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Cancer pharmacoinformatics: Databases and analytical tools

https://doi.org/10.1007/s10142-024-01445-5
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The Gene Expression Omnibus Database
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Cancer Immunology
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Computer-Aided Drug Design
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Bioinformatics for cancer immunology and immunotherapy
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The Cancer Imaging Archive (TCIA): Maintaining and Operating a Public Information Repository
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Multi-omics approaches in cancer research with applications in tumor subtyping, prognosis, and diagnosis
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Machine learning in the prediction of cancer therapy
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CRISPR-surfaceome: An online tool for designing highly efficient sgRNAs targeting cell surface proteins
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DeepCancerMap: A versatile deep learning platform for target- and cell-based anticancer drug discovery
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Molecular targeted therapy: Treating cancer with specificity
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CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines
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A new technique (COMSPARI) to facilitate the identification of minor compounds in complex mixtures by GC/MS and LC/MS: tools for the visualization of matched datasets
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Large-scale pharmacogenomic studies and drug response prediction for personalized cancer medicine
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ACP-DL: A Deep Learning Long Short-Term Memory Model to Predict Anticancer Peptides Using High-Efficiency Feature Representation
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DeepACP: A Novel Computational Approach for Accurate Identification of Anticancer Peptides by Deep Learning Algorithm
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Machine learning model for anti-cancer drug combinations: Analysis, prediction, and validation
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Computer-aided drug repurposing for cancer therapy: Approaches and opportunities to challenge anticancer targets
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Transcriptomics and solid tumors: The next frontier in precision cancer medicine
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Artificial intelligence-based multi-omics analysis fuels cancer precision medicine
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Deep-Resp-Forest: A deep forest model to predict anti-cancer drug response
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Overview of structural genomics: from structure to function
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Cancer genomics
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xDeep-AcPEP: Deep Learning Method for Anticancer Peptide Activity Prediction Based on Convolutional Neural Network and Multitask Learning
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HiDRA: Hierarchical Network for Drug Response Prediction with Attention
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EXCESP: A Structure-Based Online Database for Extracellular Interactome of Cell Surface Proteins in Humans
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A Description of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) Common Data Analysis Pipeline
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Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry
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National Cancer Institute Drug Information System 3D Database
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ZINC − A Free Database of Commercially Available Compounds for Virtual Screening
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ChemSpider: An Online Chemical Information Resource
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The CPTAC Data Portal: A Resource for Cancer Proteomics Research
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
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New approaches to molecular cancer therapeutics
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The Genotype-Tissue Expression (GTEx) project
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Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
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Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
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Cancer genomics: from discovery science to personalized medicine
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TCPA: a resource for cancer functional proteomics data
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Proteomic applications for the early detection of cancer
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Microtubules as a target for anticancer drugs
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The NCI60 human tumour cell line anticancer drug screen
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Novel cancer immunotherapy agents with survival benefit: recent successes and next steps
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Genomic-scale prioritization of drug targets: the TDR Targets database
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The druggable genome
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Utilizing somatic mutation data from numerous studies for cancer research: proof of concept and applications
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Artificial intelligence in cancer target identification and drug discovery
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A genome-wide positioning systems network algorithm for in silico drug repurposing
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ProTargetMiner as a proteome signature library of anticancer molecules for functional discovery
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Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways
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The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers
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Next-generation characterization of the Cancer Cell Line Encyclopedia
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Highly accurate protein structure prediction with AlphaFold
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The NCI Genomic Data Commons
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A pan-cancer atlas
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The gene expression profiles in response to 102 traditional Chinese medicine (TCM) components: a general template for research on TCMs
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Cancer Drug Response Profile scan (CDRscan): A Deep Learning Model That Predicts Drug Effectiveness from Cancer Genomic Signature
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TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers
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In-silico Prediction of Synergistic Anti-Cancer Drug Combinations Using Multi-omics Data
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High levels of ubidecarenone (oxidized CoQ10) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells
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ADRML: anticancer drug response prediction using manifold learning
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A stacking ensemble deep learning approach to cancer type classification based on TCGA data
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DeepInsight-3D architecture for anti-cancer drug response prediction with deep-learning on multi-omics
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Machine learning approaches to drug response prediction: challenges and recent progress
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Metabolic signatures of cancer cells and stem cells
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The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets
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Artificial intelligence identifies new cancer biomarkers
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The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website
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Developmental Therapeutics Program at the NCI: molecular target and drug discovery process
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CancerDR: Cancer Drug Resistance Database
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AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor
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Topoisomerases as anticancer targets
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Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway
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Plasma Membrane Proteomics and Its Application in Clinical Cancer Biomarker Discovery
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Cell-surface proteomics for the identification of novel therapeutic targets in cancer
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De novo sequencing of proteins by mass spectrometry
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Transforming cancer drug discovery with Big Data and AI
