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PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jamafacial.2018.1197openalex-snapshot
Risk Factors, Causes, and Costs of Hospital Readmission After Head and Neck Cancer Surgery Reconstruction
inferredcites →https://doi.org/10.1002/1097-0142(19940701)74:1<152::aid-cncr2820740124>3.0.co;2-kopenalex-snapshot
PRAD-1 (CCND1)/Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinoma
inferredcites →https://doi.org/10.1002/cncr.27986openalex-snapshot
A phase 1 study of everolimus plus docetaxel plus cisplatin as induction chemotherapy for patients with locally and/or regionally advanced head and neck cancer
inferredcites →https://doi.org/10.1002/cncr.28965openalex-snapshot
Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck
inferredcites →https://doi.org/10.1002/cncr.31841openalex-snapshot
The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status
inferredcites →https://doi.org/10.1002/gcc.22415openalex-snapshot
Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma
inferredcites →https://doi.org/10.1002/hed.23604openalex-snapshot
PI3K/PTEN/AKT/mTOR polymorphisms: Association with clinical outcome in patients with head and neck squamous cell carcinoma receiving cetuximab‐docetaxel
inferredcites →https://doi.org/10.1002/ijc.2910130509openalex-snapshot
Attempts to detect virus‐specific DNA in human tumors. I. Nucleic acid hybridizations with complementary RNA of human wart virus
inferredcites →https://doi.org/10.1002/ijc.29328openalex-snapshot
Phosphorylation of AKT ( S er473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma
inferredcites →https://doi.org/10.1002/jmv.24670openalex-snapshot
Human papillomavirus as a favorable prognostic factor in a subset of head and neck squamous cell carcinomas: A meta‐analysis
inferredcites →https://doi.org/10.1002/lary.20917openalex-snapshot
Teasing out the best molecular marker in the AKT/mTOR pathway in head and neck squamous cell cancer patients
inferredcites →https://doi.org/10.1006/viro.1995.1395openalex-snapshot
The HPV16 E5 Protein: Expression, Detection, and Stable Complex Formation with Transmembrane Proteins in COS Cells
inferredcites →https://doi.org/10.1007/978-3-642-66800-5_1openalex-snapshot
Human Papillomaviruses and Their Possible Role in Squamous Cell Carcinomas
inferredcites →https://doi.org/10.1007/s00103-018-2821-0openalex-snapshot
Tabakassoziierte Krebserkrankungen in Deutschland – Entwicklung der Inzidenz und Mortalität seit 1995
inferredcites →https://doi.org/10.1007/s00280-012-1894-yopenalex-snapshot
A phase I study of temsirolimus plus carboplatin plus paclitaxel for patients with recurrent or metastatic (R/M) head and neck squamous cell cancer (HNSCC)
inferredcites →https://doi.org/10.1007/s10555-005-5049-zopenalex-snapshot
Gene profiling in squamous cell carcinoma of the head and neck
inferredcites →https://doi.org/10.1007/s10637-012-9896-5openalex-snapshot
Preclinical evaluation of the AKT inhibitor MK-2206 in nasopharyngeal carcinoma cell lines
inferredcites →https://doi.org/10.1007/s10637-014-0124-3openalex-snapshot
A multicenter phase 1 study of PX-866 and cetuximab in patients with metastatic colorectal carcinoma or recurrent/metastatic squamous cell carcinoma of the head and neck
inferredcites →https://doi.org/10.1007/s11912-009-0016-4openalex-snapshot
Perifosine: Update on a novel Akt inhibitor
inferredcites →https://doi.org/10.1016/0092-8674(90)90409-8openalex-snapshot
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
inferredcites →https://doi.org/10.1016/j.bmcl.2013.05.007openalex-snapshot
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation
inferredcites →https://doi.org/10.1016/j.ccell.2017.04.013openalex-snapshot
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
inferredcites →https://doi.org/10.1016/j.ijrobp.2013.06.2043openalex-snapshot
A Phase 1 Study of Everolimus + Weekly Cisplatin + Intensity Modulated Radiation Therapy in Head-and-Neck Cancer
inferredcites →https://doi.org/10.1016/j.oraloncology.2014.12.013openalex-snapshot
A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic head and neck squamous cell cancer
inferredcites →https://doi.org/10.1016/j.oraloncology.2017.02.020openalex-snapshot
New drug development in head and neck squamous cell carcinoma: The PI3-K inhibitors
inferredcites →https://doi.org/10.1016/j.oraloncology.2017.07.023openalex-snapshot
A randomized, open-label, Phase III clinical trial of nivolumab vs. therapy of investigator’s choice in recurrent squamous cell carcinoma of the head and neck: A subanalysis of Asian patients versus the global population in checkmate 141
inferredcites →https://doi.org/10.1016/j.virol.2008.09.040openalex-snapshot
E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway
inferredcites →https://doi.org/10.1016/s0041-1345(98)00587-9openalex-snapshot
Chemical modification of rapamycin: the discovery of SDZ RAD
inferredcites →https://doi.org/10.1021/jm0601598openalex-snapshot
Furan-2-ylmethylene Thiazolidinediones as Novel, Potent, and Selective Inhibitors of Phosphoinositide 3-Kinase γ
inferredcites →https://doi.org/10.1021/jm4003632openalex-snapshot
Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity
inferredcites →https://doi.org/10.1038/314111a0openalex-snapshot
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
inferredcites →https://doi.org/10.1038/369756a0openalex-snapshot
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
inferredcites →https://doi.org/10.1038/bjc.1993.238openalex-snapshot
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines
inferredcites →https://doi.org/10.1038/modpathol.3800979openalex-snapshot
The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma—molecular basis and predicting favorable outcome
inferredcites →https://doi.org/10.1038/nm1284openalex-snapshot
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
inferredcites →https://doi.org/10.1038/nrc2399openalex-snapshot
Cellular mechanisms of tumour suppression by the retinoblastoma gene
inferredcites →https://doi.org/10.1038/nrc2886openalex-snapshot
Human papillomavirus oncoproteins: pathways to transformation
inferredcites →https://doi.org/10.1038/nrc798openalex-snapshot
Papillomaviruses and cancer: from basic studies to clinical application
inferredcites →https://doi.org/10.1038/onc.2008.244openalex-snapshot
Class I PI3K in oncogenic cellular transformation
inferredcites →https://doi.org/10.1038/sj.onc.1202223openalex-snapshot
Inhibition of Bak-induced apoptosis by HPV-18 E6
