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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline

https://doi.org/10.1007/s00401-016-1632-3
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/archneur.55.3.326openalex-snapshot
Clinicopathologic Studies in Cognitively Healthy Aging and Alzheimer Disease
inferredcites →https://doi.org/10.1001/archneur.58.12.2025openalex-snapshot
Correlation Between Aβx-40–, Aβx-42–, and Aβx-43–Containing Amyloid Plaques and Cognitive Decline
inferredcites →https://doi.org/10.1001/archneur.59.9.1381openalex-snapshot
β-Secretase Protein and Activity Are Increased in the Neocortex in Alzheimer Disease
inferredcites →https://doi.org/10.1001/archneur.63.1.38openalex-snapshot
Neuropathologic Substrate of Mild Cognitive Impairment
inferredcites →https://doi.org/10.1001/jama.283.12.1571openalex-snapshot
Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline
inferredcites →https://doi.org/10.1001/jamaneurol.2013.5847openalex-snapshot
Amyloid-β and Tau
inferredcites →https://doi.org/10.1002/(sici)1097-4547(19970415)48:2<128::aid-jnr5>3.0.co;2-eopenalex-snapshot
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
inferredcites →https://doi.org/10.1002/ana.10208openalex-snapshot
Increased expression of the amyloid precursor β‐secretase in Alzheimer's disease
inferredcites →https://doi.org/10.1002/ana.410300509openalex-snapshot
Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects
inferredcites →https://doi.org/10.1002/j.1460-2075.1992.tb05204.xopenalex-snapshot
The switch of tau protein to an Alzheimer‐like state includes the phosphorylation of two serine‐proline motifs upstream of the microtubule binding region.
inferredcites →https://doi.org/10.1006/exnr.2002.8014openalex-snapshot
Tau Conformational Changes Correspond to Impairments of Episodic Memory in Mild Cognitive Impairment and Alzheimer's Disease
inferredcites →https://doi.org/10.1007/s00018-015-1949-4openalex-snapshot
Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits
inferredcites →https://doi.org/10.1007/s00401-013-1083-zopenalex-snapshot
Oligomers, fact or artefact? SDS-PAGE induces dimerization of β-amyloid in human brain samples
inferredcites →https://doi.org/10.1007/s00401-014-1296-9openalex-snapshot
Pyroglutamylated amyloid-β is associated with hyperphosphorylated tau and severity of Alzheimer’s disease
inferredcites →https://doi.org/10.1007/s00401-014-1308-9openalex-snapshot
A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis
inferredcites →https://doi.org/10.1016/0006-8993(94)91702-7openalex-snapshot
Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias
inferredcites →https://doi.org/10.1016/0014-5793(94)80260-2openalex-snapshot
Assembly of Alzheimer‐like filaments from full‐length tau protein
inferredcites →https://doi.org/10.1016/0197-4580(95)00021-6openalex-snapshot
Staging of alzheimer's disease-related neurofibrillary changes
inferredcites →https://doi.org/10.1016/0304-3940(95)11484-eopenalex-snapshot
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205
inferredcites →https://doi.org/10.1016/j.febslet.2006.10.076openalex-snapshot
Altered β‐secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimer's disease brain
inferredcites →https://doi.org/10.1016/j.ijbiomac.2015.06.040openalex-snapshot
Kinetic regime of dithiothreitol-induced aggregation of bovine serum albumin
inferredcites →https://doi.org/10.1016/j.jmb.2007.06.088openalex-snapshot
Heat-induced Conversion of β2-Microglobulin and Hen Egg-white Lysozyme into Amyloid Fibrils
inferredcites →https://doi.org/10.1016/j.molbrainres.2004.08.006openalex-snapshot
Upregulation of amyloid precursor protein isoforms containing Kunitz protease inhibitor in dementia with Lewy bodies
inferredcites →https://doi.org/10.1016/j.nbd.2006.01.006openalex-snapshot
Assessments of the accumulation severities of amyloid β-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
inferredcites →https://doi.org/10.1016/j.nbd.2016.03.002openalex-snapshot
Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2003.09.009openalex-snapshot
Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2005.11.001openalex-snapshot
Tau protein abnormalities associated with the progression of alzheimer disease type dementia
