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Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

https://doi.org/10.1016/j.bbcan.2019.01.005

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The P2 receptor antagonist PPADS abrogates LPS-induced neutrophil migration in the murine air pouch via inhibition of MIP-2 and KC production

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GEF-H1-RhoA signaling pathway mediates LPS-induced NF-κB transactivation and IL-8 synthesis in endothelial cells

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IL-8 signaling is up-regulated in alcoholic hepatitis and DDC fed mice with Mallory Denk Bodies (MDBs) present

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CXC chemokine KC fails to induce neutrophil infiltration and neoangiogenesis in a mouse model of myocardial infarction

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Tumor Angiogenesis Induced by Granulocyte Chemotactic Protein-2 as a Countercurrent Principle

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Fully Humanized Neutralizing Antibodies to Interleukin-8 (ABX-IL8) Inhibit Angiogenesis, Tumor Growth, and Metastasis of Human Melanoma

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Chemokines IL-8, GROα, MCP-1, IP-10, and Mig Are Sequentially and Differentially Expressed During Phase-Specific Infiltration of Leukocyte Subsets in Human Wound Healing

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Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4.

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Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity.

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Regulation of the Immune Response by the Interaction of Chemokines and Proteases

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Target validation of G-protein coupled receptors

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Neutrophil Sequestration in Liver and Lung is Differentially Regulated by C-X-C Chemokines During Experimental Peritonitis

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CXCL7 is a predictive marker of sunitinib efficacy in clear cell renal cell carcinomas

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CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to multiple sclerosis

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Coordinated regulation of myeloid cells by tumours

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Breast tumor-associated osteoblast-derived CXCL5 increases cancer progression by ERK/MSK1/Elk-1/Snail signaling pathway

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Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling

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CXCL2/MIF-CXCR2 signaling promotes the recruitment of myeloid-derived suppressor cells and is correlated with prognosis in bladder cancer

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CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome

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Production and upregulation of granulocyte chemotactic protein-2/CXCL6 by IL-1β and hypoxia in small cell lung cancer

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KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway

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HIF-1 and NF-κB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells

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Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway

inferredcites →https://doi.org/10.1038/srep31695openalex-snapshot

Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKβ pathway and up-regulation of negative MKP-1 pathway

inferredcites →https://doi.org/10.1042/cs0820273openalex-snapshot

Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis

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Delayed Wound Healing in CXCR2 Knockout Mice

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Impaired healing of nitrogen mustard wounds in CXCR2 null mice

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Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel

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NFATc3 Regulates Trypsinogen Activation, Neutrophil Recruitment, and Tissue Damage in Acute Pancreatitis in Mice

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Reynosin fromSassurea lappaas Inhibitor on CINC-1 Induction in LPS-Stimulated NRK-52E Cells

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The Acute Respiratory Distress Syndrome

inferredcites →https://doi.org/10.1056/nejm200005043421801openalex-snapshot

Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome

inferredcites →https://doi.org/10.1056/nejm200005043421806openalex-snapshot

The Acute Respiratory Distress Syndrome

inferredcites →https://doi.org/10.1067/mai.2003.1594openalex-snapshot

Chemokines: Roles in leukocyte development, trafficking, and effector function

inferredcites →https://doi.org/10.1073/pnas.0605752103openalex-snapshot

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

inferredcites →https://doi.org/10.1073/pnas.0900196106openalex-snapshot

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

inferredcites →https://doi.org/10.1073/pnas.84.24.9233openalex-snapshot

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

inferredcites →https://doi.org/10.1073/pnas.87.19.7732openalex-snapshot

Identification of three related human GRO genes encoding cytokine functions.

inferredcites →https://doi.org/10.1073/pnas.90.8.3574openalex-snapshot

Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg.

inferredcites →https://doi.org/10.1073/pnas.93.13.6682openalex-snapshot

Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2.

inferredcites →https://doi.org/10.1073/pnas.94.7.3052openalex-snapshot

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

inferredcites →https://doi.org/10.1074/jbc.270.45.27348openalex-snapshot

The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis

inferredcites →https://doi.org/10.1074/jbc.271.34.20545openalex-snapshot

The CXC Chemokines Growth-regulated Oncogene (GRO) α, GROβ, GROγ, Neutrophil-activating Peptide-2, and Epithelial Cell-derived Neutrophil-activating Peptide-78 Are Potent Agonists for the Type B, but Not the Type A, Human Interleukin-8 Receptor

inferredcites →https://doi.org/10.1074/jbc.272.13.8207openalex-snapshot

Ligand-induced Desensitization of the Human CXC Chemokine Receptor-2 Is Modulated by Multiple Serine Residues in the Carboxyl-terminal Domain of the Receptor

