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A new non-radioactive deoxyhypusine synthase assay adaptable to high throughput screening

https://doi.org/10.1007/s00726-017-2477-3
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/9780470559277.ch100155openalex-snapshot
Miniaturized High‐Throughput Fluorescent Assay for Conversion of NAD(P)H to NAD(P)
inferredcites →https://doi.org/10.1002/cbf.1351openalex-snapshot
Inhibition of eukaryotic translation initiation factor 5A (eIF5A) hypusination impairs melanoma growth
inferredcites →https://doi.org/10.1002/wrna.1211openalex-snapshot
eIF5A and EF ‐P: two unique translation factors are now traveling the same road
inferredcites →https://doi.org/10.1007/978-1-61779-034-8_1openalex-snapshot
Current Status of the Polyamine Research Field
inferredcites →https://doi.org/10.1007/978-1-61779-034-8_12openalex-snapshot
Assay of Deoxyhypusine Synthase Activity
inferredcites →https://doi.org/10.1007/978-4-431-55212-3_10openalex-snapshot
Role of the Polyamine Spermidine as a Precursor for Hypusine Modification in eIF5A
inferredcites →https://doi.org/10.1007/978-94-017-9078-9_10openalex-snapshot
eIF5A
inferredcites →https://doi.org/10.1007/s00726-009-0408-7openalex-snapshot
Functional significance of eIF5A and its hypusine modification in eukaryotes
inferredcites →https://doi.org/10.1007/s00726-011-0986-zopenalex-snapshot
Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development
inferredcites →https://doi.org/10.1007/s00726-016-2275-3openalex-snapshot
Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer
inferredcites →https://doi.org/10.1016/j.antiviral.2016.09.006openalex-snapshot
Targeting deoxyhypusine hydroxylase activity impairs cap-independent translation initiation driven by the 5'untranslated region of the HIV-1, HTLV-1, and MMTV mRNAs
inferredcites →https://doi.org/10.1016/j.bbagrm.2015.05.002openalex-snapshot
The translation factor eIF5A and human cancer
inferredcites →https://doi.org/10.1016/j.molcel.2013.04.021openalex-snapshot
eIF5A Promotes Translation of Polyproline Motifs
inferredcites →https://doi.org/10.1016/s0021-9258(18)46861-5openalex-snapshot
Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.
inferredcites →https://doi.org/10.1016/s0021-9258(18)47333-4openalex-snapshot
Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine.
inferredcites →https://doi.org/10.1016/s0021-9258(19)34042-6openalex-snapshot
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD.
inferredcites →https://doi.org/10.1016/s0021-9258(19)38631-4openalex-snapshot
Features of the spermidine-binding site of deoxyhypusine synthase as derived from inhibition studies. Effective inhibition by bis- and mono-guanylated diamines and polyamines
inferredcites →https://doi.org/10.1016/s0969-2126(98)00004-5openalex-snapshot
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site
inferredcites →https://doi.org/10.1039/a806431hopenalex-snapshot
The catalysed NADH reduction of resazurin to resorufin
inferredcites →https://doi.org/10.1042/0264-6021:3400273openalex-snapshot
Complex formation between deoxyhypusine synthase and its protein substrate, the eukaryotic translation initiation factor 5A (eIF5A) precursor
inferredcites →https://doi.org/10.1042/0264-6021:3520851openalex-snapshot
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates
inferredcites →https://doi.org/10.1073/pnas.0509348102openalex-snapshot
Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: A HEAT-repeat-containing metalloenzyme
inferredcites →https://doi.org/10.1073/pnas.0710970105openalex-snapshot
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine
inferredcites →https://doi.org/10.1074/jbc.270.38.22386openalex-snapshot
Cloning and Expression of Human Deoxyhypusine Synthase cDNA
inferredcites →https://doi.org/10.1074/jbc.272.25.15865openalex-snapshot
Enzyme-Substrate Intermediate Formation at Lysine 329 of Human Deoxyhypusine Synthase
inferredcites →https://doi.org/10.1074/jbc.275.13.9170openalex-snapshot
Deoxyhypusine Synthase Generates and Uses Bound NADH in a Transient Hydride Transfer Mechanism
inferredcites →https://doi.org/10.1074/jbc.m404095200openalex-snapshot
A New Crystal Structure of Deoxyhypusine Synthase Reveals the Configuration of the Active Enzyme and of an Enzyme·NAD·Inhibitor Ternary Complex
inferredcites →https://doi.org/10.1074/jbc.r116.731661openalex-snapshot
Functions of Polyamines in Mammals