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2015.10.012openalex-snapshot
Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment
inferredcites →https://doi.org/10.1016/s0002-9440(10)65184-xopenalex-snapshot
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
inferredcites →https://doi.org/10.1016/s0165-0173(00)00019-9openalex-snapshot
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
inferredcites →https://doi.org/10.1016/s0197-4580(00)00157-3openalex-snapshot
Conformational change as one of the earliest alterations of tau in Alzheimer's disease
inferredcites →https://doi.org/10.1016/s1474-4422(13)70044-9openalex-snapshot
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
inferredcites →https://doi.org/10.1021/bi061850fopenalex-snapshot
Solution State Characterization of Amyloid β-Derived Diffusible Ligands
inferredcites →https://doi.org/10.1021/bi1016233openalex-snapshot
Preparation and Characterization of Neurotoxic Tau Oligomers
inferredcites →https://doi.org/10.1021/bi2009147openalex-snapshot
Heat Shock Protein 70 Prevents both Tau Aggregation and the Inhibitory Effects of Preexisting Tau Aggregates on Fast Axonal Transport
inferredcites →https://doi.org/10.1021/bi800250popenalex-snapshot
Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β
inferredcites →https://doi.org/10.1038/nature04533openalex-snapshot
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
inferredcites →https://doi.org/10.1038/nature11060openalex-snapshot
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
inferredcites →https://doi.org/10.1038/srep14809openalex-snapshot
SDS-PAGE analysis of Aβ oligomers is disserving research into Alzheimer´s disease: appealing for ESI-IM-MS
inferredcites →https://doi.org/10.1038/srep19393openalex-snapshot
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory
inferredcites →https://doi.org/10.1042/bj20071499openalex-snapshot
How do surfactants and DTT affect the size, dynamics, activity and growth of soluble lysozyme aggregates?
inferredcites →https://doi.org/10.1042/bj20110512openalex-snapshot
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
inferredcites →https://doi.org/10.1046/j.1471-4159.2000.0741749.xopenalex-snapshot
Differential Assembly of Human Tau Isoforms in the Presence of Arachidonic Acid
inferredcites →https://doi.org/10.1073/pnas.88.20.8910openalex-snapshot
Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.
inferredcites →https://doi.org/10.1074/jbc.m111.237974openalex-snapshot
Characterization of Prefibrillar Tau Oligomers in Vitro and in Alzheimer Disease
inferredcites →https://doi.org/10.1074/jbc.m114.594846openalex-snapshot
Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphisms in Vitro and in Alzheimer Disease Brain
inferredcites →https://doi.org/10.1074/jbc.m701078200openalex-snapshot
Accelerating Amyloid-β Fibrillization Reduces Oligomer Levels and Functional Deficits in Alzheimer Disease Mouse Models
inferredcites →https://doi.org/10.1074/jbc.m805300200openalex-snapshot
Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation
inferredcites →https://doi.org/10.1080/13506120500106958openalex-snapshot
Neurotoxic protein oligomers — what you see is not always what you get
inferredcites →https://doi.org/10.1093/brain/awt062openalex-snapshot
Brain amyloid-β oligomers in ageing and Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/awt362openalex-snapshot
Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/awv024openalex-snapshot
Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease
inferredcites →https://doi.org/10.1093/brain/awv199openalex-snapshot
Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects
inferredcites →https://doi.org/10.1093/jnen/59.8.733openalex-snapshot
Sequence of Aβ-Protein Deposition in the Human Medial Temporal Lobe
inferredcites →https://doi.org/10.1093/jnen/nlv001openalex-snapshot
Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy
inferredcites →https://doi.org/10.1093/jnen/nlw026openalex-snapshot
Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum
inferredcites →https://doi.org/10.1097/00005072-199902000-00008openalex-snapshot
Neurons May Live for Decades with Neurofibrillary Tangles
inferredcites →https://doi.org/10.1097/nen.0b013e31802c3e7dopenalex-snapshot
Brain Protein Preservation Largely Depends on the Postmortem Storage Temperature