inferredcites →https://doi.org/10.1074/jbc.273.17.10690openalex-snapshot

Multiple Signaling Pathways of Human Interleukin-8 Receptor A

inferredcites →https://doi.org/10.1074/jbc.m006115200openalex-snapshot

Nuclear Factor-κB Activation by the CXC Chemokine Melanoma Growth-stimulatory Activity/Growth-regulated Protein Involves the MEKK1/p38 Mitogen-activated Protein Kinase Pathway

inferredcites →https://doi.org/10.1074/jbc.m113.502641openalex-snapshot

Proteasome Inhibition Increases Recruitment of IκB Kinase β (IKKβ), S536P-p65, and Transcription Factor EGR1 to Interleukin-8 (IL-8) Promoter, Resulting in Increased IL-8 Production in Ovarian Cancer Cells

inferredcites →https://doi.org/10.1074/jbc.m800945200openalex-snapshot

NF-κB-dependent Transcriptional Activation in Lung Carcinoma Cells by Farnesol Involves p65/RelA(Ser276) Phosphorylation via the MEK-MSK1 Signaling Pathway

inferredcites →https://doi.org/10.1074/jbc.m805611200openalex-snapshot

Parallel Phosphatidylinositol 3-Kinase (PI3K)-dependent and Src-dependent Pathways Lead to CXCL8-mediated Rac2 Activation and Chemotaxis

inferredcites →https://doi.org/10.1080/019021490951504openalex-snapshot

AMORPHOUS SILICA PARTICLES PROMOTE INFLAMMATORY GENE EXPRESSION THROUGH THE REDOX SENSITIVE TRANSCRIPTION FACTOR, AP-1, IN ALVEOLAR EPITHELIAL CELLS

inferredcites →https://doi.org/10.1080/08923973.2017.1327964openalex-snapshot

Mitigation of inflammation using the intravenous anesthetic dexmedetomidine in the mouse air pouch model

inferredcites →https://doi.org/10.1080/19382014.2016.1199303openalex-snapshot

Reparixin, a CXCR1/2 inhibitor in islet allotransplantation

inferredcites →https://doi.org/10.1080/2162402x.2015.1100788openalex-snapshot

Immunological correlates of treatment and response in stage IV malignant melanoma patients treated with Ipilimumab

inferredcites →https://doi.org/10.1080/2162402x.2018.1442167openalex-snapshot

Metformin blocks myeloid-derived suppressor cell accumulation through AMPK-DACH1-CXCL1 axis

inferredcites →https://doi.org/10.1084/jem.167.5.1547openalex-snapshot

A novel neutrophil-activating factor produced by human mononuclear phagocytes.

inferredcites →https://doi.org/10.1084/jem.169.3.1185openalex-snapshot

Identification and characterization of specific receptors for monocyte-derived neutrophil chemotactic factor (MDNCF) on human neutrophils.

inferredcites →https://doi.org/10.1084/jem.171.2.449openalex-snapshot

Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases.

inferredcites →https://doi.org/10.1086/315682openalex-snapshot

Role of Nitric Oxide in the Failure of Neutrophil Migration in Sepsis

inferredcites →https://doi.org/10.1086/315750openalex-snapshot

Expression of the Chemokine Receptors CXCR1 and CXCR2 on Granulocytes in Human Endotoxemia and Tuberculosis: Involvement of the p38 Mitogen–Activated Protein Kinase Pathway

inferredcites →https://doi.org/10.1089/10799900260442557openalex-snapshot

Elevated Serum Levels of Interleukin-8 in Advanced Non-Small Cell Lung Cancer Patients: Relationship with Prognosis

inferredcites →https://doi.org/10.1089/ars.2011.4487openalex-snapshot

Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction

inferredcites →https://doi.org/10.1089/jir.2018.0070openalex-snapshot

Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway

inferredcites →https://doi.org/10.1089/scd.2014.0381openalex-snapshot

CXCR2 and Its Related Ligands Play a Novel Role in Supporting the Pluripotency and Proliferation of Human Pluripotent Stem Cells

inferredcites →https://doi.org/10.1091/mbc.e07-01-0004openalex-snapshot

Transactivation of Vascular Endothelial Growth Factor Receptor-2 by Interleukin-8 (IL-8/CXCL8) Is Required for IL-8/CXCL8-induced Endothelial Permeability

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Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFκB

inferredcites →https://doi.org/10.1093/carcin/bgs123openalex-snapshot

Tumor-associated neutrophils: friend or foe?

