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Dissolution Improvement and the Mechanism of the Improvement from Cocrystallization of Poorly Water-soluble Compounds

https://doi.org/10.1007/s11095-008-9676-2

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What this work says

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Quantitative Analysis of the Effect of Supersaturation on in Vivo Drug Absorption

inferred← citeshttps://doi.org/10.1021/mp400176yopenalex-snapshot

Formulation of a Danazol Cocrystal with Controlled Supersaturation Plays an Essential Role in Improving Bioavailability

inferred← citeshttps://doi.org/10.1021/mp400465popenalex-snapshot

In Vitro–in VivoCorrelation of the Effect of Supersaturation on the Intestinal Absorption of BCS Class 2 Drugs

inferred← citeshttps://doi.org/10.1038/s41598-025-20755-7openalex-snapshot

Enhancing the solubility of celecoxib via lyophilized solid dispersions using computational and experimental approaches

inferred← citeshttps://doi.org/10.1039/9781849733502-00338openalex-snapshot

Monographs of most Frequent Co-Crystal Formers

inferred← citeshttps://doi.org/10.1039/b910136eopenalex-snapshot

Attempted construction of minoxidil: carboxylic acid cocrystals; 7 salts and 1 cocrystal resulted

inferred← citeshttps://doi.org/10.1039/c002045aopenalex-snapshot

Nutraceutical cocrystals: utilizing pterostilbene as a cocrystal former

inferred← citeshttps://doi.org/10.1039/c0ce00214copenalex-snapshot

Cocrystals of nutraceuticalp-coumaric acid with caffeine and theophylline: polymorphism and solid-state stability explored in detail using their crystal graphs

inferred← citeshttps://doi.org/10.1039/c1ce05458aopenalex-snapshot

Multicomponent solids of lamotrigine with some selected coformers and their characterization by thermoanalytical, spectroscopic and X-ray diffraction methods

inferred← citeshttps://doi.org/10.1039/c1ce05902eopenalex-snapshot

Are meloxicam dimers really the structure-forming units in the ‘meloxicam–carboxylic acid’ co-crystals family? Relation between crystal structures and dissolution behaviour

inferred← citeshttps://doi.org/10.1039/c2nj40093fopenalex-snapshot

How good are the crystallisation methods for co-crystals? A comparative study of piroxicam

inferred← citeshttps://doi.org/10.1039/c3ce41285gopenalex-snapshot

Cocrystals of fisetin, luteolin and genistein with pyridinecarboxamide coformers: crystal structures, analysis of intermolecular interactions, spectral and thermal characterization

inferred← citeshttps://doi.org/10.1039/c4ce01713gopenalex-snapshot

Improving solubility of fisetin by cocrystallization

inferred← citeshttps://doi.org/10.1039/c5ce00777aopenalex-snapshot

Novel co-crystals of the nutraceutical sinapic acid

inferred← citeshttps://doi.org/10.1039/c6ce02003hopenalex-snapshot

Manifestation of cocrystals and eutectics among structurally related molecules: towards understanding the factors that control their formation

inferred← citeshttps://doi.org/10.1039/c7ce00037eopenalex-snapshot

Anhydrous ionic co-crystals of cyanuric acid with LiCl and NaCl

inferred← citeshttps://doi.org/10.1039/c7ce00284jopenalex-snapshot

Solubility improvement of epalrestat by layered structure formation via cocrystallization

inferred← citeshttps://doi.org/10.1039/d0ra06608gopenalex-snapshot

Improving the solubility and bioavailability of anti-hepatitis B drug PEC via PEC–fumaric acid cocrystal

inferred← citeshttps://doi.org/10.1039/d4tc03209hopenalex-snapshot

Deciphering colour mechanisms in co-crystals and salts containing violuric acid and chosen l -amino acids

inferred← citeshttps://doi.org/10.1080/03639045.2018.1435687openalex-snapshot

Development of paracetamol-caffeine co-crystals to improve compressional, formulation and in vivo performance

inferred← citeshttps://doi.org/10.1080/03639045.2019.1571504openalex-snapshot

Co-crystallization for enhanced dissolution rate of bicalutamide: preparation and evaluation of rapidly disintegrating tablets