inferredcites →https://doi.org/10.1097/nen.0b013e31815c5efbopenalex-snapshot
Clinicopathologic Correlations in a Large Alzheimer Disease Center Autopsy Cohort
inferredcites →https://doi.org/10.1111/j.1471-4159.2005.03407.xopenalex-snapshot
Globular amyloid β‐peptide 1−42 oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease
inferredcites →https://doi.org/10.1111/j.1471-4159.2006.03784.xopenalex-snapshot
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo
inferredcites →https://doi.org/10.1111/j.1471-4159.2009.06528.xopenalex-snapshot
BACE1 and BACE2 enzymatic activities in Alzheimer’s disease
inferredcites →https://doi.org/10.1111/j.1750-3639.2008.00147.xopenalex-snapshot
Staging of Neurofibrillary Pathology in Alzheimer's Disease: A Study of the BrainNet Europe Consortium
inferredcites →https://doi.org/10.1111/nan.12160openalex-snapshot
Memory deficits correlate with tau and spine pathology in P 301 S MAPT transgenic mice
inferredcites →https://doi.org/10.1126/science.1113694openalex-snapshot
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
inferredcites →https://doi.org/10.1126/science.1566067openalex-snapshot
Alzheimer's Disease: The Amyloid Cascade Hypothesis
inferredcites →https://doi.org/10.1126/scitranslmed.aaf2362openalex-snapshot
Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease
inferredcites →https://doi.org/10.1159/000111270openalex-snapshot
FAC1, a Novel Gene Identified with the Monoclonal Antibody Alz50, Is Developmentally Regulated in Human Brain (Part 1 of 2)
inferredcites →https://doi.org/10.1159/000337230openalex-snapshot
Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy
inferredcites →https://doi.org/10.1186/1750-1326-6-39openalex-snapshot
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
inferredcites →https://doi.org/10.1186/1750-1326-7-8openalex-snapshot
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
inferredcites →https://doi.org/10.1186/1756-0500-2-243openalex-snapshot
Crude subcellular fractionation of cultured mammalian cell lines
inferredcites →https://doi.org/10.1186/preaccept-1342777270140958openalex-snapshot
Inconsistencies and Controversies Surrounding the Amyloid Hypothesis of Alzheimer's Disease
inferredcites →https://doi.org/10.1186/s40478-014-0083-0openalex-snapshot
Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity
inferredcites →https://doi.org/10.1212/01.wnl.0000063311.58879.01openalex-snapshot
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
inferredcites →https://doi.org/10.1212/wnl.58.12.1791openalex-snapshot
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
inferredcites →https://doi.org/10.1371/journal.pone.0114041openalex-snapshot
Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains
inferredcites →https://doi.org/10.1523/jneurosci.0433-14.2014openalex-snapshot
Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes
inferredcites →https://doi.org/10.1523/jneurosci.0560-11.2011openalex-snapshot
Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases
inferredcites →https://doi.org/10.1523/jneurosci.0587-07.2007openalex-snapshot
Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy
inferredcites →https://doi.org/10.3233/jad-131235openalex-snapshot
TOC1: Characterization of a Selective Oligomeric Tau Antibody
inferredcites →https://doi.org/10.3233/jad-2005-8104openalex-snapshot
Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease
inferredcites →https://doi.org/10.3233/jad-2010-100879openalex-snapshot
EEG, Activity, and Sleep Architecture in a Transgenic AβPPswe/PSEN1A246E Alzheimer's Disease Mouse
inferredcites →https://doi.org/10.3233/jad-2011-111337openalex-snapshot
Measurement of Altered AβPP Isoform Expression in Frontal Cortex of Patients with Alzheimer's Disease by Absolute Quantification Real-Time PCR
inferredcites →https://doi.org/10.3389/fneur.2013.00112openalex-snapshot
Hyperphosphorylation-Induced Tau Oligomers

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3751054openalex-extracted
A Complex Containing HNRNPA2B1 and N 6-Methyladenosine Modified Transcripts Mediates Actions of Toxic Tau Oligomers
inferred← citeshttps://doi.org/10.1002/alz.12502openalex-snapshot
Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/alz.70101openalex-snapshot