inferredcites →https://doi.org/10.1038/sj.onc.1208935openalex-snapshot
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
inferredcites →https://doi.org/10.1038/srep42700openalex-snapshot
Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity
inferredcites →https://doi.org/10.1056/nejm199503163321104openalex-snapshot
Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck
inferredcites →https://doi.org/10.1056/nejmoa1813904openalex-snapshot
Alpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
inferredcites →https://doi.org/10.1074/jbc.m104130200openalex-snapshot
Sp1 Plays a Critical Role in the Transcriptional Activation of the Human Cyclin-dependent Kinase Inhibitor p21 Gene by the p53 Tumor Suppressor Protein
inferredcites →https://doi.org/10.1093/annonc/mdu571openalex-snapshot
TEMHEAD: a single-arm multicentre phase II study of temsirolimus in platin- and cetuximab refractory recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN) of the German SCCHN Group (AIO)
inferredcites →https://doi.org/10.1093/annonc/mdx346openalex-snapshot
A phase II study of temsirolimus added to low-dose weekly carboplatin and paclitaxel for patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC)
inferredcites →https://doi.org/10.1093/eurheartj/ehi752openalex-snapshot
Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks
inferredcites →https://doi.org/10.1093/jnci/92.9.709openalex-snapshot
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
inferredcites →https://doi.org/10.1093/jnci/dju215openalex-snapshot
mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations
inferredcites →https://doi.org/10.1093/nar/gkp995openalex-snapshot
COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer
inferredcites →https://doi.org/10.1111/1523-1747.ep12265517openalex-snapshot
Analysis of Oral Papillomas, Leukoplakias, and Invasive Carcinomas for Human Papillomavirus Type Related DNA
inferredcites →https://doi.org/10.1111/jop.12779openalex-snapshot
Potential clinical implications of HPV status and expressions of p53 and cyclin D1 among oropharyngeal cancer patients
inferredcites →https://doi.org/10.1111/odi.12206openalex-snapshot
The PI 3 K / A kt/m TOR axis in head and neck cancer: functions, aberrations, cross‐talk, and therapies
inferredcites →https://doi.org/10.1124/mol.111.072546openalex-snapshot
Isoform-Selective Inhibition of Phosphoinositide 3-Kinase: Identification of a New Region of Nonconserved Amino Acids Critical for p110α Inhibition
inferredcites →https://doi.org/10.1126/science.1715094openalex-snapshot
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
inferredcites →https://doi.org/10.1126/science.2537532openalex-snapshot
The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product
inferredcites →https://doi.org/10.1128/jvi.69.10.6389-6399.1995openalex-snapshot
Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation
inferredcites →https://doi.org/10.1128/jvi.75.9.4467-4472.2001openalex-snapshot
Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein
inferredcites →https://doi.org/10.1128/jvi.76.1.220-231.2002openalex-snapshot
E5 Protein of Human Papillomavirus Type 16 Protects Human Foreskin Keratinocytes from UV B-Irradiation-Induced Apoptosis
inferredcites →https://doi.org/10.1158/0008-5472.can-05-0917openalex-snapshot
Activation of Akt and eIF4E Survival Pathways by Rapamycin-Mediated Mammalian Target of Rapamycin Inhibition
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2925openalex-snapshot
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
inferredcites →https://doi.org/10.1158/0008-5472.can-06-0499openalex-snapshot
Human Papillomavirus Type 16 E7 Up-regulates AKT Activity through the Retinoblastoma Protein
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-0722openalex-snapshot
Genetic and Expression Profiles of Squamous Cell Carcinoma of the Head and Neck Correlate with Cisplatin Sensitivity and Resistance in Cell Lines and Patients
inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-2033openalex-snapshot
Radiosensitization of Squamous Cell Carcinoma by the Alkylphospholipid Perifosine in Cell Culture and Xenografts
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-0760openalex-snapshot
Pharmacodynamic Markers of Perifosine Efficacy
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-1041openalex-snapshot
Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-2824openalex-snapshot
mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-3072openalex-snapshot
Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models
inferredcites →https://doi.org/10.1158/1078-0432.ccr-15-2245openalex-snapshot
Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations
inferredcites →https://doi.org/10.1158/1535-7163.763.3.7openalex-snapshot
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling
inferredcites →https://doi.org/10.1158/1535-7163.mct-09-1012openalex-snapshot
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0474openalex-snapshot
Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
inferredcites →https://doi.org/10.1158/1535-7163.mct-12-0993-topenalex-snapshot
BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0639openalex-snapshot
Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors
inferredcites →https://doi.org/10.1158/1535-7163.mct-14-0833openalex-snapshot
The Selective PI3K Inhibitor XL147 (SAR245408) Inhibits Tumor Growth and Survival and Potentiates the Activity of Chemotherapeutic Agents in Preclinical Tumor Models
inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0103openalex-snapshot
Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers
inferredcites →https://doi.org/10.1158/2159-8290.cd-16-0512openalex-snapshot
A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors
inferredcites →https://doi.org/10.1159/000458166openalex-snapshot
Human Papillomavirus and the Development of Different Cancers
inferredcites →https://doi.org/10.1186/1471-2407-11-388openalex-snapshot
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways
inferredcites →https://doi.org/10.1186/1756-8722-7-1openalex-snapshot
Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors
inferredcites →https://doi.org/10.1186/gm453openalex-snapshot
Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors
inferredcites →https://doi.org/10.1186/s12943-015-0361-xopenalex-snapshot
The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses
inferredcites →https://doi.org/10.1200/jco.1993.11.10.1873openalex-snapshot
Expression of epidermal growth factor receptor and survival in upper aerodigestive tract cancer.
