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Kynurenine regulates NLRP2 inflammasome in astrocytes and its implications in depression

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/glia.22499openalex-snapshot
Human astrocytes express a novel NLRP2 inflammasome
inferredcites →https://doi.org/10.1002/glia.23143openalex-snapshot
An astroglial basis of major depressive disorder? An overview
inferredcites →https://doi.org/10.1007/978-3-642-79451-3_8openalex-snapshot
Cellular and Molecular Biology of Aryl Hydrocarbon (Ah) Receptor — Mediated Gene Expression
inferredcites →https://doi.org/10.1007/s11481-016-9712-7openalex-snapshot
Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats
inferredcites →https://doi.org/10.1016/j.bbi.2016.04.007openalex-snapshot
Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression
inferredcites →https://doi.org/10.1016/j.bbi.2017.02.010openalex-snapshot
Desipramine decreases expression of human and murine indoleamine-2,3-dioxygenases
inferredcites →https://doi.org/10.1016/j.bbi.2017.03.002openalex-snapshot
NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings
inferredcites →https://doi.org/10.1016/j.bbi.2017.10.025openalex-snapshot
Depression and sterile inflammation: Essential role of danger associated molecular patterns
inferredcites →https://doi.org/10.1016/j.bbrc.2016.09.157openalex-snapshot
NLRP2 is highly expressed in a mouse model of ischemic stroke
inferredcites →https://doi.org/10.1016/j.biopsych.2008.06.008openalex-snapshot
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
inferredcites →https://doi.org/10.1016/j.biopsych.2008.11.029openalex-snapshot
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
inferredcites →https://doi.org/10.1016/j.biopsych.2013.03.032openalex-snapshot
From Pathophysiology to Novel Antidepressant Drugs: Glial Contributions to the Pathology and Treatment of Mood Disorders
inferredcites →https://doi.org/10.1016/j.cell.2014.07.051openalex-snapshot
Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression
inferredcites →https://doi.org/10.1016/j.febslet.2012.02.045openalex-snapshot
TLR‐induced NF‐κB activation regulates NLRP3 expression in murine macrophages
inferredcites →https://doi.org/10.1016/j.immuni.2013.08.037openalex-snapshot
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
inferredcites →https://doi.org/10.1016/j.it.2009.06.005openalex-snapshot
The aryl hydrocarbon receptor in immunity
inferredcites →https://doi.org/10.1016/j.it.2018.10.010openalex-snapshot
The Aryl Hydrocarbon Receptor: Connecting Immunity to the Microenvironment
inferredcites →https://doi.org/10.1016/j.redox.2016.08.006openalex-snapshot
Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression
inferredcites →https://doi.org/10.1016/s0149-7634(05)80194-0openalex-snapshot
Chronic mild stress-induced anhedonia: A realistic animal model of depression
inferredcites →https://doi.org/10.1038/cddis.2014.576openalex-snapshot
The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine
inferredcites →https://doi.org/10.1038/mp.2009.116openalex-snapshot
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationship to CNS immune responses and depression
inferredcites →https://doi.org/10.1038/mp.2009.91openalex-snapshot
Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury
inferredcites →https://doi.org/10.1038/nature10491openalex-snapshot
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
inferredcites →https://doi.org/10.1038/ncomms5738openalex-snapshot
Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription
inferredcites →https://doi.org/10.1038/nn.4113openalex-snapshot
Neuroimmune mechanisms of depression
inferredcites →https://doi.org/10.1038/nrd.2017.16openalex-snapshot
Targeting glutamate signalling in depression: progress and prospects
inferredcites →https://doi.org/10.1038/nrdp.2016.65openalex-snapshot
Major depressive disorder
inferredcites →https://doi.org/10.1038/nri.2015.5openalex-snapshot
The role of inflammation in depression: from evolutionary imperative to modern treatment target
inferredcites →https://doi.org/10.1038/nrn3257openalex-snapshot
Kynurenines in the mammalian brain: when physiology meets pathology
inferredcites →https://doi.org/10.1038/s41418-018-0127-2openalex-snapshot
Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3
inferredcites →https://doi.org/10.1074/jbc.m406741200openalex-snapshot
PAN1/NALP2/PYPAF2, an Inducible Inflammatory Mediator That Regulates NF-κB and Caspase-1 Activation in Macrophages
inferredcites →https://doi.org/10.1074/jbc.r116.767723openalex-snapshot
Control of immune-mediated pathology via the aryl hydrocarbon receptor
inferredcites →https://doi.org/10.1096/fj.201700853ropenalex-snapshot
Regulation of proinflammatory monocyte activation by the kynurenine–AhR axis underlies immunometabolic control of depressive behavior in mice
inferredcites →https://doi.org/10.1126/science.aaf9794openalex-snapshot
Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health
inferredcites →https://doi.org/10.1146/annurev.iy.12.040194.001041openalex-snapshot
Function and Activation of NF-Kappa B in the Immune System
inferredcites →https://doi.org/10.1146/annurev.pharmtox.43.100901.135828openalex-snapshot
Activation of the Aryl Hydrocarbon Receptor by Structurally Diverse Exogenous and Endogenous Chemicals
inferredcites →https://doi.org/10.1210/mend.13.9.0338openalex-snapshot
Transcriptional Activation of c-fos Protooncogene by 17β-Estradiol: Mechanism of Aryl Hydrocarbon Receptor-Mediated Inhibition
inferredcites →https://doi.org/10.12688/f1000research.10300.1openalex-snapshot
Recent advances in predicting responses to antidepressant treatment
inferredcites →https://doi.org/10.1517/14728222.2012.718331openalex-snapshot
Targeting IL-1 in depression
inferredcites →https://doi.org/10.2174/13894501113146660214openalex-snapshot
Glia: An Important Target for Anti-Inflammatory and Antidepressant Activity
inferredcites →https://doi.org/10.2174/13894501113149990156openalex-snapshot
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
inferredcites →https://doi.org/10.3389/fncel.2015.00268openalex-snapshot
Glia in the cytokine-mediated onset of depression: fine tuning the immune response
inferredcites →https://doi.org/10.3389/fncel.2017.00063openalex-snapshot
NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies
inferredcites →https://doi.org/10.4049/jimmunol.179.12.8519openalex-snapshot
NLRP2, an Inhibitor of the NF-κB Pathway, Is Transcriptionally Activated by NF-κB and Exhibits a Nonfunctional Allelic Variant

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4650110openalex-extracted
inferred← citeshttps://doi.org/10.1002/cbin.11755openalex-snapshot
NLRP2 inhibits cell proliferation and migration by regulating EMT in lung adenocarcinoma cells
inferred← citeshttps://doi.org/10.1007/s00109-023-02289-5openalex-snapshot
Activation of aryl hydrocarbon receptor (AhR) in Alzheimer’s disease: role of tryptophan metabolites generated by gut host-microbiota
inferred← citeshttps://doi.org/10.1007/s00726-023-03311-3openalex-snapshot
Metagenomics-based inference of microbial metabolism towards neuroactive amino acids and the response to antibiotics in piglet colon
inferred← citeshttps://doi.org/10.1007/s10495-023-01823-7openalex-snapshot
Dissection of pyroptosis-related prognostic signature and CASP6-mediated regulation in pancreatic adenocarcinoma: new sights to clinical decision-making
inferred← citeshttps://doi.org/10.1007/s10571-020-01027-6openalex-snapshot
Role of Microgliosis and NLRP3 Inflammasome in Parkinson’s Disease Pathogenesis and Therapy
inferred← citeshttps://doi.org/10.1007/s10753-024-02190-4openalex-snapshot
Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide-induced Depression-like Behavior in Mice
inferred← citeshttps://doi.org/10.1007/s11064-022-03714-wopenalex-snapshot
The Emerging Role of Astrocytic Autophagy in Central Nervous System Disorders
inferred← citeshttps://doi.org/10.1007/s12013-024-01596-zopenalex-snapshot
METTL14 Promotes Ischemic Stroke-induced Brain Injury by Stabilizing HDAC3 Expression in an m6A-IGF2BP3 Mechanism
inferred← citeshttps://doi.org/10.1007/s12035-021-02509-4openalex-snapshot
Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses
inferred← citeshttps://doi.org/10.1007/s12035-024-04513-wopenalex-snapshot
Gut Microbiota Mediates Neuroinflammation in Alzheimer’s Disease: Unraveling Key Factors and Mechanistic Insights
inferred← citeshttps://doi.org/10.1007/s12035-026-06152-9openalex-snapshot