Targeting of phosphorylated tau at threonine 181 by a Qβ virus‐like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques
inferred← citeshttps://doi.org/10.1002/cne.25466openalex-snapshot
Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal–hippocampal connectome across stages of Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/gps.5530openalex-snapshot
Affective symptoms and regional cerebral tau burden in early‐stage Alzheimer's disease
inferred← citeshttps://doi.org/10.1002/jnr.24418openalex-snapshot
Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes
inferred← citeshttps://doi.org/10.1002/pro.4639openalex-snapshot
Structural polymorphism and cytotoxicity of brain‐derived β‐amyloid extracts
inferred← citeshttps://doi.org/10.1002/trc2.12029openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-1-4939-7404-7_2openalex-snapshot
Recent Advances in Computational Approaches for Designing Potential Anti-Alzheimer’s Agents
inferred← citeshttps://doi.org/10.1007/978-3-031-52641-1_69-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/978-3-031-81908-7_10openalex-snapshot
Excessive Alcohol Use as a Risk Factor for Alzheimer’s Disease: Epidemiological and Preclinical Evidence
inferred← citeshttps://doi.org/10.1007/978-981-16-2546-6_4openalex-snapshot
Alzheimer’s Disease—Molecular Defect, Public Perceptions and Stigma in South Africa
inferred← citeshttps://doi.org/10.1007/s00018-022-04572-zopenalex-snapshot
Characterization of microtubule-associated protein tau isoforms and Alzheimer’s disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s00401-018-1922-zopenalex-snapshot
Evidence of intraneuronal Aβ accumulation preceding tau pathology in the entorhinal cortex
inferred← citeshttps://doi.org/10.1007/s00401-020-02251-6openalex-snapshot
Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation
inferred← citeshttps://doi.org/10.1007/s00401-024-02691-4openalex-snapshot
Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change
inferred← citeshttps://doi.org/10.1007/s00702-017-1702-2openalex-snapshot
Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts
inferred← citeshttps://doi.org/10.1007/s00702-020-02232-9openalex-snapshot
Neuropathological assessment of the Alzheimer spectrum
inferred← citeshttps://doi.org/10.1007/s10571-020-01020-zopenalex-snapshot
GSK-3β Disrupts Neuronal Oscillatory Function to Inhibit Learning and Memory in Male Rats
inferred← citeshttps://doi.org/10.1007/s10571-022-01228-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11011-025-01781-wopenalex-snapshot
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Anti-diabetic vanadyl complexes reduced Alzheimer’s disease pathology independent of amyloid plaque deposition
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Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease
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Sex differences in the timing behavior performance of 3xTg-AD and wild-type mice in the peak interval procedure
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Attenuated task-responsive representations of hippocampal place cells induced by amyloid-beta accumulation
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Olfactory impairment and the risk of cognitive decline and dementia in older adults: a meta-analysis
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Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease
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The microtubule-dynamin binding inhibitor peptide PHDP5 rescues spatial learning and memory deficits in Alzheimer’s disease model mice
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Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus
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iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau
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Pharmacological PTP1B inhibition rescues motor learning, neuroinflammation, and hyperglycaemia in a mouse model of Alzheimer's disease
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Cu, Fe, and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101766openalex-snapshot
Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease
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Differences in amyloid-β and tau/p-tau deposition in blood-injected mouse brains using micro-syringe to mimic traumatic brain microhemorrhages