inferredcites →https://doi.org/10.1200/jco.2011.36.1360openalex-snapshot
Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
inferredcites →https://doi.org/10.1200/jco.2013.31.15_suppl.6036openalex-snapshot
CAPRA: Safety, efficacy, and translational biomarkers of weekly everolimus, carboplatin, and paclitaxel as induction therapy for locally advanced head and neck squamous cell carcinoma (HNSCC).
inferredcites →https://doi.org/10.1200/jco.2015.33.15_suppl.2516openalex-snapshot
Genomic mutation profiling (GMP) and clinical outcome of patients treated with buparlisib (PI3K inhibitor) in the “Signature” program.
inferredcites →https://doi.org/10.1200/jco.2016.34.15_suppl.6008openalex-snapshot
BERIL-1: A phase II, placebo-controlled study of buparlisib (BKM120) plus paclitaxel in patients with platinum-pretreated recurrent/metastatic head and neck squamous cell carcinoma (HNSCC).
inferredcites →https://doi.org/10.1242/dev.137075openalex-snapshot
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
inferredcites →https://doi.org/10.1371/journal.pone.0140479openalex-snapshot
Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092
inferredcites →https://doi.org/10.1371/journal.pone.0154745openalex-snapshot
Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells
inferredcites →https://doi.org/10.15585/mmwr.mm6444a2openalex-snapshot
Current Cigarette Smoking Among Adults — United States, 2005–2014
inferredcites →https://doi.org/10.15585/mmwr.mm6702a1openalex-snapshot
Current Cigarette Smoking Among Adults - United States, 2016.
inferredcites →https://doi.org/10.1634/theoncologist.2016-0257openalex-snapshot
Phase I Dose-Escalation Study of Pilaralisib (SAR245408, XL147) in Combination with Paclitaxel and Carboplatin in Patients with Solid Tumors
inferredcites →https://doi.org/10.1634/theoncologist.2016-0496openalex-snapshot
FDA Approval Summary: Pembrolizumab for the Treatment of Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma with Disease Progression on or After Platinum-Containing Chemotherapy
inferredcites →https://doi.org/10.18632/oncotarget.12742openalex-snapshot
Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents
inferredcites →https://doi.org/10.18632/oncotarget.25854openalex-snapshot
A Phase Ib, open-label, dose-finding study of alpelisib in combination with paclitaxel in patients with advanced solid tumors
inferredcites →https://doi.org/10.25646/6266openalex-snapshot
Tabakassoziierte Krebserkrankungen in Deutschland – Entwicklung der Inzidenz und Mortalität seit 1995
inferredcites →https://doi.org/10.3322/caac.21492openalex-snapshot
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
inferredcites →https://doi.org/10.3389/fonc.2017.00330openalex-snapshot
Heterogeneity of Phosphatidylinositol-3-Kinase (PI3K)/AKT/Mammalian Target of Rapamycin Activation in Cancer: Is PI3K Isoform Specificity Important?
inferredcites →https://doi.org/10.3390/cancers9050052openalex-snapshot
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
inferredcites →https://doi.org/10.3892/ijo.31.5.1141openalex-snapshot
Enhanced susceptibility to apoptosis of oral squamous cell carcinoma cells subjected to combined treatment with anticancer drugs and phosphatidylinositol 3-kinase inhibitors
inferredcites →https://doi.org/10.4161/cbt.5.7.2874openalex-snapshot
A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer
inferredcites →https://doi.org/10.4161/epi.26881openalex-snapshot
Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma
inferredcites →https://doi.org/10.5306/wjco.v7.i5.352openalex-snapshot
Role of Akt signaling in resistance to DNA-targeted therapy
inferredcites →https://doi.org/10.7150/jca.12452openalex-snapshot
Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4688894openalex-extracted
Villosol Inhibits Cdkn2a Gene to Regulate Tp53-Pi3k/Akt Signaling Axis to Reverse 5-Fu Resistance in Colorectal Cancer
inferred← citeshttps://doi.org/10.1002/advs.202202858openalex-snapshot
An Optogenetic‐Controlled Cell Reprogramming System for Driving Cell Fate and Light‐Responsive Chimeric Mice
inferred← citeshttps://doi.org/10.1002/ardp.202200479openalex-snapshot
Recent updates on 1,2,3‐, 1,2,4‐, and 1,3,5‐triazine hybrids (2017–present): The anticancer activity, structure–activity relationships, and mechanisms of action
inferred← citeshttps://doi.org/10.1002/btm2.10741openalex-snapshot
Establishment of a chemoresistant laryngeal cancer cell model to study chemoresistance and chemosensitization responses via transcriptomic analysis and a tumor‐on‐a‐chip platform
inferred← citeshttps://doi.org/10.1002/cac2.12273openalex-snapshot
Aberrant translation regulated by METTL1/WDR4‐mediated tRNA N7‐methylguanosine modification drives head and neck squamous cell carcinoma progression
inferred← citeshttps://doi.org/10.1002/cam4.4163openalex-snapshot
Expression and prognostic potential of PLEK2 in head and neck squamous cell carcinoma based on bioinformatics analysis
inferred← citeshttps://doi.org/10.1002/cam4.4861openalex-snapshot
Characterization of RNA modifications in gastric cancer to identify prognosis‐relevant gene signatures
inferred← citeshttps://doi.org/10.1002/cam4.7309openalex-snapshot
Novel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K / AKT / mTOR pathway
inferred← citeshttps://doi.org/10.1002/ccs3.12027openalex-snapshot
Matricellular proteins: Potential biomarkers in head and neck cancer
inferred← citeshttps://doi.org/10.1002/cnr2.70023openalex-snapshot
Alpelisib and Immunotherapy: A Promising Combination for Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck
inferred← citeshttps://doi.org/10.1002/ddr.21846openalex-snapshot
Sodium Danshensu inhibits the progression of lung cancer by regulating PI3K /Akt signaling pathway
inferred← citeshttps://doi.org/10.1002/iub.2446openalex-snapshot
The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies
inferred← citeshttps://doi.org/10.1002/jbt.23115openalex-snapshot
Cdc42 promotes thyroid cancer cell proliferation and migration and tumor‐associated macrophage polarization through the PTEN/AKT pathway
inferred← citeshttps://doi.org/10.1002/jmv.29315openalex-snapshot
The effects of HPV oncoproteins on host communication networks: Therapeutic connotations