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MiR-629-3p-induced downregulation of SFTPC promotes cell proliferation and predicts poor survival in lung adenocarcinoma
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DeepDRK: a deep learning framework for drug repurposing through kernel-based multi-omics integration
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Decoding Connectivity Map-based drug repurposing for oncotherapy
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Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration
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A review of connectivity map and computational approaches in pharmacogenomics
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A comparative study of multi-omics integration tools for cancer driver gene identification and tumour subtyping
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An omics perspective on drug target discovery platforms
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Deep learning for drug response prediction in cancer
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SurfaceGenie: a web-based application for prioritizing cell-type-specific marker candidates
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DCDB: Drug combination database
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miRCancer: a microRNA–cancer association database constructed by text mining on literature
inferredcites →https://doi.org/10.1093/bioinformatics/btw228openalex-snapshot
Drug repositioning based on comprehensive similarity measures and Bi-Random walk algorithm
inferredcites →https://doi.org/10.1093/bioinformatics/bty451openalex-snapshot
ACPred-FL: a sequence-based predictor using effective feature representation to improve the prediction of anti-cancer peptides
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Neural inductive matrix completion with graph convolutional networks for miRNA-disease association prediction
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Proteomics: Technologies and Their Applications
inferredcites →https://doi.org/10.1093/database/baaa004openalex-snapshot
dbPepNeo: a manually curated database for human tumor neoantigen peptides
inferredcites →https://doi.org/10.1093/database/baaa094openalex-snapshot
CMBD: a manually curated cancer metabolic biomarker knowledge database
inferredcites →https://doi.org/10.1093/database/bar026openalex-snapshot
International Cancer Genome Consortium Data Portal--a one-stop shop for cancer genomics data
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CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network
inferredcites →https://doi.org/10.1093/database/baz156openalex-snapshot
RBPTD: a database of cancer-related RNA-binding proteins in humans
inferredcites →https://doi.org/10.1093/gigascience/giac087openalex-snapshot
SYNPRED: prediction of drug combination effects in cancer using different synergy metrics and ensemble learning
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Introduction to Genomics
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KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/28.1.27openalex-snapshot
KEGG: Kyoto Encyclopedia of Genes and Genomes
inferredcites →https://doi.org/10.1093/nar/30.1.163openalex-snapshot
PharmGKB: the Pharmacogenetics Knowledge Base
inferredcites →https://doi.org/10.1093/nar/30.1.207openalex-snapshot
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
inferredcites →https://doi.org/10.1093/nar/30.1.412openalex-snapshot
TTD: Therapeutic Target Database
inferredcites →https://doi.org/10.1093/nar/gkaa1059openalex-snapshot
canSAR: update to the cancer translational research and drug discovery knowledgebase
inferredcites →https://doi.org/10.1093/nar/gkaa1084openalex-snapshot
Integration of the Drug–Gene Interaction Database (DGIdb 4.0) with open crowdsource efforts
inferredcites →https://doi.org/10.1093/nar/gkaa805openalex-snapshot
CancerImmunityQTL: a database to systematically evaluate the impact of genetic variants on immune infiltration in human cancer
inferredcites →https://doi.org/10.1093/nar/gkaa968openalex-snapshot
CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics
inferredcites →https://doi.org/10.1093/nar/gkab1011openalex-snapshot
HIT 2.0: an enhanced platform for Herbal Ingredients' Targets
inferredcites →https://doi.org/10.1093/nar/gkab1061openalex-snapshot
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
inferredcites →https://doi.org/10.1093/nar/gkab1062openalex-snapshot
HMDB 5.0: the Human Metabolome Database for 2022
inferredcites →https://doi.org/10.1093/nar/gkab382openalex-snapshot
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
inferredcites →https://doi.org/10.1093/nar/gkab860openalex-snapshot
CTR-DB, an omnibus for patient-derived gene expression signatures correlated with cancer drug response
inferredcites →https://doi.org/10.1093/nar/gkab970openalex-snapshot
OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer
inferredcites →https://doi.org/10.1093/nar/gkac1004openalex-snapshot
canSAR: update to the cancer translational research and drug discovery knowledgebase
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CREAMMIST: an integrative probabilistic database for cancer drug response prediction
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The Universal Protein Resource (UniProt)
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DrugBank: a comprehensive resource for in silico drug discovery and exploration
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LIPID MAPS online tools for lipid research
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STITCH: interaction networks of chemicals and proteins
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miR2Disease: a manually curated database for microRNA deregulation in human disease
inferredcites →https://doi.org/10.1093/nar/gkp1002openalex-snapshot
SMPDB: The Small Molecule Pathway Database
inferredcites →https://doi.org/10.1093/nar/gkr1162openalex-snapshot
MMDB: 3D structures and macromolecular interactions
inferredcites →https://doi.org/10.1093/nar/gkr777openalex-snapshot
ChEMBL: a large-scale bioactivity database for drug discovery
inferredcites →https://doi.org/10.1093/nar/gks1111openalex-snapshot
Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells
inferredcites →https://doi.org/10.1093/nar/gks1193openalex-snapshot
NCBI GEO: archive for functional genomics data sets—update
inferredcites →https://doi.org/10.1093/nar/gkt1182openalex-snapshot
canSAR: updated cancer research and drug discovery knowledgebase
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canSAR: an updated cancer research and drug discovery knowledgebase
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ccmGDB: a database for cancer cell metabolism genes
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GPCRdb: an information system for G protein-coupled receptors
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The Reactome pathway Knowledgebase
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PubChem Substance and Compound databases
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DrugCentral: online drug compendium
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BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes
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PharmacoDB: an integrative database for mining in vitro anticancer drug screening studies
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The MetaCyc database of metabolic pathways and enzymes
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The reactome pathway knowledgebase
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Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
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Systematic analysis of genetic alterations in tumors using Cancer Genome WorkBench (CGWB)
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Protein Data Bank (PDB): Database of Three-Dimensional Structural Information of Biological Macromolecules
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DeepDSC: A Deep Learning Method to Predict Drug Sensitivity of Cancer Cell Lines
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Genetic association of molecular traits: A help to identify causative variants in complex diseases
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Pharmacogenomic biomarkers for personalized cancer treatment
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The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
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Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
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A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73
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Cancer Digital Slide Archive: an informatics resource to support integrated in silico analysis of TCGA pathology data
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Checkpoint therapeutic target database (CKTTD): the first comprehensive database for checkpoint targets and their modulators in cancer immunotherapy
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Immune Regulatory Function of B Cells
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Advances in Proteomic Technologies and Its Contribution to the Field of Cancer
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Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors
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The Future of Respiratory Bioinformatics
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