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UPLC-Orbitrap HRMS metabolic profiling of Cymbopogon citratus cultivated in Egypt; neuroprotective effect against AlCl3-induced neurotoxicity in rats
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Synthesis and anti-diabetic activity of new N,N-dimethylphenylenediamine-derivatized nitrilotriacetic acid vanadyl complexes
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Pore-former enabled seeding of tau in rats: Alleviation by memantine and lithium chloride
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Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy
inferred← citeshttps://doi.org/10.1016/j.nbd.2022.105915openalex-snapshot
Chemotherapy promotes astrocytic response to Aβ deposition, but not Aβ levels, in a mouse model of amyloid and APOE
inferred← citeshttps://doi.org/10.1016/j.nbd.2023.106142openalex-snapshot
BACE cleavage of APP does not drive the diabetic phenotype of PLB4 mice
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Differential activation of the mTOR/autophagy pathway predicts cognitive performance in APP/PS1 mice
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Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau
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Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains
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Early amygdala and ERC atrophy linked to 3D reconstruction of rostral neurofibrillary tau tangle pathology in Alzheimer’s disease
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Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy
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Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease
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Synapse pathology in Alzheimer’s disease
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Increased intestinal bile acid absorption contributes to age-related cognitive impairment
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Shapeshifter W-Tau Peptide Inhibits Tau Aggregation and Disintegrates Paired Helical Filaments
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In Vivo Assessment of Retinal Biomarkers by Hyperspectral Imaging: Early Detection of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1038/s41467-025-65536-yopenalex-snapshot
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1038/s41467-026-68864-9openalex-snapshot
Integrative epigenomic landscape of Alzheimer’s Disease brains reveals oligodendrocyte molecular perturbations associated with tau
inferred← citeshttps://doi.org/10.1038/s41541-025-01147-4openalex-snapshot
pS396/pS404 (PHF1) tau vaccine outperforms pS199/pS202 (AT8) in rTg4510 tauopathy model
inferred← citeshttps://doi.org/10.1038/s41582-022-00665-2openalex-snapshot
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility
inferred← citeshttps://doi.org/10.1038/s41591-024-03400-0openalex-snapshot
Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1042/bst20230596openalex-snapshot
Biochemical approaches to assess the impact of post-translational modifications on pathogenic tau conformations using recombinant protein
inferred← citeshttps://doi.org/10.1055/a-1019-9819openalex-snapshot
Natural Compounds with Anti-BACE1 Activity as Promising Therapeutic Drugs for Treating Alzheimerʼs Disease
inferred← citeshttps://doi.org/10.1073/pnas.1914593117openalex-snapshot
Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain
inferred← citeshttps://doi.org/10.1074/jbc.ra119.010532openalex-snapshot
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays
inferred← citeshttps://doi.org/10.1080/09168451.2019.1659721openalex-snapshot
Dietary supplementation of a high-temperature-processed green tea extract attenuates cognitive impairment in PS2 and Tg2576 mice
inferred← citeshttps://doi.org/10.1080/1028415x.2020.1806190openalex-snapshot
High-fat diet exacerbates cognitive and metabolic abnormalities in neuronal BACE1 knock-in mice – partial prevention by Fenretinide
inferred← citeshttps://doi.org/10.1080/13543784.2021.2017881openalex-snapshot
What have we learned from past failures of investigational drugs for Alzheimer’s disease?