inferredcites →https://doi.org/10.1093/carcin/bgs299openalex-snapshot

CXCL1/GROα increases cell migration and invasion of prostate cancer by decreasing fibulin-1 expression through NF-κB/HDAC1 epigenetic regulation

inferredcites →https://doi.org/10.1093/carcin/bgs312openalex-snapshot

Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

inferredcites →https://doi.org/10.1093/carcin/bgv086openalex-snapshot

Identification of a common variant with potential pleiotropic effect on risk of inflammatory bowel disease and colorectal cancer

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CXCL1–CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration

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Negative regulation of DSS-induced experimental colitis by PILRα

inferredcites →https://doi.org/10.1093/molehr/gax041openalex-snapshot

A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes

inferredcites →https://doi.org/10.1096/fj.06-7301comopenalex-snapshot

Enhanced CXCL1 production and angiogenesis in adenosine‐mediated lung disease

inferredcites →https://doi.org/10.1097/00008390-199506000-00006openalex-snapshot

Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load

inferredcites →https://doi.org/10.1097/00008390-200512000-00006openalex-snapshot

Decline in angiogenic factors, such as interleukin-8, indicates response to chemotherapy of metastatic melanoma

inferredcites →https://doi.org/10.1097/01.alc.0000171927.66130.aaopenalex-snapshot

Effects of Systemic and Local CXC Chemokine Administration on the Ethanol‐Induced Suppression of Pulmonary Neutrophil Recruitment

inferredcites →https://doi.org/10.1097/01.ccm.0000057843.47705.e8openalex-snapshot

Neutrophils and acute lung injury

inferredcites →https://doi.org/10.1097/01.lab.0000048719.53282.00openalex-snapshot

The CXC Chemokine GCP-2/CXCL6 Is Predominantly Induced in Mesenchymal Cells by Interleukin-1β and Is Down-Regulated by Interferon-γ: Comparison with Interleukin-8/CXCL8

inferredcites →https://doi.org/10.1097/cad.0000000000000301openalex-snapshot

Combined inhibition of IL1, CXCR1/2, and TGFβ signaling pathways modulates in-vivo resistance to anti-VEGF treatment

inferredcites →https://doi.org/10.1097/j.pain.0000000000000339openalex-snapshot

Spinal translocator protein alleviates chronic neuropathic pain behavior and modulates spinal astrocyte–neuronal function in rats with L5 spinal nerve ligation model

inferredcites →https://doi.org/10.1097/mca.0000000000000292openalex-snapshot

CXCL5 is associated with the increased risk of coronary artery disease

inferredcites →https://doi.org/10.1111/1523-1747.ep12371803openalex-snapshot

Differential Expression of GRO-α and IL-8 mRNA Psoriasis: A Model for Neutrophil Migration and Accumulation In Vivo

inferredcites →https://doi.org/10.1111/bph.12670openalex-snapshot

Neutrophil migration towards C 5a and CXCL 8 is prevented by non‐steroidal anti‐inflammatory drugs via inhibition of different pathways

inferredcites →https://doi.org/10.1111/cas.13414openalex-snapshot

Expression level of CXCL 7 in peripheral blood cells is a potential biomarker for the diagnosis of renal cell carcinoma

inferredcites →https://doi.org/10.1111/cea.12224openalex-snapshot

CXCL 1 is a negative regulator of mast cell chemotaxis to airway smooth muscle cell products in vitro

inferredcites →https://doi.org/10.1111/ced.12164openalex-snapshot

Stimulated human melanocytes express and release interleukin-8, which is inhibited by luteolin: relevance to early vitiligo

inferredcites →https://doi.org/10.1111/cei.12488openalex-snapshot

A pilot study on reparixin, a CXCR1/2 antagonist, to assess safety and efficacy in attenuating ischaemia–reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery

showing the first 200 of 373 · page through all 373

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Targeting CXCR2 ameliorated tacrolimus-induced nephrotoxicity by alleviating overactivation of PI3K/AKT/mTOR pathway and calcium overload

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SB225002 enhances radiosensitivity in cervical cancer via direct neutrophil inhibition and tumor cell suppression

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CXCL5/CXCR2 modulates inflammation-mediated neural repair after optic nerve injury

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Network pharmacology and molecular docking reveal the potential mechanisms of edible Fritillariae cirrhosae bulbus in alleviating asthma-related symptoms: A transcriptomics-supported study

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Immunomodulatory potential of Lignosus rhinocerus TM02®: Bioactive components and mechanistic perspectives

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Genome-wide identification, evolutionary analysis, and antimicrobial activity prediction of CC chemokines in allotetraploid common carp, Cyprinus carpio

