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Berberine Ameliorates MCAO Induced Cerebral Ischemia/Reperfusion Injury via Activation of the BDNF–TrkB–PI3K/Akt Signaling Pathway

https://doi.org/10.1007/s11064-018-2472-4
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1 of the 35 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1007/s10571-016-0459-8 (notice 2021-10-29).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dneu.20765openalex-snapshot
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
inferredcites →https://doi.org/10.1006/nbdi.1999.0275openalex-snapshot
BDNF Blocks Caspase-3 Activation in Neonatal Hypoxia–Ischemia
inferredcites →https://doi.org/10.1007/s10495-014-0977-0openalex-snapshot
Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats
inferredcites →https://doi.org/10.1007/s10571-016-0459-8openalex-snapshot
RETRACTED ARTICLE: Metformin Attenuates Cognitive Impairments in Hypoxia–Ischemia Neonatal Rats via Improving Remyelination
inferredcites →https://doi.org/10.1007/s11064-012-0871-5openalex-snapshot
Quercetin Attenuates Cell Apoptosis in Focal Cerebral Ischemia Rat Brain Via Activation of BDNF–TrkB–PI3K/Akt Signaling Pathway
inferredcites →https://doi.org/10.1007/s11064-014-1272-8openalex-snapshot
Propofol Reduces Inflammatory Reaction and Ischemic Brain Damage in Cerebral Ischemia in Rats
inferredcites →https://doi.org/10.1016/j.bbr.2015.07.018openalex-snapshot
Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis
inferredcites →https://doi.org/10.1016/j.bbrc.2016.07.068openalex-snapshot
Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway
inferredcites →https://doi.org/10.1016/j.brainres.2008.11.048openalex-snapshot
Neuroprotective effects of hydrogen saline in neonatal hypoxia–ischemia rat model
inferredcites →https://doi.org/10.1016/j.brainres.2014.02.021openalex-snapshot
Berberine was neuroprotective against an in vitro model of brain ischemia: Survival and apoptosis pathways involved
inferredcites →https://doi.org/10.1016/j.brainres.2014.02.028openalex-snapshot
Testosterone enhances functional recovery after stroke through promotion of antioxidant defenses, BDNF levels and neurogenesis in male rats
inferredcites →https://doi.org/10.1016/j.brainres.2016.02.030openalex-snapshot
Evidence of CCR2-independent transmigration of Ly6C hi monocytes into the brain after permanent cerebral ischemia in mice
inferredcites →https://doi.org/10.1016/j.cellsig.2007.04.005openalex-snapshot
Opposing effects of Bad phosphorylation at two distinct sites by Akt1 and JNK1/2 on ischemic brain injury
inferredcites →https://doi.org/10.1016/j.expneurol.2008.11.007openalex-snapshot
RETRACTED: Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model
inferredcites →https://doi.org/10.1016/j.ijdevneu.2007.11.005openalex-snapshot
Neuroprotection of brain‐derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal‐regulated kinase and phosphatidylinositol 3‐kinase
inferredcites →https://doi.org/10.1016/j.jchemneu.2017.04.008openalex-snapshot
Berberine confers neuroprotection in coping with focal cerebral ischemia by targeting inflammatory cytokines
inferredcites →https://doi.org/10.1016/j.neulet.2008.09.064openalex-snapshot
Neuroprotective effects of berberine on stroke models in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.neulet.2016.01.002openalex-snapshot
Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive-like behavior in mice
inferredcites →https://doi.org/10.1016/j.neuroscience.2017.01.010openalex-snapshot
Downregulation of Iduna is associated with AIF nuclear translocation in neonatal brain after hypoxia–ischemia
inferredcites →https://doi.org/10.1016/s0002-9149(03)00533-2openalex-snapshot
Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
inferredcites →https://doi.org/10.1016/s0006-8993(98)00385-0openalex-snapshot
Enhanced expression of full-length TrkB receptors in young rat brain with hypoxic/ischemic injury
inferredcites →https://doi.org/10.1016/s0306-4522(03)00066-6openalex-snapshot
Continuous low-dose treatment with brain-derived neurotrophic factor or neurotrophin-3 protects striatal medium spiny neurons from mild neonatal hypoxia/ischemia: a stereological study