inferred← citeshttps://doi.org/10.1080/13543784.2024.2396911openalex-snapshot
Application of engineered antibodies (scFvs and nanobodies) targeting pathological protein aggregates in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1080/14728222.2023.2206561openalex-snapshot
Focusing on oligomeric tau as a therapeutic target in Alzheimer’s disease and other tauopathies
inferred← citeshttps://doi.org/10.1093/brain/awaa445openalex-snapshot
Severe oligomeric tau toxicity can be reversed without long-term sequelae
inferred← citeshttps://doi.org/10.1093/brain/awab243openalex-snapshot
Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy
inferred← citeshttps://doi.org/10.1093/brain/awx243openalex-snapshot
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1093/braincomms/fcz046openalex-snapshot
Is tau in the absence of amyloid on the Alzheimer’s continuum?: A study of discordant PET positivity
inferred← citeshttps://doi.org/10.1093/hmg/ddab363openalex-snapshot
Mitochondrial oxidative stress contributes to the pathological aggregation and accumulation of tau oligomers in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1096/fj.202301281rropenalex-snapshot
Elevated concentrations of amyloid‐β oligomers and their proapoptotic effects on age‐related cataract
inferred← citeshttps://doi.org/10.1096/fj.202602361rropenalex-snapshot
SIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential
inferred← citeshttps://doi.org/10.1097/nrl.0000000000000320openalex-snapshot
Alzheimer Disease Clinical Trials Targeting Amyloid
inferred← citeshttps://doi.org/10.1101/2020.12.03.409334openalex-snapshot
A Complex Containing HNRNPA2B1 and N 6 -methyladenosine Modified Transcripts Mediates Actions of Toxic Tau Oligomers
inferred← citeshttps://doi.org/10.1101/2021.10.20.465125openalex-snapshot
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
inferred← citeshttps://doi.org/10.1101/2022.06.24.497452openalex-snapshot
The tau oligomer antibody APNmAb005 detects early-stage pathological tau enriched at synapses and rescues neuronal loss in long-term treatments
inferred← citeshttps://doi.org/10.1101/2023.03.03.530990openalex-snapshot
How stra(i)nge are your controls? A comparative analysis of metabolic phenotypes in commonly used C57 substrains
inferred← citeshttps://doi.org/10.1101/2023.08.26.554940openalex-snapshot
Differential seeding by exogenous R2 and R3 fibrils influences autophagic degradation of intracellular tau aggregates in Tau K18 P301S cells
inferred← citeshttps://doi.org/10.1101/2023.09.15.23295595openalex-snapshot
Development and Performance Assessment of a Novel Plasma p-Tau181 Assay Reflecting Tau Tangle Pathology in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1101/2023.09.27.559720openalex-snapshot
Post-mortem AT-8 reactive tau species correlate with non-plaque Aβ levels in the frontal cortex of non-AD and AD brains
inferred← citeshttps://doi.org/10.1101/2024.04.05.588338openalex-snapshot
Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy
inferred← citeshttps://doi.org/10.1101/2024.11.07.24316927openalex-snapshot
Exploratory Blood Biomarker Patterns in a Mixed Dementia Cohort
inferred← citeshttps://doi.org/10.1101/2025.01.30.635618openalex-snapshot
Aβ-induced distress of astrocytes triggers Alzheimer disease pathology through non-canonical δ secretase activity
inferred← citeshttps://doi.org/10.1101/2025.05.28.656730openalex-snapshot
Peptides alleviate cognitive impairment by inhibiting and disassembling amyloid-β aggregates in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1111/bpa.12783openalex-snapshot
Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of Alzheimer's disease
inferred← citeshttps://doi.org/10.1142/s0192415x19500757openalex-snapshot
Puerariae Radix Prevents Anxiety and Cognitive Deficits in Mice Under Oligomeric Aβ-Induced Stress
inferred← citeshttps://doi.org/10.1155/2018/2764831openalex-snapshot
Possible Clues for Brain Energy Translation via Endolysosomal Trafficking of APP‐CTFs in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1186/s13024-022-00592-2openalex-snapshot
Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins
inferred← citeshttps://doi.org/10.1186/s13195-022-01141-1openalex-snapshot
Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.1186/s40035-021-00270-1openalex-snapshot
The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases
inferred← citeshttps://doi.org/10.1186/s40035-026-00538-4openalex-snapshot
Implications of virus-induced stress granules in tauopathies
inferred← citeshttps://doi.org/10.1186/s40478-018-0557-6openalex-snapshot
Phosphorylation of different tau sites during progression of Alzheimer’s disease
inferred← citeshttps://doi.org/10.1186/s40478-019-0858-4openalex-snapshot
Epidemiological pathology of Aβ deposition in the ageing brain in CFAS: addition of multiple Aβ-derived measures does not improve dementia assessment using logistic regression and machine learning approaches
inferred← citeshttps://doi.org/10.1186/s40478-020-00896-8openalex-snapshot
Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
inferred← citeshttps://doi.org/10.1186/s40478-021-01246-yopenalex-snapshot
Synaptic tau: A pathological or physiological phenomenon?
