On the public citation graph

Brief in vitro IL-12 conditioning of CD8 + T Cells for anticancer adoptive T cell therapy

https://doi.org/10.1007/s00262-021-02887-7

0 signed · 75 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf02488992openalex-snapshot

Clinical efficacy of adoptive immunotherapy by IL-4 activated tumor-infiltrating lymphocytes in patients with advanced cancer

inferredcites →https://doi.org/10.1007/s00262-007-0394-0openalex-snapshot

Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic murine model

inferredcites →https://doi.org/10.1007/s00262-009-0666-yopenalex-snapshot

Incubation of antigen-sensitized T lymphocytes activated with bryostatin 1 + ionomycin in IL-7 + IL-15 increases yield of cells capable of inducing regression of melanoma metastases compared to culture in IL-2

inferredcites →https://doi.org/10.1007/s00262-015-1655-yopenalex-snapshot

Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8+ T cells

inferredcites →https://doi.org/10.1007/s10616-013-9620-0openalex-snapshot

Immunomodulatory effects of IL-12 released from poly-N-acetyl glucosamine gel matrix during schistosomiasis infection

inferredcites →https://doi.org/10.1016/0167-5699(84)90224-xopenalex-snapshot

Interleukin 2: the molecule and its function

inferredcites →https://doi.org/10.1016/j.canlet.2019.07.017openalex-snapshot

Adoptive CD8+ T cell therapy against cancer:Challenges and opportunities

inferredcites →https://doi.org/10.1016/j.cytogfr.2004.03.009openalex-snapshot

The role of IL-12, IL-23 and IFN-γ in immunity to viruses

inferredcites →https://doi.org/10.1016/j.jamcollsurg.2011.12.034openalex-snapshot

Ex Vivo Interleukin-12-Priming During CD8+ T Cell Activation Dramatically Improves Adoptive T Cell Transfer Antitumor Efficacy in a Lymphodepleted Host

inferredcites →https://doi.org/10.1016/s1286-4579(03)00024-8openalex-snapshot

IL-12Rβ2-deficient mice of a genetically resistant background are susceptible to Leishmania major infection and develop a parasite-specific Th2 immune response

inferredcites →https://doi.org/10.1016/s1359-6101(01)00032-6openalex-snapshot

Interleukin-12 in anti-tumor immunity and immunotherapy

inferredcites →https://doi.org/10.1016/s1359-6101(03)00043-1openalex-snapshot

The biology of IL-12: coordinating innate and adaptive immune responses

inferredcites →https://doi.org/10.1024/0036-7281/a000262openalex-snapshot

In vivo induction of interferon gamma expression in grey horses with metastatic melanoma resulting from direct injection of plasmid DNA coding for equine interleukin 12

inferredcites →https://doi.org/10.1038/cgt.2015.28openalex-snapshot

IL-12 conditioning improves retrovirally mediated transduction efficiency of CD8+ T cells

inferredcites →https://doi.org/10.1038/mt.2010.313openalex-snapshot

Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment

inferredcites →https://doi.org/10.1038/nri1001openalex-snapshot

Interleukin-12 and the regulation of innate resistance and adaptive immunity

inferredcites →https://doi.org/10.1038/pcan.2008.57openalex-snapshot

Therapeutic effects of gelatin matrix-embedded IL-12 gene-modified macrophages in a mouse model of residual prostate cancer

inferredcites →https://doi.org/10.1038/s41598-017-12488-zopenalex-snapshot

Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells

inferredcites →https://doi.org/10.1038/sj.cgt.7700013openalex-snapshot

Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12

inferredcites →https://doi.org/10.1038/sj.cgt.7700072openalex-snapshot

Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12

inferredcites →https://doi.org/10.1038/sj.cgt.7700432openalex-snapshot

Eradication of osteosarcoma lung metastases following intranasal interleukin-12 gene therapy using a nonviral polyethylenimine vector

inferredcites →https://doi.org/10.1038/sj.gt.3300834openalex-snapshot

Adenovirus-mediated interleukin-12 gene therapy for prostate cancer: suppression of orthotopic tumor growth and pre-established lung metastases in an orthotopic model

inferredcites →https://doi.org/10.1046/j.1365-3083.1999.00633.xopenalex-snapshot

In Vitro and In Vivo Bioactivity of Single‐Chain Interleukin‐12

inferredcites →https://doi.org/10.1053/jhep.2001.20796openalex-snapshot

Gene Therapy of Orthotopic Hepatocellular Carcinoma in Rats Using Adenovirus Coding for Interleukin 12

inferredcites →https://doi.org/10.1056/nejm198812223192527openalex-snapshot

Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma

inferredcites →https://doi.org/10.1080/14653240410006040openalex-snapshot

Generation of Aspergillus- and CMV- specific T-cell responses using autologous fast DC

inferredcites →https://doi.org/10.1080/2162402x.2018.1542917openalex-snapshot

Safety and efficacy of Tet-regulated IL-12 expression in cancer-specific T cells

inferredcites →https://doi.org/10.1084/jem.175.3.789openalex-snapshot

Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.

