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Crocin Inhibits Oxidative Stress and Pro-inflammatory Response of Microglial Cells Associated with Diabetic Retinopathy Through the Activation of PI3K/Akt Signaling Pathway
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cne.22516openalex-snapshot
Early microglia activation in a mouse model of chronic glaucoma
inferredcites →https://doi.org/10.1002/glia.20419openalex-snapshot
Microglia instruct subventricular zone neurogenesis
inferredcites →https://doi.org/10.1002/ptr.2597openalex-snapshot
Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice
inferredcites →https://doi.org/10.1002/ptr.3044openalex-snapshot
Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats
inferredcites →https://doi.org/10.1002/ptr.3566openalex-snapshot
Effects of Saffron (Crocus sativus L.) and its Active Constituent, Crocin, on Recognition and Spatial Memory after Chronic Cerebral Hypoperfusion in Rats
inferredcites →https://doi.org/10.1002/ptr.3736openalex-snapshot
Effect of Linalool on Morphine Tolerance and Dependence in Mice
inferredcites →https://doi.org/10.1007/978-1-62703-327-5_19openalex-snapshot
Evaluation of Antibody-Dependent Cell Cytotoxicity Using Lactate Dehydrogenase (LDH) Measurement
inferredcites →https://doi.org/10.1007/s00125-006-0503-1openalex-snapshot
Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population: the Shanghai Diabetes Studies, a cross-sectional 3-year follow-up study in Shanghai urban communities
inferredcites →https://doi.org/10.1007/s00401-009-0622-0openalex-snapshot
Microglia: biology and pathology
inferredcites →https://doi.org/10.1007/s10571-009-9441-zopenalex-snapshot
Protective Effect of Saffron Extract and Crocin on Reactive Oxygen Species-Mediated High Glucose-Induced Toxicity in PC12 Cells
inferredcites →https://doi.org/10.1007/s11064-016-1905-1openalex-snapshot
Crocin Upregulates CX3CR1 Expression by Suppressing NF-κB/YY1 Signaling and Inhibiting Lipopolysaccharide-Induced Microglial Activation
inferredcites →https://doi.org/10.1007/s12035-010-8105-9openalex-snapshot
Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons
inferredcites →https://doi.org/10.1016/j.bbagen.2006.11.012openalex-snapshot
Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.bbcan.2013.11.001openalex-snapshot
Saffron and natural carotenoids: Biochemical activities and anti-tumor effects
inferredcites →https://doi.org/10.1016/j.bbi.2015.08.002openalex-snapshot
NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice
inferredcites →https://doi.org/10.1016/j.cdp.2004.09.002openalex-snapshot
Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials
inferredcites →https://doi.org/10.1016/j.cell.2007.11.031openalex-snapshot
Synapse Remodeling, Compliments of the Complement System
inferredcites →https://doi.org/10.1016/j.ejphar.2010.09.003openalex-snapshot
Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells
inferredcites →https://doi.org/10.1016/j.ejphar.2013.02.007openalex-snapshot
Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice
inferredcites →https://doi.org/10.1016/j.ejphar.2014.06.037openalex-snapshot
Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid β and interferon-γ in rat brain microglia
inferredcites →https://doi.org/10.1016/j.exer.2012.11.011openalex-snapshot
Crocin prevents retinal ischaemia/reperfusion injury-induced apoptosis in retinal ganglion cells through the PI3K/AKT signalling pathway
inferredcites →https://doi.org/10.1016/j.exer.2015.05.010openalex-snapshot
Time-dependent retinal ganglion cell loss, microglial activation and blood-retina-barrier tightness in an acute model of ocular hypertension
inferredcites →https://doi.org/10.1016/j.expneurol.2013.04.009openalex-snapshot
SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation
inferredcites →https://doi.org/10.1016/j.fct.2012.11.016openalex-snapshot
Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment
inferredcites →https://doi.org/10.1016/j.foodchem.2012.06.092openalex-snapshot
Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms
inferredcites →https://doi.org/10.1016/j.nec.2009.08.009openalex-snapshot
Microglia and Central Nervous System Immunity
inferredcites →https://doi.org/10.1016/j.neulet.2004.02.067openalex-snapshot
Crocin prevents the death of rat pheochromyctoma (PC-12) cells by its antioxidant effects stronger than those of α-tocopherol
inferredcites →https://doi.org/10.1016/j.neulet.2015.02.016openalex-snapshot
Neuroprotective effects of crocin against traumatic brain injury in mice: Involvement of notch signaling pathway
inferredcites →https://doi.org/10.1016/j.pneurobio.2005.02.004openalex-snapshot
Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
inferredcites →https://doi.org/10.1016/j.pnpbp.2006.11.010openalex-snapshot
Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial
inferredcites →https://doi.org/10.1016/s0024-3205(01)01357-1openalex-snapshot
Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells
inferredcites →https://doi.org/10.1016/s0197-0186(03)00174-8openalex-snapshot
Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis
inferredcites →https://doi.org/10.1021/jf991263jopenalex-snapshot
Antioxidant Properties of Crocin from Gardenia jasminoides Ellis and Study of the Reactions of Crocin with Linoleic Acid and Crocin with Oxygen
inferredcites →https://doi.org/10.1111/ceo.12724openalex-snapshot
Retinal ganglion cell neuronal damage in diabetes and diabetic retinopathy
inferredcites →https://doi.org/10.1155/2013/549174openalex-snapshot
Botanical Compounds: Effects on Major Eye Diseases
inferredcites →https://doi.org/10.1155/2014/465694openalex-snapshot
Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases
inferredcites →https://doi.org/10.1155/2014/705783openalex-snapshot
The Role of Microglia in Diabetic Retinopathy
inferredcites →https://doi.org/10.1155/2014/728709openalex-snapshot
Crocin Suppresses LPS-Stimulated Expression of Inducible Nitric Oxide Synthase by Upregulation of Heme Oxygenase-1 via Calcium/Calmodulin-Dependent Protein Kinase 4
inferredcites →https://doi.org/10.1155/2015/729509openalex-snapshot
Trimethyltin‐Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV‐2 Microglial Cells
inferredcites →https://doi.org/10.1155/2016/4856431openalex-snapshot
Thioredoxin Binding Protein‐2 Regulates Autophagy of Human Lens Epithelial Cells under Oxidative Stress via Inhibition of Akt Phosphorylation
inferredcites →https://doi.org/10.1159/000113717openalex-snapshot
Effects of Aging on Neuroprotective and Neurotoxic Properties of Microglia in Neurodegenerative Diseases
inferredcites →https://doi.org/10.1159/000337115openalex-snapshot
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
inferredcites →https://doi.org/10.1161/circresaha.116.305510openalex-snapshot
lncRNA-MIAT Regulates Microvascular Dysfunction by Functioning as a Competing Endogenous RNA
inferredcites →https://doi.org/10.1167/iovs.07-0438openalex-snapshot
Saffron Supplement Maintains Morphology and Function after Exposure to Damaging Light in Mammalian Retina
inferredcites →https://doi.org/10.1177/135245850000600108openalex-snapshot
Macrophages: their myelinotrophic or neurotoxic actions depend upon tissue oxidative stress
inferredcites →https://doi.org/10.1242/dmm.018788openalex-snapshot
Neurodegeneration severity can be predicted from early microglia alterations monitoredin vivoin a mouse model of chronic glaucoma
inferredcites →https://doi.org/10.1248/bpb.28.2106openalex-snapshot
Antihyperlipidemic Effect of Crocin Isolated from the Fructus of Gardenia jasminoides and Its Metabolite Crocetin
inferredcites →https://doi.org/10.1371/journal.pone.0043602openalex-snapshot
Early Reduction of Microglia Activation by Irradiation in a Model of Chronic Glaucoma
inferredcites →https://doi.org/10.2337/db07-1761openalex-snapshot
Suppressors of Cytokine-Signaling Proteins Induce Insulin Resistance in the Retina and Promote Survival of Retinal Cells
inferredcites →https://doi.org/10.2337/db10-0454openalex-snapshot
Diabetic Retinopathy: Targeting Vasoregression
