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A pan-cancer analysis of the human tumor coagulome and its link to the tumor immune microenvironment

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Incidence of Venous Thromboembolism and Its Effect on Survival Among Patients With Common Cancers
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Identification of Four Immune Subtypes Characterized by Distinct Composition and Functions of Tumor Microenvironment in Intrahepatic Cholangiocarcinoma
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Pathophysiology 1. Mechanisms of Thrombosis in Cancer Patients
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The contribution of tumor and host tissue factor expression to oncogene-driven gliomagenesis
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The Cancer Genome Atlas: Creating Lasting Value beyond Its Data
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SnapShot: TCGA-Analyzed Tumors
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Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer
inferredcites →https://doi.org/10.1016/j.immuni.2018.03.023openalex-snapshot
The Immune Landscape of Cancer
inferredcites →https://doi.org/10.1016/j.thromres.2018.01.021openalex-snapshot
Single cell coagulomes as constituents of the oncogene-driven coagulant phenotype in brain tumours
inferredcites →https://doi.org/10.1016/j.thromres.2020.01.019openalex-snapshot
Targeting hemostasis-related moieties for tumor treatment
inferredcites →https://doi.org/10.1016/j.trecan.2019.02.006openalex-snapshot
RNA Sequencing of the Tumor Microenvironment in Precision Cancer Immunotherapy
inferredcites →https://doi.org/10.1016/s1470-2045(19)30336-5openalex-snapshot
2019 international clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer
inferredcites →https://doi.org/10.1038/s41416-020-0811-0openalex-snapshot
Prognostic and clinical impact of PD-L2 and PD-L1 expression in a cohort of 437 oesophageal cancers
inferredcites →https://doi.org/10.1038/s41580-018-0080-4openalex-snapshot
New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer
inferredcites →https://doi.org/10.1038/s41586-019-1922-8openalex-snapshot
B cells and tertiary lymphoid structures promote immunotherapy response
inferredcites →https://doi.org/10.1038/s41591-018-0014-xopenalex-snapshot
Understanding the tumor immune microenvironment (TIME) for effective therapy
inferredcites →https://doi.org/10.1055/s-0039-1687891openalex-snapshot
Oncogenes and Clotting Factors: The Emerging Role of Tumor Cell Genome and Epigenome in Cancer-Associated Thrombosis
inferredcites →https://doi.org/10.1055/s-0039-1687895openalex-snapshot
Role of Tissue Factor in Tumor Progression and Cancer-Associated Thrombosis
inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-snapshot
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
inferredcites →https://doi.org/10.1073/pnas.1919764117openalex-snapshot
Combining microenvironment normalization strategies to improve cancer immunotherapy
inferredcites →https://doi.org/10.1111/j.1538-7836.2006.01804.xopenalex-snapshot
Incidence of venous thrombosis in a large cohort of 66 329 cancer patients: results of a record linkage study
inferredcites →https://doi.org/10.1111/jth.12070openalex-snapshot
International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer
inferredcites →https://doi.org/10.1111/jth.13871openalex-snapshot
Tissue factor‐bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer
inferredcites →https://doi.org/10.1126/science.aaw7875openalex-snapshot
Vascular regulation of antitumor immunity
inferredcites →https://doi.org/10.1126/scisignal.2004088openalex-snapshot
Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-0876openalex-snapshot
A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-1434openalex-snapshot
Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-2428openalex-snapshot
Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy
inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0095openalex-snapshot
The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data
inferredcites →https://doi.org/10.1158/2159-8290.cd-18-0367openalex-snapshot
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
inferredcites →https://doi.org/10.1161/atvbaha.117.309846openalex-snapshot
Tissue Factor
inferredcites →https://doi.org/10.1161/circresaha.116.306853openalex-snapshot
Cross Talk Pathways Between Coagulation and Inflammation
inferredcites →https://doi.org/10.1182/blood-2013-04-460121openalex-snapshot
Epidemiology of cancer-associated venous thrombosis
inferredcites →https://doi.org/10.1186/s13059-016-1070-5openalex-snapshot
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inferredcites →https://doi.org/10.1200/jco.19.01461openalex-snapshot
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update
inferredcites →https://doi.org/10.18632/oncotarget.10344openalex-snapshot
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inferredcites →https://doi.org/10.18632/oncotarget.25458openalex-snapshot