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Cancer-associated fibroblasts-derived CXCL1 activates DEC2-mediated dormancy in oral squamous cell carcinoma

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Chemokines in bone-metastatic breast cancer: Therapeutic opportunities

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Short-Term Prognostic Role of Peripheral Lymphocyte Subsets in Patients with Gastric Cancer

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CXCL1 enhances COX-II expression in rheumatoid arthritis synovial fibroblasts by CXCR2, PLC, PKC, and NF-κB signal pathway

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Neutrophil accumulation raises defence against Streptococcus equi ssp. zooepidemicus in the absence of Gasdermin D

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CXCR2 promotes tacrolimus-related cardiotoxicity via activating the Src-mediated PI3K/Akt/mTOR pathway

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MIF is a critical regulator of mononuclear phagocytic infiltration in hepatocellular carcinoma

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Simultaneous isolation of hormone receptor–positive breast cancer organoids and fibroblasts reveals stroma-mediated resistance mechanisms

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High-affinity ELR+ chemokine ligands show G protein bias over β-arrestin recruitment and receptor internalization in CXCR1 signaling

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Breast tumor-on-chip models: From disease modeling to personalized drug screening

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Anti-CXCR2 antibody-coated nanoparticles with an erythrocyte-platelet hybrid membrane layer for atherosclerosis therapy

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Nanomaterials as an advanced nano-tool for the Doxorubicin delivery/ Co-Delivery—A Comprehensive Review

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Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expression

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Modified Bushen Yiqi formula enhances antitumor immunity by reducing the chemotactic recruitment of M2-TAMs and PMN-MDSCs in Lewis lung cancer-bearing mice

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Targeting chemokine-receptor mediated molecular signaling by ethnopharmacological approaches

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System pharmacology reveals the mechanism of action of Shengbai Oral Liquid alleviates chemotherapy-induced leukopenia by interfering the pro-platelet basic protein: Integrated network study of multi-omics

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Identification of novel targets and mechanisms of wogonin on lung cancer, bladder cancer, and colon cancer

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Basic fibroblast growth factor promotes meniscus regeneration through the cultivation of synovial mesenchymal stem cells via the CXCL6–CXCR2 pathway

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The ERβ‐CXCL19/CXCR4‐NFκB pathway is critical in mediating the E2-induced inflammation response in the orange-spotted grouper (Epinephelus coioides)

inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122691openalex-snapshot

CXCL3: A key player in tumor microenvironment and inflammatory diseases

inferred← citeshttps://doi.org/10.1016/j.metabol.2021.154804openalex-snapshot

The IL-8-CXCR1/2 axis contributes to diabetic kidney disease

inferred← citeshttps://doi.org/10.1016/j.molmed.2023.09.003openalex-snapshot

CXCR2 chemokine receptor – a master regulator in cancer and physiology

inferred← citeshttps://doi.org/10.1016/j.nantod.2022.101597openalex-snapshot

Genetically engineered exosomes for targetedly preventing premetastatic niche formation and suppressing postoperative melanoma lung metastasis

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107556openalex-snapshot

Rational targeting of immunosuppressive neutrophils in cancer

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2020.107692openalex-snapshot

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

inferred← citeshttps://doi.org/10.1016/j.phrs.2023.106996openalex-snapshot

Neutrophils as potential therapeutic targets for breast cancer

inferred← citeshttps://doi.org/10.1016/j.phymed.2023.154662openalex-snapshot

Herbal formula Jiawei Xiaochengqi decoction prevents postoperative abdominal adhesion in a rat model through inhibition of CXCL2-CXCR2 pathway

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2025.111506openalex-snapshot

New frontier for epilepsy treatment through targeting cellular senescence

inferred← citeshttps://doi.org/10.1016/j.semcancer.2021.12.011openalex-snapshot

Multifaceted role of chemokines in solid tumors: From biology to therapy

inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.01.006openalex-snapshot

Surgery-mediated tumor-promoting effects on the immune microenvironment

inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.02.017openalex-snapshot

Chemokines and cytokines: Axis and allies in prostate cancer pathogenesis

inferred← citeshttps://doi.org/10.1016/j.semcancer.2022.06.010openalex-snapshot

Chemokines and NSCLC: Emerging role in prognosis, heterogeneity, and therapeutics

inferred← citeshttps://doi.org/10.1016/j.surg.2023.04.054openalex-snapshot

Liver resection modulates hepatic chemokine levels in breast cancer

inferred← citeshttps://doi.org/10.1016/j.surg.2023.12.018openalex-snapshot

Inhibition of chemokine receptor CXCR2 attenuates postoperative peritoneal adhesion formation

