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Intervertebral disc swelling maintains strain homeostasis throughout the annulus fibrosus: A finite element analysis of healthy and degenerated discs

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jor.21232openalex-snapshot
Human intervertebral disc internal strain in compression: The effect of disc region, loading position, and degeneration
inferredcites →https://doi.org/10.1002/jor.23311openalex-snapshot
T1ρ and T2‐based characterization of regional variations in intervertebral discs to detect early degenerative changes
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Permeability of solutes through hydrated polymer membranes. Part I. Diffusion of sodium chloride
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Residual Stress in Arteries
inferredcites →https://doi.org/10.1007/bf02584301openalex-snapshot
What are the residual stresses doing in our blood vessels?
inferredcites →https://doi.org/10.1007/s00586-006-0112-1openalex-snapshot
Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure
inferredcites →https://doi.org/10.1007/s00586-015-3917-yopenalex-snapshot
Disc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?
inferredcites →https://doi.org/10.1007/s00586-016-4416-5openalex-snapshot
A new dynamic six degrees of freedom disc-loading simulator allows to provoke disc damage and herniation
inferredcites →https://doi.org/10.1007/s00586-016-4704-0openalex-snapshot
Analysis of the impact of the course of hydration on the mechanical properties of the annulus fibrosus of the intervertebral disc
inferredcites →https://doi.org/10.1007/s10237-004-0043-xopenalex-snapshot
On the significance of fiber branching in the human myocardium
inferredcites →https://doi.org/10.1007/s10237-004-0053-8openalex-snapshot
Single lamellar mechanics of the human lumbar anulus fibrosus
inferredcites →https://doi.org/10.1007/s10237-017-0934-2openalex-snapshot
Effect of collagen fibre orientation on intervertebral disc torsion mechanics
inferredcites →https://doi.org/10.1007/s10237-018-1105-9openalex-snapshot
GAG content, fiber stiffness, and fiber angle affect swelling-based residual stress in the intact annulus fibrosus
inferredcites →https://doi.org/10.1007/s10439-007-9407-6openalex-snapshot
Hydrostatic Pressure Differentially Regulates Outer and Inner Annulus Fibrosus Cell Matrix Production in 3D Scaffolds
inferredcites →https://doi.org/10.1007/s10439-009-9792-0openalex-snapshot
A Conductivity Approach to Measuring Fixed Charge Density in Intervertebral Disc Tissue
inferredcites →https://doi.org/10.1016/0020-7101(87)90031-6openalex-snapshot
Frontiers in biomechanics
inferredcites →https://doi.org/10.1016/0304-4165(79)90415-xopenalex-snapshot
The measurement of fixed charged density in the intervertebral disc
inferredcites →https://doi.org/10.1016/b978-0-08-030145-7.50078-7openalex-snapshot
ESTIMATION OF RESIDUAL STRAINS IN AORTIC SEGMENTS
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Biomedical Engineering II
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Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: Biomimetic glycosaminoglycan analogues
inferredcites →https://doi.org/10.1016/j.actbio.2018.01.050openalex-snapshot
Towards the scale up of tissue engineered intervertebral discs for clinical application
inferredcites →https://doi.org/10.1016/j.actbio.2019.05.021openalex-snapshot
Synchrotron tomography of intervertebral disc deformation quantified by digital volume correlation reveals microstructural influence on strain patterns
inferredcites →https://doi.org/10.1016/j.bpj.2009.08.058openalex-snapshot
A Biomechanical Triphasic Approach to the Transport of Nondilute Solutions in Articular Cartilage
inferredcites →https://doi.org/10.1016/j.clinbiomech.2007.07.008openalex-snapshot
The risk of disc prolapses with complex loading in different degrees of disc degeneration – A finite element analysis
inferredcites →https://doi.org/10.1016/j.jbiomech.2005.07.026openalex-snapshot