inferred← citeshttps://doi.org/10.1002/mc.23372openalex-snapshot
Autophagy awakens—the myriad roles of autophagy in head and neck cancer development and therapeutic response
inferred← citeshttps://doi.org/10.1002/mc.23422openalex-snapshot
Risk SNP‐mediated LINC01614 upregulation drives head and neck squamous cell carcinoma progression via PI3K/AKT signaling pathway
inferred← citeshttps://doi.org/10.1002/mc.23511openalex-snapshot
Bicarbonate transporter SLC4A7 promotes EMT and metastasis of HNSCC by activating the PI3K/AKT/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1002/mc.70029openalex-snapshot
Noncanonical Pathways of Proteasome Inhibition in HPV‐Negative Head & Neck Cancer
inferred← citeshttps://doi.org/10.1002/mco2.702openalex-snapshot
Head and neck cancer: pathogenesis and targeted therapy
inferred← citeshttps://doi.org/10.1002/mco2.70295openalex-snapshot
PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
inferred← citeshttps://doi.org/10.1002/med.21806openalex-snapshot
Recent insights in the PI3K/Akt pathway as a promising therapeutic target in combination with EGFR‐targeting agents to treat head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1007/978-3-031-05973-5_8openalex-snapshot
Epidemiology and Genomics of Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1007/s00210-024-02963-6openalex-snapshot
Paeonol upregulates expression of tumor suppressors TNNC1 and SCARA5, exerting anti-tumor activity in non-small cell lung cancer cells
inferred← citeshttps://doi.org/10.1007/s10142-025-01612-2openalex-snapshot
The CRISPR-Cas revolution in head and neck cancer: a new era of targeted therapy
inferred← citeshttps://doi.org/10.1007/s10142-025-01677-zopenalex-snapshot
CircSHPRH inhibits malignancy progression of head and neck squamous cell carcinoma by regulating PI3K/AKT/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1007/s11095-025-03836-0openalex-snapshot
Phytochemicals and their Nanoformulations for Overcoming Drug Resistance in Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1007/s11596-024-2898-7openalex-snapshot
Traditional Chinese Medicine Erhuang Suppository for Treatment of Persistent High-risk Human Papillomavirus Infection and Its Impact on Transcriptome of Uterine Cervix
inferred← citeshttps://doi.org/10.1007/s12032-024-02358-wopenalex-snapshot
P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway
inferred← citeshttps://doi.org/10.1007/s12032-026-03315-5openalex-snapshot
Unraveling the link between genomic instability and tumor immune evasion in oral squamous cell carcinoma: Role of CBMN assay and emerging perspectives
inferred← citeshttps://doi.org/10.1007/s12094-022-02856-1openalex-snapshot
Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
inferred← citeshttps://doi.org/10.1007/s12105-023-01580-8openalex-snapshot
Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review
inferred← citeshttps://doi.org/10.1007/s12105-026-01921-3openalex-snapshot
Genetic Landscape of Oral Carcinoma Cuniculatum and its Histological Mimics
inferred← citeshttps://doi.org/10.1007/s12250-021-00413-8openalex-snapshot
Current Status of Human Papillomavirus-Related Head and Neck Cancer: From Viral Genome to Patient Care
inferred← citeshttps://doi.org/10.1007/s12291-023-01166-9openalex-snapshot
Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy
inferred← citeshttps://doi.org/10.1007/s12672-023-00782-4openalex-snapshot
Identification of galactosamine-(N-acetyl)-6-sulfatase (GALNS) as a novel therapeutic target in progression of nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1007/s12672-025-03604-xopenalex-snapshot
Pharmacological inhibition of NMDA receptors reduces migration and viability in triple-negative inflammatory breast cancer cell lines
inferred← citeshttps://doi.org/10.1007/s12672-025-03849-6openalex-snapshot
Identification of lactylation-related biomarkers in HNSC by integrating machine learning and Spatial transcriptomics analysis
inferred← citeshttps://doi.org/10.1007/s12672-026-05356-8openalex-snapshot
Multi-omic discovery of SCG5 as a shared driver and prognostic biomarker in head-neck and non-small cell lung cancers
inferred← citeshttps://doi.org/10.1007/s13273-023-00361-2openalex-snapshot
Improvement of ventricular remodeling and regulation of PI3K/Akt/mTOR signaling pathway in rats with heart failure by polysaccharides from Stropharia rugosoannulata
inferred← citeshttps://doi.org/10.1007/s13402-021-00645-6openalex-snapshot
AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer
inferred← citeshttps://doi.org/10.1007/s13770-023-00579-0openalex-snapshot
Exosomes Derived from Human Adipose Mesenchymal Stem Cells Inhibits Fibrosis and Treats Oral Submucous Fibrosis via the miR-181a-5p/Smad2 Axis
inferred← citeshttps://doi.org/10.1016/b978-0-323-91287-7.00026-0openalex-snapshot
Kinase inhibitors: An overview
inferred← citeshttps://doi.org/10.1016/b978-0-443-15968-8.00001-6openalex-snapshot
Epidemiology, pathology, and genomic topography of head and neck cancers
inferred← citeshttps://doi.org/10.1016/bs.acr.2023.03.004openalex-snapshot
Head and neck cancer treatment in the era of molecular medicine
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2024.106172openalex-snapshot
Effects of ionizing radiation on osteoblastic cells: In vitro insights into the etiopathogenesis of osteoradionecrosis
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2025.106425openalex-snapshot
TWF1 promotes tumor progression in head and neck squamous cell carcinoma via AKT phosphorylation
inferred← citeshttps://doi.org/10.1016/j.bbadis.2026.168283openalex-snapshot
Schisandrin A inhibits head and neck squamous cell carcinoma progression via the PI3K/AKT/GSK3β pathway
inferred← citeshttps://doi.org/10.1016/j.bbcan.2024.189216openalex-snapshot
The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer
inferred← citeshttps://doi.org/10.1016/j.bbcan.2024.189230openalex-snapshot
New advances in the therapeutic strategy of head and neck squamous cell carcinoma: A review of latest therapies and cutting-edge research
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116221openalex-snapshot