inferred← citeshttps://doi.org/10.1016/j.tice.2025.103185openalex-snapshot

IL-8/CXCR2 mediates resistance to apatinib through PI3K/AKT and vasculogenic mimicry in gastric cancer cells

inferred← citeshttps://doi.org/10.1016/j.trecan.2019.10.013openalex-snapshot

Unmasking the Many Faces of Tumor-Associated Neutrophils and Macrophages: Considerations for Targeting Innate Immune Cells in Cancer

inferred← citeshttps://doi.org/10.1016/j.trecan.2020.02.001openalex-snapshot

Tumor Plasticity and Resistance to Immunotherapy

inferred← citeshttps://doi.org/10.1016/j.trecan.2020.03.012openalex-snapshot

Zebrafish Xenografts for Drug Discovery and Personalized Medicine

inferred← citeshttps://doi.org/10.1016/j.trecan.2021.04.007openalex-snapshot

Metabolic Plasticity of Neutrophils: Relevance to Pathogen Responses and Cancer

inferred← citeshttps://doi.org/10.1016/j.ymthe.2022.07.008openalex-snapshot

Engineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis

inferred← citeshttps://doi.org/10.1016/j.ymthe.2024.11.022openalex-snapshot

Neuroplasticity therapy using glia-like cells derived from human mesenchymal stem cells for the recovery of cerebral infarction sequelae

inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.05.025openalex-snapshot

Reprogramming the neuroblastoma tumor immune microenvironment to enhance GPC2 CAR T cells

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01219openalex-snapshot

Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00849openalex-snapshot

Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00958openalex-snapshot

Sesquiterpene Polygodial from Drimys brasiliensis (Winteraceae) Down-Regulates Implant-Induced Inflammation and Fibrogenesis in Mice

inferred← citeshttps://doi.org/10.1038/s12276-022-00784-2openalex-snapshot

Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps

inferred← citeshttps://doi.org/10.1038/s41388-022-02406-7openalex-snapshot

Co-dependencies in the tumor immune microenvironment

inferred← citeshttps://doi.org/10.1038/s41392-021-00658-5openalex-snapshot

Inflammation and tumor progression: signaling pathways and targeted intervention

inferred← citeshttps://doi.org/10.1038/s41392-024-02049-yopenalex-snapshot

Neutrophil diversity and function in health and disease

inferred← citeshttps://doi.org/10.1038/s41418-025-01496-6openalex-snapshot

Targeting the poliovirus receptor to activate T cells and induce myeloid-derived suppressor cells to differentiate to pro-inflammatory macrophages via the IFN-γ-p-STAT1-IRF8 axis in cancer therapy

inferred← citeshttps://doi.org/10.1038/s41467-020-16890-6openalex-snapshot

Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

inferred← citeshttps://doi.org/10.1038/s41467-022-28533-zopenalex-snapshot

RETRACTED ARTICLE: Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection

inferred← citeshttps://doi.org/10.1038/s41551-023-01091-5openalex-snapshot

Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells

inferred← citeshttps://doi.org/10.1038/s41575-021-00444-2openalex-snapshot

Regulation and functional roles of chemokines in liver diseases

inferred← citeshttps://doi.org/10.1038/s41586-020-2492-5openalex-snapshot

Structural basis of CXC chemokine receptor 2 activation and signalling

inferred← citeshttps://doi.org/10.1038/s41598-019-54175-1openalex-snapshot

Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation

inferred← citeshttps://doi.org/10.1038/s41598-021-03294-9openalex-snapshot

Postoperative proliferative vitreoretinopathy development is linked to vitreal CXCL5 concentrations

inferred← citeshttps://doi.org/10.1038/s41598-025-02576-wopenalex-snapshot

Osteotropic properties of mesenchymal stromal cells generated in Masquelet’s induced membrane technique

inferred← citeshttps://doi.org/10.1038/s41598-025-05435-wopenalex-snapshot

CXCL8 is essential for cervical cancer cell acquired radioresistance and acts as a promising therapeutic target in cervical cancer

inferred← citeshttps://doi.org/10.1038/s41598-026-36514-1openalex-snapshot

Therapeutic potency and the related mechanism of deinoxanthin in experimental animal and cell models of periodontitis

inferred← citeshttps://doi.org/10.1038/s41598-026-47408-7openalex-snapshot

Temporal expression of CXCR2 ligands in a rat model of LPS—induced pulpitis

inferred← citeshttps://doi.org/10.1038/s42003-024-05837-yopenalex-snapshot

Bronchial epithelial transcriptomics and experimental validation reveal asthma severity-related neutrophilc signatures and potential treatments