Analysis of the influence of disc degeneration on the mechanical behaviour of a lumbar motion segment using the finite element method
inferredcites →https://doi.org/10.1016/j.jbiomech.2006.10.001openalex-snapshot
Three-dimensional inhomogeneous triphasic finite-element analysis of physical signals and solute transport in human intervertebral disc under axial compression
inferredcites →https://doi.org/10.1016/j.jbiomech.2006.11.006openalex-snapshot
Direct measurement of intervertebral disc maximum shear strain in six degrees of freedom: Motions that place disc tissue at risk of injury
inferredcites →https://doi.org/10.1016/j.jbiomech.2011.11.018openalex-snapshot
Osmotic swelling and residual stress in cardiovascular tissues
inferredcites →https://doi.org/10.1016/j.jbiomech.2012.01.042openalex-snapshot
Large residual strains are present in the intervertebral disc annulus fibrosus in the unloaded state
inferredcites →https://doi.org/10.1016/j.jbiomech.2013.12.021openalex-snapshot
Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering
inferredcites →https://doi.org/10.1016/j.jbiomech.2014.04.002openalex-snapshot
Comparison of eight published static finite element models of the intact lumbar spine: Predictive power of models improves when combined together
inferredcites →https://doi.org/10.1016/j.jbiomech.2014.04.014openalex-snapshot
Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration
inferredcites →https://doi.org/10.1016/j.jbiomech.2014.06.008openalex-snapshot
Validation and application of an intervertebral disc finite element model utilizing independently constructed tissue-level constitutive formulations that are nonlinear, anisotropic, and time-dependent
inferredcites →https://doi.org/10.1016/j.jmbbm.2017.02.010openalex-snapshot
Residual strains in the intervertebral disc annulus fibrosus suggest complex tissue remodeling in response to in-vivo loading
inferredcites →https://doi.org/10.1016/j.jmbbm.2018.03.039openalex-snapshot
Swelling of fiber-reinforced soft tissues is affected by fiber orientation, fiber stiffness, and lamella structure
inferredcites →https://doi.org/10.1016/j.orthres.2004.04.004openalex-snapshot
Anabolic and catabolic mRNA levels of the intervertebral disc vary with the magnitude and frequency of in vivo dynamic compression
inferredcites →https://doi.org/10.1016/j.spinee.2017.08.261openalex-snapshot
From the international space station to the clinic: how prolonged unloading may disrupt lumbar spine stability
inferredcites →https://doi.org/10.1016/s0003-9993(96)90071-4openalex-snapshot
Changes in spine height throughout 32 hours of bedrest
inferredcites →https://doi.org/10.1016/s0021-9258(18)76611-8openalex-snapshot
THE OSMOTIC COEFFICIENT OF SODIUM IN SODIUM HEMOGLOBINATE AND OF SODIUM CHLORIDE IN HEMOGLOBIN SOLUTION
inferredcites →https://doi.org/10.1016/s0021-9290(02)00444-xopenalex-snapshot
Residual strains in conduit arteries
inferredcites →https://doi.org/10.1016/s0268-0033(01)00042-0openalex-snapshot
Replacing the nucleus pulposus of the intervertebral disc
inferredcites →https://doi.org/10.1038/s41598-017-15887-4openalex-snapshot
In Vitro Maturation and In Vivo Integration and Function of an Engineered Cell-Seeded Disc-like Angle Ply Structure (DAPS) for Total Disc Arthroplasty
inferredcites →https://doi.org/10.1080/00140130210127639openalex-snapshot
Effects of posture on dynamic back loading during a cable lifting task
inferredcites →https://doi.org/10.1089/biores.2015.0034openalex-snapshot
Tissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation
inferredcites →https://doi.org/10.1097/00007632-198802000-00009openalex-snapshot
Swelling Pressure of the Lumbar Intervertebral Discs
inferredcites →https://doi.org/10.1097/00007632-198902000-00005openalex-snapshot
Biochemical and Structural Properties of the Cartilage End-Plate and its Relation to the Intervertebral Disc
inferredcites →https://doi.org/10.1097/00007632-199005000-00012openalex-snapshot