inferredcites →https://doi.org/10.2337/diab.44.1.11openalex-snapshot
Retinopathy, Glucose, and Insulin in an Elderly Population: The Rotterdam Study
inferredcites →https://doi.org/10.2337/diabetes.54.6.1615openalex-snapshot
The Pathobiology of Diabetic Complications
inferredcites →https://doi.org/10.2337/diacare.27.5.1047openalex-snapshot
Global Prevalence of Diabetes
inferredcites →https://doi.org/10.3892/ijmm.2015.2418openalex-snapshot
Crocin protects retinal ganglion cells against H2O2-induced damage through the mitochondrial pathway and activation of NF-κB
inferredcites →https://doi.org/10.4196/kjpp.2014.18.1.79openalex-snapshot
Phosphorylation of Akt Mediates Anti-Inflammatory Activity of 1-p-Coumaroyl β-D-Glucoside Against Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/brb3.3503openalex-snapshot
Crocin ameliorates neuroinflammation and cognitive impairment in mice with Alzheimer's disease by activating PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1002/jbt.22957openalex-snapshot
Autophagy‐lysosome dysfunction is involved in gastric ischemia‑reperfusion injury by promoting microglial activation in the paraventricular nucleus
inferred← citeshttps://doi.org/10.1002/jcb.28252openalex-snapshot
Knockdown of FOXO6 inhibits high glucose–induced oxidative stress and apoptosis in retinal pigment epithelial cells
inferred← citeshttps://doi.org/10.1002/jcp.27843openalex-snapshot
Antidiabetic potential of saffron and its active constituents
inferred← citeshttps://doi.org/10.1002/ptr.6445openalex-snapshot
Clinical and metabolic responses to crocin in patients under methadone maintenance treatment: A randomized clinical trial
inferred← citeshttps://doi.org/10.1002/ptr.6748openalex-snapshot
Effects of saffron ( Crocus sativus L.) supplementation on inflammatory biomarkers: A systematic review and meta‐analysis
inferred← citeshttps://doi.org/10.1002/ptr.70028openalex-snapshot
Targeting Ferroptosis With Natural Products to Treat Diabetes and Its Complications: Opportunities and Challenges
inferred← citeshttps://doi.org/10.1002/ptr.7286openalex-snapshot
The therapeutic potential of Crocus sativus Linn.: A comprehensive narrative review of clinical trials
inferred← citeshttps://doi.org/10.1007/978-981-16-3529-8_9openalex-snapshot
Saffron: A Prized Herb with Therapeutic Potential Against Diabetes
inferred← citeshttps://doi.org/10.1007/s00210-024-02970-7openalex-snapshot
Oral supplementation with crocin (a constituent of saffron) in subjects with cigarette smoking: a clinical trial
inferred← citeshttps://doi.org/10.1007/s00210-025-03866-wopenalex-snapshot
Natural remedies proposed for the management of diabetic retinopathy (DR): diabetic complications
inferred← citeshttps://doi.org/10.1007/s00424-020-02372-7openalex-snapshot
MiR-155 inhibition alleviates suppression of osteoblastic differentiation by high glucose and free fatty acids in human bone marrow stromal cells by upregulating SIRT1
inferred← citeshttps://doi.org/10.1007/s11010-022-04545-7openalex-snapshot
Research progress of ferroptosis in glaucoma and optic nerve damage
inferred← citeshttps://doi.org/10.1007/s11010-022-04644-5openalex-snapshot
Ferroptosis: mechanisms and advances in ocular diseases
inferred← citeshttps://doi.org/10.1007/s11011-021-00748-xopenalex-snapshot
The effect of Crocin on TFAM and PGC-1α expression and Catalase and Superoxide dismutase activities following cholestasis-induced neuroinflammation in the striatum of male Wistar rats
inferred← citeshttps://doi.org/10.1007/s13258-023-01431-4openalex-snapshot
Crocin alleviates neurotoxicity induced by bupivacaine in SH-SY5Y cells with inhibition of PI3K/AKT signaling
inferred← citeshttps://doi.org/10.1007/s40200-020-00686-yopenalex-snapshot
Crocin attenuates oxidative stress and inflammation in myocardial infarction induced by isoprenaline via PPARγ activation in diabetic rats
inferred← citeshttps://doi.org/10.1016/b978-0-12-815776-3.00017-6openalex-snapshot
Antioxidant supplementation in diabetic retinopathy
inferred← citeshttps://doi.org/10.1016/b978-0-12-817780-8.00023-2openalex-snapshot