inferred← citeshttps://doi.org/10.1039/d3tb03044jopenalex-snapshot

Immunologically effective biomaterials enhance immunotherapy of prostate cancer

inferred← citeshttps://doi.org/10.1039/d5nr00638dopenalex-snapshot

Type-dependent effects of nanoplastics on microglial activation and CXCR2-mediated chemotactic migration

inferred← citeshttps://doi.org/10.1073/pnas.2315894121openalex-snapshot

Breaking the symmetry of cell contractility drives tubulogenesis via CXCL1 polarization

inferred← citeshttps://doi.org/10.1073/pnas.2317694121openalex-snapshot

Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumors

inferred← citeshttps://doi.org/10.1080/07391102.2023.2171136openalex-snapshot

In silico approach to identify novel allosteric intracellular antagonist for blocking the interleukin-8/CXCR2 receptor signaling pathway

inferred← citeshttps://doi.org/10.1080/10428194.2023.2232492openalex-snapshot

Role of IL8 in myeloid malignancies

inferred← citeshttps://doi.org/10.1080/1062936x.2022.2132536openalex-snapshot

LY3041658/ interleukin-8 complex structure as targets for IL-8 small molecule inhibitors discovery using a combination of in silico methods

inferred← citeshttps://doi.org/10.1080/13510002.2024.2447778openalex-snapshot

Ginkgo biloba attenuates complete Freund’s adjuvant-induced inflammatory pain by suppressing the NF-κB-CXCL1/CXCR2 signaling cascade in the rat spinal cord

inferred← citeshttps://doi.org/10.1080/13880209.2023.2198560openalex-snapshot

Daphnetin alleviates neuropathic pain in chronic constrictive injury rats via regulating the NF-κB dependent CXCL1/CXCR2 signaling pathway

inferred← citeshttps://doi.org/10.1080/15384101.2019.1689471openalex-snapshot

C-X-C chemokine receptor 2 correlates with unfavorable prognosis and facilitates malignant cell activities via activating JAK2/STAT3 pathway in non-small cell lung cancer

inferred← citeshttps://doi.org/10.1080/17425255.2020.1711884openalex-snapshot

Clinical significance of chemokine receptor antagonists

inferred← citeshttps://doi.org/10.1080/1744666x.2024.2305808openalex-snapshot

The CXCLs-CXCR2 axis modulates the cross-communication between tumor-associated neutrophils and tumor cells in cervical cancer

inferred← citeshttps://doi.org/10.1080/17460441.2026.2622372openalex-snapshot

Advancing label-free screening technologies to enhance drug discovery efficiency

inferred← citeshttps://doi.org/10.1080/19420862.2020.1831880openalex-snapshot

Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody

inferred← citeshttps://doi.org/10.1080/2162402x.2025.2481109openalex-snapshot

Cellular and secretome profiling uncover immunological biomarkers in the prognosis of renal cell carcinoma patients

inferred← citeshttps://doi.org/10.1080/21655979.2021.1947442openalex-snapshot

Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer

inferred← citeshttps://doi.org/10.1083/jcb.202212031openalex-snapshot

Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration

inferred← citeshttps://doi.org/10.1093/cvr/cvad117openalex-snapshot

Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXC motif chemokine receptor 2

inferred← citeshttps://doi.org/10.1093/icvts/ivab021openalex-snapshot

Microvasculature in murine tracheal allografts after combined therapy with clopidogrel and everolimus

inferred← citeshttps://doi.org/10.1093/jimmun/vkaf191openalex-snapshot

CXCL1 augments host defense against Legionella pneumophila through the IL-18–IFN-γ axis and neutrophil homeostasis

inferred← citeshttps://doi.org/10.1093/jleuko/qiad085openalex-snapshot

Human CXCR1 knock-in mice infer functional expression of a murine ortholog

inferred← citeshttps://doi.org/10.1093/jleuko/qiad159openalex-snapshot

Cxcl1 monomer–dimer equilibrium controls neutrophil extravasation

inferred← citeshttps://doi.org/10.1096/fba.2025-00265openalex-snapshot

Unlocking the Power of CXCR2 Inhibition to Overcome Gemcitabine Resistance in Pancreatic Cancer

inferred← citeshttps://doi.org/10.1096/fj.202001455ropenalex-snapshot

Crosstalk between head and neck cancer cells and lymphatic endothelial cells promotes tumor metastasis via CXCL5‐CXCR2 signaling

inferred← citeshttps://doi.org/10.1096/fj.202201213ropenalex-snapshot

D‐dopachrome tautomerase in cardiovascular and inflammatory diseases—A new kid on the block or just another MIF ?

