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Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury
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What this work says Outgoing claims: the papers this work cites, builds on, or argues with.
inferred cites → https://doi.org/10.1002/glia.22382 openalex-snapshot Local production of serum amyloid a is implicated in the induction of macrophage chemoattractants in Schwann cells during wallerian degeneration of peripheral nerves
inferred cites → https://doi.org/10.1002/jnr.21166 openalex-snapshot Macrophage depletion alters the blood–nerve barrier without affecting Schwann cell function after neural injury
inferred cites → https://doi.org/10.1006/exnr.1996.0142 openalex-snapshot Reduced Hyperalgesia in Nerve-Injured WLD Mice: Relationship to Nerve Fiber Phagocytosis, Axonal Degeneration, and Regeneration in Normal Mice
inferred cites → https://doi.org/10.1007/bf02150231 openalex-snapshot Myelin-stimulated macrophages release neurotrophic factors for adult dorsal root ganglion neurons in culture
inferred cites → https://doi.org/10.1007/s10753-013-9621-3 openalex-snapshot The Adenosine-Dependent Angiogenic Switch of Macrophages to an M2-Like Phenotype is Independent of Interleukin-4 Receptor Alpha (IL-4Rα) Signaling
inferred cites → https://doi.org/10.1016/j.ccr.2010.11.009 openalex-snapshot HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PlGF
inferred cites → https://doi.org/10.1016/j.jim.2015.03.013 openalex-snapshot Interleukin-10 conjugated electrospun polycaprolactone (PCL) nanofibre scaffolds for promoting alternatively activated (M2) macrophages around the peripheral nerve in vivo
inferred cites → https://doi.org/10.1016/j.nbd.2013.01.003 openalex-snapshot Deletion of Nrf2 impairs functional recovery, reduces clearance of myelin debris and decreases axonal remyelination after peripheral nerve injury
inferred cites → https://doi.org/10.1016/j.neures.2004.01.004 openalex-snapshot Enhanced production of monocyte chemoattractant protein-1 in the dorsal root ganglia in a rat model of neuropathic pain: possible involvement in the development of neuropathic pain
inferred cites → https://doi.org/10.1016/j.pain.2013.06.042 openalex-snapshot P-selectin is required for neutrophils and macrophage infiltration into injured site and contributes to generation of behavioral hypersensitivity following peripheral nerve injury in mice
inferred cites → https://doi.org/10.1016/s0006-8993(97)01327-9 openalex-snapshot Painful mononeuropathy in C57BL/Wld mice with delayed Wallerian degeneration: differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity
inferred cites → https://doi.org/10.1038/ki.2014.216 openalex-snapshot The calcium-binding protein complex S100A8/A9 has a crucial role in controlling macrophage-mediated renal repair following ischemia/reperfusion
inferred cites → https://doi.org/10.1038/ncb1507 openalex-snapshot Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
inferred cites → https://doi.org/10.1038/ni.1889 openalex-snapshot Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development
inferred cites → https://doi.org/10.1038/ni.2109 openalex-snapshot Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
inferred cites → https://doi.org/10.1038/nrn3722 openalex-snapshot Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
inferred cites → https://doi.org/10.1093/brain/awh407 openalex-snapshot Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1 and interleukin-1 in Wallerian degeneration
inferred cites → https://doi.org/10.1155/2013/828354 openalex-snapshot S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease
inferred cites → https://doi.org/10.1172/jci200519229 openalex-snapshot Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
inferred cites → https://doi.org/10.1186/1744-8069-7-74 openalex-snapshot Toll-Like Receptor 2 Contributes to Chemokine Gene Expression and Macrophage Infiltration in the Dorsal Root Ganglia after Peripheral Nerve Injury
inferred cites → https://doi.org/10.1189/jlb.1008647 openalex-snapshot The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
inferred cites → https://doi.org/10.1523/jneurosci.22-15-06696.2002 openalex-snapshot Denervated Schwann Cells Attract Macrophages by Secretion of Leukemia Inhibitory Factor (LIF) and Monocyte Chemoattractant Protein-1 in a Process Regulated by Interleukin-6 and LIF