The role of saffron and its main components on oxidative stress in neurological diseases: A review
inferred← citeshttps://doi.org/10.1016/b978-0-12-817903-1.00010-3openalex-snapshot
Physiological effects of carotenoids on hyperglycemia and associated events
inferred← citeshttps://doi.org/10.1016/b978-0-12-818462-2.00016-4openalex-snapshot
The Effects of Saffron (Crocus sativus) and its Constituents on Immune System
inferred← citeshttps://doi.org/10.1016/b978-0-12-818638-1.00032-0openalex-snapshot
Saffron’s role in metabolic disorders
inferred← citeshttps://doi.org/10.1016/j.ajo.2018.03.007openalex-snapshot
Effects of Crocin on Diabetic Maculopathy: A Placebo-Controlled Randomized Clinical Trial
inferred← citeshttps://doi.org/10.1016/j.aninu.2023.06.002openalex-snapshot
Multi-omics reveals the mechanisms underlying Lactiplantibacillus plantarum P8-mediated attenuation of oxidative stress in broilers challenged with dexamethasone
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115544openalex-snapshot
Natural compounds efficacy in complicated diabetes: A new twist impacting ferroptosis
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116230openalex-snapshot
Natural compounds efficacy in Ophthalmic Diseases: A new twist impacting ferroptosis
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2019.05.023openalex-snapshot
Crocin attenuation of neurological deficits in a mouse model of intracerebral hemorrhage
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2026.112128openalex-snapshot
PI3K/AKT signaling contributes to prenatal nicotine exposure-induced developmental impairment of the pontomedullary respiratory network in neonatal rats
inferred← citeshttps://doi.org/10.1016/j.clnesp.2022.01.022openalex-snapshot
The potential role of saffron (Crocus Sativus L.) and its components in oxidative stress in diabetes mellitus: A systematic review
inferred← citeshttps://doi.org/10.1016/j.dsx.2021.102365openalex-snapshot
The mechanisms of saffron (Crocus sativus') on the inflammatory pathways of diabetes mellitus: A systematic review
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114829openalex-snapshot
Redox signaling in diabetic retinopathy and opportunity for therapeutic intervention through natural products
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174014openalex-snapshot
Lactucaxanthin protects retinal pigment epithelium from hyperglycemia-regulated hypoxia/ER stress/VEGF pathway mediated angiogenesis in ARPE-19 cell and rat model
inferred← citeshttps://doi.org/10.1016/j.exer.2026.111124openalex-snapshot
Bridging the gap: Integrating oxidative stress profiling with retinal imaging for precision management of diabetic retinopathy
inferred← citeshttps://doi.org/10.1016/j.exger.2022.111756openalex-snapshot
Improvement of inflammatory status following saffron (Crocus sativus L.) and resistance training in elderly hypertensive men: A randomized controlled trial
inferred← citeshttps://doi.org/10.1016/j.fct.2017.07.007openalex-snapshot
Protective effect of crocin on BPA-induced liver toxicity in rats through inhibition of oxidative stress and downregulation of MAPK and MAPKAP signaling pathway and miRNA-122 expression
inferred← citeshttps://doi.org/10.1016/j.fct.2020.111521openalex-snapshot
Crocin: A fighter against inflammation and pain
inferred← citeshttps://doi.org/10.1016/j.fct.2020.111803openalex-snapshot
Curcumin anti-diabetic effect mainly correlates with its anti-apoptotic actions and PI3K/Akt signal pathway regulation in the liver
inferred← citeshttps://doi.org/10.1016/j.gene.2025.149599openalex-snapshot
MiR-29a-5p engages in the mechanism of diabetic retinopathy by specifically targeting SIRT3
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e28837openalex-snapshot
Modulating effects of crocin on lipids and lipoproteins: Mechanisms and potential benefits
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.10.198openalex-snapshot
Identification of tear-based protein and non-protein biomarkers: Its application in diagnosis of human diseases using biosensors