inferred← citeshttps://doi.org/10.1096/fj.202403208ropenalex-snapshot

Genomic Locus Tagged by Lung Function GWAS SNV rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype

inferred← citeshttps://doi.org/10.1097/md.0000000000030982openalex-snapshot

A novel gene signature derived from the CXC subfamily of chemokine receptors predicts the prognosis and immune infiltration of patients with lung adenocarcinoma

inferred← citeshttps://doi.org/10.1097/md.0000000000039458openalex-snapshot

Expression of interleukin-8 and integrin β3 predicts prognosis of patients with hepatocellular carcinoma after hepatectomy

inferred← citeshttps://doi.org/10.1101/2021.10.21.464997openalex-snapshot

SiglecF high neutrophils in lung tumor tissues suppress local CD8 T cell responses and limit the efficacy of anti PD-L1 antibodies

inferred← citeshttps://doi.org/10.1101/2022.01.14.476395openalex-snapshot

Allometric tissue-scale forces activate mechanoresponsive immune cells to drive pathological foreign body response to biomedical implants

inferred← citeshttps://doi.org/10.1101/2022.10.17.512528openalex-snapshot

Overexpression of Interleukin-8 and Interleukin-13 as potent immune markers associated with survival and dietary habits in esophageal squamous cell carcinoma

inferred← citeshttps://doi.org/10.1101/2022.12.01.518424openalex-snapshot

Keratinocyte desmosomal cadherin Desmoglein 1 as a mediator and target of paracrine signaling in the melanoma niche

inferred← citeshttps://doi.org/10.1101/2023.06.20.542249openalex-snapshot

GATA1-defective immune-megakaryocytes as possible drivers of idiopathic pulmonary fibrosis

inferred← citeshttps://doi.org/10.1101/2025.02.20.639389openalex-snapshot

Autocrine CXCL1-CXCR2 Signaling Mediates Leptomeningeal Resistance to Radiation Therapy

inferred← citeshttps://doi.org/10.1109/trpms.2020.3020686openalex-snapshot

The Plasma-Induced Leukemia Cell Death is Dictated by the ROS Chemistry and the HO-1/CXCL8 Axis

inferred← citeshttps://doi.org/10.1111/cei.13527openalex-snapshot

Increased expression of CXCL2 in ACPA-positive rheumatoid arthritis and its role in osteoclastogenesis

inferred← citeshttps://doi.org/10.1111/cns.70302openalex-snapshot

Anwulignan Alleviates Bone Cancer Pain by Modulating the PPARα / CXCR2 Signaling Pathway in the Rat Spinal Cord

inferred← citeshttps://doi.org/10.1111/cns.70609openalex-snapshot

Network Pharmacology‐Based and Experimental Validation Elucidate the Target Mechanism of Vinorine in Ameliorating Secondary Brain Injury After Intracerebral Hemorrhage

inferred← citeshttps://doi.org/10.1111/febs.15865openalex-snapshot

Structural insights into the activation of chemokine receptor CXCR2

inferred← citeshttps://doi.org/10.1124/jpet.123.001787openalex-snapshot

The Neutrophil Dynamic Mass Redistribution Assay as a Medium throughput Primary Cell Screening Assay

inferred← citeshttps://doi.org/10.1126/sciadv.ade5111openalex-snapshot

Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development

inferred← citeshttps://doi.org/10.1126/scitranslmed.aeh7968openalex-snapshot

CXCL1-CXCR2 signaling mediates cancer cell growth and response to radiation therapy in leptomeningeal metastasis

inferred← citeshttps://doi.org/10.1134/s0026893324700031openalex-snapshot

Zebrafish Xenographs in Oncology and Personalized Medicine

inferred← citeshttps://doi.org/10.1155/2021/5350232openalex-snapshot

Prognostic and Immunological Significance of CXCR2 in Ovarian Cancer: A Promising Target for Survival Outcome and Immunotherapeutic Response Assessment

inferred← citeshttps://doi.org/10.1155/2021/5563746openalex-snapshot

Role of Cytokines and Chemokines in NSCLC Immune Navigation and Proliferation

inferred← citeshttps://doi.org/10.1155/2022/4558159openalex-snapshot

CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance

inferred← citeshttps://doi.org/10.1155/2022/7966089openalex-snapshot

CXCR2 Is Essential for Radiation-Induced Intestinal Injury by Initiating Neutrophil Infiltration

inferred← citeshttps://doi.org/10.1155/dth/7880209openalex-snapshot

From Skin to Lungs: The Causal Pathways Linking Skin Microbiota and Asthma

inferred← citeshttps://doi.org/10.1158/0008-5472.c.6513285.v1openalex-snapshot

Data from Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non–Small Cell Lung Cancer