Preliminary Evaluation of a Scheme for Grading the Gross Morphology of the Human Intervertebral Disc
inferredcites →https://doi.org/10.1097/00007632-199406000-00002openalex-snapshot
Regional Variation in Tensile Properties and Biochemical Composition of the Human Lumbar Anulus Fibrosus
inferredcites →https://doi.org/10.1097/00007632-199901010-00011openalex-snapshot
Differentiating Lumbar Disc Protrusions, Disc Bulges, and Discs With Normal Contour but Abnormal Signal Intensity
inferredcites →https://doi.org/10.1097/00007632-199904150-00005openalex-snapshot
New In Vivo Measurements of Pressures in the Intervertebral Disc in Daily Life
inferredcites →https://doi.org/10.1097/00007632-199912010-00008openalex-snapshot
In Vivo Intradiscal Pressure Measurement in Healthy Individuals and in Patients With Ongoing Back Problems
inferredcites →https://doi.org/10.1097/00007632-200109010-00011openalex-snapshot
Magnetic Resonance Classification of Lumbar Intervertebral Disc Degeneration
inferredcites →https://doi.org/10.1097/01.brs.0000217708.54880.51openalex-snapshot
Assessment of Human Disc Degeneration and Proteoglycan Content Using T1ρ-weighted Magnetic Resonance Imaging
inferredcites →https://doi.org/10.1097/01.brs.0000231761.73859.2copenalex-snapshot
What is Intervertebral Disc Degeneration, and What Causes It?
inferredcites →https://doi.org/10.1097/01.brs.0000253961.40910.c1openalex-snapshot
Comparison of Animals Used in Disc Research to Human Lumbar Disc Geometry
inferredcites →https://doi.org/10.1097/brs.0000000000000560openalex-snapshot
Simulation of the Progression of Intervertebral Disc Degeneration Due to Decreased Nutritional Supply
inferredcites →https://doi.org/10.1097/brs.0000000000001699openalex-snapshot
Influence of Complex Loading Conditions on Intervertebral Disc Failure
inferredcites →https://doi.org/10.1097/brs.0000000000001873openalex-snapshot
Lumbar Spine Paraspinal Muscle and Intervertebral Disc Height Changes in Astronauts After Long-Duration Spaceflight on the International Space Station
inferredcites →https://doi.org/10.1097/brs.0000000000002061openalex-snapshot
Quantifying Baseline Fixed Charge Density in Healthy Human Cartilage Endplate
inferredcites →https://doi.org/10.1097/brs.0b013e31815b75fbopenalex-snapshot
Human Internal Disc Strains in Axial Compression Measured Noninvasively Using Magnetic Resonance Imaging
inferredcites →https://doi.org/10.1098/rsos.170807openalex-snapshot
Annulus fibrosus functional extrafibrillar and fibrous mechanical behaviour: experimental and computational characterisation
inferredcites →https://doi.org/10.1109/51.677166openalex-snapshot
The biomechanics of back pain
inferredcites →https://doi.org/10.1111/j.1469-7580.2009.01197.xopenalex-snapshot
How age influences unravelling morphology of annular lamellae – a study of interfibre cohesivity in the lumbar disc
inferredcites →https://doi.org/10.1115/1.2894880openalex-snapshot
A Triphasic Theory for the Swelling and Deformation Behaviors of Articular Cartilage
inferredcites →https://doi.org/10.1115/1.3212104openalex-snapshot
Theoretical and Uniaxial Experimental Evaluation of Human Annulus Fibrosus Degeneration
inferredcites →https://doi.org/10.1115/1.4005694openalex-snapshot
FEBio: Finite Elements for Biomechanics
inferredcites →https://doi.org/10.1115/1.4031416openalex-snapshot
Effect of Hydration on Healthy Intervertebral Disk Mechanical Stiffness
inferredcites →https://doi.org/10.1115/1.4043029openalex-snapshot
Relative Nucleus Pulposus Area and Position Alter Disk Joint Mechanics
inferredcites →https://doi.org/10.1136/aim.22.4.178openalex-snapshot
Biomechanics of Back Pain
inferredcites →https://doi.org/10.1152/ajpheart.00402.2007openalex-snapshot
Effect of osmolarity on the zero-stress state and mechanical properties of aorta
inferredcites →https://doi.org/10.1152/ajpheart.01027.2007openalex-snapshot
Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta
inferredcites →https://doi.org/10.1172/jci118884openalex-snapshot
The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.