Celecoxib and sulindac sulfide elicit anticancer effects on PIK3CA-mutated head and neck cancer cells through endoplasmic reticulum stress, reactive oxygen species, and mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.bioorg.2020.103737openalex-snapshot
Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113087openalex-snapshot
LINC00958: A promising long non-coding RNA related to cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116217openalex-snapshot
β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118871openalex-snapshot
Nanotechnology-based approaches for head and neck cancer treatment
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116265openalex-snapshot
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway
inferred← citeshttps://doi.org/10.1016/j.cdc.2021.100817openalex-snapshot
Anticancer evaluation of difunctional substituted 1,2-dihydrophthalazines
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.111908openalex-snapshot
Panx3 mediates ferroptosis via the AKT/mTOR signaling pathway in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2021.131149openalex-snapshot
Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis
inferred← citeshttps://doi.org/10.1016/j.chmed.2023.01.004openalex-snapshot
Magnolol and 5-fluorouracil synergy inhibition of metastasis of cervical cancer cells by targeting PI3K/AKT/mTOR and EMT pathways
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2020.107426openalex-snapshot
Down regulation of lactotransferrin enhanced radio-sensitivity of nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1016/j.ctarc.2026.101218openalex-snapshot
Human microbiome influence on head and neck cancer
inferred← citeshttps://doi.org/10.1016/j.currproblcancer.2024.101146openalex-snapshot
Mapping the intricacies of GLI1 in hedgehog signaling: A combined bioinformatics and clinical analysis in Head & Neck cancer in Western India
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112953openalex-snapshot
2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113837openalex-snapshot
Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176952openalex-snapshot
The efficacy and safety of PI3K and AKT inhibitors for patients with cancer: A systematic review and network meta-analysis
inferred← citeshttps://doi.org/10.1016/j.ejps.2021.105961openalex-snapshot
The inhibitors of KDM4 and KDM6 histone lysine demethylases enhance the anti-growth effects of erlotinib and HS-173 in head and neck cancer cells
inferred← citeshttps://doi.org/10.1016/j.envres.2023.116432openalex-snapshot
Tumor microenvironment remodeling in oral cancer: Application of plant derived-natural products and nanomaterials
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e29291openalex-snapshot
Melatonin inhibits tongue squamous cell carcinoma: Interplay of ER stress-induced apoptosis and autophagy with cell migration
inferred← citeshttps://doi.org/10.1016/j.ijrobp.2021.12.009openalex-snapshot
Comprehensive Next-Generation Sequencing Reveals Novel Predictive Biomarkers of Recurrence and Thoracic Toxicity Risks After Chemoradiation Therapy in Limited Stage Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113532openalex-snapshot
Biomarkers associated with papillary thyroid carcinoma and Hashimoto’s thyroiditis: Bioinformatic analysis and experimental validation
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117351openalex-snapshot
A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways and by modulating endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1016/j.jep.2024.117907openalex-snapshot
Villosol reverses 5-FU resistance in colorectal cancer by inhibiting the CDKN2A gene regulated TP53-PI3K/Akt signaling axis
inferred← citeshttps://doi.org/10.1016/j.jtumed.2023.04.006openalex-snapshot
New drug-like small molecule antagonizes phosphatidylinositol (3,4,5)-trisphosphate (PIP3) in patients with conotruncal heart defects
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122719openalex-snapshot
Deciphering the complex landscape of post-translational modifications on PKM2: Implications in head and neck cancer pathogenesis
inferred← citeshttps://doi.org/10.1016/j.mcp.2020.101574openalex-snapshot
MicroRNA-330-3p represses the proliferation and invasion of laryngeal squamous cell carcinoma through downregulation of Tra2β-mediated Akt signaling
inferred← citeshttps://doi.org/10.1016/j.oooo.2021.10.020openalex-snapshot
Expression profile of the PI3K-AKT-mTOR pathway in head and neck squamous cell carcinoma: Data from Brazilian population
inferred← citeshttps://doi.org/10.1016/j.oraloncology.2022.105939openalex-snapshot
Simultaneously targeting ErbB family kinases and PI3K in HPV-positive head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.patol.2022.06.003openalex-snapshot
Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: A Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105575openalex-snapshot
Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154133openalex-snapshot
Saucerneol attenuates nasopharyngeal carcinoma cells proliferation and metastasis through selectively targeting Grp94
inferred← citeshttps://doi.org/10.1016/j.phymed.2026.158283openalex-snapshot
Targeting oncogenic signaling pathways in head and neck cancer using nano-phytomedicine: Molecular insights and therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.prenap.2025.100388openalex-snapshot
Elucidating the potential of phytochemicals in targeting various signalling pathways of oral cancer: Current update on their clinical translational potential
inferred← citeshttps://doi.org/10.1016/j.tice.2026.104047openalex-snapshot
Kinesin superfamily proteins in head and neck cancer: Mechanisms, clinical implications, and therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.tranon.2022.101364openalex-snapshot
The PI3K/Akt/mTOR pathway in lung cancer; oncogenic alterations, therapeutic opportunities, challenges, and a glance at the application of nanoparticles
inferred← citeshttps://doi.org/10.1016/j.wneu.2023.05.010openalex-snapshot
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway
inferred← citeshttps://doi.org/10.1016/j.yexcr.2024.114365openalex-snapshot