inferred← citeshttps://doi.org/10.1158/0008-5472.c.6514316.v1openalex-snapshot

Data from KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer

inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-3564openalex-snapshot

Inhibition of Granulocytic Myeloid-Derived Suppressor Cells Overcomes Resistance to Immune Checkpoint Inhibition in LKB1-Deficient Non–Small Cell Lung Cancer

inferred← citeshttps://doi.org/10.1158/0008-5472.can-22-0968openalex-snapshot

KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer

inferred← citeshttps://doi.org/10.1158/0008-5472.can-22-1890openalex-snapshot

Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors

inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-25-0251openalex-snapshot

Myeloid-Derived Suppressor Cells: Orchestrators of Tumor Immune Evasion and Therapeutic Vulnerabilities

inferred← citeshttps://doi.org/10.1159/000545659openalex-snapshot

Inhibition of Interleukin-8/C-X-C Chemokine Receptor 2 Signaling Axis Prevents Tumor Growth and Metastasis in Triple-Negative Breast Cancer Cells

inferred← citeshttps://doi.org/10.1172/jci171164openalex-snapshot

YAP1 induces bladder cancer progression and promotes immune evasion through IL-6/STAT3 pathway and CXCL deregulation

inferred← citeshttps://doi.org/10.1177/15353702231220662openalex-snapshot

TGFβ1 induces CXCL1 to promote stemness features in lung cancer

inferred← citeshttps://doi.org/10.1177/2040620720958586openalex-snapshot

High CXCR2 expression predicts poor prognosis in adult patients with acute myeloid leukemia

inferred← citeshttps://doi.org/10.1186/s12879-024-09133-2openalex-snapshot

The pathogenicity of vancomycin-resistant Enterococcus faecalis to colon cancer cells

inferred← citeshttps://doi.org/10.1186/s12885-025-14142-8openalex-snapshot

Abnormal proportions and functions of myeloid-derived suppressor cells in peripheral blood of patients with diffuse large B-cell lymphoma

inferred← citeshttps://doi.org/10.1186/s12920-026-02335-4openalex-snapshot

Shared molecular signatures between atrial fibrillation and chronic obstructive pulmonary disease: an integrated bioinformatic analysis with experimental validation

inferred← citeshttps://doi.org/10.1186/s12929-022-00881-4openalex-snapshot

Tumor-associated macrophages promote resistance of hepatocellular carcinoma cells against sorafenib by activating CXCR2 signaling

inferred← citeshttps://doi.org/10.1186/s12935-022-02771-zopenalex-snapshot

Targeted blocking of CCR2 and CXCR2 improves the efficacy of transarterial chemoembolization of hepatocarcinoma

inferred← citeshttps://doi.org/10.1186/s12935-025-03709-xopenalex-snapshot

Association between cancer-associated fibroblasts and prognosis of neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma: a bioinformatics analysis based on single-cell RNA sequencing

inferred← citeshttps://doi.org/10.1186/s12943-020-01260-zopenalex-snapshot

Overcoming immunotherapy resistance in non-small cell lung cancer (NSCLC) - novel approaches and future outlook

inferred← citeshttps://doi.org/10.1186/s12943-021-01355-1openalex-snapshot

Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin

inferred← citeshttps://doi.org/10.1186/s12950-022-00321-yopenalex-snapshot

The immunological function of CXCR2 in the liver during sepsis

inferred← citeshttps://doi.org/10.1186/s12964-023-01460-2openalex-snapshot

Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization

inferred← citeshttps://doi.org/10.1186/s12967-019-2053-6openalex-snapshot

Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness

inferred← citeshttps://doi.org/10.1186/s12967-023-03929-7openalex-snapshot

Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin

inferred← citeshttps://doi.org/10.1186/s12967-023-04060-3openalex-snapshot

Tumor cell density dependent IL-8 secretion induces the fluctuation of tregs/CD8 + T cells infiltration in hepatocellular carcinoma: one prompt for the existence of density checkpoint

inferred← citeshttps://doi.org/10.1186/s12967-025-06649-2openalex-snapshot

Platelet membrane-coated nanoparticles inhibit platelet activation and neutrophil extracellular traps formation in acute lung injury

inferred← citeshttps://doi.org/10.1186/s12967-025-06707-9openalex-snapshot

CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway

inferred← citeshttps://doi.org/10.1186/s13014-026-02814-zopenalex-snapshot

Machine-learning with multiomics for radiotherapy-induced acute rectal toxicities and survival outcome in patients with cervical cancer

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