inferredcites →https://doi.org/10.1177/0006355x2004041003004007openalex-snapshot
Role of cell‐associated matrix in the development of free‐swelling and dynamically loaded chondrocyte‐seeded agarose gels
inferredcites →https://doi.org/10.1177/1947603518775795openalex-snapshot
Differential Response of Bovine Mature Nucleus Pulposus and Notochordal Cells to Hydrostatic Pressure and Glucose Restriction
inferredcites →https://doi.org/10.2106/jbjs.g.00667openalex-snapshot
Noninvasive Quantification of Human Nucleus Pulposus Pressure with Use of T1ρ-Weighted Magnetic Resonance Imaging
inferredcites →https://doi.org/10.3109/03008208909103905openalex-snapshot
Hierarchical Structure of the Intervertebral Disc
inferredcites →https://doi.org/10.3109/07420528409059129openalex-snapshot
Orcadian Variation in Human Stature

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4638786openalex-extracted
Impact of Cartilaginous Endplate Degeneration on Quasi-Static Biomechanical Characteristics of Intervertebral Discs in Finite Element Models
inferred← citeshttps://doi.org/10.2139/ssrn.4789192openalex-extracted
Finite Element Model Reveals the Involvement of Cartilage Endplate in Quasi-Static Biomechanics of Intervertebral Disc Degeneration
inferred← citeshttps://doi.org/10.1002/jbm.b.35532openalex-snapshot
Application of Self‐Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration
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Direct Quantification of Intervertebral Disc Water Content Using MRI
inferred← citeshttps://doi.org/10.1002/jor.25596openalex-snapshot
Moderate mechanical stimulation antagonizes inflammation of annulus fibrosus cells through YAP‐mediated suppression of NF‐κB signaling
inferred← citeshttps://doi.org/10.1002/jor.25788openalex-snapshot
Geometric determinants of the mechanical behavior of image‐based finite element models of the intervertebral disc
inferred← citeshttps://doi.org/10.1002/jsp2.1138openalex-snapshot
Spine biomechanical testing methodologies: The controversy of consensus vs scientific evidence
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Multiaxial validation of a finite element model of the intervertebral disc with multigenerational fibers to establish residual strain
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Flexible support material maintains disc height and supports the formation of hydrated tissue engineered intervertebral discs in vivo
inferred← citeshttps://doi.org/10.1002/jsp2.70000openalex-snapshot
Neural network segmentation of disc volume from magnetic resonance images and the effect of degeneration and spinal level
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Vertebral Growth Modulation Through Periosteal Resection and Fixed Length Deformity Overcorrection: Computational and In Vivo Pilot Study
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Detection of lumbar disc herniation and degeneration using photon-counting detector CT with virtual non-calcium imaging
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Multiscale composite model of fiber-reinforced tissues with direct representation of sub-tissue properties
inferred← citeshttps://doi.org/10.1007/s40964-026-01841-2openalex-snapshot
First insights into 3D-printing of biomimetic TPU-made annulus fibrosus with a hydrogel nucleus pulposus: Does fiber orientation matter?