Long non-coding RNAs and their role in breast cancer pathogenesis and drug resistance: Navigating the non-coding landscape review
inferred← citeshttps://doi.org/10.1016/s1875-5364(26)61175-2openalex-snapshot
Structurally diverse flavonoids from Selaginella doederleinii and their biological activity against laryngeal cancer
inferred← citeshttps://doi.org/10.1021/acs.biomac.3c00988openalex-snapshot
Coexpression of TP53, BIM, and PTEN Enhances the Therapeutic Efficacy of Non-Small-Cell Lung Cancer
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.2c00457openalex-snapshot
Mechanisms of Biochanin A Alleviating PM2.5 Organic Extracts-Induced EMT of A549 Cells through the PI3K/Akt Pathway
inferred← citeshttps://doi.org/10.1021/acsnano.5c01078openalex-snapshot
Toehold-Based CRISPR-dCas9 Transcriptional Activation Platform for Spatiotemporally Controllable Gene Therapy in Tumor and Diabetic Mouse Models
inferred← citeshttps://doi.org/10.1021/acsptsci.4c00518openalex-snapshot
Curcumin: A Potential Weapon in the Prevention and Treatment of Head and Neck Cancer
inferred← citeshttps://doi.org/10.1038/s41368-023-00249-wopenalex-snapshot
Oral squamous cell carcinomas: state of the field and emerging directions
inferred← citeshttps://doi.org/10.1038/s41388-021-02055-2openalex-snapshot
A highly annotated database of genes associated with platinum resistance in cancer
inferred← citeshttps://doi.org/10.1038/s41392-022-01297-0openalex-snapshot
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
inferred← citeshttps://doi.org/10.1038/s41419-021-03582-2openalex-snapshot
Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells
inferred← citeshttps://doi.org/10.1038/s41419-025-07959-5openalex-snapshot
Pharmacological activation of SIRT6 suppresses progression of head and neck and esophageal squamous cell carcinoma by modulation of cellular metabolism and protein translation
inferred← citeshttps://doi.org/10.1038/s41420-022-01047-9openalex-snapshot
FAM126A interacted with ENO1 mediates proliferation and metastasis in pancreatic cancer via PI3K/AKT signaling pathway
inferred← citeshttps://doi.org/10.1038/s41420-024-01842-6openalex-snapshot
NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1038/s41467-021-26570-8openalex-snapshot
Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function
inferred← citeshttps://doi.org/10.1038/s41598-025-01867-6openalex-snapshot
Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro
inferred← citeshttps://doi.org/10.1038/s44318-025-00449-6openalex-snapshot
Inhibitors of eIF1A-ribosome interaction unveil uORF-dependent regulation of translation initiation and antitumor and antiviral effects
inferred← citeshttps://doi.org/10.1039/d5fo04145gopenalex-snapshot
Agaricus bisporus polysaccharide ABP alleviates X-ray-induced spermatogonial injury via the PI3K/AKT/mTOR pathway: toward a novel dietary radioprotectant
inferred← citeshttps://doi.org/10.1039/d5pm00313jopenalex-snapshot
Microneedles as an effective and minimally invasive delivery strategy for oral cancer treatment
inferred← citeshttps://doi.org/10.1073/pnas.2120339119openalex-snapshot
Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation
inferred← citeshttps://doi.org/10.1080/07357907.2021.1954190openalex-snapshot
Mechanisms and Molecular Targets of Artemisinin in Cancer Treatment
inferred← citeshttps://doi.org/10.1080/07391102.2020.1861980openalex-snapshot
In-silico prediction of potential inhibitors against phosphatidylinositol 3-kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas
inferred← citeshttps://doi.org/10.1080/07391102.2022.2132293openalex-snapshot
Development of PI3Kα inhibitors for tumor therapy
inferred← citeshttps://doi.org/10.1080/13543776.2021.1940137openalex-snapshot
A patent review of mTOR inhibitors for cancer therapy (2011–2020)
inferred← citeshttps://doi.org/10.1080/14737140.2024.2417038openalex-snapshot
Future investigative directions for novel therapeutic targets in head and neck cancer
inferred← citeshttps://doi.org/10.1080/15384101.2022.2054245openalex-snapshot
MiR-1306-5p predicts favorable prognosis and inhibits proliferation, migration, and invasion of colorectal cancer cells via PI3K/AKT/mTOR pathway
inferred← citeshttps://doi.org/10.1080/15592294.2023.2175168openalex-snapshot
Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1080/21655979.2021.2001218openalex-snapshot
Integral membrane protein 2A enhances sensitivity to chemotherapy via notch signaling pathway in cervical cancer
inferred← citeshttps://doi.org/10.1080/21655979.2022.2064205openalex-snapshot
Everolimus (RAD001) combined with programmed death-1 (PD-1) blockade enhances radiosensitivity of cervical cancer and programmed death-ligand 1 (PD-L1) expression by blocking the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR)/S6 kinase 1 (S6K1) pathway
inferred← citeshttps://doi.org/10.1084/jem.20210836openalex-snapshot
An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy
inferred← citeshttps://doi.org/10.1089/jmf.2021.k.0059openalex-snapshot
Ginkgolic Acid Suppresses Nasopharyngeal Carcinoma Growth by Inducing Apoptosis and Inhibiting AKT/NF-κB Signaling
inferred← citeshttps://doi.org/10.1097/cm9.0000000000002535openalex-snapshot
Effects of radiation therapy on tumor microenvironment: an updated review
inferred← citeshttps://doi.org/10.1097/pai.0000000000001195openalex-snapshot
Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase Acts as a Tumor Suppressor in Oral Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1097/rct.0000000000001213openalex-snapshot
Prediction of Genetic Alterations in Oncogenic Signaling Pathways in Squamous Cell Carcinoma of the Head and Neck: Radiogenomic Analysis Based on Computed Tomography Images
inferred← citeshttps://doi.org/10.1101/2020.04.10.028217openalex-snapshot
Inhibition of histone acetyltranserase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a novel gain of function
inferred← citeshttps://doi.org/10.1101/2024.09.24.614705openalex-snapshot
Tumor microenvironment distinctions between esophageal cancer subtypes explain varied immunotherapy responses
inferred← citeshttps://doi.org/10.1111/1759-7714.14354openalex-snapshot
