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Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Relationships between Parts A and B of the Trail Making Test
inferredcites →https://doi.org/10.1002/jmri.22366openalex-snapshot
Lower brain glutamate is associated with cognitive deficits in HIV patients: A new mechanism for HIV‐associated neurocognitive disorder
inferredcites →https://doi.org/10.1007/s00394-014-0698-8openalex-snapshot
Changes in the serum metabolite profile in obese children with weight loss
inferredcites →https://doi.org/10.1016/0014-2999(96)00371-8openalex-snapshot
Long-term plasticity in cingulate cortex requires both NMDA and metabotropic glutamate receptor activation
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2013.07.004openalex-snapshot
Serum lipopolysaccharide-binding protein as a marker of atherosclerosis
inferredcites →https://doi.org/10.1016/j.cmet.2009.02.002openalex-snapshot
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
inferredcites →https://doi.org/10.1037/10299-006openalex-snapshot
Neuropsychological assessment.
inferredcites →https://doi.org/10.1038/mp.2015.37openalex-snapshot
GWAS for executive function and processing speed suggests involvement of the CADM2 gene
inferredcites →https://doi.org/10.1038/nm.4358openalex-snapshot
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
inferredcites →https://doi.org/10.1038/nmeth.1923openalex-snapshot
Fast gapped-read alignment with Bowtie 2
inferredcites →https://doi.org/10.1073/pnas.0703360104openalex-snapshot
Protection of the glutamate pool concentration in enteric bacteria
inferredcites →https://doi.org/10.1080/15622975.2017.1386324openalex-snapshot
Genetic analysis for cognitive flexibility in the trail-making test in attention deficit hyperactivity disorder patients from single nucleotide polymorphism, gene to pathway level
inferredcites →https://doi.org/10.1093/nar/gkm957openalex-snapshot
BioMagResBank
inferredcites →https://doi.org/10.1093/nar/gkn449openalex-snapshot
Phenotypic engineering by reprogramming gene transcription using novel artificial transcription factors in Escherichia coli
inferredcites →https://doi.org/10.1093/nar/gks1065openalex-snapshot
HMDB 3.0—The Human Metabolome Database in 2013
inferredcites →https://doi.org/10.1097/mco.0000000000000221openalex-snapshot
The impact of gut microbiota on brain and behaviour
inferredcites →https://doi.org/10.1126/science.291.5505.881openalex-snapshot
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
inferredcites →https://doi.org/10.1128/jb.117.3.1248-1260.1974openalex-snapshot
Two Pathways of Glutamate Fermentation by Anaerobic Bacteria
inferredcites →https://doi.org/10.1159/000343204openalex-snapshot
Childhood Obesity Is Associated with Changes in the Serum Metabolite Profile
inferredcites →https://doi.org/10.1161/circulationaha.111.067827openalex-snapshot
Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans
inferredcites →https://doi.org/10.1186/s13059-017-1194-2openalex-snapshot
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
inferredcites →https://doi.org/10.1210/jc.2015-3076openalex-snapshot
Gut Microbiota Interacts With Brain Microstructure and Function
inferredcites →https://doi.org/10.1210/jc.2017-02114openalex-snapshot
Connection Between BMI-Related Plasma Metabolite Profile and Gut Microbiota
inferredcites →https://doi.org/10.1210/me.2014-1108openalex-snapshot
Minireview: Gut Microbiota: The Neglected Endocrine Organ
inferredcites →https://doi.org/10.17219/acem/70796openalex-snapshot
The influence of a 3-week body mass reduction program on the metabolic parameters and free amino acid profiles in adult Polish people with obesity
inferredcites →https://doi.org/10.2323/jgam.3.193openalex-snapshot
STUDIES ON THE AMINO ACID FERMENTATION
inferredcites →https://doi.org/10.3389/fmicb.2016.01934openalex-snapshot
The Neuro-endocrinological Role of Microbial Glutamate and GABA Signaling
inferredcites →https://doi.org/10.3389/fpls.2016.00318openalex-snapshot
Editorial: Amino Acids of the Glutamate Family: Functions beyond Primary Metabolism
inferredcites →https://doi.org/10.3390/ijms130810041openalex-snapshot
Blood Glutamate Scavenging: Insight into Neuroprotection
inferredcites →https://doi.org/10.3945/ajcn.2009.27462fopenalex-snapshot
History of glutamate production
inferredcites →https://doi.org/10.4014/jmb.1601.01053openalex-snapshot
The Actinobacterium Corynebacterium glutamicum, an Industrial Workhorse