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The growth modulating effects of tether tension on vertebral growth are biphasic: a study of posterior vertebral body tethering (pVBT) in a novel kyphotic porcine model
inferred← citeshttps://doi.org/10.1007/s43390-025-01247-0openalex-snapshot
Physeal effects of posterior VBT are not uniform throughout a multi-tether construct in the kyphotic swine model
inferred← citeshttps://doi.org/10.1016/j.actbio.2021.09.017openalex-snapshot
Modeling multiaxial damage regional variation in human annulus fibrosus
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Regional variations in discrete collagen fibre mechanics within intact intervertebral disc resolved using synchrotron computed tomography and digital volume correlation
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Comprehensive modeling of annulus fibrosus: From biphasic refined characterization to damage accumulation under viscous loading
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A data-driven microstructure-based model for predicting circumferential behavior and failure in degenerated human annulus fibrosus
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A multiscale finite element model of fluid-microstructure interactions in human intervertebral disc compression
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A multiscale and multiaxial model for anisotropic damage and failure of human annulus fibrosus
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Research on the role and mechanism of IL-17 in intervertebral disc degeneration
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Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases
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Saline-polyethylene glycol blends preserve in vitro annulus fibrosus hydration and mechanics: An experimental and finite-element analysis
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inferred← citeshttps://doi.org/10.1016/j.jmbbm.2026.107555openalex-snapshot
Distinct stress-relaxation behaviour of the interlamellar matrix and transition zone in the intervertebral disc
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Tenomodulin and Chondromodulin-1 Are Both Required to Maintain Biomechanical Function and Prevent Intervertebral Disc Degeneration
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Electroacupuncture attenuates intervertebral disc degeneration by upregulating aquaporins via the cAMP/PKA pathway
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Electroacupuncture attenuates degeneration by upregulating of aquaporins via the cAMP/PKA pathway in a rabbit model of disc degeneration
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Finite element model reveals the involvement of cartilage endplate in quasi-static biomechanics of intervertebral disc degeneration
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A method for measuring intra-tissue swelling pressure using a needle micro-osmometer
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Diurnal Variation in Hydration of the Cervical Intervertebral Disc Assessed Using T2 Mapping of Magnetic Resonance Imaging
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Microgravity and Radiation Effects on Astronaut Intervertebral Disc Health
inferred← citeshttps://doi.org/10.3389/fbioe.2021.660013openalex-snapshot
Sensitivity of Intervertebral Disc Finite Element Models to Internal Geometric and Non-geometric Parameters
inferred← citeshttps://doi.org/10.3389/fbioe.2021.685799openalex-snapshot
A Robust Multiscale and Multiphasic Structure-Based Modeling Framework for the Intervertebral Disc
inferred← citeshttps://doi.org/10.3389/fbioe.2022.1034441openalex-snapshot
A novel approach for tetrahedral-element-based finite element simulations of anisotropic hyperelastic intervertebral disc behavior
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1355503openalex-snapshot
From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration
inferred← citeshttps://doi.org/10.3389/fmed.2026.1889003openalex-snapshot
Quantitative study on water and glycosaminoglycan contents based on T2 relaxation time of intervertebral disks
inferred← citeshttps://doi.org/10.3390/bioengineering13030312openalex-snapshot
Degeneration-Driven and Load-Modulated Fluid-Driven Viscoelasticity of the Human Intervertebral Disc: A Probabilistic Biphasic Swelling Modeling Study
inferred← citeshttps://doi.org/10.3390/biom14040393openalex-snapshot
Stress-Activated Protein Kinases in Intervertebral Disc Degeneration: Unraveling the Impact of JNK and p38 MAPK
inferred← citeshttps://doi.org/10.3390/gels10090571openalex-snapshot
Papain Injection Creates a Nucleotomy-like Cavity for Testing Gels in Intervertebral Discs
inferred← citeshttps://doi.org/10.3390/ijms27104249openalex-snapshot
Wogonin Ameliorates the Oxidative Stress, Apoptosis, and Extracellular Matrix Degradation of Nucleus Pulposus Cells Mediated by Cutibacterium acnes via the MAPK Signaling Pathway: An In Vivo and In Vitro Study
inferred← citeshttps://doi.org/10.3390/ma15196684openalex-snapshot
Development of a Computational Model of the Mechanical Behavior of the L4–L5 Lumbar Spine: Application to Disc Degeneration
inferred← citeshttps://doi.org/10.4067/s0717-95022022000300824openalex-snapshot
Study of Nonlinear Viscoelastic Mechanical Properties of Degenerated Intervertebral Discs
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