Upregulation of ADAMDEC1 correlates with tumor progression and predicts poor prognosis in non‐small cell lung cancer ( NSCLC ) via the PI3K / AKT pathway
inferred← citeshttps://doi.org/10.1111/cas.14911openalex-snapshot
AKT3 is a key regulator of head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.1111/jcmm.18556openalex-snapshot
Hypomethylation‐associated Sox11 upregulation promotes oncogenesis via the PI3K/AKT pathway in OLP‐associated OSCC
inferred← citeshttps://doi.org/10.1111/jop.13233openalex-snapshot
The combinatorial inhibition of Wnt signaling and Akt kinase is beneficial for reducing the survival and glycolytic activity of tongue cancer cells
inferred← citeshttps://doi.org/10.1111/odi.14271openalex-snapshot
Curcumin nanoemulsions inhibit oral squamous cell carcinoma cell proliferation by PI3K /Akt/ mTOR suppression and miR ‐199a upregulation: A preliminary study
inferred← citeshttps://doi.org/10.1111/odi.15293openalex-snapshot
Emerging Preclinical and Clinical Evidence on the Impact of Phytochemicals in Oral Cancer Metastasis
inferred← citeshttps://doi.org/10.1126/sciadv.abh2358openalex-snapshot
A far-red light–inducible CRISPR-Cas12a platform for remote-controlled genome editing and gene activation
inferred← citeshttps://doi.org/10.1136/jmedgenet-2020-107410openalex-snapshot
Genetic variants associated with expression of TCF19 contribute to the risk of head and neck cancer in Chinese population
inferred← citeshttps://doi.org/10.1155/2021/1334571openalex-snapshot
Identification of an Immune-Related Biomarker Model Based on the CircRNA-Associated Regulatory Network for Esophageal Carcinoma
inferred← citeshttps://doi.org/10.1155/2022/1091042openalex-snapshot
PTPN18 Stimulates the Development of Ovarian Cancer by Activating the PI3K/AKT Signaling
inferred← citeshttps://doi.org/10.1155/2022/3543948openalex-snapshot
Long Noncoding RNA LEMD1‐AS1 Increases LEMD1 Expression and Activates PI3K‐AKT Pathway to Promote Metastasis in Oral Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1155/2022/5871188openalex-snapshot
The Involvement of WDHD1 in the Occurrence of Esophageal Cancer as a Downstream Target of PI3K/AKT Pathway
inferred← citeshttps://doi.org/10.1158/2767-9764.crc-23-0155openalex-snapshot
Immune Cell Abundance and T-cell Receptor Landscapes Suggest New Patient Stratification Strategies in Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1161/jaha.123.029745openalex-snapshot
Ovarian Tumor Domain‐Containing 7B Attenuates Pathological Cardiac Hypertrophy by Inhibiting Ubiquitination and Degradation of Krüppel‐Like Factor 4
inferred← citeshttps://doi.org/10.1186/s12935-022-02545-7openalex-snapshot
PGM1 suppresses colorectal cancer cell migration and invasion by regulating the PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1186/s12935-023-02982-yopenalex-snapshot
The effect of matrices on the gene expression profile of patient-derived head and neck carcinoma cells for in vitro therapy testing
inferred← citeshttps://doi.org/10.1186/s12935-026-04218-1openalex-snapshot
The inhibition of the MRN complex by Mirin radiosensitizes particularly HPV-negative HNSCC cell lines
inferred← citeshttps://doi.org/10.1186/s12943-023-01905-9openalex-snapshot
Immunosignatures associated with TP53 status and co-mutations classify prognostically head and neck cancer patients
inferred← citeshttps://doi.org/10.1186/s12967-022-03821-wopenalex-snapshot
PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS
inferred← citeshttps://doi.org/10.1186/s12967-025-06169-zopenalex-snapshot
Targeted inhibition of the PTEN/PI3K/AKT pathway by YSV induces cell cycle arrest and apoptosis in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1186/s13048-026-02005-0openalex-snapshot
Targeting epigenetic networks to overcome cisplatin resistance in ovarian cancer: from mechanisms to clinical translation
inferred← citeshttps://doi.org/10.1200/po.23.00003openalex-snapshot
Six-MicroRNA Prognostic Signature in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.1371/journal.pone.0269166openalex-snapshot
Signal peptidase complex catalytic subunit SEC11A upregulation is a biomarker of poor prognosis in patients with head and neck squamous cell carcinoma
inferred← citeshttps://doi.org/10.15430/jcp.24.027openalex-snapshot
Advances in Preventive and Therapeutic Strategies for Oral Cancer: A Short Review
inferred← citeshttps://doi.org/10.1615/jenvironpatholtoxicoloncol.2022042281openalex-snapshot
PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer
inferred← citeshttps://doi.org/10.18632/oncoscience.511openalex-snapshot
A highway to carcinogenesis: the role of IQGAP1, a signaling scaffolding protein, in head and neck cancer development
inferred← citeshttps://doi.org/10.18632/oncotarget.27763openalex-snapshot
Combination of copanlisib with cetuximab improves tumor response in cetuximab-resistant patient-derived xenografts of head and neck cancer
inferred← citeshttps://doi.org/10.20944/preprints202402.0503.v1openalex-snapshot
Evaluation of Co-Inhibition of ErbB Family and PI3K Kinases for HPV-Negative Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.21037/atm-22-3650openalex-snapshot
Circ_0001658 regulates PI3K/AKT signaling via the miR-671-5p/ITGA2 axis and affects the progress of papillary thyroid carcinoma
inferred← citeshttps://doi.org/10.21037/jgo-21-467openalex-snapshot
A dual-targeted molecular therapy of PP242 and cetuximab plays an anti-tumor effect through EGFR downstream signaling pathways in colorectal cancer
inferred← citeshttps://doi.org/10.21037/tcr-21-2325openalex-snapshot
Dual inhibition of autophagy and PI3K/mTOR pathway as a potential therapeutic strategy against laryngeal squamous cell carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1293225/v1openalex-snapshot
Genomic analyses identify signaling pathways and biological processes in Human papillomavirus (HPV) infected oral cancer patients
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2013818/v1openalex-snapshot
Brusatol Suppresses Bladder Cancer by downregulating the expression of Nrf2
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2620802/v1openalex-snapshot
TP53 mutation-associated immunosignatures impact on anti-PD-L1 treatment response in head and neck cancer patients.