inferredcites →https://doi.org/10.5271/sjweh.2366openalex-snapshot
Radon in homes--a possible cause of lung cancer.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Genome-Scale Metabolic Modelling of the Human Gut Microbiome Reveals Changes of the Glyoxylate and Dicarboxylate Metabolism in Metabolic Disorders
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Our second genome and the impact on metabolic disorders: why gut microbiome is an important player in diabetes and associated abnormalities
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Decreased fasting serum glucogenic amino acids with a higher compared to normal protein diet during energy restriction in women: a randomized controlled trial
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Microbiota impacts on chronic inflammation and metabolic syndrome - related cognitive dysfunction
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High fat diet reveals sex-specific fecal and liver metabolic alterations in C57BL/6J obese mice
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The Gut-Brain Axis in Alzheimer’s Disease: Exploring Microbial Influences and Therapeutic Strategies
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Development of a simultaneous quantification method for the gut microbiota-derived core nutrient metabolome in mice and its application in studying host-microbiota interaction
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Diet, inflammation and the gut microbiome: Mechanisms for obesity-associated cognitive impairment
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Gut microbiota and metabolites in diabetic retinopathy: Insights into pathogenesis for novel therapeutic strategies
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Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice
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Unlocking the mind-gut connection: Impact of human microbiome on cognition
inferred← citeshttps://doi.org/10.1016/j.clnu.2019.10.022openalex-snapshot
Combining metabolic profiling of plasma and faeces as a fingerprint of insulin resistance in obesity
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.09.002openalex-snapshot
Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids
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Deciphering the dual role of N-methyl-D-Aspartate receptor in postoperative cognitive dysfunction: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.foodres.2023.112597openalex-snapshot
Dietary glutamate enhances intestinal immunity by modulating microbiota and Th17/Treg balance-related immune signaling in piglets after lipopolysaccharide challenge
inferred← citeshttps://doi.org/10.1016/j.foodres.2026.120038openalex-snapshot
Opposite metabolic and gut responses to oral glutamine in male and female mice with diet-induced obesity
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104513openalex-snapshot
Genome-scale metabolic modelling of the human gut microbiome reveals changes in the glyoxylate and dicarboxylate metabolism in metabolic disorders
inferred← citeshttps://doi.org/10.1016/j.jenvman.2022.116270openalex-snapshot
Risk assessment of three sheep stocking modes via identification of bacterial genomes carrying antibiotic resistance genes and virulence factor genes
inferred← citeshttps://doi.org/10.1016/j.jpsychires.2022.07.006openalex-snapshot
Characterizing serum amino acids in schizophrenic patients: Correlations with gut microbes
inferred← citeshttps://doi.org/10.1016/j.jpsychires.2024.08.016openalex-snapshot
Association of EEG and cognitive impairment in overweight and non-overweight patients with schizophrenia
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122471openalex-snapshot
Impacts of glutamate, an exercise-responsive metabolite on insulin signaling
inferred← citeshttps://doi.org/10.1016/j.metabol.2024.155941openalex-snapshot
Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men
inferred← citeshttps://doi.org/10.1016/j.micpath.2023.106149openalex-snapshot
Analysis of gut microbiota in rats with bile duct obstruction after biliary drainage
inferred← citeshttps://doi.org/10.1016/j.molimm.2022.06.013openalex-snapshot
Alteration of intestinal microecology by oral antibiotics promotes oral squamous cell carcinoma development
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2020.07.002openalex-snapshot
The microbiota-gut-brain axis: An emerging therapeutic target in chemotherapy-induced cognitive impairment
