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The potential of vitamin K3 as an anticancer agent against breast cancer that acts via the mitochondria-related apoptotic pathway
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jlb.43.4.304openalex-snapshot
Measurement of Intracellular Fluorescence of Human Monocytes Relative to Oxidative Metabolism
inferredcites →https://doi.org/10.1006/jmcc.1994.1106openalex-snapshot
Cellular Thiols as a Determinant of Responsiveness to Menadione in Cardiomyocytes
inferredcites →https://doi.org/10.1007/bf02254975openalex-snapshot
How Mitochondrial Damage Affects Cell Function
inferredcites →https://doi.org/10.1007/bf02254976openalex-snapshot
On the Release of Cytochrome c from Mitochondria during Cell Death Signaling
inferredcites →https://doi.org/10.1016/0003-9861(84)90206-6openalex-snapshot
Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes
inferredcites →https://doi.org/10.1016/0006-2952(89)90330-4openalex-snapshot
The toxicity of menadione and mitozantrone in human liver-derived Hep G2 hepatoma cells
inferredcites →https://doi.org/10.1016/0022-2828(95)90021-7openalex-snapshot
The role of lipid peroxidation in menadione-mediated toxicity in cardiomyocytes
inferredcites →https://doi.org/10.1016/j.jchemneu.2003.12.004openalex-snapshot
Induction of neuronal death by ER stress in Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.lfs.2005.08.003openalex-snapshot
Clofibrate-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation
inferredcites →https://doi.org/10.1016/s0006-2952(03)00478-7openalex-snapshot
Quercetin protects the hydrogen peroxide-induced apoptosis via inhibition of mitochondrial dysfuntion in H9c2 cardiomyoblast cells
inferredcites →https://doi.org/10.1016/s0092-8674(00)81334-3openalex-snapshot
Human ICE/CED-3 Protease Nomenclature
inferredcites →https://doi.org/10.1016/s0300-483x(00)00321-8openalex-snapshot
The roles of glutathione and antioxidant enzymes in menadione-induced oxidative stress
inferredcites →https://doi.org/10.1016/s1535-6108(02)00087-9openalex-snapshot
A mitochondrial Achilles' heel in cancer?
inferredcites →https://doi.org/10.1023/b:mcbi.0000009881.01943.68openalex-snapshot
Subcellular heterogeneity of mitochondrial function and dysfunction: Evidence obtained by confocal imaging
inferredcites →https://doi.org/10.1038/sj.onc.1204815openalex-snapshot
Apoptosis in the absence of caspase 3
inferredcites →https://doi.org/10.1055/s-2006-957326openalex-snapshot
Anticoagulants and Cancer Survival
inferredcites →https://doi.org/10.1073/pnas.0407613101openalex-snapshot
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy
inferredcites →https://doi.org/10.1073/pnas.88.9.3671openalex-snapshot
Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.
inferredcites →https://doi.org/10.1074/jbc.m010604200openalex-snapshot
The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell Death
inferredcites →https://doi.org/10.1074/jbc.m210826200openalex-snapshot
Mitochondrial Membrane Permeabilization and Superoxide Production during Apoptosis
inferredcites →https://doi.org/10.1074/jbc.m502685200openalex-snapshot
Caspase-12 and Caspase-4 Are Not Required for Caspase-dependent Endoplasmic Reticulum Stress-induced Apoptosis
inferredcites →https://doi.org/10.1083/jcb.200310015openalex-snapshot
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
inferredcites →https://doi.org/10.1084/jem.182.2.367openalex-snapshot
Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.
inferredcites →https://doi.org/10.1093/carcin/18.1.43openalex-snapshot
Quinone-induced DNA single strand breaks in a human colon carcinoma cell line
inferredcites →https://doi.org/10.1093/hmg/ddl105openalex-snapshot
Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL
inferredcites →https://doi.org/10.1097/00000441-193107000-00022openalex-snapshot
THE METABOLISM OF TUMORS
inferredcites →https://doi.org/10.1101/gad.13.15.1899openalex-snapshot
BCL-2 family members and the mitochondria in apoptosis
inferredcites →https://doi.org/10.1126/science.123.3191.309openalex-snapshot
On the Origin of Cancer Cells
inferredcites →https://doi.org/10.1126/science.281.5381.1309openalex-snapshot
Mitochondria and Apoptosis
inferredcites →https://doi.org/10.1146/annurev.physiol.60.1.619openalex-snapshot
THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS
inferredcites →https://doi.org/10.1158/1535-7163.mct-06-0681openalex-snapshot
Loss of mitochondrial membrane potential is inhibited by bombesin in etoposide-induced apoptosis in PC-3 prostate carcinoma cells
inferredcites →https://doi.org/10.1159/000083834openalex-snapshot
Biological and Clinical Aspects of Anticancer Effects of Antithrombotics
inferredcites →https://doi.org/10.1160/th07-04-0266openalex-snapshot
Vitamin K: The coagulation vitamin that became omnipotent
inferredcites →https://doi.org/10.1186/1476-4598-1-9openalex-snapshot
Mitochondrial defects in cancer.