inferredcites →https://doi.org/10.1084/jem.176.5.1387openalex-snapshot

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

inferredcites →https://doi.org/10.1084/jem.178.4.1223openalex-snapshot

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

inferredcites →https://doi.org/10.1084/jem.20100209openalex-snapshot

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

inferredcites →https://doi.org/10.1089/hum.1996.7.3-333openalex-snapshot

Construction of a Double Recombinant Adenovirus Vector Expressing a Heterodimeric Cytokine: In Vitro and In Vivo Production of Biologically Active Interleukin-12

inferredcites →https://doi.org/10.1089/jir.2006.26.593openalex-snapshot

Review: Novel Nonviral Delivery Approaches for Interleukin-12 Protein and Gene Systems: Curbing Toxicity and Enhancing Adjuvant Activity

inferredcites →https://doi.org/10.1089/jir.2018.0019openalex-snapshot

Cytokines in the Treatment of Cancer

inferredcites →https://doi.org/10.1093/jnci/89.14.1049openalex-snapshot

Antitumor Efficacy of Adenocarcinoma Cells Engineered to Produce Interleukin 12 (IL-12) or Other Cytokines Compared With Exogenous IL-12

inferredcites →https://doi.org/10.1097/00002371-200303000-00002openalex-snapshot

Generating Potent Th1/Tc1 T Cell Adoptive Immunotherapy Doses Using Human IL-12: Harnessing the Immunomodulatory Potential of IL-12 Without the In Vivo-Associated Toxicity

inferredcites →https://doi.org/10.1111/j.1365-2249.2005.02699.xopenalex-snapshot

Generation of Th1 T cell responses directed to a HLA Class II restricted epitope from theAspergillusf16 allergen

inferredcites →https://doi.org/10.1126/science.8023142openalex-snapshot

Ability of HIV to Promote a T H 1 to T H 0 Shift and to Replicate Preferentially in T H 2 and T H 0 Cells

inferredcites →https://doi.org/10.1126/science.abb9847openalex-snapshot

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

inferredcites →https://doi.org/10.1128/cvi.00090-08openalex-snapshot

Influenza Virus Vaccination Induces Interleukin-12/23 Receptor β1 (IL-12/23Rβ1)-Independent Production of Gamma Interferon (IFN-γ) and Humoral Immunity in Patients with Genetic Deficiencies in IL-12/23Rβ1 or IFN-γ Receptor I

inferredcites →https://doi.org/10.1128/jvi.75.14.6705-6709.2001openalex-snapshot

Interleukin-12 (IL-12) and IL-18 Are Important in Innate Defense against Genital Herpes Simplex Virus Type 2 Infection in Mice but Are Not Required for the Development of Acquired Gamma Interferon-Mediated Protective Immunity

inferredcites →https://doi.org/10.1158/0008-5472.can-05-3507openalex-snapshot

Ex vivoCulture with Interleukin (IL)-12 Improves CD8+ T-Cell Adoptive Immunotherapy for Murine Leukemia Independent of IL-18 or IFN-γ but Requires Perforin

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-0776openalex-snapshot

Interleukin-12: Biological Properties and Clinical Application

inferredcites →https://doi.org/10.1158/1078-0432.ccr-18-1512openalex-snapshot

First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors

inferredcites →https://doi.org/10.1186/1479-5876-10-234openalex-snapshot

IL-12 based gene therapy in veterinary medicine

inferredcites →https://doi.org/10.1186/s12967-015-0460-xopenalex-snapshot

A phase I clinical trial of adoptive T cell therapy using IL-12 secreting MUC-16ecto directed chimeric antigen receptors for recurrent ovarian cancer

inferredcites →https://doi.org/10.2174/1381612033454261openalex-snapshot

Gene Therapy of Cancer with Interleukin-12

inferredcites →https://doi.org/10.3109/08923973.2011.603339openalex-snapshot

In vitroexpansion of human γδ and CD56+T-cells byAspergillus-antigen loaded fast dendritic cells in the presence of exogenous interleukin-12

inferredcites →https://doi.org/10.3389/fimmu.2020.02049openalex-snapshot

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

inferredcites →https://doi.org/10.3389/fimmu.2020.575597openalex-snapshot

Localized Interleukin-12 for Cancer Immunotherapy

inferredcites →https://doi.org/10.3747/co.27.5223openalex-snapshot

A Review of Cancer Immunotherapy: From the Past, to the Present, to the Future

inferredcites →https://doi.org/10.3855/jidc.541openalex-snapshot

Using poly-N-acetyl glucosamine gel matrix to deliver IL-12 with anti-schistosomasis vaccination

inferredcites →https://doi.org/10.4049/jimmunol.147.3.874openalex-snapshot

Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)

inferredcites →https://doi.org/10.4049/jimmunol.151.5.2444openalex-snapshot

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes.