What points at this work Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred ← cites https://doi.org/10.2139/ssrn.3945933 openalex-extracted Inhibition of Nav1.8 Transport Promotes Axon Regeneration Via Regulating Dynamic Changes in Macrophage Phenotype after Sciatic Nerve Injury
inferred ← cites https://doi.org/10.1002/adhm.202302994 openalex-snapshot Bredigite‐Based Bioactive Nerve Guidance Conduit for Pro‐Healing Macrophage Polarization and Peripheral Nerve Regeneration
inferred ← cites https://doi.org/10.1002/adhm.202501123 openalex-snapshot Light‐Responsive Oxygen Generation from Chlorella Hydrogels for Facial Nerve Injury Recovery: Crosstalk between M1/M2 Macrophages and Schwann Cells
inferred ← cites https://doi.org/10.1002/adma.202202513 openalex-snapshot Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System
inferred ← cites https://doi.org/10.1002/advs.202512592 openalex-snapshot Near‐Infrared Switch‐Driven Macrophage Dynamically Reprogramming for Anti‐Infection and Tissue Healing on Polyetheretherketone Implants
inferred ← cites https://doi.org/10.1002/advs.202520323 openalex-snapshot Schwann Cell Synthesized Cholesterol Orchestrates Peripheral Nerve Regeneration via Structural and IGF1‐Dependent Signaling Mechanisms
inferred ← cites https://doi.org/10.1002/brb3.1400 openalex-snapshot Miconazole alleviates peripheral nerve crush injury by mediating a macrophage phenotype change through the NF‐κB pathway
inferred ← cites https://doi.org/10.1002/brb3.1747 openalex-snapshot Intra and inter: Alterations in functional brain resting‐state networks after peripheral nerve injury
inferred ← cites https://doi.org/10.1002/brb3.659 openalex-snapshot Patterns of production of collagen‐rich deposits in peripheral nerves in response to injury: A pilot study in a rabbit model
inferred ← cites https://doi.org/10.1002/exp.20230098 openalex-snapshot Decoding the regulatory role of ATP synthase inhibitory factor 1 (ATPIF1) in Wallerian degeneration and peripheral nerve regeneration
inferred ← cites https://doi.org/10.1002/glia.23204 openalex-snapshot Siglec‐H is a microglia‐specific marker that discriminates microglia from CNS‐associated macrophages and CNS‐infiltrating monocytes
inferred ← cites https://doi.org/10.1002/glia.24220 openalex-snapshot Transforming growth factor‐beta signaling modulates perineurial glial bridging following peripheral spinal motor nerve injury in zebrafish
inferred ← cites https://doi.org/10.1002/glia.24309 openalex-snapshot Electrical stimulation accelerates Wallerian degeneration and promotes nerve regeneration after sciatic nerve injury
inferred ← cites https://doi.org/10.1002/glia.24568 openalex-snapshot Myelinated peripheral axons are more vulnerable to mechanical trauma in a model of enlarged axonal diameters
inferred ← cites https://doi.org/10.1002/jat.3710 openalex-snapshot Evaluation of neurobehavioral impairment in methylmercury‐treated KK‐Ay mice by dynamic weight‐bearing test
inferred ← cites https://doi.org/10.1002/jbm.a.36090 openalex-snapshot A novel technique for decellularization of allogenic nerves and in vivo study of their use for peripheral nerve reconstruction
inferred ← cites https://doi.org/10.1002/jbm.a.38008 openalex-snapshot Adipose‐Derived Stem Cell‐Loaded Fish‐ GelMA / CMC Hydrogel Accelerates Wound Healing via Macrophage Polarization Suppression and Promoting Angiogenesis
inferred ← cites https://doi.org/10.1002/jcb.27105 openalex-snapshot FGF9 modulates Schwann cell myelination in developing nerves and induces a pro‐inflammatory environment during injury
inferred ← cites https://doi.org/10.1002/mabi.202300476 openalex-snapshot Nerve Guide Conduits Integrated with Fisetin‐Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration
inferred ← cites https://doi.org/10.1002/mco2.71019 openalex-snapshot Myelination and Remyelination in Peripheral Nerve Injury: Mechanisms, Regulation, and Therapeutic Perspectives
inferred ← cites https://doi.org/10.1002/mus.26097 openalex-snapshot Monitoring of macrophage recruitment enhanced by Toll‐like receptor 4 activation with MR imaging in nerve injury
inferred ← cites https://doi.org/10.1002/mus.26862 openalex-snapshot Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis
inferred ← cites https://doi.org/10.1002/stem.2534 openalex-snapshot Secreted Ectodomain of Sialic Acid-Binding Ig-Like Lectin-9 and Monocyte Chemoattractant Protein-1 Synergistically Regenerate Transected Rat Peripheral Nerves by Altering Macrophage Polarity