The Gut Microbiota-Astrocyte Axis: New Insights into the Mechanisms of Comorbid Major Depressive Disorder in Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1016/b978-0-128-24465-4.00101-0openalex-snapshot
Inflammasomes
inferred← citeshttps://doi.org/10.1016/b978-0-323-85841-0.00005-5openalex-snapshot
Inflammasome elements in epilepsy and seizures
inferred← citeshttps://doi.org/10.1016/b978-0-443-14158-4.00079-8openalex-snapshot
Theanine and amelioration of brain stress
inferred← citeshttps://doi.org/10.1016/b978-0-443-23565-8.00006-5openalex-snapshot
Depressive Disorders
inferred← citeshttps://doi.org/10.1016/b978-0-443-23565-8.09996-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.cca.2023.117441openalex-snapshot
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The interplay between Kynurenine and Nociceptin/Orphanin FQ pathways can be related to depressive-like phenotype
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Bisphenol F exposure induces depression-like changes: Roles of the kynurenine metabolic pathway along the “liver-brain” axis
inferred← citeshttps://doi.org/10.1016/j.expneurol.2025.115419openalex-snapshot
Sleep deprivation-induced cognitive impairment: Unraveling the role of neuroinflammation
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Inflammasome activation and signalling in the ischemic-reperfused myocardium
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Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress
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Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway
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Ginsenoside Rg1 exerts antidepressant effect by regulating hepatic kynurenine metabolism through promoting the interaction between HNF4α and PGC1α
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Chronic restraint stress induced changes in colonic homeostasis-related indexes and tryptophan-kynurenine metabolism in rats
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Hypericum perforatum L. attenuates depression by regulating Akkermansia muciniphila, tryptophan metabolism and NFκB-NLRP2-Caspase1-IL1β pathway
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Metabolomic changes in animal models of depression: a systematic analysis
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Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression
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Effects of pharmacological treatment on metabolomic alterations in animal models of depression
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Neuroinflammation and NeuroHIV: understanding the role of HIV-1 related factors in microglial activation
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Novel insights into NOD-like receptors in renal diseases
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Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity
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Injectable hydrogel-based localized delivery of IDO-galectin-3 mitigates neuroinflammation and promotes neuronal sparing after spinal cord contusion in rats
inferred← citeshttps://doi.org/10.1073/pnas.2509798122openalex-snapshot
Modulation of the PGRMC1/NLRP7/HLA-C axis by autophagy is linked to both spontaneous preterm birth and gestational choriocarcinoma
inferred← citeshttps://doi.org/10.1093/cei/uxaf030openalex-snapshot
1-methyl-tryptophan improves anxiety-like behavior in colitis mice by inhibiting neuroinflammation, promoting cell regeneration, and decreasing apoptosis
inferred← citeshttps://doi.org/10.1097/fbp.0000000000000851openalex-snapshot
Gut–brain axis and depression: focus on the amino acid and short-chain fatty acid metabolism
inferred← citeshttps://doi.org/10.1097/md.0000000000038898openalex-snapshot
Research on acupuncture and glial cells: A bibliometric analysis
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Exploring the mechanism of Si-Ni-San against depression by UPLC-Q-TOF-MS/MS integrated with network pharmacology: experimental research
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Alpha‐Asarone modulates kynurenine disposal in muscle and mediates resilience to stress‐induced depression via PGC ‐1α induction