inferredcites →https://doi.org/10.1210/en.2003-1350openalex-snapshot
Increased Expression of CYR61, an Extracellular Matrix Signaling Protein, in Human Benign Prostatic Hyperplasia and Its Regulation by Lysophosphatidic Acid
inferredcites →https://doi.org/10.1242/jcs.115.3.485openalex-snapshot
Menadione-induced apoptosis: roles of cytosolic Ca2+elevations and the mitochondrial permeability transition pore
inferredcites →https://doi.org/10.1248/bpb.31.1270openalex-snapshot
An Attempt to Evaluate the Effect of Vitamin K3 Using as an Enhancer of Anticancer Agents
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4755895openalex-extracted
In Vitro Investigation of Vitamin K3 and Doxorubicin Administration Regimens for Anticancer Activity in Free and Liposomal Forms
inferred← citeshttps://doi.org/10.1002/cptx.66openalex-snapshot
High‐Throughput Assessment of Mechanistic Toxicity of Chemicals in Miniaturized 3D Cell Culture
inferred← citeshttps://doi.org/10.1002/jps.22573openalex-snapshot
Evaluation of Pharmacokinetic, Biodistribution, Pharmacodynamic, and Toxicity Profile of Free Juglone and Its Sterically Stabilized Liposomes
inferred← citeshttps://doi.org/10.1007/978-1-4614-9545-1_3openalex-snapshot
Regulating Mitochondrial Respiration in Cancer
inferred← citeshttps://doi.org/10.1007/s00210-014-0997-xopenalex-snapshot
Menadione induces the formation of reactive oxygen species and depletion of GSH-mediated apoptosis and inhibits the FAK-mediated cell invasion
inferred← citeshttps://doi.org/10.1007/s00404-016-4097-7openalex-snapshot
Vitamin K3 induces antiproliferative effect in cervical epithelial cells transformed by HPV 16 (SiHa cells) through the increase in reactive oxygen species production
inferred← citeshttps://doi.org/10.1007/s10616-014-9739-7openalex-snapshot
Cytotoxic and apoptotic effects of menadione on rat hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1007/s10637-011-9680-yopenalex-snapshot
Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells
inferred← citeshttps://doi.org/10.1007/s10637-019-00775-7openalex-snapshot
Anticancer activity, apoptosis and a structure–activity analysis of a series of 1,4-naphthoquinone-2,3-bis-sulfides
inferred← citeshttps://doi.org/10.1007/s10637-019-00855-8openalex-snapshot
Anticancer activities of vitamin K3 analogues
inferred← citeshttps://doi.org/10.1007/s10930-010-9237-5openalex-snapshot
Recombinant Analogs of a Novel Milk Pro-Apoptotic Peptide, Lactaptin, and Their Effect on Cultured Human Cells
inferred← citeshttps://doi.org/10.1007/s11010-015-2485-0openalex-snapshot
Differential behaviors of trastuzumab-sensitive and -resistant SKBR3 cells treated with menadione reveal the involvement of Notch1/Akt/FOXO1 signaling elements
inferred← citeshttps://doi.org/10.1007/s12156-010-0068-6openalex-snapshot
Signal transduction of vitamin K3 for pancreas cancer therapy
inferred← citeshttps://doi.org/10.1007/s12272-011-0812-xopenalex-snapshot
1-oxoeudesm-11(13)-ene-12,8α-lactone-induced apoptosis via ROS generation and mitochondria activation in MCF-7 cells
inferred← citeshttps://doi.org/10.1016/b978-0-12-394384-2.00004-8openalex-snapshot
Somatic Mitochondrial DNA Mutations in Human Cancers
inferred← citeshttps://doi.org/10.1016/b978-0-323-99710-2.00006-8openalex-snapshot
Anticancer drugs from hormones and vitamins
inferred← citeshttps://doi.org/10.1016/b978-0-444-63749-9.00003-7openalex-snapshot
Plant-Derived Prooxidants as Potential Anticancer Therapeutics
inferred← citeshttps://doi.org/10.1016/j.abb.2011.07.014openalex-snapshot
Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury
inferred← citeshttps://doi.org/10.1016/j.biocel.2024.106697openalex-snapshot
Antitumor effect of bromo-naphthoquinone associated with tannic acid in triple negative breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2018.08.065openalex-snapshot
Cancer-specific chemotherapeutic strategy based on the vitamin K3 mediated ROS regenerative feedback and visualized drug release in vivo
inferred← citeshttps://doi.org/10.1016/j.biopha.2016.05.007openalex-snapshot
Plumbagin triggers DNA damage response, telomere dysfunction and genome instability of human breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.02.032openalex-snapshot
Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities
inferred← citeshttps://doi.org/10.1016/j.cbi.2011.03.008openalex-snapshot
Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells
inferred← citeshttps://doi.org/10.1016/j.cbi.2023.110538openalex-snapshot
A PKM2 inhibitor induces apoptosis and autophagy through JAK2 in human oral squamous cell carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.jpba.2019.03.006openalex-snapshot
A concise review of quantification methods for determination of vitamin K in various biological matrices
inferred← citeshttps://doi.org/10.1016/j.lfs.2014.01.068openalex-snapshot
Effects of vitamin K3 and K5 on proliferation, cytokine production, and regulatory T cell-frequency in human peripheral-blood mononuclear cells
inferred← citeshttps://doi.org/10.1016/j.mam.2009.12.003openalex-snapshot
Small mitochondria-targeting molecules as anti-cancer agents
inferred← citeshttps://doi.org/10.1016/j.mam.2010.02.008openalex-snapshot
The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.molstruc.2011.09.022openalex-snapshot
Azide derivatized anticancer agents of Vitamin K3: X-ray structural, DSC, resonance spectral and API studies
inferred← citeshttps://doi.org/10.1016/j.redox.2018.101073openalex-snapshot
Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors
inferred← citeshttps://doi.org/10.1016/j.taap.2012.04.030openalex-snapshot
Rapid generation of mitochondrial superoxide induces mitochondrion-dependent but caspase-independent cell death in hippocampal neuronal cells that morphologically resembles necroptosis
inferred← citeshttps://doi.org/10.1016/j.taap.2013.10.007openalex-snapshot
CR108, a novel vitamin K3 derivative induces apoptosis and breast tumor inhibition by reactive oxygen species and mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.talanta.2014.04.039openalex-snapshot
A novel liquid chromatography-tandem mass spectrometry method for determination of menadione in human plasma after derivatization with 3-mercaptopropionic acid
inferred← citeshttps://doi.org/10.1016/j.tifs.2021.12.012openalex-snapshot
Vitamin K in human health and metabolism: A nutri-genomics review
inferred← citeshttps://doi.org/10.1016/j.tiv.2018.02.014openalex-snapshot
High-content imaging assays on a miniaturized 3D cell culture platform
inferred← citeshttps://doi.org/10.1016/j.tox.2017.11.014openalex-snapshot
Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative
inferred← citeshttps://doi.org/10.1038/s41598-018-31636-7openalex-snapshot
Protective effect of 1950 MHz electromagnetic field in human neuroblastoma cells challenged with menadione
inferred← citeshttps://doi.org/10.1038/s41598-020-75262-8openalex-snapshot
Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
inferred← citeshttps://doi.org/10.1039/c9mt00133fopenalex-snapshot
The production of reactive oxygen species enhanced with the reduction of menadione by active thioredoxin reductase
inferred← citeshttps://doi.org/10.1080/01635581.2011.597537openalex-snapshot
Inhibitory Effect of Vitamin C in Combination With Vitamin K3 on Tumor Growth and Metastasis of Lewis Lung Carcinoma Xenografted in C57BL/6 Mice
inferred← citeshttps://doi.org/10.1080/15257770.2016.1139125openalex-snapshot
Interaction Mode between Inclusion Complex of Vitamin K3with γ- Cyclodextrin and Herring-Sperm DNA
inferred← citeshttps://doi.org/10.1088/1555-6611/aaf2d5openalex-snapshot
Enhanced efficacy of chemo-photodynamic therapy of rhabdomyosarcoma cells by using vitamin K3 as a neoadjuvant agent
inferred← citeshttps://doi.org/10.1089/ars.2015.6532openalex-snapshot
Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy
inferred← citeshttps://doi.org/10.1155/2019/5692958openalex-snapshot
Autophagy: A Player in response to Oxidative Stress and DNA Damage
inferred← citeshttps://doi.org/10.1155/2022/2998132openalex-snapshot
Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells
inferred← citeshttps://doi.org/10.1248/bpb.35.10openalex-snapshot
Antiproliferative and Apoptosis-Inducing Effects of Lipophilic Vitamins on Human Melanoma A375 Cells in Vitro
inferred← citeshttps://doi.org/10.1248/yakushi.19-00178openalex-snapshot
Research on Analysis of Final Diagnosis and Prognostic Factors, and Development of New Therapeutic Drugs for Malignant Tumors (Especially Malignant Pediatric Tumors)
inferred← citeshttps://doi.org/10.12750/jet.2014.29.1.73openalex-snapshot
Effects of Vitamin K1on the Developmental and Survival Rate of PorcineIn VitroFertilized Embryos
inferred← citeshttps://doi.org/10.12865/chsj.43.04.08openalex-snapshot
Biological Evaluation of Two 1,4-Naphthoquinone Derivatives Against a Breast Human Adenocarcinoma Cell Line.