Biomarkers for the risk of thrombosis in pancreatic adenocarcinoma are related to cancer process
inferredcites →https://doi.org/10.3390/ijms20112838openalex-snapshot
Thrombosis Risk Associated with Head and Neck Cancer: A Review

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cancer progression and tumor hypercoagulability: a platelet perspective
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Integrated pan-cancer and scRNA-seq analyses identify a prognostic coagulation-related gene signature associated with tumor microenvironment in lower-grade glioma
inferred← citeshttps://doi.org/10.1007/s12672-025-02316-6openalex-snapshot
A coagulation-related long non-coding RNA signature to predict prognosis and immune features of breast cancer
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The role of coagulome in the tumor immune microenvironment
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A novel prognostic signature of coagulation-related genes leveraged by machine learning algorithms for lung squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.jtha.2024.01.003openalex-snapshot
The breast cancer coagulome in the tumor microenvironment and its role in prognosis and treatment response to chemotherapy
inferred← citeshttps://doi.org/10.1016/j.jtha.2025.06.030openalex-snapshot
Venous thromboembolism in patients with cancer and factor XI deficiency
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2020.105068openalex-snapshot
The coagulome of Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1016/j.thromres.2024.04.015openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.trecan.2021.12.008openalex-snapshot
Coagulome and the tumor microenvironment: an actionable interplay
inferred← citeshttps://doi.org/10.1016/j.trecan.2025.05.006openalex-snapshot
Advancing cancer precision surgery with the tumor coagulome
inferred← citeshttps://doi.org/10.1038/s41388-025-03296-1openalex-snapshot
The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin
inferred← citeshttps://doi.org/10.1038/s41586-026-11002-8openalex-snapshot
A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion
inferred← citeshttps://doi.org/10.1038/s41598-021-94360-9openalex-snapshot
CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
inferred← citeshttps://doi.org/10.1038/s41598-022-21473-0openalex-snapshot
Identification of a novel ceRNA network related to prognosis and immunity in HNSCC based on integrated bioinformatic investigation
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Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma
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inferred← citeshttps://doi.org/10.1038/s41598-025-99909-6openalex-snapshot
The value of GULP1 in cancer prognosis and immunotherapy, validated from pan-cancer analysis to pancreatic cancer
inferred← citeshttps://doi.org/10.1080/07391102.2023.2300754openalex-snapshot
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inferred← citeshttps://doi.org/10.1080/2162402x.2022.2045696openalex-snapshot
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inferred← citeshttps://doi.org/10.1089/gtmb.2025.0046openalex-snapshot
Functional Characterization of Plasminogen Activator Urokinase as a Key Gene in Papillary Thyroid Carcinoma Lymph Node Metastasis
inferred← citeshttps://doi.org/10.1093/bib/bbac291openalex-snapshot
Immune infiltration and clinical significance analyses of the coagulation-related genes in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1097/js9.0000000000004473openalex-snapshot
Potential neutrophil activation-related pathogenic genes in venous thromboembolism: a multi-omics Mendelian randomization study
inferred← citeshttps://doi.org/10.1097/moo.0000000000000870openalex-snapshot
The coagulome of oral squamous cell carcinoma: examining the role and regulation of coagulation in oral cancers using a systems approach
inferred← citeshttps://doi.org/10.1101/2023.07.05.547825openalex-snapshot
KISS1 is a potential immunological and prognostic biomarker for cancer metastasis in pan-cancer and affects breast cancer in a different way
inferred← citeshttps://doi.org/10.1101/2023.09.01.555882openalex-snapshot
Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma
inferred← citeshttps://doi.org/10.1101/2025.06.11.659098openalex-snapshot
Plasminogen activator inhibitors orchestrate the immunosuppressive tumor microenvironment in pancreatic cancer
inferred← citeshttps://doi.org/10.1109/access.2022.3203436openalex-snapshot
Multiple Omics Analysis of the Rac3 Roles in Different Types of Human Cancer
inferred← citeshttps://doi.org/10.1111/1759-7714.15121openalex-snapshot
Identification of a coagulation‐related signature correlated with immune infiltration and their prognostic implications in lung adenocarcinoma
inferred← citeshttps://doi.org/10.1111/cpr.13591openalex-snapshot
Single‐cell RNA sequencing reveals immune cell dysfunction in the peripheral blood of patients with highly aggressive gastric cancer