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The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidating Crucial Factors and Mechanistic Underpinnings
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NLRP2 in health and disease
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NPAS2 Deficiency Leads to Antidepressant‐Like Behaviors in Mice by Modulating Astrocyte‐Mediated Neuroinflammation
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IDO1 promotes CSFV replication by mediating tryptophan metabolism to inhibit NF-κB signaling
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Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation
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NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression
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“Other Than NLRP3” Inflammasomes: Multiple Roles in Brain Disease
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Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders
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Fluoxetine inhibited the activation of A1 reactive astrocyte in a mouse model of major depressive disorder through astrocytic 5-HT2BR/β-arrestin2 pathway
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Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway
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β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
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OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
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Colitis-associated gut–vagus–brain signaling integrates tumorigenesis and neuroinflammation: comparative regulation by vagotomy and atropine
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Ultrasound-guided renal subcapsular transplantation of mesenchymal stem cells for treatment of acute kidney injury in a minipig model: safety and efficacy evaluation
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NLRP inflammasomes in health and disease
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Role of the Tryptophan-Kynurenine Metabolic Pathway and Aerobic Exercise in the Treatment of Depression
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The Neglected Sibling: NLRP2 Inflammasome in the Nervous System
inferred← citeshttps://doi.org/10.1515/revneuro-2024-0065openalex-snapshot
Neurobiological mechanisms in the kynurenine pathway and major depressive disorder
inferred← citeshttps://doi.org/10.2174/011570159x353752250227113751openalex-snapshot
Research Trends and Evolution of Astrocytes in Depression and Antidepressant Treatment: A Bibliometric Analysis
inferred← citeshttps://doi.org/10.2174/1566524023666230731095431openalex-snapshot
The Role of Histone Deacetylases in NLRP3 Inflammasomesmediated Epilepsy
inferred← citeshttps://doi.org/10.3389/fcell.2022.839041openalex-snapshot
Inflammasomes in Cancer Progression and Anti-Tumor Immunity
inferred← citeshttps://doi.org/10.3389/fcimb.2025.1692110openalex-snapshot
Liqi Yangyin formula ameliorates CUMS-induced depression and comorbid constipation via ACE/FFAR2 modulation of the microbiota-gut-brain axis
inferred← citeshttps://doi.org/10.3389/fimmu.2021.731701openalex-snapshot
Tryptophan Catabolism and Inflammation: A Novel Therapeutic Target For Aortic Diseases
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1089200openalex-snapshot
DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota
inferred← citeshttps://doi.org/10.3389/fmicb.2023.1278162openalex-snapshot
The fecal microbiota from children with autism impact gut metabolism and learning and memory abilities of honeybees
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1936353openalex-snapshot
Tryptophan metabolism: a critical bridge linking gut microbiota to depression
inferred← citeshttps://doi.org/10.3389/fncel.2022.929529openalex-snapshot
Glial Cells and Brain Diseases: Inflammasomes as Relevant Pathological Entities
inferred← citeshttps://doi.org/10.3389/fncel.2025.1572462openalex-snapshot
Decoding serotonin: the molecular symphony behind depression
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An integrated cytokine and kynurenine network as the basis of neuroimmune communication
inferred← citeshttps://doi.org/10.3389/fphar.2022.832590openalex-snapshot