inferredcites →https://doi.org/10.1089/adt.2016.706openalex-snapshot
Diaphorase Coupling Protocols for Red-Shifting Dehydrogenase Assays
inferredcites →https://doi.org/10.1089/dna.2016.3446openalex-snapshot
A Negative Feedback Loop Between Autophagy and Immune Responses in Mycobacterium leprae Infection
inferredcites →https://doi.org/10.1089/dna.2016.3611openalex-snapshot
Hypusination of eIF5A as a Target for Antiviral Therapy
inferredcites →https://doi.org/10.1093/jb/mvj034openalex-snapshot
The Post-Translational Synthesis of a Polyamine-Derived Amino Acid, Hypusine, in the Eukaryotic Translation Initiation Factor 5A (eIF5A)
inferredcites →https://doi.org/10.1093/protein/gzq110openalex-snapshot
Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes
inferredcites →https://doi.org/10.1111/j.1742-4658.2006.05135.xopenalex-snapshot
Differential expression of eIF5A‐1 and eIF5A‐2 in human cancer cells
inferredcites →https://doi.org/10.1172/jci38924openalex-snapshot
The unique hypusine modification of eIF5A promotes islet β cell inflammation and dysfunction in mice
inferredcites →https://doi.org/10.1177/1087057104264031openalex-snapshot
Screening Assay for the Identification of Deoxyhypusine Synthase Inhibitors
inferredcites →https://doi.org/10.1186/1742-4690-6-90openalex-snapshot
Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A
inferredcites →https://doi.org/10.1242/dmm.014449openalex-snapshot
A novel mouse model for inhibition of DOHH mediated hypusine modification reveals crucial function for embryonic development, proliferation and oncogenic transformation
inferredcites →https://doi.org/10.1371/journal.pone.0154842openalex-snapshot
Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial
inferredcites →https://doi.org/10.2174/1381612822666160530151209openalex-snapshot
Repositioning the Old Fungicide Ciclopirox for New Medical Uses
inferredcites →https://doi.org/10.3109/10409238.2014.939608openalex-snapshot
The hypusine-containing translation factor eIF5A
inferredcites →https://doi.org/10.7150/ijbs.7191openalex-snapshot
Roles of Eukaryotic Initiation Factor 5A2 in Human Cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4460014openalex-extracted
Development and Evaluation of Novel Deoxyhypusine Synthase (Dhps) Inhibitors as a New Strategy for Melanoma Treatment: In Vitro and in Vivo
inferred← citeshttps://doi.org/10.1002/2211-5463.13046openalex-snapshot
Development of an activity assay for characterizing deoxyhypusine synthase and its diverse reaction products
inferred← citeshttps://doi.org/10.1007/s00726-021-03120-6openalex-snapshot
Hypusinated EIF5A as a feasible drug target for Advanced Medicinal Therapies in the treatment of pathogenic parasites and therapy-resistant tumors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.118061openalex-snapshot
In silico design, synthesis and biological evaluation of 2-benzyl-5-(2-methoxybenzyl)-1,3,4-oxadiazole derivates as allosteric deoxyhypusine synthase (DHPS) inhibitors for melanoma treatment
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107453openalex-snapshot
Novel deoxyhypusine synthase (DHPS) inhibitors target hypusination-induced vasculogenic mimicry (VM) against malignant melanoma
inferred← citeshttps://doi.org/10.1074/jbc.tm118.003341openalex-snapshot
Hypusine, a polyamine-derived amino acid critical for eukaryotic translation
inferred← citeshttps://doi.org/10.1134/s0006297918080011openalex-snapshot
Translation Factor eIF5A, Modification with Hypusine and Role in Regulation of Gene Expression. eIF5A as a Target for Pharmacological Interventions
inferred← citeshttps://doi.org/10.1371/journal.pntd.0008762openalex-snapshot
Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major
inferred← citeshttps://doi.org/10.1371/journal.pone.0308049openalex-snapshot
Development of a reliable, sensitive, and convenient assay for the discovery of new eIF5A hypusination inhibitors
inferred← citeshttps://doi.org/10.3389/fcimb.2025.1638906openalex-snapshot
The hypusine pathway in Ixodes ricinus: molecular cloning and validation of deoxyhypusine synthase as a novel target for drug discovery to treat and prevent vector borne diseases
inferred← citeshttps://doi.org/10.3390/plants10071261openalex-snapshot
Hypusination, a Metabolic Posttranslational Modification of eIF5A in Plants during Development and Environmental Stress Responses
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