.org/10.1016/j.biocel.2010.02.004openalex-snapshot
Hexafluoroisopropanol-induced helix–sheet transition of stem bromelain: Correlation to function
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2011.08.017openalex-snapshot
Production of plant proteases in vivo and in vitro — A review
inferred← citeshttps://doi.org/10.1016/j.bse.2021.104380openalex-snapshot
Metabolomics as a tool to discriminate species of the Ananas genus and assist in taxonomic identification
inferred← citeshttps://doi.org/10.1016/j.burns.2020.12.006openalex-snapshot
Protective effect of bromelain on corrosive burn in rats
inferred← citeshttps://doi.org/10.1016/j.canlet.2009.08.001openalex-snapshot
Bromelain’s activity and potential as an anti-cancer agent: Current evidence and perspectives
inferred← citeshttps://doi.org/10.1016/j.carbpol.2016.01.055openalex-snapshot
Enhancement of anti-inflammatory activity of bromelain by its encapsulation in katira gum nanoparticles
inferred← citeshttps://doi.org/10.1016/j.cbi.2015.04.018openalex-snapshot
Acute and sub-chronic oral toxicity profiles of lipopeptides from Bacillus mojavensis A21 and evaluation of their in vitro anticoagulant activity
inferred← citeshttps://doi.org/10.1016/j.cbi.2016.05.017openalex-snapshot
Bacoside A and bromelain relieve dichlorvos induced changes in oxidative responses in mice serum
inferred← citeshttps://doi.org/10.1016/j.cbi.2016.11.027openalex-snapshot
Protective propensity of bacoside A and bromelain on renal cholinesterases, γ-Aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos
inferred← citeshttps://doi.org/10.1016/j.cellimm.2005.10.002openalex-snapshot
Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease
inferred← citeshttps://doi.org/10.1016/j.cep.2007.08.006openalex-snapshot
Liquid–liquid extraction of bromelain and polyphenol oxidase using aqueous two-phase system
inferred← citeshttps://doi.org/10.1016/j.cis.2018.03.006openalex-snapshot
Bromelain-loaded nanoparticles: A comprehensive review of the state of the art
inferred← citeshttps://doi.org/10.1016/j.clim.2008.02.015openalex-snapshot
Bromelain treatment decreases neutrophil migration to sites of inflammation
inferred← citeshttps://doi.org/10.1016/j.clnesp.2023.02.028openalex-snapshot
Bromelain supplementation and inflammatory markers: A systematic review of clinical trials
inferred← citeshttps://doi.org/10.1016/j.colsurfb.2018.05.034openalex-snapshot
Identifying three routes of the sensing mechanism for casein-directed gold nanoclusters
inferred← citeshttps://doi.org/10.1016/j.cscee.2024.100683openalex-snapshot
Characterization of bromelain enzyme treated Bamboo petung fiber (BPF) for composite reinforcement
inferred← citeshttps://doi.org/10.1016/j.ejpb.2016.06.002openalex-snapshot
Hyaluronic acid grafted PLGA copolymer nanoparticles enhance the targeted delivery of Bromelain in Ehrlich’s Ascites Carcinoma
inferred← citeshttps://doi.org/10.1016/j.ejps.2020.105224openalex-snapshot
Recent advances in electrospun nanofibers for some biomedical applications
inferred← citeshttps://doi.org/10.1016/j.enzmictec.2006.07.011openalex-snapshot
Characterization of news proteolytic enzymes from ripe fruits of Bromelia antiacantha Bertol. (Bromeliaceae)
inferred← citeshttps://doi.org/10.1016/j.eurpolymj.2018.05.016openalex-snapshot
Characterization of PNIPAAm-co-AAm hydrogels for modified release of bromelain
inferred← citeshttps://doi.org/10.1016/j.exppara.2013.03.021openalex-snapshot
In vitro activity of pineapple extracts (Ananas comosus, Bromeliaceae) on Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)
inferred← citeshttps://doi.org/10.1016/j.fbp.2011.12.006openalex-snapshot
Pineapple wastes: A potential source for bromelain extraction
inferred← citeshttps://doi.org/10.1016/j.fbp.2019.01.008openalex-snapshot
Preparation of temperature-sensitive magnetic microspheres for separation and purification of bromelain
inferred← citeshttps://doi.org/10.1016/j.foodchem.2010.06.016openalex-snapshot