inferred← citeshttps://doi.org/10.1016/j.intimp.2019.105865openalex-snapshot
Crocin inhibits titanium particle-induced inflammation and promotes osteogenesis by regulating macrophage polarization
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108238openalex-snapshot
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.02.043openalex-snapshot
Mucoadhesive liposomal delivery system synergizing anti-inflammation and anti-oxidation for enhanced treatment against dry eye disease
inferred← citeshttps://doi.org/10.1016/j.jff.2024.106396openalex-snapshot
What are the effects of crocin supplementation on lipid profile and oxidative stress in patients with type 2 diabetes? A randomized clinical trial
inferred← citeshttps://doi.org/10.1016/j.jff.2024.106507openalex-snapshot
The beneficial effects of crocin supplementation on metabolic and genetic parameters in type 2 diabetic patients under metformin treatment: A randomized double-blind controlled clinical trial
inferred← citeshttps://doi.org/10.1016/j.mad.2022.111686openalex-snapshot
Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy
inferred← citeshttps://doi.org/10.1016/j.metop.2025.100397openalex-snapshot
The role of AMPK signaling pathway in the pathogenesis of type 2 diabetes mellitus with its complications and related metabolic disorders
inferred← citeshttps://doi.org/10.1016/j.micpath.2020.104530openalex-snapshot
Cl-amidine attenuates lipopolysaccharide-induced mouse mastitis by inhibiting NF-κB, MAPK, NLRP3 signaling pathway and neutrophils extracellular traps release
inferred← citeshttps://doi.org/10.1016/j.msard.2024.105454openalex-snapshot
Effects of crocin on inflammatory biomarkers and mental health status in patients with multiple sclerosis: A randomized, double-blinded clinical trial
inferred← citeshttps://doi.org/10.1016/j.ncrna.2024.01.005openalex-snapshot
Crosstalk between MiRNAs/lncRNAs and PI3K/AKT signaling pathway in diabetes mellitus: Mechanistic and therapeutic perspectives
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.104966openalex-snapshot
Lycopene in protection against obesity and diabetes: A mechanistic review
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106292openalex-snapshot
Redoxisome and diabetic retinopathy: Pathophysiology and therapeutic interventions
inferred← citeshttps://doi.org/10.1016/j.rvsc.2022.11.009openalex-snapshot
Forsythin inhibits β-hydroxybutyrate-induced oxidative stress in bovine macrophages by regulating p38/ERK, PI3K/Akt, and Nrf2/HO-1 signaling pathways
inferred← citeshttps://doi.org/10.1016/j.tice.2024.102675openalex-snapshot
Crocin facilitates osteogenesis and angiogenesis by moderating oxidative stress and ferroptosis via Nrf2/GPX4 pathway
inferred← citeshttps://doi.org/10.1016/j.tice.2025.103133openalex-snapshot
Investigation of the effects of resveratrol, lutein, and crocetin on ARPE-19 cells induced with oxidative damage by H2O2
inferred← citeshttps://doi.org/10.1017/s0952523821000031openalex-snapshot
Retinal microglia polarization in diabetic retinopathy
inferred← citeshttps://doi.org/10.1038/s41420-023-01717-2openalex-snapshot
Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy
inferred← citeshttps://doi.org/10.1038/s41433-024-03371-zopenalex-snapshot
Ferroptosis in eye diseases: a systematic review
inferred← citeshttps://doi.org/10.1039/d0ra00343copenalex-snapshot
Identification of key lipid metabolites during metabolic dysregulation in the diabetic retinopathy disease mouse model and efficacy of Keluoxin capsule using an UHPLC-MS-based non-targeted lipidomics approach
inferred← citeshttps://doi.org/10.1042/bst20170121openalex-snapshot
The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders
inferred← citeshttps://doi.org/10.1080/01480545.2026.2624484openalex-snapshot
Protective potential of crocin against cadmium-induced oxidative pancreatitis and liver injury in female rats
inferred← citeshttps://doi.org/10.1080/08164622.2022.2039554openalex-snapshot
Crocin as a vision supplement