inferredcites →https://doi.org/10.4049/jimmunol.164.9.4752openalex-snapshot

Biosynthesis and Posttranslational Regulation of Human IL-12

inferredcites →https://doi.org/10.4049/jimmunol.166.9.5720openalex-snapshot

A Heritable Defect in IL-12 Signaling in B10.Q/J Mice. II. Effect on Acute Resistance to Toxoplasma gondii and Rescue by IL-18 Treatment

inferredcites →https://doi.org/10.4049/jimmunol.169.12.6842openalex-snapshot

The Roles of IL-12 in Providing a Third Signal for Clonal Expansion of Naive CD8 T Cells

inferredcites →https://doi.org/10.4049/jimmunol.171.10.5165openalex-snapshot

CD8 T Cell Clonal Expansion and Development of Effector Function Require Prolonged Exposure to Antigen, Costimulation, and Signal 3 Cytokine

inferredcites →https://doi.org/10.4049/jimmunol.171.7.3691openalex-snapshot

IFN-γ-Independent Effects of IL-12 During Intestinal Nematode Infection

inferredcites →https://doi.org/10.4049/jimmunol.174.2.600openalex-snapshot

Cutting Edge: Bcl-3 Up-Regulation by Signal 3 Cytokine (IL-12) Prolongs Survival of Antigen-Activated CD8 T Cells

inferredcites →https://doi.org/10.4049/jimmunol.177.10.6962openalex-snapshot

Reversing Tumor Immune Suppression with Intratumoral IL-12: Activation of Tumor-Associated T Effector/Memory Cells, Induction of T Suppressor Apoptosis, and Infiltration of CD8+ T Effectors

inferredcites →https://doi.org/10.4161/21624011.2014.968001openalex-snapshot

Neoadjuvant immunotherapy with chitosan and interleukin-12 to control breast cancer metastasis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4760648openalex-extracted

Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1002/advs.202520838openalex-snapshot

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

inferred← citeshttps://doi.org/10.1002/cam4.4526openalex-snapshot

Nocardia rubra cell‐wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells

inferred← citeshttps://doi.org/10.1007/s11686-026-01296-zopenalex-snapshot

Prophylactic Administration of Gypsophila oldhamiana Extract Restricts Acute Toxoplasma gondii Infection via the DC-IL-12-CD8⁺ T Cell Axis in a Murine Model

inferred← citeshttps://doi.org/10.1016/j.cyto.2026.157180openalex-snapshot

Harnessing the Power of IL-12: Revolutionizing Cancer Therapy with Combinatorial Strategies

inferred← citeshttps://doi.org/10.1016/j.fsi.2023.108974openalex-snapshot

Interleukin-12 induces IFN-γ secretion and STAT signaling implying its potential regulation of Th1 cell response in Nile tilapia

inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109402openalex-snapshot

IL-12 conditioning of peripheral blood mononuclear cells from breast cancer patients promotes the zoledronate-induced expansion of γδ T cells in vitro and enhances their cytotoxic activity and cytokine production

inferred← citeshttps://doi.org/10.1016/j.jdermsci.2022.12.012openalex-snapshot

Upregulation of CD86 and IL-12 by rhododendrol in THP-1 cells cocultured with melanocytes through ROS and ATP

inferred← citeshttps://doi.org/10.1016/j.jtauto.2024.100263openalex-snapshot

IL-12 family cytokines and autoimmune diseases: A potential therapeutic target?

inferred← citeshttps://doi.org/10.1016/j.tranon.2025.102484openalex-snapshot

CRISPR/Cas9-mediated PD-1 attenuation enhances tumor infiltrating lymphocyte-based adoptive cellular therapy in humanized-PDX model of hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1038/s41420-025-02415-xopenalex-snapshot

Ferroptosis: CD8+T cells’ blade to destroy tumor cells or poison for self-destruction

inferred← citeshttps://doi.org/10.1080/2314808x.2025.2492432openalex-snapshot

Short-term stimulation of mouse CD8 + T cells in vitro with the TLR9 agonist CpG enhances their antigen-specific expansion in vivo after administration of the TLR3 agonist Poly(I:C)

inferred← citeshttps://doi.org/10.2147/ijn.s442446openalex-snapshot

IL-12-Overexpressed Nanoparticles Suppress the Proliferation of Melanoma Through Inducing ICD and Activating DC, CD8+ T, and CD4+ T Cells

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.