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.02.044openalex-snapshot
Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2021.05.031openalex-snapshot
Unravelling the impacts of western-style diets on brain, gut microbiota and cognition
inferred← citeshttps://doi.org/10.1016/j.nutres.2025.04.002openalex-snapshot
Microbiota-induced inflammation mediates the impacts of a Western diet on hippocampal-dependent memory
inferred← citeshttps://doi.org/10.1016/j.phrs.2023.106952openalex-snapshot
Possible role of tryptophan metabolism along the microbiota-gut-brain axis on cognitive & behavioral aspects in Phenylketonuria
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.158219openalex-snapshot
Effect of exposure to endocrine disrupting chemicals in obesity and neurodevelopment: The genetic and microbiota link
inferred← citeshttps://doi.org/10.1021/acs.jproteome.1c00220openalex-snapshot
Influence of Age, Sex, and Diet on the Human Fecal Metabolome Investigated by 1H NMR Spectroscopy
inferred← citeshttps://doi.org/10.1038/s12276-024-01282-3openalex-snapshot
The potential role of gut microbiota-derived metabolites as regulators of metabolic syndrome-associated mitochondrial and endolysosomal dysfunction in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1038/s41430-022-01119-0openalex-snapshot
Circulatory amino acid responses to milk consumption in dairy and lactose intolerant individuals
inferred← citeshttps://doi.org/10.1038/s41522-022-00271-6openalex-snapshot
Socioeconomic disparities and household crowding in association with the fecal microbiome of school-age children
inferred← citeshttps://doi.org/10.1038/s41531-021-00191-wopenalex-snapshot
Early constipation predicts faster dementia onset in Parkinson’s disease
inferred← citeshttps://doi.org/10.1080/19490976.2026.2740906openalex-snapshot
Gut bacteria and their metabolites may influence our decisions, intelligence, cognition, and consciousness
inferred← citeshttps://doi.org/10.1101/2024.11.21.624683openalex-snapshot
Sex-dependent effects of a glutamine supplementation on metabolic disorders, intestinal barrier function and gut microbiota in mice with diet-induced obesity
inferred← citeshttps://doi.org/10.1111/cns.70101openalex-snapshot
Prevention and Treatment of Alzheimer's Disease Via the Regulation of the Gut Microbiota With Traditional Chinese Medicine
inferred← citeshttps://doi.org/10.1111/jfbc.14297openalex-snapshot
Dietary olive oil enhances the oral tolerance of the food allergen ovalbumin in mice by regulating intestinal microecological homeostasis
inferred← citeshttps://doi.org/10.1126/sciadv.adi0497openalex-snapshot
Gut-resident microorganisms and their genes are associated with cognition and neuroanatomy in children
inferred← citeshttps://doi.org/10.1128/msystems.00465-22openalex-snapshot
Role of the Gut Microbiota in the Increased Infant Body Mass Index Induced by Gestational Diabetes Mellitus
inferred← citeshttps://doi.org/10.1155/2020/3687498openalex-snapshot
Letrozole and the Traditional Chinese Medicine, Shaofu Zhuyu Decoction, Reduce Endometriotic Disease Progression in Rats: A Potential Role for Gut Microbiota
inferred← citeshttps://doi.org/10.1177/0269881120972331openalex-snapshot
Plasma d -glutamate levels for detecting mild cognitive impairment and Alzheimer’s disease: Machine learning approaches
inferred← citeshttps://doi.org/10.1177/1535370221995785openalex-snapshot
Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis
inferred← citeshttps://doi.org/10.1186/s12866-020-02002-3openalex-snapshot
Lifestyle modifications result in alterations in the gut microbiota in obese children
inferred← citeshttps://doi.org/10.1186/s12866-025-04245-4openalex-snapshot
Moderate altitude exposure induced gut microbiota enterotype shifts impacting host serum metabolome and phenome
inferred← citeshttps://doi.org/10.1186/s12902-026-02197-yopenalex-snapshot
Accelerated biological aging is associated with the negative relationship between dietary intake of live microbes and diabetic retinopathy in US diabetic patients
inferred← citeshttps://doi.org/10.1186/s13099-022-00487-zopenalex-snapshot
A prospective investigation into the association between the gut microbiome composition and cognitive performance among healthy young adults
inferred← citeshttps://doi.org/10.1186/s40104-024-01076-7openalex-snapshot
Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens
inferred← citeshttps://doi.org/10.1590/s0004-2803.202301000-17openalex-snapshot
ALZHEIMER’S DISEASE AND ITS RELATIONSHIP WITH THE MICROBIOTA-GUT-BRAIN AXIS