inferred ← cites https://doi.org/10.1007/s12035-021-02607-3 openalex-snapshot SIRT6 Negatively Regulates Schwann Cells Dedifferentiation via Targeting c-Jun During Wallerian Degeneration After Peripheral Nerve Injury
inferred ← cites https://doi.org/10.1007/s12035-023-03590-7 openalex-snapshot Unleashing Axonal Regeneration Capacities: Neuronal and Non-neuronal Changes After Injuries to Dorsal Root Ganglion Neuron Central and Peripheral Axonal Branches
inferred ← cites https://doi.org/10.1007/s13311-021-01125-3 openalex-snapshot Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases
inferred ← cites https://doi.org/10.1007/s13365-017-0529-9 openalex-snapshot An oral form of methylglyoxal-bis-guanylhydrazone reduces monocyte activation and traffic to the dorsal root ganglia in a primate model of HIV-peripheral neuropathy
inferred ← cites https://doi.org/10.1016/j.bbih.2022.100548 openalex-snapshot CD206+/MHCII− macrophage accumulation at nerve injury site correlates with attenuation of allodynia in TASTPM mouse model of Alzheimer's disease
inferred ← cites https://doi.org/10.1016/j.biopha.2024.116769 openalex-snapshot Lactobacillus Plantarum intake mitigates neuropathic pain behavior via enhancing macrophage M2 polarization in a rat model of peripheral neuropathy
inferred ← cites https://doi.org/10.1016/j.cej.2026.179316 openalex-snapshot Aligned-to-random bilayered collagen nerve conduit enhances pain relief and nerve repair following surgical decompression in diabetic entrapment neuropathy
inferred ← cites https://doi.org/10.1016/j.expneurol.2022.114139 openalex-snapshot Exosomes from LPS-preconditioned bone marrow MSCs accelerated peripheral nerve regeneration via M2 macrophage polarization: Involvement of TSG-6/NF-κB/NLRP3 signaling pathway
inferred ← cites https://doi.org/10.1016/j.ijbiomac.2026.154152 openalex-snapshot A gelatin methacryloyl (GelMA)-based biomimetic melatonin/vascular endothelial growth factor-encoding plasmid (pVEGF) nerve conduit regulates the early redox-angiogenic microenvironment for long-gap peripheral nerve repair
inferred ← cites https://doi.org/10.1016/j.jare.2026.07.045 openalex-snapshot Chiral MoS2-based nanozymes co-delivering indole-3-propionic acid synergistically inhibit ferroptosis and reprogram metabolism for enhanced peripheral nerve regeneration
inferred ← cites https://doi.org/10.1016/j.jconrel.2026.114797 openalex-snapshot Ultrasound-guided nanocomposite hydrogel injection to enhance nerve repair via temporal delivery of a colony-stimulating factor 1 receptor inhibitor
inferred ← cites https://doi.org/10.1016/j.jep.2020.113063 openalex-snapshot Augmented Buyang Huanwu Decoction facilitates axonal regeneration after peripheral nerve transection through the regulation of inflammatory cytokine production
inferred ← cites https://doi.org/10.1016/j.jhsg.2025.100784 openalex-snapshot Hyaluronate-Alginate Gel-Coated Porcine Small Intestine Submucosa for Nerve Protection Minimizes Extraneural Collagen Deposition in a Preclinical Model
inferred ← cites https://doi.org/10.1016/j.jor.2020.03.026 openalex-snapshot Tobacco use and neurogenesis: A theoretical review of pathophysiological mechanism affecting the outcome of peripheral nerve regeneration
inferred ← cites https://doi.org/10.1016/j.lfs.2021.119422 openalex-snapshot Minocycline alleviates peripheral nerve adhesion by promoting regulatory macrophage polarization via the TAK1 and its downstream pathway
inferred ← cites https://doi.org/10.1016/j.nbd.2026.107262 openalex-snapshot Multi-omics analysis identifies mitochondrial dysfunction in CD83+ macrophages as a key event in diabetic peripheral neuropathy progression
inferred ← cites https://doi.org/10.1016/j.neuint.2025.105940 openalex-snapshot Temporal and spatial expression of Phosphodiesterase-4B after sciatic nerve compression in rats and its mechanism of action on sciatic nerve repair
inferred ← cites https://doi.org/10.1016/j.neulet.2024.137813 openalex-snapshot OTULIN of exosomes derived from Schwann cells promotes peripheral nerve injury repair by regulating macrophage polarization via deubiquitination of ERBB2
inferred ← cites https://doi.org/10.1016/j.phymed.2026.158214 openalex-snapshot Hyperoside accelerates myelin debris clearance by inhibiting signal transducer and activator of transcription 3 phosphorylation in peripheral nerve injury
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