inferredcites →https://doi.org/10.1016/s0959-4388(00)00211-7openalex-snapshot
Transcription-dependent and -independent control of neuronal survival by the PI3K–Akt signaling pathway
inferredcites →https://doi.org/10.1016/s1044-7431(03)00159-3openalex-snapshot
Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum
inferredcites →https://doi.org/10.1038/nm.2399openalex-snapshot
The immunology of stroke: from mechanisms to translation
inferredcites →https://doi.org/10.1111/cns.12428openalex-snapshot
The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation
inferredcites →https://doi.org/10.1155/2012/591654openalex-snapshot
Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis
inferredcites →https://doi.org/10.1161/strokeaha.108.531632openalex-snapshot
Apoptotic Mechanisms After Cerebral Ischemia
inferredcites →https://doi.org/10.1186/1471-2202-7-78openalex-snapshot
Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease
inferredcites →https://doi.org/10.1248/bpb.29.623openalex-snapshot
Berberry Extract Reduces Neuronal Damage and N-Methyl-D-aspartate Receptor 1 Immunoreactivity in the Gerbil Hippocampus after Transient Forebrain Ischemia
inferredcites →https://doi.org/10.1248/bpb.31.558openalex-snapshot
Berberine Induces G1 Arrest and Apoptosis in Human Glioblastoma T98G Cells through Mitochondrial/Caspases Pathway
inferredcites →https://doi.org/10.12659/msm.898139openalex-snapshot
The Specific Protein Kinase R (PKR) Inhibitor C16 Protects Neonatal Hypoxia-Ischemia Brain Damages by Inhibiting Neuroinflammation in a Neonatal Rat Model
inferredcites →https://doi.org/10.12688/f1000research.8434.1openalex-snapshot
Recent advances in understanding neurotrophin signaling
inferredcites →https://doi.org/10.1556/aphysiol.99.2012.3.8openalex-snapshot
Hypoxia-inducible factor 1 mediates the anti-apoptosis of berberine in neurons during hypoxia/ischemia
inferredcites →https://doi.org/10.3892/mmr.2014.2577openalex-snapshot
Protective effect of polydatin on learning and memory impairments in neonatal rats with hypoxic-ischemic brain injury by up-regulating brain-derived neurotrophic factor

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4563612openalex-extracted
Multidimensional Integration of Technologies to Develop an Effective Prescription of Coptidis Rhizoma, Astragalus Membranaceus, and Panax Notoginseng in the Protection Against Cerebral Ischemic Injury
inferred← citeshttps://doi.org/10.1002/cbdv.202500170openalex-snapshot
Unraveling Berberine's Molecular Mechanisms in Neuroprotection Against Neurodegeneration
inferred← citeshttps://doi.org/10.1002/fsn3.70563openalex-snapshot
The Beneficial Effects of Berberine on Brain Functions in Age‐Related Neurological Disorders: From Molecular Signaling to Treatment
inferred← citeshttps://doi.org/10.1002/jcp.27717openalex-snapshot
Annexin A3 gene silencing promotes myocardial cell repair through activation of the PI3K/Akt signaling pathway in rats with acute myocardial infarction
inferred← citeshttps://doi.org/10.1002/kjm2.12486openalex-snapshot
Gingerol ameliorates neuronal damage induced by hypoxia‐reoxygenation via the miR ‐210/ brain‐derived neurotrophic factor axis
inferred← citeshttps://doi.org/10.1002/med.21703openalex-snapshot
Biologically active isoquinoline alkaloids covering 2014–2018
inferred← citeshttps://doi.org/10.1002/ptr.7490openalex-snapshot
Vagus nerve stimulated by microbiota‐derived hydrogen sulfide mediates the regulation of berberine on microglia in transient middle cerebral artery occlusion rats
inferred← citeshttps://doi.org/10.1002/ptr.7621openalex-snapshot
Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway
inferred← citeshttps://doi.org/10.1002/ptr.7994openalex-snapshot
Advances of phytotherapy in ischemic stroke targeting PI3K /Akt signaling
inferred← citeshttps://doi.org/10.1002/ptr.8040openalex-snapshot
The pharmacological effects of Berberine and its therapeutic potential in different diseases: Role of the phosphatidylinositol 3‐kinase/ AKT signaling pathway
inferred← citeshttps://doi.org/10.1007/978-981-33-6679-4_1openalex-snapshot
Rodent Stroke Model Guidelines: An Update