inferred← citeshttps://doi.org/10.1080/03639045.2021.1892744openalex-snapshot

Amelioration of physicochemical, pharmaceutical, and pharmacokinetic properties of lornoxicam by cocrystallization with a novel coformer

inferred← citeshttps://doi.org/10.1080/10837450.2018.1455210openalex-snapshot

Piroxicam cocrystals with phenolic coformers: preparation, characterization, and dissolution properties

inferred← citeshttps://doi.org/10.1080/10837450.2026.2624727openalex-snapshot

Zoomlab™-guided co-crystal engineering of nilotinib for improved dissolution

inferred← citeshttps://doi.org/10.1080/15421406.2013.782207openalex-snapshot

Thermodynamic Studies on Solid Dispersions of Nicotinamide – Khellin Drug System

inferred← citeshttps://doi.org/10.1080/15421406.2014.963278openalex-snapshot

Nicotinamide–Indole Binary Drug System: Thermodynamic and Interfacial Studies

inferred← citeshttps://doi.org/10.1080/17518253.2017.1339832openalex-snapshot

Mechanochemical solid acid/base reactions for obtaining biologically active preparations and extracting plant materials

inferred← citeshttps://doi.org/10.1080/2331205x.2018.1480572openalex-snapshot

Advanced colloidal technologies for the enhanced bioavailability of drugs

inferred← citeshttps://doi.org/10.1107/s2052252519016142openalex-snapshot

Crystal engineering of exemestane to obtain a co-crystal with enhanced urease inhibition activity

inferred← citeshttps://doi.org/10.1111/j.2042-7158.2010.01189.xopenalex-snapshot

Bioavailability of indomethacin-saccharin cocrystals

inferred← citeshttps://doi.org/10.1111/j.2042-7158.2010.01226.xopenalex-snapshot

Supersaturated dissolution data and their interpretation: the TPGS–carbamazepine model case

inferred← citeshttps://doi.org/10.1124/pr.112.005660openalex-snapshot

Strategies to Address Low Drug Solubility in Discovery and Development

inferred← citeshttps://doi.org/10.1139/cjc-2020-0073openalex-snapshot

No regioselectivity for the steroid α-face in cocrystallization of exemestane with aromatic cocrystal formers based on phenanthrene and pyrene

inferred← citeshttps://doi.org/10.11606/t.75.2016.tde-09032016-135907openalex-snapshot

Estudo termoanalítico e caracterização no estado sólido da interação química entre cetoprofeno e alguns compostos orgânicos

inferred← citeshttps://doi.org/10.1208/s12249-015-0362-5openalex-snapshot

Small-Scale Assays for Studying Dissolution of Pharmaceutical Cocrystals for Oral Administration

inferred← citeshttps://doi.org/10.1248/cpb.c18-00812openalex-snapshot

Improving the Solid-State Photostability of Furosemide by Its Cocrystal Formation

inferred← citeshttps://doi.org/10.1252/jcej.18we281openalex-snapshot

Effect of Two Kinds of Supersaturation on Crystal Qualities during Cocrystallization

inferred← citeshttps://doi.org/10.1254/fpj.150.36openalex-snapshot

Current status and promising future of pharmaceutical cocrystals in development of oral dosage forms

inferred← citeshttps://doi.org/10.1515/ncrs-2019-0758openalex-snapshot

The crystal structure of 6-methyl-3,20-dioxo-19-norpregna-4,6-dien-17-yl acetate–2,4-dihydroxybenzoic acid (1/1), C30H36O8

inferred← citeshttps://doi.org/10.1517/17425247.2013.747508openalex-snapshot

Cocrystallization for successful drug delivery

inferred← citeshttps://doi.org/10.1517/17425250902835506openalex-snapshot

Introduction to computational oral absorption simulation

inferred← citeshttps://doi.org/10.15171/apb.2017.048openalex-snapshot

Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation

inferred← citeshttps://doi.org/10.15272/ajbps.v3i27.445openalex-snapshot

Insights of Dosage form Design: Polymorphs and Cocrystals

inferred← citeshttps://doi.org/10.1590/s2175-97902022e18768openalex-snapshot

Effects of polyvinylpyrrolidone and poly (ethylene glycol) on preparation of ibuprofen pharmaceutical cocrystal

inferred← citeshttps://doi.org/10.17219/pim/105609openalex-snapshot

Formulation and solid state characterization of carboxylic acid-based co-crystals of tinidazole: An approach to enhance solubility

inferred← citeshttps://doi.org/10.2147/dddt.s270742openalex-snapshot

Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile

inferred← citeshttps://doi.org/10.2174/13816128113199990396openalex-snapshot

Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions

inferred← citeshttps://doi.org/10.2174/1877946813666230822113606openalex-snapshot