inferred← citeshttps://doi.org/10.21203/rs.3.rs-131500/v1openalex-snapshot
Alterations of the Gut Microbiome and Metabolome in Patients with Proliferative Diabetic Retinopathy
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2012853/v1openalex-snapshot
Altered microbiome and metabolome features provide clues in understanding strain- specific regulation of Streptococcus thermophilus in the host
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5279461/v1openalex-snapshot
Transcriptome and metabolome changes uncover the potential mechanism of high-fat diet induced obesity under hypoxia condition
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Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health
inferred← citeshttps://doi.org/10.26599/fshw.2022.9250233openalex-snapshot
Strain-specific effect of Streptococcus thermophilus consumption on host physiology
inferred← citeshttps://doi.org/10.3389/fmicb.2021.667632openalex-snapshot
Alterations of the Gut Microbiome and Metabolome in Patients With Proliferative Diabetic Retinopathy
inferred← citeshttps://doi.org/10.3389/fnagi.2025.1677896openalex-snapshot
Exercise modulation of gut microbiota in Alzheimer’s disease: pathophysiological mechanisms and therapeutic perspectives
inferred← citeshttps://doi.org/10.3389/fphar.2022.893567openalex-snapshot
Gut Microbial Dysbiosis and Cognitive Impairment in Bipolar Disorder: Current Evidence
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The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders
inferred← citeshttps://doi.org/10.3390/biom11070999openalex-snapshot
Multiomic Approach to Analyze Infant Gut Microbiota: Experimental and Analytical Method Optimization
inferred← citeshttps://doi.org/10.3390/biomedicines11102658openalex-snapshot
From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes
inferred← citeshttps://doi.org/10.3390/cells15161492openalex-snapshot
Metabolic Outputs of the Gut Microbiome: Implications for Epilepsy
inferred← citeshttps://doi.org/10.3390/ijms20205232openalex-snapshot
The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review
inferred← citeshttps://doi.org/10.3390/ijms21082676openalex-snapshot
d-glutamate and Gut Microbiota in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/metabo13050644openalex-snapshot
Identification of Novel Biomarkers in Late Preterm Neonates with Respiratory Distress Syndrome (RDS) Using Urinary Metabolomic Analysis
inferred← citeshttps://doi.org/10.3390/nu12123701openalex-snapshot
Understanding the Heterogeneity of Obesity and the Relationship to the Brain-Gut Axis
inferred← citeshttps://doi.org/10.3390/nu14214623openalex-snapshot
Examining the Influence of the Human Gut Microbiota on Cognition and Stress: A Systematic Review of the Literature
inferred← citeshttps://doi.org/10.3892/ijmm.2025.5487openalex-snapshot
Linking microRNA to metabolic reprogramming and gut microbiota in the pathogenesis of colorectal cancer (Review)
inferred← citeshttps://doi.org/10.55905/cuadv17n10-090openalex-snapshot
Função cognitiva em indivíduos obesos e em indivíduos com apneia obstrutiva do sono
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Identifying the Role of Vasopressin and Oxytocin in the Microbiota-Gut-Brain-Behavior Axis
inferred← citeshttps://doi.org/10.6084/m9.figshare.13535846openalex-snapshot
Additional file 1 of Lifestyle modifications result in alterations in the gut microbiota in obese children
inferred← citeshttps://doi.org/10.6084/m9.figshare.13535849openalex-snapshot
Additional file 2 of Lifestyle modifications result in alterations in the gut microbiota in obese children
inferred← citeshttps://doi.org/10.6084/m9.figshare.13535852openalex-snapshot
Additional file 3 of Lifestyle modifications result in alterations in the gut microbiota in obese children
inferred← citeshttps://doi.org/10.6084/m9.figshare.26966402openalex-snapshot
Additional file 1 of Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens
inferred← citeshttps://doi.org/10.6084/m9.figshare.26966405openalex-snapshot
Additional file 2 of Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens
inferred← citeshttps://doi.org/10.6084/m9.figshare.26966411openalex-snapshot
Additional file 3 of Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens
inferred← citeshttps://doi.org/10.6084/m9.figshare.26966414openalex-snapshot
Additional file 4 of Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens
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