inferred← citeshttps://doi.org/10.1007/s00221-023-06716-4openalex-snapshot
Recombinant human brain natriuretic peptide attenuates ischemic brain injury in mice by inhibiting oxidative stress and cell apoptosis via activation of PI3K/AKT/Nrf2/HO-1 pathway
inferred← citeshttps://doi.org/10.1007/s00580-023-03502-0openalex-snapshot
Effects of berberine on pentylenetetrazole-induced seizures during estrus cycle in rats
inferred← citeshttps://doi.org/10.1007/s10571-019-00675-7openalex-snapshot
Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling
inferred← citeshttps://doi.org/10.1007/s10787-020-00769-5openalex-snapshot
Donepezil attenuates injury following ischaemic stroke by stimulation of neurogenesis, angiogenesis, and inhibition of inflammation and apoptosis
inferred← citeshttps://doi.org/10.1007/s10863-025-10063-0openalex-snapshot
Mollugin attenuates oxygen-glucose deprivation/reperfusion-induced brain microvascular endothelial cell death and permeability through activation of BDNF/TrkB-modulated Akt pathway
inferred← citeshttps://doi.org/10.1007/s11011-024-01517-2openalex-snapshot
Chitosan lactate improves repeated closed head injury-generated motor and neurological dysfunctions in mice by impacting microbiota gut-brain axis
inferred← citeshttps://doi.org/10.1007/s11064-022-03562-8openalex-snapshot
Acute Sleep Deprivation-Induced Anxiety and Disruption of Hypothalamic Cell Survival and Plasticity: A Mechanistic Study of Protection by Butanol Extract of Tinospora cordifolia
inferred← citeshttps://doi.org/10.1007/s11101-026-10321-yopenalex-snapshot
Evidence-based evaluation of berberine in neurodegenerative diseases: targeting multiple signaling pathways and modulating neuroinflammation, oxidative stress, and apoptosis
inferred← citeshttps://doi.org/10.1007/s12017-021-08683-xopenalex-snapshot
Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats
inferred← citeshttps://doi.org/10.1016/b978-0-443-40578-5.00003-9openalex-snapshot
Natural products as potential neuroprotective agents for ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.ajp.2025.104694openalex-snapshot
Mitochondrial dysfunction in depression: Mechanisms and targeted therapy strategies
inferred← citeshttps://doi.org/10.1016/j.bbr.2024.115267openalex-snapshot
Astragaloside IV plays a neuroprotective role by promoting PPARγ in cerebral ischemia-reperfusion rats
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.06.058openalex-snapshot
MIF protects against oxygen-glucose deprivation-induced ototoxicity in HEI-OC1 cochlear cells by enhancement of Akt-Nrf2-HO-1 pathway
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.08.015openalex-snapshot
Salidroside alleviates ischemic brain injury in mice with ischemic stroke through regulating BDNK mediated PI3K/Akt pathway
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.110123openalex-snapshot
Protection of the Geum japonicum Thunb. var. chinense extracts against oxygen-glucose deprivation and re-oxygenation induced astrocytes injury via BDNF/PI3K/Akt/CREB pathway
inferred← citeshttps://doi.org/10.1016/j.biopha.2020.111021openalex-snapshot
Protection against acute cerebral ischemia/reperfusion injury by Leonuri Herba Total Alkali via modulation of BDNF-TrKB-PI3K/Akt signaling pathway in rats
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115511openalex-snapshot
The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo
inferred← citeshttps://doi.org/10.1016/j.brainres.2020.146902openalex-snapshot
Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats
inferred← citeshttps://doi.org/10.1016/j.brainres.2021.147399openalex-snapshot
Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2021.09.005openalex-snapshot
Berberine exerts neuroprotective activities against cerebral ischemia/reperfusion injury through up-regulating PPAR-γ to suppress NF-κB-mediated pyroptosis
inferred← citeshttps://doi.org/10.1016/j.canlet.2024.217019openalex-snapshot
Unlocking the potential of Berberine: Advancing cancer therapy through chemosensitization and combination treatments
inferred← citeshttps://doi.org/10.1016/j.cca.2024.119683openalex-snapshot
Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction
inferred← citeshttps://doi.org/10.1016/j.ejphar.2020.173412openalex-snapshot
Neuroprotective role of polyphenols against oxidative stress-mediated neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175782openalex-snapshot
Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice
inferred← citeshttps://doi.org/10.1016/j.fct.2023.113721openalex-snapshot
New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: Possible role of BDNF–TrkB–PI3K/Akt and NF-κB signaling
inferred← citeshttps://doi.org/10.1016/j.gene.2019.144277openalex-snapshot
KLF2 protects BV2 microglial cells against oxygen and glucose deprivation injury by modulating BDNF/TrkB pathway
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2024.124782openalex-snapshot
Panax notoginseng saponins and acetylsalicylic acid co-delivered liposomes for targeted treatment of ischemic stroke
inferred← citeshttps://doi.org/10.1016/j.intimp.2022.109057openalex-snapshot
Purpurogallin improves neurological functions of cerebral ischemia and reperfusion mice by inhibiting endoplasmic reticulum stress and neuroinflammation
inferred← citeshttps://doi.org/10.1016/j.jchemneu.2024.102393openalex-snapshot
Oxyberberine protects middle cerebral artery occlusion triggered cerebral injury through TLR4/NLRP3 pathway in rats
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117153openalex-snapshot
Understanding mechanistic aspect of the therapeutic role of herbal agents on neuroplasticity in cerebral ischemic-reperfusion injury
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2022.111716openalex-snapshot
Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways
inferred← citeshttps://doi.org/10.1016/j.phrs.2019.104385openalex-snapshot
Berberine protects against ischemia-reperfusion injury: A review of evidence from animal models and clinical studies
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.104795openalex-snapshot
Nose to brain drug delivery - A promising strategy for active components from herbal medicine for treating cerebral ischemia reperfusion
inferred← citeshttps://doi.org/10.1016/j.phymed.2021.153664openalex-snapshot
Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.prenap.2026.100576openalex-snapshot
Berberine and its therapeutic legacy from Huanglian (黄连), Huangbai (黄柏), Amur Cork Tree (黄檗), and Gong Lao Mu (亮叶十大功劳) in cancer, metabolic disorders, cardio- and neuroprotection"
inferred← citeshttps://doi.org/10.1016/j.tice.2025.102972openalex-snapshot
BDNF alleviates senescence and enhances osteogenic differentiation in bone marrow mesenchymal stem cells via the TrkB/PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1021/acs.cgd.5c01691openalex-snapshot
Novel Berberine Ionic Cocrystals with Halogen-Substituted Salicylic Acid Derivatives: From Chloride-Retaining Hydrate to Chloride-Free Anhydrous
inferred← citeshttps://doi.org/10.1021/acschemneuro.0c00730openalex-snapshot
Systematic Study of Crucial Transcription Factors of Coptidis rhizoma Alkaloids against Cerebral Ischemia-Reperfusion Injury
inferred← citeshttps://doi.org/10.1021/acschemneuro.5c00863openalex-snapshot
4-(1-Methylethoxy)- N -(2-methyl-8-quinolinyl)-benzamide (CDN1163) Attenuates Glutamate-Induced Excitotoxicity by Suppressing ER Stress and Restoring Mitochondrial Dynamics in N2a Cells
inferred← citeshttps://doi.org/10.1021/acsptsci.5c00151openalex-snapshot
A Small-Molecule Activator of Sarco/Endoplasmic Reticulum Ca 2+ -ATPase Attenuates Cerebral Ischemia–Reperfusion Injury by Suppressing Endoplasmic Reticulum Stress and Apoptosis
inferred← citeshttps://doi.org/10.1038/s41401-023-01137-zopenalex-snapshot
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog
inferred← citeshttps://doi.org/10.1038/s41598-024-83019-wopenalex-snapshot
Resolvin D1 combined with exercise rehabilitation alleviates neurological injury in mice with intracranial hemorrhage via the BDNF/TrkB/PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1038/s41598-025-95656-wopenalex-snapshot
Region-specific brain decellularized extracellular matrix promotes cell recovery in an in vitro model of stroke
inferred← citeshttps://doi.org/10.1080/08923973.2022.2052893openalex-snapshot