inferred← citeshttps://doi.org/10.1136/jitc-2024-009565openalex-snapshot
FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription
inferred← citeshttps://doi.org/10.1155/2022/6792850openalex-snapshot
A Novel Thrombosis-Related Signature for Predicting Survival and Drug Compounds in Glioblastoma
inferred← citeshttps://doi.org/10.1155/ijog/5902518openalex-snapshot
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Estudo translacional da regulação metabólica do microambiente tumoral através do treinamento físico na modulação da resposta imune antitumoral em pacientes com câncer
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Prediction of Neoadjuvant Chemoradiotherapy Sensitivity in Patients With Esophageal Squamous Cell Carcinoma Using CT-Based Radiomics Combined With Clinical Features
inferred← citeshttps://doi.org/10.1186/s12859-023-05220-4openalex-snapshot
Development and validation of a coagulation-related genes prognostic model for hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1186/s12885-023-11032-9openalex-snapshot
The coagulation-related genes for prognosis and tumor microenvironment in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.1186/s12935-023-03103-5openalex-snapshot
Systematic analysis of integrated bioinformatics to identify upregulated THBS2 expression in colorectal cancer cells inhibiting tumour immunity through the HIF1A/Lactic Acid/GPR132 pathway
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Integrative bioinformatics analysis of WDHD1: a potential biomarker for pan-cancer prognosis, diagnosis, and immunotherapy
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EBV Reactivation-associated gene signature predicts poor prognosis in nasopharyngeal carcinoma
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Small cell lung cancer: emerging subtypes, signaling pathways, and therapeutic vulnerabilities
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inferred← citeshttps://doi.org/10.1615/critreveukaryotgeneexpr.2023048608openalex-snapshot
Identification of a Diagnosis and Therapeutic Inflammatory Response-Related Gene Signature Associated with Esophageal Adenocarcinoma
inferred← citeshttps://doi.org/10.18632/aging.205699openalex-snapshot
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A Risk Signature Established From Three Coagulation-fibrinolysis Genes Predicts Prognosis in Digestive System Pancancer
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A Pan-cancer Analysis of the Role of the Transmembrane Protein 91(TMEM91) in Human Tumors
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A Systematic pan-cancer analysis of ATIC as a prognostic biomarker in human tumors
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Comprehensive pan-cancer analysis reveals that FBXO2 as a potential therapeutic target associated with immune infiltration
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Transcriptional Induction of SERPINE1 and Fibrinolysis Inhibition as Predominant Effects of Glucocorticoids on the Cancer Coagulome
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Investigation of the feasibility of NRAV as a biomarker for hepatocellular carcinoma
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HNRNPC as a pan-cancer biomarker and therapeutic target involved in tumor progression and immune regulation
inferred← citeshttps://doi.org/10.3389/fcell.2022.819484openalex-snapshot
Methylation-Driven Gene PLAU as a Potential Prognostic Marker for Differential Thyroid Carcinoma
inferred← citeshttps://doi.org/10.3389/fgene.2022.938796openalex-snapshot
Characterization of Platelet Function-Related Gene Predicting Survival and Immunotherapy Efficacy in Gastric Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2022.845585openalex-snapshot
The Prognostic and Immunotherapeutic Significance of AHSA1 in Pan-Cancer, and Its Relationship With the Proliferation and Metastasis of Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1097403openalex-snapshot
NCAPG2 could be an immunological and prognostic biomarker: From pan-cancer analysis to pancreatic cancer validation
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1131870openalex-snapshot
The prognostic and immune significance of C15orf48 in pan-cancer and its relationship with proliferation and apoptosis of thyroid carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1200941openalex-snapshot
Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1462755openalex-snapshot
Coagulation-related genes for thyroid cancer prognosis, immune infltration, staging, and drug sensitivity
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1836706openalex-snapshot
Establishment and evaluation of novel prognostic biomarkers based on systemic coagulation-inflammation index and related genes in breast cancer
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Oncogenes and cancer associated thrombosis: what can we learn from single cell genomics about risks and mechanisms?