inferred← citeshttps://doi.org/10.1080/10408398.2022.2164557openalex-snapshot
The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials
inferred← citeshttps://doi.org/10.1080/15321819.2020.1726774openalex-snapshot
Biomarkers of inflammation and oxidative stress in ophthalmic disorders
inferred← citeshttps://doi.org/10.1080/15476286.2019.1637696openalex-snapshot
RETRACTED ARTICLE: Salidroside alleviates high-glucose-induced injury in retinal pigment epithelial cell line ARPE-19 by down-regulation of miR-138
inferred← citeshttps://doi.org/10.1080/17425247.2024.2431577openalex-snapshot
Advanced drug delivery strategies for diabetic retinopathy: current therapeutic advancement, and delivery methods overcoming barriers, and experimental modalities
inferred← citeshttps://doi.org/10.1080/17590914.2025.2603409openalex-snapshot
Crocetin as a Neuroprotective Agent: Targeting Western Diet-Induced Cognitive Dysfunction Through Antioxidant, Anti-Inflammatory and Gut-Brain Axis Modulation
inferred← citeshttps://doi.org/10.1093/nutrit/nuae121openalex-snapshot
Effect of Saffron (Crocus sativus) Supplementation on Oxidative Stress, Inflammatory Indices, and Renal and Liver Function Parameters in Patients With Type 2 Diabetes Mellitus: A GRADE-Assessed Systematic Review and Meta-analysis of Randomized Clinical Trials
inferred← citeshttps://doi.org/10.1111/joa.13722openalex-snapshot
Saffron and retinal neurodegenerative diseases: Relevance of chemical composition
inferred← citeshttps://doi.org/10.1111/nep.13683openalex-snapshot
Helix B surface peptide reduces sepsis‐induced kidney injury via PI3K/Akt pathway
inferred← citeshttps://doi.org/10.1155/2019/8458472openalex-snapshot
Perturbed Biochemical Pathways and Associated Oxidative Stress Lead to Vascular Dysfunctions in Diabetic Retinopathy
inferred← citeshttps://doi.org/10.1155/2021/6642600openalex-snapshot
Network Pharmacology-Based Approach to Comparatively Predict the Active Ingredients and Molecular Targets of Compound Xueshuantong Capsule and Hexuemingmu Tablet in the Treatment of Proliferative Diabetic Retinopathy
inferred← citeshttps://doi.org/10.1155/2022/5728408openalex-snapshot
Investigating the Mechanisms of Pollen Typhae in the Treatment of Diabetic Retinopathy Based on Network Pharmacology and Molecular Docking
inferred← citeshttps://doi.org/10.1155/2024/8300428openalex-snapshot
Herbal Products as Complementary or Alternative Medicine for the Management of Hyperglycemia and Dyslipidemia in Patients with Type 2 Diabetes: Current Evidence Based on Findings of Interventional Studies
inferred← citeshttps://doi.org/10.1155/2024/8520489openalex-snapshot
Advances in Research Related to MicroRNA for Diabetic Retinopathy
inferred← citeshttps://doi.org/10.1155/bmri/6654976openalex-snapshot
The Role of Diet and Oral Supplementation for the Management of Diabetic Retinopathy and Diabetic Macular Edema: A Narrative Review
inferred← citeshttps://doi.org/10.1166/jbt.2022.3201openalex-snapshot
miR-139 Protects Liver Tissue Damage and Oxidative Stress in Diabetic Mice by Up-Regulating (Silent Mating Type Information Regulation 2 Homolog-1) SIRT1
inferred← citeshttps://doi.org/10.1177/11786388221095223openalex-snapshot
A review of the anti-diabetic potential of saffron
inferred← citeshttps://doi.org/10.1186/s12944-018-0955-6openalex-snapshot
Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice
inferred← citeshttps://doi.org/10.1186/s12974-023-02740-xopenalex-snapshot
Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies
inferred← citeshttps://doi.org/10.18240/ijo.2020.10.05openalex-snapshot
Scutellarein alleviates the dysfunction of inner blood-retinal-barrier initiated by hyperglycemia-stimulated microglia cells
inferred← citeshttps://doi.org/10.18502/ajmb.v16i2.14858openalex-snapshot
The Protective Effect of Crocin on Rat Bone Marrow Mesenchymal Stem Cells Exposed to Aluminum Chloride as an Endocrine Disruptor
inferred← citeshttps://doi.org/10.19070/2332-2977-2000054openalex-snapshot
Crocin Ameliorated Atopic Dermatitis Induced in Mice by Inhibiting E-Cadherin/AKT Pathway