Drug Polymorphism: An Important Pre-formulation Tool in the Formulation Development of a Dosage Form

inferred← citeshttps://doi.org/10.2174/2210303111666210111142458openalex-snapshot

A Comparative Study of Selected Drug Delivery Systems: Key Emphasis on Cocrystallization

inferred← citeshttps://doi.org/10.22159/ijap.2026v18i2.57537openalex-snapshot

FORMULATION, CHARACTERIZATION AND PHARMACOKINETIC EVALUATION OF RIVAROXABAN-CITRIC ACID COCRYSTALS WITH ENHANCED SOLUBILITY, STABILITY AND BIOAVAILABILITY

inferred← citeshttps://doi.org/10.22377/ajp.v17i2.4848openalex-snapshot

inferred← citeshttps://doi.org/10.29090/psa.2024.02.24.1491openalex-snapshot

Improved dissolution of ketoconazole by coprecipitation with nicotinamide using gas anti-solvent process

inferred← citeshttps://doi.org/10.3109/02652048.2015.1035684openalex-snapshot

Enhanced dissolution and stability of artemisinin by nano-confinement in ordered mesoporous SBA-15 particles

inferred← citeshttps://doi.org/10.3109/03639041003642065openalex-snapshot

Crystal engineering to improve physicochemical properties of mefloquine hydrochloride

inferred← citeshttps://doi.org/10.3109/03639045.2012.689764openalex-snapshot

Evaluation of performance of co crystals of mefloquine hydrochloride in tablet dosage form

inferred← citeshttps://doi.org/10.3109/03639045.2012.692378openalex-snapshot

Effects of spray drying process parameters on the solubility behavior and physical stability of solid dispersions prepared using a laboratory-scale spray dryer

inferred← citeshttps://doi.org/10.3109/03639045.2013.807280openalex-snapshot

Enhancing the solubility and masking the bitter taste of propiverine using crystalline complex formation

inferred← citeshttps://doi.org/10.3109/03639045.2014.971027openalex-snapshot

Solubility and dissolution enhancement strategies: current understanding and recent trends

inferred← citeshttps://doi.org/10.3109/03639045.2015.1118495openalex-snapshot

Sucralose as co-crystal co-former for hydrochlorothiazide: development of oral disintegrating tablets

inferred← citeshttps://doi.org/10.3109/10837450.2010.546412openalex-snapshot

Physicochemical and mechanical properties of carbamazepine cocrystals with saccharin

inferred← citeshttps://doi.org/10.3109/10837450.2012.696270openalex-snapshot

Hydrochloride salt co-crystals: preparation, characterization and physicochemical studies

inferred← citeshttps://doi.org/10.3136/fstr.26.17openalex-snapshot

Development of Rebaudioside D Polymorphs with Improved Solubility

inferred← citeshttps://doi.org/10.32383/farmpol/116127openalex-snapshot

Influence of co-crystallization on bioavailability of drug substances

inferred← citeshttps://doi.org/10.3390/colorants2020018openalex-snapshot

Multicomponent Crystals of Phthalocyanines–A Possibility of Fine-Tuning Properties

inferred← citeshttps://doi.org/10.3390/cryst12101337openalex-snapshot

Cocrystals and Drug–Drug Cocrystals of Anticancer Drugs: A Perception towards Screening Techniques, Preparation, and Enhancement of Drug Properties

inferred← citeshttps://doi.org/10.3390/ijms23169013openalex-snapshot

The Relevance of Crystal Forms in the Pharmaceutical Field: Sword of Damocles or Innovation Tools?