inferred← citeshttps://doi.org/10.1186/s40478-022-01403-xopenalex-snapshot
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
inferred← citeshttps://doi.org/10.1186/s44477-026-00036-xopenalex-snapshot
Spatial transcriptomics in Alzheimer's disease: technologies, challenges and discoveries
inferred← citeshttps://doi.org/10.1371/journal.pone.0289472openalex-snapshot
How stra(i)nge are your controls? A comparative analysis of metabolic phenotypes in commonly used C57BL/6 substrains
inferred← citeshttps://doi.org/10.1523/jneurosci.0082-23.2023openalex-snapshot
Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiationin Vivo
inferred← citeshttps://doi.org/10.1523/jneurosci.0394-25.2025openalex-snapshot
Common Mechanism Underlying Synaptic Dysfunction Caused by Preformed Fibril-Induced Accumulation of α-Synuclein or Tau in a Culture Propagation Model
inferred← citeshttps://doi.org/10.1523/jneurosci.1996-17.2018openalex-snapshot
TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease
inferred← citeshttps://doi.org/10.17879/freeneuropathology-2020-3050openalex-snapshot
Neuropathology of the Alzheimer's continuum: an update
inferred← citeshttps://doi.org/10.21203/rs.3.rs-10436119/v1openalex-snapshot
Thermogenic stimulation with a β3-adrenergic receptor agonist prevents the cold- induced rise of phosphorylated tau in a mouse model of Alzheimer’s disease
inferred← citeshttps://doi.org/10.21769/bioprotoc.3043openalex-snapshot
Purification of Soluble Recombinant Human Tau Protein from Bacteria Using Double-tag Affinity Purification
inferred← citeshttps://doi.org/10.26599/fshw.2022.9250049openalex-snapshot
Diet and physical activity influence the composition of gut microbiota, benefit on Alzheimer’s disease
inferred← citeshttps://doi.org/10.3233/bpl-180078openalex-snapshot
Pathogenic Feed-Forward Mechanisms in Alzheimer’s and Parkinson’s Disease Converge on GSK-3
inferred← citeshttps://doi.org/10.3233/jad-180336openalex-snapshot
Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse
inferred← citeshttps://doi.org/10.3233/jad-210523openalex-snapshot
Sex Differences in Behavior and Molecular Pathology in the 5XFAD Model
inferred← citeshttps://doi.org/10.3233/jad-221202openalex-snapshot
Evolution of Detecting Early Onset of Alzheimer’s Disease: From Neuroimaging to Optical Immunoassays
inferred← citeshttps://doi.org/10.3233/jad-231362openalex-snapshot
Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent
inferred← citeshttps://doi.org/10.3389/fmolb.2023.1120416openalex-snapshot
Amyloid oligomers as on-pathway precursors or off-pathway competitors of fibrils
inferred← citeshttps://doi.org/10.3389/fnagi.2020.537712openalex-snapshot
Soluble 4R0N Tau Abrogates Endocytic Vesicular Dynamics
inferred← citeshttps://doi.org/10.3389/fnagi.2021.640677openalex-snapshot
Passive Immunization With a Novel Monoclonal Anti-PrP Antibody TW1 in an Alzheimer’s Mouse Model With Tau Pathology
inferred← citeshttps://doi.org/10.3389/fnagi.2021.653334openalex-snapshot
Role of Neuron and Glia in Alzheimer’s Disease and Associated Vascular Dysfunction
inferred← citeshttps://doi.org/10.3389/fnagi.2024.1356656openalex-snapshot
Seeing beyond the symptoms: biomarkers and brain regions linked to cognitive decline in Alzheimer’s disease
inferred← citeshttps://doi.org/10.3389/fnagi.2024.1495615openalex-snapshot
Apolipoprotein E dysfunction in Alzheimer’s disease: a study on miRNA regulation, glial markers, and amyloid pathology
inferred← citeshttps://doi.org/10.3389/fncel.2021.695479openalex-snapshot
Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3389/fnins.2019.00491openalex-snapshot