Fraxetin protects rat brains from the cerebral stroke via promoting angiogenesis and activating PI3K/Akt pathway
inferred← citeshttps://doi.org/10.1080/10286020.2025.2539987openalex-snapshot
The mechanism of Yizhi Qingxin formula to improve neuroinflammation in Alzheimer’s disease by regulating the TLR4/NF‑κB/NLRP3 pathway
inferred← citeshttps://doi.org/10.1080/21655979.2021.1978617openalex-snapshot
The protective effects of Pimavanserin against cerebral ischemia-induced brain injury
inferred← citeshttps://doi.org/10.1093/jnen/nlaa069openalex-snapshot
LncRNA BC083743 Promotes the Proliferation of Schwann Cells and Axon Regeneration Through miR-103-3p/BDNF After Sciatic Nerve Crush
inferred← citeshttps://doi.org/10.1111/1440-1681.13398openalex-snapshot
Tenacissoside H promotes neurological recovery of cerebral ischaemia/reperfusion injury in mice by modulating inflammation and oxidative stress via TrkB pathway
inferred← citeshttps://doi.org/10.1155/2020/3495836openalex-snapshot
Electroacupuncture Ameliorates Cerebral I/R‐Induced Inflammation through DOR‐BDNF/TrkB Pathway
inferred← citeshttps://doi.org/10.1155/2021/5514175openalex-snapshot
Huang-Pu-Tong-Qiao Formula Ameliorates the Hippocampus Apoptosis in Diabetic Cognitive Dysfunction Mice by Activating CREB/BDNF/TrkB Signaling Pathway
inferred← citeshttps://doi.org/10.1155/2021/6687386openalex-snapshot
Neuroprotective Phytochemicals in Experimental Ischemic Stroke: Mechanisms and Potential Clinical Applications
inferred← citeshttps://doi.org/10.1155/2022/2443615openalex-snapshot
Exploring Active Compounds and Mechanisms of Angong Niuhuang Wan on Ischemic Stroke Based on Network Pharmacology and Molecular Docking
inferred← citeshttps://doi.org/10.1159/000516889openalex-snapshot
p53 Inhibition Provides a Pivotal Protective Effect against Cerebral Ischemia-Reperfusion Injury via the Wnt Signaling Pathway
inferred← citeshttps://doi.org/10.1186/s40246-025-00794-xopenalex-snapshot
DNA methylation in adaptation to high-altitude environments and pathogenesis of related diseases
inferred← citeshttps://doi.org/10.1186/s40360-022-00620-3openalex-snapshot
Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.1186/s40360-025-00843-0openalex-snapshot
Neuroprotective effects of berberine in preclinical models of ischemic stroke: a systematic review
inferred← citeshttps://doi.org/10.12659/msm.924781openalex-snapshot
Long Non-Coding RNA (lncRNA) NEAT1 Aggravates Cerebral Ischemia-Reperfusion Injury by Suppressing the Inhibitory Effect of miR-214 on PTEN
inferred← citeshttps://doi.org/10.13040/ijpsr.0975-8232.13(4).1411-27openalex-snapshot
inferred← citeshttps://doi.org/10.14336/ad.2022.0311openalex-snapshot
Ancient Chinese Herbal Recipe Huanglian Jie Du Decoction for Ischemic Stroke: An Overview of Current Evidence
inferred← citeshttps://doi.org/10.14336/ad.2024.0203openalex-snapshot
Inflammatory Pathogenesis of Post-stroke Depression
inferred← citeshttps://doi.org/10.18632/aging.205369openalex-snapshot
METTL3-dependent N6-methyladenosine modification is involved in berberine-mediated neuroprotection in ischemic stroke by enhancing the stability of NEAT1 in astrocytes
inferred← citeshttps://doi.org/10.21037/atm-22-6639openalex-snapshot
Dexmedetomidine ameliorates ischemia-induced nerve injury by up-regulating Sox11 expression
inferred← citeshttps://doi.org/10.21203/rs.3.rs-104132/v1openalex-snapshot
Buyang Huanwu Decoction Alleviates Cerebral Ischemia-Reperfusion Injury via Sirtuin 1/Autophagy Pathway
inferred← citeshttps://doi.org/10.21203/rs.3.rs-107304/v1openalex-snapshot
A Novel Method for Screening the Effective Compatibility Fractions of Naomaitong for the Treatment of Cerebral Ischemic Stroke Using Support Vector Machine Model
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1554658/v1openalex-snapshot
Mechanism of Cornin in Preventing Astrocyte Autophagy Induced by Cerebral Ischemia/Reperfusion Injury
inferred← citeshttps://doi.org/10.2139/ssrn.4818811openalex-snapshot
The Combination Of Coptidis Rhizoma, Astragalus Membranaceus, and Panax Notoginseng Protected Against Cerebral Ischemic Injury Via C3-Mediated Complement Signaling Pathway