inferred← citeshttps://doi.org/10.3390/molecules21020197openalex-snapshot

New Biopolymer Nanoparticles Improve the Solubility of Lipophilic Megestrol Acetate

inferred← citeshttps://doi.org/10.3390/pharmaceutics12010023openalex-snapshot

Dissolution Advantage of Nitazoxanide Cocrystals in the Presence of Cellulosic Polymers

inferred← citeshttps://doi.org/10.3390/pharmaceutics14112321openalex-snapshot

Crystal Engineering of Ionic Cocrystals Sustained by Azolium···Azole Heterosynthons

inferred← citeshttps://doi.org/10.3390/pharmaceutics5040508openalex-snapshot

Influence of Sodium Lauryl Sulfate and Tween 80 on Carbamazepine–Nicotinamide Cocrystal Solubility and Dissolution Behaviour

inferred← citeshttps://doi.org/10.34172/apb.2020.024openalex-snapshot

Pharmaceutical Co-Crystallization: Regulatory Aspects, Design, Characterization, and Applications

inferred← citeshttps://doi.org/10.36306/konjes.998111openalex-snapshot

ANALYSIS OF THE EFFECT OF PHYSICAL PROPERTIES OF DRUG CO-CRYSTALS ON DISSOLUTION CONCENTRATION

inferred← citeshttps://doi.org/10.36721/pjps/28/2(sup)/2015/254/799-806openalex-snapshot

Improvement on solubility of fluticasone propionate with cyclodextrins by mechanochemical activation

inferred← citeshttps://doi.org/10.4011/shikizai.97.304openalex-snapshot

Recent Trends in Laboratory Preparation and Industrial Production Methods on Cocrystals

inferred← citeshttps://doi.org/10.4103/0250-474x.57283openalex-snapshot

Co-crystals: A novel approach to modify physicochemical properties of active pharmaceutical ingredients

inferred← citeshttps://doi.org/10.4155/tde-2022-0072openalex-snapshot

Solid-state Characterization of ibuprofen-isonicotinamide Cocrystals Prepared By Electrospraying and Solvent Evaporation

inferred← citeshttps://doi.org/10.4164/sptj.49.184openalex-snapshot

Carbamazepine-dicarboxylic Acid Cocrystal Formation Induced by Multicomponent Cogrinding and Exchange Reaction of Dicarboxylic Acids

inferred← citeshttps://doi.org/10.4274/tjps.15013openalex-snapshot

Superior solubility and dissolution of zaltoprofen via pharmaceutical cocrystal

inferred← citeshttps://doi.org/10.4274/tjps.galenos.2018.15013openalex-snapshot

Superior Solubility and Dissolution of Zaltoprofen via Pharmaceutical Cocrystals

inferred← citeshttps://doi.org/10.47583/ijpsrr.2022.v74i02.024openalex-snapshot

Role of Coformers in Solubility Enhancement of Poorly Soluble Drugs through Cocrystallization: An Overview

inferred← citeshttps://doi.org/10.53879/id.61.08.14201openalex-snapshot

SOLUBILITY ENHANCEMENT TECHNIQUE FOR BCS CLASS II DRUG - ONDANSETRON HYDROCHLORIDE BY CO-CRYSTALLIZATION METHOD

inferred← citeshttps://doi.org/10.5530/ijper.53.4s.147openalex-snapshot

Insight into Concept and Progress on Pharmaceutical Co-Crystals: An overview

inferred← citeshttps://doi.org/10.5530/ijper.53.4s.151openalex-snapshot

Design and Preparation of Zaltoprofen-Nicotinamide Pharmaceutical Cocrystals via Liquid Assisted Grinding Method

inferred← citeshttps://doi.org/10.5772/28954openalex-snapshot

Novel Challenges in Crystal Engineering: Polymorphs and New Crystal Forms of Active Pharmaceutical Ingredients

inferred← citeshttps://doi.org/10.5772/intechopen.105307openalex-snapshot

Drug Formulation Design

inferred← citeshttps://doi.org/10.5772/intechopen.110129openalex-snapshot

Modification of Physicochemical Properties of Active Pharmaceutical Ingredient by Pharmaceutical Co-Crystals

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