Analysis of pineapple [Ananas comosus (L.) Merr.] fruit proteinases by 2-D zymography and direct identification of the major zymographic spots by mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.foodchem.2010.07.087openalex-snapshot
Bromelain from pineapple stem in alcoholic–acidic buffers for wine application
inferred← citeshttps://doi.org/10.1016/j.foodchem.2011.05.119openalex-snapshot
Pineapple fruit bromelain affinity to different protein substrates
inferred← citeshttps://doi.org/10.1016/j.foodchem.2018.05.125openalex-snapshot
Comparative structural analysis of fruit and stem bromelain from Ananas comosus
inferred← citeshttps://doi.org/10.1016/j.foodhyd.2018.09.009openalex-snapshot
Optimization of bromelain isolation from pineapple byproducts by polysaccharide complex formation
inferred← citeshttps://doi.org/10.1016/j.fsc.2009.06.011openalex-snapshot
Pearls in Facelift Management
inferred← citeshttps://doi.org/10.1016/j.ifset.2015.12.026openalex-snapshot
Modeling the inactivation kinetics of fruit bromelain in pineapple during high-pressure and thermal treatments
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2011.06.006openalex-snapshot
Trifluoroethanol stabilizes the molten globule state and induces non-amyloidic turbidity in stem bromelain near its isoelectric point
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2014.10.068openalex-snapshot
Insights into the interactions between enzyme and co-solvents: Stability and activity of stem bromelain
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2016.05.107openalex-snapshot
Amyloidogenic behavior of different intermediate state of stem bromelain: A biophysical insight
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2017.07.083openalex-snapshot
Cysteine as a potential anti-amyloidogenic agent with protective ability against amyloid induced cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2017.08.150openalex-snapshot
Fluorescence spectroscopic analysis of the interaction of papain and bromelain with l-ascorbic acid, α-tocopherol, β-carotene and astaxanthin
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2018.04.076openalex-snapshot
RETRACTED: Bromelain-immobilized and lactobionic acid-modified chitosan nanoparticles for enhanced drug penetration in tumor tissues
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2019.01.061openalex-snapshot
Stabilizing bromelain for therapeutic applications by adsorption immobilization on spores of probiotic Bacillus
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.10.065openalex-snapshot
Excellency of pyrimidinyl moieties containing α-aminophosphonates over benzthiazolyl moieties for thermal and structural stability of stem bromelain
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.132368openalex-snapshot
Addressing the interaction of stem bromelain with different anionic surfactants, below, at and above the critical micelle concentration (cmc) in phosphate buffer at pH 7: Physicochemical, spectroscopic, & molecular docking study
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.133089openalex-snapshot
A review on the immobilization of bromelain
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2020.119152openalex-snapshot
Halloysite nanotube-embedded microparticles for intestine-targeted co-delivery of biopharmaceuticals
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.125304openalex-snapshot
Enhancing burn wound care with pre-crosslinked 3D-printed patches: Bromelain delivery and aloe vera bioactives integration for improved healing outcomes
inferred← citeshttps://doi.org/10.1016/j.ijsu.2014.12.024openalex-snapshot
Bromelain: A natural proteolytic for intra-abdominal adhesion prevention
inferred← citeshttps://doi.org/10.1016/j.indcrop.2014.04.042openalex-snapshot
A new procedure based on column chromatography to purify bromelain by ion exchange plus gel filtration chromatographies
inferred← citeshttps://doi.org/10.1016/j.indcrop.2017.04.048openalex-snapshot
Characteristics and potential utilizations of starch from pineapple stem waste
inferred← citeshttps://doi.org/10.1016/j.jaad.2011.06.030openalex-snapshot