Shuangxinfang Prevents S100A9-Induced Macrophage/Microglial Inflammation to Improve Cardiac Function and Depression-Like Behavior in Rats After Acute Myocardial Infarction
inferred← citeshttps://doi.org/10.3389/fphar.2022.955672openalex-snapshot
Inflammatory pathophysiological mechanisms implicated in postpartum depression
inferred← citeshttps://doi.org/10.3389/fphar.2026.1844902openalex-snapshot
Interplay between the gut microbiota and MAPK/NF-κ B/Nrf2 signaling in depression: pharmacological insights from traditional Chinese medicine
inferred← citeshttps://doi.org/10.3390/biomedicines11040999openalex-snapshot
NLRP3 Inflammasome’s Activation in Acute and Chronic Brain Diseases—An Update on Pathogenetic Mechanisms and Therapeutic Perspectives with Respect to Other Inflammasomes
inferred← citeshttps://doi.org/10.3390/biomedicines11102775openalex-snapshot
Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease
inferred← citeshttps://doi.org/10.3390/cells13131157openalex-snapshot
Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes
inferred← citeshttps://doi.org/10.3390/encyclopedia4040110openalex-snapshot
Dysfunctional K+ Homeostasis as a Driver for Brain Inflammation
inferred← citeshttps://doi.org/10.3390/ijms21239036openalex-snapshot
Danger-Sensing/Patten Recognition Receptors and Neuroinflammation in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms22010193openalex-snapshot
Theanine, Antistress Amino Acid in Tea Leaves, Causes Hippocampal Metabolic Changes and Antidepressant Effects in Stress-Loaded Mice
inferred← citeshttps://doi.org/10.3390/ijms222111408openalex-snapshot
NLRP2 Is Overexpressed in Spinal Astrocytes at the Peak of Mechanical Pain Sensitivity during Complete Freund Adjuvant-Induced Persistent Pain
inferred← citeshttps://doi.org/10.3390/ijms231810822openalex-snapshot
Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model
inferred← citeshttps://doi.org/10.3390/ijms241310820openalex-snapshot
Host–Microbiome Interactions: Tryptophan Metabolism and Aromatic Hydrocarbon Receptors after Traumatic Brain Injury
inferred← citeshttps://doi.org/10.3390/ijms27052449openalex-snapshot
The Role of Exosomes in the Regulation of Molecular Mechanisms Underlying Treatment Resistance—Linking Cellular Crosstalk to Clinical Implications in Depression
inferred← citeshttps://doi.org/10.3390/molecules26164897openalex-snapshot
Green Tea Suppresses Brain Aging
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Bupleurum in Treatment of Depression Disorder: A Comprehensive Review
inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-24-01574openalex-snapshot
The roles of microglia and astrocytes in inflammasomes and neurological disorders
inferred← citeshttps://doi.org/10.4103/nrr.nrr-d-25-00324openalex-snapshot
Relationship of immune-inflammatory pathway and stress-induced depression with neural regeneration
inferred← citeshttps://doi.org/10.6084/m9.figshare.19863054openalex-snapshot
Additional file 1 of Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway
inferred← citeshttps://doi.org/10.6084/m9.figshare.21258290openalex-snapshot
Additional file 1 of β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
inferred← citeshttps://doi.org/10.6084/m9.figshare.21258293openalex-snapshot
Additional file 2 of β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression
inferred← citeshttps://doi.org/10.6084/m9.figshare.22662453openalex-snapshot
Additional file 1 of Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders
inferred← citeshttps://doi.org/10.6084/m9.figshare.22662456openalex-snapshot
Additional file 2 of Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders
inferred← citeshttps://doi.org/10.6084/m9.figshare.22662459openalex-snapshot
Additional file 3 of Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders
inferred← citeshttps://doi.org/10.6084/m9.figshare.24647270openalex-snapshot
Additional file 1 of OTUD1 ameliorates cerebral ischemic injury through inhibiting inflammation by disrupting K63-linked deubiquitination of RIP2
inferred← citeshttps://doi.org/10.9734/jpri/2021/v33i1831312openalex-snapshot
The Role of Immune-related NLR Pyrin Domain Containing 2 (NLRP2) Gene in the Development and Diseases
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