Insulin and Autophagy in Neurodegeneration
inferred← citeshttps://doi.org/10.3389/fnins.2022.964654openalex-snapshot
Age-dependent microstructure alterations in 5xFAD mice by high-resolution diffusion tensor imaging
inferred← citeshttps://doi.org/10.3389/fnmol.2017.00202openalex-snapshot
Amyloid-β Impairs Vesicular Secretion in Neuronal and Astrocyte Peptidergic Transmission
inferred← citeshttps://doi.org/10.3390/biom12111676openalex-snapshot
Linking the Amyloid, Tau, and Mitochondrial Hypotheses of Alzheimer’s Disease and Identifying Promising Drug Targets
inferred← citeshttps://doi.org/10.3390/biom15050638openalex-snapshot
From Obesity to Mitochondrial Dysfunction in Peripheral Tissues and in the Central Nervous System
inferred← citeshttps://doi.org/10.3390/biomedicines10051141openalex-snapshot
Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/biomedicines11123232openalex-snapshot
Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/pharmaceutics15030916openalex-snapshot
Photobiomodulation in Alzheimer’s Disease—A Complementary Method to State-of-the-Art Pharmaceutical Formulations and Nanomedicine?
inferred← citeshttps://doi.org/10.6084/m9.figshare.16599510openalex-snapshot
Additional file 1 of Synaptic tau: A pathological or physiological phenomenon?
inferred← citeshttps://doi.org/10.6084/m9.figshare.20252738openalex-snapshot
Additional file 1 of Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
inferred← citeshttps://doi.org/10.6084/m9.figshare.20252741openalex-snapshot
Additional file 2 of Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
inferred← citeshttps://doi.org/10.6084/m9.figshare.20252744openalex-snapshot
Additional file 3 of Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
inferred← citeshttps://doi.org/10.6084/m9.figshare.20252747openalex-snapshot
Additional file 4 of Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612324openalex-snapshot
Additional file 1 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612327openalex-snapshot
Additional file 2 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612330openalex-snapshot
Additional file 3 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612333openalex-snapshot
Additional file 4 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612336openalex-snapshot
Additional file 5 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612339openalex-snapshot
Additional file 6 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612342openalex-snapshot
Additional file 7 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612345openalex-snapshot
Additional file 8 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.6084/m9.figshare.22612348openalex-snapshot
Additional file 9 of Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
inferred← citeshttps://doi.org/10.64898/2026.09.07.749800openalex-snapshot
Targeted dephosphorylation of Tau at the endogenous level promotes its association with microtubules
inferred← citeshttps://doi.org/10.65092/autfm.1733075openalex-snapshot
Synaptic Dysfunction in Alzheimer’s Disease: A Narrative Review of Neuronal Changes
inferred← citeshttps://doi.org/10.7150/thno.36722openalex-snapshot
Coniferaldehyde attenuates Alzheimer's pathology via activation of Nrf2 and its targets
inferred← citeshttps://doi.org/10.7150/thno.61601openalex-snapshot
Activating AhR alleviates cognitive deficits of Alzheimer's disease model mice by upregulating endogenous Aβ catabolic enzyme Neprilysin
inferred← citeshttps://doi.org/10.7554/elife.73542openalex-snapshot
Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
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