Common complementary and alternative therapies with potential use in dermatologic surgery: Risks and benefits
inferred← citeshttps://doi.org/10.1016/j.jaad.2016.05.025openalex-snapshot
The proteolytic effect of bromelain on bullous pemphigoid antigen-2
inferred← citeshttps://doi.org/10.1016/j.jchromb.2024.124027openalex-snapshot
Purification of pineapple bromelain by IMAC chromatography using chlorophyll-activated macroporous matrices
inferred← citeshttps://doi.org/10.1016/j.jclinane.2024.111473openalex-snapshot
Use of herbal medication in the perioperative period: Potential adverse drug interactions
inferred← citeshttps://doi.org/10.1016/j.jddst.2020.102225openalex-snapshot
Freeze-dried chitosan nanoparticles to stabilize and deliver bromelain
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102483openalex-snapshot
PVA-CO-AAM and peg-co-aam hydrogels as bromelain carriers
inferred← citeshttps://doi.org/10.1016/j.jep.2013.08.024openalex-snapshot
Enzymatic, antimicrobial and toxicity studies of the aqueous extract of Ananas comosus (pineapple) crown leaf
inferred← citeshttps://doi.org/10.1016/j.jep.2017.02.021openalex-snapshot
Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms
inferred← citeshttps://doi.org/10.1016/j.jep.2018.04.049openalex-snapshot
Toxicological evaluation and anti-inflammatory potential of an ethanolic extract from Bromelia balansae (Bromeliaceae) fruit
inferred← citeshttps://doi.org/10.1016/j.jlumin.2014.09.002openalex-snapshot
Study on the interaction between gold nanoparticles and papain by spectroscopic methods
inferred← citeshttps://doi.org/10.1016/j.joms.2013.12.035openalex-snapshot
Perioperative Bromelain Reduces Pain and Swelling and Improves Quality of Life Measures After Mandibular Third Molar Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
inferred← citeshttps://doi.org/10.1016/j.jss.2005.12.005openalex-snapshot
Combined Enzymatic and Antioxidative Treatment Reduces Ischemia-Reperfusion Injury in Rabbit Skeletal Muscle
inferred← citeshttps://doi.org/10.1016/j.jss.2006.10.004openalex-snapshot
Bromelain Ameliorates Hepatic Microcirculation After Warm Ischemia
inferred← citeshttps://doi.org/10.1016/j.jtice.2017.04.001openalex-snapshot
Single step purification of bromelain from Ananas comosus pulp using a polymer/salt aqueous biphasic system
inferred← citeshttps://doi.org/10.1016/j.lfs.2005.06.007openalex-snapshot
Bromelain improves decrease in defecation in postoperative rats: Modulation of colonic gene expression of inducible nitric oxide synthase
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.05.028openalex-snapshot
Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models
inferred← citeshttps://doi.org/10.1016/j.livsci.2015.07.013openalex-snapshot
Dietary bromelain-C.3.4.22.32 supplementation improves performance and gut health in sows and piglets
inferred← citeshttps://doi.org/10.1016/j.lwt.2017.09.039openalex-snapshot
Preservation of the antibacterial activity of enzymes against Alicyclobacillus spp. through microencapsulation
inferred← citeshttps://doi.org/10.1016/j.lwt.2022.113775openalex-snapshot
Microencapsulation of bromelain from pineapple extract powder by industrially scalable complex coacervation
inferred← citeshttps://doi.org/10.1016/j.matlet.2015.06.118openalex-snapshot
A novel process for size controlled biosynthesis of gold nanoparticles using bromelain
inferred← citeshttps://doi.org/10.1016/j.matpr.2016.10.007openalex-snapshot
Removal and recovery of lead(II) and chromium(VI) by bromelain immobilized on activated charcoal
inferred← citeshttps://doi.org/10.1016/j.maturitas.2013.05.006openalex-snapshot
Nutraceuticals for older people: Facts, fictions and gaps in knowledge
inferred← citeshttps://doi.org/10.1016/j.mayocp.2014.05.015openalex-snapshot
Over-the-Counter Enzyme Supplements: What a Clinician Needs to Know
inferred← citeshttps://doi.org/10.1016/j.molcatb.2010.01.018openalex-snapshot
Chemical modification of stem bromelain with anhydride groups to enhance its stability and catalytic activity
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