inferred← citeshttps://doi.org/10.1371/journal.pone.0144033openalex-snapshot
The Combination of Vitamin K3 and Vitamin C Has Synergic Activity against Forms of Trypanosoma cruzi through a Redox Imbalance Process
inferred← citeshttps://doi.org/10.17343/sdutfd.1099504openalex-snapshot
ANTIPROLIFERATIVE EFFECTS OF VITAMIN K2 IN OSTEOSARCOMA CELLS: COMPARISON OF DIFFERENT CYTOTOXICITY ANALYZES
inferred← citeshttps://doi.org/10.18632/oncotarget.27743openalex-snapshot
Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis
inferred← citeshttps://doi.org/10.2174/0929867321666140915142219openalex-snapshot
Redox-active and Redox-silent Compounds: Synergistic Therapeutics in Cancer
inferred← citeshttps://doi.org/10.2174/0929867326666190712150638openalex-snapshot
Targeting Mitochondria through the Use of Mitocans as Emerging Anticancer Agents
inferred← citeshttps://doi.org/10.2174/138945012802009044openalex-snapshot
Pro-Oxidant Natural Products as Anticancer Agents
inferred← citeshttps://doi.org/10.3109/10715762.2011.585647openalex-snapshot
Vitamin K3 suppressed inflammatory and immune responses in a redox-dependent manner
inferred← citeshttps://doi.org/10.3389/fnut.2022.811827openalex-snapshot
Comparison of the Index of Nutritional Quality in Breast Cancer Patients With Healthy Women
inferred← citeshttps://doi.org/10.3389/fonc.2026.1849057openalex-snapshot
Targeting mitochondria as a potential therapeutic strategy against radioresistance in cancer
inferred← citeshttps://doi.org/10.3390/ijms21196992openalex-snapshot
Natural Agents Targeting Mitochondria in Cancer
inferred← citeshttps://doi.org/10.3390/ijms25094968openalex-snapshot
Micronutrient Status and Breast Cancer: A Narrative Review
inferred← citeshttps://doi.org/10.3390/nu14163401openalex-snapshot
Role of Vitamin K in Selected Malignant Neoplasms in Women
inferred← citeshttps://doi.org/10.3390/ph19081181openalex-snapshot
Disproportionality Analysis of Breast Cancer-Related Reports Across Vitamin K Homologs in the FDA Adverse Event Reporting System
inferred← citeshttps://doi.org/10.3390/reactions4030026openalex-snapshot
Various Techniques for the Synthesis of 2-Nitrophenylamino-1,4-naphthoquinone Derivatives
inferred← citeshttps://doi.org/10.3892/ijo.2015.3113openalex-snapshot
Novel therapy for locally advanced triple-negative breast cancer
inferred← citeshttps://doi.org/10.3892/mmr.2010.347openalex-snapshot
Knockdown of Beclin 1 inhibits vitamin K3‑induced autophagy, but promotes apoptosis of human hepatoma SMMC-7721 cells
inferred← citeshttps://doi.org/10.3892/mmr.2016.6001openalex-snapshot
Vitamin K4 inhibits the proliferation and induces apoptosis of U2OS osteosarcoma cells via mitochondrial dysfunction
inferred← citeshttps://doi.org/10.3945/jn.113.187740openalex-snapshot
Dietary Intake of Vitamin K Is Inversely Associated with Mortality Risk
inferred← citeshttps://doi.org/10.4172/1948-5956.1000223openalex-snapshot
Vitamin C and K3 Combination Causes Enhanced Anticancer Activity against RT-4 Bladder Cancer Cells
inferred← citeshttps://doi.org/10.5402/2012/307102openalex-snapshot
Menadione : Sodium Orthovanadate Combination Eliminates and Inhibits Migration of Detached Cancer Cells
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