inferred← citeshttps://doi.org/10.2147/dmso.s244432openalex-snapshot
Integrated Datasets of Proteomic and Metabolomic Biomarkers to Predict Its Impacts on Comorbidities of Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.2147/dmso.s255783openalex-snapshot
The Therapeutic Role of Carotenoids in Diabetic Retinopathy: A Systematic Review
inferred← citeshttps://doi.org/10.2147/opth.s307009openalex-snapshot
Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence
inferred← citeshttps://doi.org/10.21516/2072-0076-2022-15-1-89-98openalex-snapshot
The impact of biologically active additive complexes “Doppelherz® active Vitamins for eyes with lutein” and “Doppelherz® active Vitamins for eyes with chromium, zinc and selenium” on the functional state of the eye in patients with chronic ischemic optic neuropathy
inferred← citeshttps://doi.org/10.2174/0113816128293824240517113238openalex-snapshot
Protective Effect and Related Mechanism of Modified Danggui Buxue Decoction on Retinal Oxidative Damage in Mice based on Network Pharmacology
inferred← citeshttps://doi.org/10.2174/1567202615666180319151244openalex-snapshot
Novel Treatment Strategies for the Nervous System: Circadian Clock Genes, Non-coding RNAs, and Forkhead Transcription Factors
inferred← citeshttps://doi.org/10.2174/1567202616666181128120003openalex-snapshot
Sirtuins: Developing Innovative Treatments for Aged-Related Memory Loss and Alzheimer’s Disease
inferred← citeshttps://doi.org/10.2174/1567202617999200327134835openalex-snapshot
Heightened Attention for Wnt Signaling in Diabetes Mellitus
inferred← citeshttps://doi.org/10.2174/1567202620666230721122957openalex-snapshot
The Metabolic Basis for Nervous System Dysfunction in Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease
inferred← citeshttps://doi.org/10.2174/1570159x18666200507083346openalex-snapshot
Pharmacological Effects of Saffron and its Constituents in Ocular Disorders from in vitro Studies to Clinical Trials: A Systematic Review
inferred← citeshttps://doi.org/10.21802/acm.2021.1.11openalex-snapshot
Age features of morphological changes of vessels of testicular hemomicrocirculatory flow in streptozotocin diabetes mellitus
inferred← citeshttps://doi.org/10.21856/j-pep.2021.4.13openalex-snapshot
EVIDENCE OF APOPTOSIS IN PARVOCELLULAR NUCLEI OF HYPOTHALAMUS IN DIABETES MELLITUS
inferred← citeshttps://doi.org/10.22038/ijbms.2022.51597.11708openalex-snapshot
Crocin protects the renal tubular epithelial cells against high glucose-induced injury and oxidative stress via regulation of the SIRT1/Nrf2 pathway.
inferred← citeshttps://doi.org/10.26641/1997-9665.2019.3.170-175openalex-snapshot
Morphological characteristics of the visual cortex in experimental diabetes mellitus.
inferred← citeshttps://doi.org/10.26641/1997-9665.2021.1.60-66openalex-snapshot
Age features of morphological changes of the hematotesticular barrier in experimental diabetes mellitus.
inferred← citeshttps://doi.org/10.30525/978-9934-26-260-9-23openalex-snapshot
MORPHOLOGICAL CHANGES OF RETINAL GANGLION NEURONS IN THE LONG TERM OF THE COURSE OF EXPERIMENTAL DIABETES IN CASE OF COMORBIDITIES
inferred← citeshttps://doi.org/10.3389/fendo.2022.945446openalex-snapshot
Protective effects of safranal on diabetic retinopathy in human microvascular endothelial cells and related pathways analyzed with transcriptome sequencing
inferred← citeshttps://doi.org/10.3389/fendo.2026.1772128openalex-snapshot
The hemoglobin-red blood cell distribution width ratio is a reliable predictor of recurrence of ketoacidosis in patients with type 2 diabetes
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1273570openalex-snapshot
The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1709354openalex-snapshot
Redefining cell death: ferroptosis as a game-changer in ophthalmology
inferred← citeshttps://doi.org/10.3389/fnins.2019.01089openalex-snapshot
Carbamazepine Alleviates Retinal and Optic Nerve Neural Degeneration in Diabetic Mice via Nerve Growth Factor-Induced PI3K/Akt/mTOR Activation