inferred← citeshttps://doi.org/10.3389/fmolb.2024.1394585openalex-snapshot
Unraveling breast cancer prognosis: a novel model based on coagulation-related genes
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Pro-inflammatory cytokines in cystic glioblastoma: A quantitative study with a comparison with bacterial brain abscesses. With an MRI investigation of displacement and destruction of the brain tissue surrounding a glioblastoma
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Unraveling the role of coagulation-related genes in esophageal squamous cell carcinoma: development of a prognostic model and exploration of potential clinical significance
inferred← citeshttps://doi.org/10.3389/fonc.2026.1574236openalex-snapshot
Bioinformatics and experimental analysis revealed the cancer-promoting role of NCAPG2 in epithelial ovarian cancer
inferred← citeshttps://doi.org/10.3389/froh.2021.764386openalex-snapshot
Therapeutic Perspectives for the Perioperative Period in Oral Squamous Cell Carcinoma (OSCC)
inferred← citeshttps://doi.org/10.3389/froh.2025.1554739openalex-snapshot
The tumor coagulome as a potential biological determinant of postsurgical recurrence of oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.3390/cancers14020460openalex-snapshot
Molecular Landscape of the Coagulome of Oral Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.3390/cancers14092125openalex-snapshot
Therapeutic Strategies Focused on Cancer-Associated Hypercoagulation for Ovarian Clear Cell Carcinoma
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The Tumor Coagulome as a Transcriptional Target and a Potential Effector of Glucocorticoids in Human Cancers
inferred← citeshttps://doi.org/10.3390/cancers16071289openalex-snapshot
An MRI Radiomics Approach to Predict the Hypercoagulable Status of Gliomas
inferred← citeshttps://doi.org/10.3390/cancers18071055openalex-snapshot
Tumor-Specific Pro-Thrombotic Gene Expression in Head and Neck Squamous Cell Carcinoma: A Multi-Cohort Transcriptomic Analysis
inferred← citeshttps://doi.org/10.3390/ijms241612904openalex-snapshot
OLR1 Is a Pan-Cancer Prognostic and Immunotherapeutic Predictor Associated with EMT and Cuproptosis in HNSCC
inferred← citeshttps://doi.org/10.3390/ijms25041998openalex-snapshot
uPAR (PLAUR) Marks Two Intra-Tumoral Subtypes of Glioblastoma: Insights from Single-Cell RNA Sequencing
inferred← citeshttps://doi.org/10.3390/ijms26041435openalex-snapshot
The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma
inferred← citeshttps://doi.org/10.3892/ol.2025.15035openalex-snapshot
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inferred← citeshttps://doi.org/10.3892/ol.2026.15878openalex-snapshot
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inferred← citeshttps://doi.org/10.56397/jimr/2024.03.05openalex-snapshot
Coagulation Function Testing Clinical Demand and Current Status in China
inferred← citeshttps://doi.org/10.6084/m9.figshare.22624418openalex-snapshot
Additional file 1 of Development and validation of a coagulation-related genes prognostic model for hepatocellular carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.22624421openalex-snapshot
Additional file 2 of Development and validation of a coagulation-related genes prognostic model for hepatocellular carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.23606783openalex-snapshot
Additional file 1 of The coagulation-related genes for prognosis and tumor microenvironment in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.23606786openalex-snapshot
Additional file 2 of The coagulation-related genes for prognosis and tumor microenvironment in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.23606792openalex-snapshot
Additional file 3 of The coagulation-related genes for prognosis and tumor microenvironment in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.23606795openalex-snapshot
Additional file 4 of The coagulation-related genes for prognosis and tumor microenvironment in pancreatic ductal adenocarcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.26632929openalex-snapshot
Additional file 1 of Systematic analysis of integrated bioinformatics to identify upregulated THBS2 expression in colorectal cancer cells inhibiting tumour immunity through the HIF1A/Lactic Acid/GPR132 pathway
inferred← citeshttps://doi.org/10.62347/dlvs6991openalex-snapshot
Prognostic and immunological roles of RSPO1 in pan-cancer and its correlation with LUAD proliferation and metastasis
inferred← citeshttps://doi.org/10.64898/2026.06.03.729507openalex-snapshot
Tumor-derived FXII engages the intrinsic coagulation cascade to support breast cancer liver metastasis
inferred← citeshttps://doi.org/10.70675/156d914aze7c5z424cz8478z47ab5e54396fopenalex-snapshot
Biomarqueurs du microenvironnement tumoral pour la stratification thérapeutique des cancers tête et cou
inferred← citeshttps://doi.org/10.7150/ijbs.94555openalex-snapshot
Machine Learning-based Framework Develops a Tumor Thrombus Coagulation Signature in Multicenter Cohorts for Renal Cancer
inferred← citeshttps://doi.org/10.7150/jca.115334openalex-snapshot
Pan-cancer analysis reveals SGO1 as a potential cancer prognostic and immunological biomarker
inferred← citeshttps://doi.org/10.7150/jca.88650openalex-snapshot
Pan-cancer Analysis of the Disulfidptosis-related Gene NCKAP1 and Its Prognostic Value for Lung Adenocarcinoma
inferred← citeshttps://doi.org/10.7717/peerj.16364openalex-snapshot
Head and neck squamous cell carcinoma-specific prognostic signature and drug sensitive subtypes based on programmed cell death-related genes
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