inferred← citeshttps://doi.org/10.2147/ndt.s228417openalex-snapshot
Cornel Iridoid Glycoside Protects Against White Matter Lesions Induced by Cerebral Ischemia in Rats via Activation of the Brain-Derived Neurotrophic Factor/Neuregulin-1 Pathway
inferred← citeshttps://doi.org/10.2147/ndt.s313807openalex-snapshot
The Cerebroprotein Hydrolysate-I Plays a Neuroprotective Effect on Cerebral Ischemic Stroke by Inhibiting MEK/ERK1/2 Signaling Pathway in Rats
inferred← citeshttps://doi.org/10.2174/0122150838440323260213055029openalex-snapshot
Natural Medicines in Stroke: Mechanisms and Therapeutic Potential
inferred← citeshttps://doi.org/10.2174/1381612827666210827104316openalex-snapshot
Upregulated Long Non-coding RNA ALMS1-IT1 Promotes Neuroinflammation by Activating NF-κB Signaling in Ischemic Cerebral Injury
inferred← citeshttps://doi.org/10.2174/1871527321666220124140323openalex-snapshot
Berberine Ameliorates Cognitive Impairment by Regulating Microglial Polarization and Increasing Expression of Anti-inflammatory Factors following Permanent Bilateral Common Carotid Artery Occlusion in Rats
inferred← citeshttps://doi.org/10.22038/ijbms.2022.62811.13895openalex-snapshot
Berberine protects against diclofenac sodium-induced testicular impairment in mice by its anti-oxidant and anti-apoptotic activities.
inferred← citeshttps://doi.org/10.22038/ijbms.2022.65053.14326openalex-snapshot
Berberine hydrochloride improves cognitive deficiency through hippocampal up-regulation of neurotrophins following inhalant self-administration of methamphetamine.
inferred← citeshttps://doi.org/10.3389/fendo.2025.1665391openalex-snapshot
Hypothalamic FTO upregulates BDNF to promote GnRH expression through the PI3K/Akt pathway, leading to precocious puberty
inferred← citeshttps://doi.org/10.3389/fncel.2018.00475openalex-snapshot
TAT-Ngn2 Enhances Cognitive Function Recovery and Regulates Caspase-Dependent and Mitochondrial Apoptotic Pathways After Experimental Stroke
inferred← citeshttps://doi.org/10.3389/fphar.2020.00510openalex-snapshot
RETRACTED: Yizhi Qingxin Formula Extract Ameliorates Cognitive Decline in Aged Rats via the Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Pathway
inferred← citeshttps://doi.org/10.3389/fphar.2021.607412openalex-snapshot
Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review
inferred← citeshttps://doi.org/10.3389/fphar.2021.609693openalex-snapshot
Berberine Attenuates Cerebral Ischemia-Reperfusion Injury Induced Neuronal Apoptosis by Down-Regulating the CNPY2 Signaling Pathway
inferred← citeshttps://doi.org/10.3389/fphar.2021.772485openalex-snapshot
Neuroprotective Effect of Daidzein Extracted From Pueraria lobate Radix in a Stroke Model Via the Akt/mTOR/BDNF Channel
inferred← citeshttps://doi.org/10.3389/fphar.2025.1664784openalex-snapshot
The potential value of the use of berberine in depression: a systematic review and meta-analysis of preclinical studies
inferred← citeshttps://doi.org/10.3390/cells11050796openalex-snapshot
Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms
inferred← citeshttps://doi.org/10.3390/ijms232012694openalex-snapshot
Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils
inferred← citeshttps://doi.org/10.3390/molecules24101898openalex-snapshot
Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia
inferred← citeshttps://doi.org/10.34172/icnj.2021.04openalex-snapshot
Berberine Supplement and Resistance Training May Ameliorate Diazinon Induced Neural Toxicity in Rat Hippocampus Via the Activation of the TrkB and ERK Signaling Pathway
inferred← citeshttps://doi.org/10.3892/ijmm.2024.5373openalex-snapshot
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway
inferred← citeshttps://doi.org/10.3892/mmr.2021.12431openalex-snapshot
Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model
inferred← citeshttps://doi.org/10.6084/m9.figshare.21393888openalex-snapshot
Additional file 1 of Cornin protects against cerebral ischemia/reperfusion injury by preventing autophagy via the PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.7150/thno.30787openalex-snapshot
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
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