inferred← citeshttps://doi.org/10.3389/fnut.2022.844757openalex-snapshot
Molecular Mechanisms of Iron Mediated Programmed Cell Death and Its Roles in Eye Diseases
inferred← citeshttps://doi.org/10.3389/fnut.2023.1267839openalex-snapshot
Saffron extract interferes with lipopolysaccharide-induced brain activation of the kynurenine pathway and impairment of monoamine neurotransmission in mice
inferred← citeshttps://doi.org/10.3389/fnut.2025.1698135openalex-snapshot
Integrative effects of saffron and physical activity on endurance performance, quality of life, cognitive, emotional, and metabolic outcomes in age-related and neurodegenerative diseases
inferred← citeshttps://doi.org/10.3389/fphar.2022.903485openalex-snapshot
A Mechanistic Exploratory Study on the Therapeutic Efficacy of Astragaloside IV Against Diabetic Retinopathy Revealed by Network Pharmacology
inferred← citeshttps://doi.org/10.3389/fphar.2025.1658881openalex-snapshot
Integrating clinical evidence with natural product therapies for elderly-onset type 2 diabetes
inferred← citeshttps://doi.org/10.3389/fpubh.2023.1128008openalex-snapshot
Global trends and performances in diabetic retinopathy studies: A bibliometric analysis
inferred← citeshttps://doi.org/10.3390/antiox9060561openalex-snapshot
Update on the Effects of Antioxidants on Diabetic Retinopathy: In Vitro Experiments, Animal Studies and Clinical Trials
inferred← citeshttps://doi.org/10.3390/biom13050816openalex-snapshot
Cellular Metabolism: A Fundamental Component of Degeneration in the Nervous System
inferred← citeshttps://doi.org/10.3390/cells14181455openalex-snapshot
The Form and Function of Retinal Ganglion Cells in Diabetes
inferred← citeshttps://doi.org/10.3390/ijms20174110openalex-snapshot
Neuroprotective and Anti-Inflammatory Effects of a Hydrophilic Saffron Extract in a Model of Glaucoma
inferred← citeshttps://doi.org/10.3390/molecules26040849openalex-snapshot
Crosslinked Hyaluronic Acid with Liposomes and Crocin Confers Cytoprotection in an Experimental Model of Dry Eye
inferred← citeshttps://doi.org/10.3390/nu11040771openalex-snapshot
Nutraceuticals for the Treatment of Diabetic Retinopathy
inferred← citeshttps://doi.org/10.3390/nu14030597openalex-snapshot
Saffron (Crocus sativus L.): A Source of Nutrients for Health and for the Treatment of Neuropsychiatric and Age-Related Diseases
inferred← citeshttps://doi.org/10.3390/ph16010050openalex-snapshot
Advances in Anti-Diabetic Cognitive Dysfunction Effect of Erigeron Breviscapus (Vaniot) Hand-Mazz
inferred← citeshttps://doi.org/10.3390/pharmaceutics16070840openalex-snapshot
Functional Mechanisms of Dietary Crocin Protection in Cardiovascular Models under Oxidative Stress
inferred← citeshttps://doi.org/10.3390/sports10110167openalex-snapshot
Effect of 8 Weeks Aerobic Training and Saffron Supplementation on Inflammation and Metabolism in Middle-Aged Obese Women with Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.3762/bjoc.20.68openalex-snapshot
Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins
inferred← citeshttps://doi.org/10.3892/mmr.2019.10267openalex-snapshot
Crocin protects against dexamethasone‑induced osteoblast apoptosis by inhibiting the ROS/Ca2+‑mediated mitochondrial pathway
inferred← citeshttps://doi.org/10.4103/1673-5374.274325openalex-snapshot
Beneficial effects of saffron (Crocus sativus L.) in ocular pathologies, particularly neurodegenerative retinal diseases
inferred← citeshttps://doi.org/10.4103/abr.abr_51_22openalex-snapshot
Effects of Aqueous Saffron Extract on Glucoregulation as Well as Hepatic Agt and TNF-α Gene Expression in Rats Subjected to Sub-Chronic Stress
inferred← citeshttps://doi.org/10.5582/bst.2018.01240openalex-snapshot
Crocin inhibits obesity via AMPK-dependent inhibition of adipocyte differentiation and promotion of lipolysis
inferred← citeshttps://doi.org/10.5812/jjcmb-165145openalex-snapshot
Crocin and Multiple Sclerosis: Exploring the Therapeutic Potential of Saffron's Bioactive Compound; A Literature Review
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