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5551946/v1openalex-snapshot
WITHDRAWN: Tumor Microenvironment In Head And Neck Cancer: Insights From Spheroids
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5551946/v2openalex-snapshot
WITHDRAWN: Tumor Microenvironment In Head And Neck Cancer: Insights From Spheroids
inferred← citeshttps://doi.org/10.21203/rs.3.rs-569563/v1openalex-snapshot
Efficacy of Dual PI3K/mTOR Inhibitor Combined With Autophagy Suppression Against Laryngeal Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.21203/rs.3.rs-944736/v1openalex-snapshot
PGM1 Suppresses Colorectal Cancer Cell Migration And Invasion by Regulating PI3K/ AKT Pathway
inferred← citeshttps://doi.org/10.2139/ssrn.6250427openalex-snapshot
Active Liposomal Targeting for Head and Neck Squamous Cell Carcinoma Treatment
inferred← citeshttps://doi.org/10.2147/dddt.s365279openalex-snapshot
Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis
inferred← citeshttps://doi.org/10.2147/ijn.s270939openalex-snapshot
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer
inferred← citeshttps://doi.org/10.2174/0929866527666200916141730openalex-snapshot
Acetogenin Extracted from Annona muricata Prevented the Actions of EGF in PA-1 Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.2174/1566524022666220517102423openalex-snapshot
Transcriptome Profiling of Cisplatin Resistance in Triple-negative Breast Cancer: New Insight into the Role of PI3k/Akt Pathway
inferred← citeshttps://doi.org/10.2174/1568026620666200310122741openalex-snapshot
1,3,5-Triazine-azole Hybrids and their Anticancer Activity
inferred← citeshttps://doi.org/10.22363/2313-0245-2024-28-4-413-426openalex-snapshot
Molecular genetic signatures of head and neck squamous cell carcinoma and their changes induced by proton irradiation
inferred← citeshttps://doi.org/10.23868/202104013openalex-snapshot
The hipotises of the immune system's role in carcinogenesis
inferred← citeshttps://doi.org/10.2478/jtim-2021-0025openalex-snapshot
Effects of des-acyl ghrelin on insulin sensitivity and macrophage polarization in adipose tissue
inferred← citeshttps://doi.org/10.31083/j.fbl2802037openalex-snapshot
To Investigate the Occurrence and Development of Colorectal Cancer Based on the PI3K/AKT/mTOR Signaling Pathway
inferred← citeshttps://doi.org/10.3342/kjorl-hns.2022.01102openalex-snapshot
The Mechanisms and Overcoming Strategies of the Radioresistance in Head and Neck Cancer
inferred← citeshttps://doi.org/10.3342/kjorl-hns.2024.00038openalex-snapshot
Synergistic Inhibition of Head and Neck Cancer Cell Proliferation by Combined Metformin and Radiotherapy Treatment
inferred← citeshttps://doi.org/10.3389/fbioe.2023.1248421openalex-snapshot
Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms
inferred← citeshttps://doi.org/10.3389/fcell.2021.797005openalex-snapshot
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance
inferred← citeshttps://doi.org/10.3389/fendo.2023.1221705openalex-snapshot
Current status and progress in research on dressing management for diabetic foot ulcer
inferred← citeshttps://doi.org/10.3389/fgene.2021.691592openalex-snapshot
The Expression Regulatory Network in the Lung Tissue of Tibetan Pigs Provides Insight Into Hypoxia-Sensitive Pathways in High-Altitude Hypoxia
inferred← citeshttps://doi.org/10.3389/fgene.2022.914646openalex-snapshot
Identification of Molecular Targets and Potential Mechanisms of Yinchen Wuling San Against Head and Neck Squamous Cell Carcinoma by Network Pharmacology and Molecular Docking
inferred← citeshttps://doi.org/10.3389/fimmu.2021.718621openalex-snapshot
Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and –γ
inferred← citeshttps://doi.org/10.3389/fimmu.2021.724200openalex-snapshot
SNAIL1: Linking Tumor Metastasis to Immune Evasion
inferred← citeshttps://doi.org/10.3389/fmolb.2021.707461openalex-snapshot
MicroRNAs in Transforming Growth Factor-Beta Signaling Pathway Associated With Fibrosis Involving Different Systems of the Human Body
inferred← citeshttps://doi.org/10.3389/fmolb.2022.838006openalex-snapshot
ROS-Induced DCTPP1 Upregulation Contributes to Cisplatin Resistance in Ovarian Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2020.01260openalex-snapshot
Improving the Efficacy of Tumor Radiosensitization Through Combined Molecular Targeting
inferred← citeshttps://doi.org/10.3389/fonc.2020.565669openalex-snapshot
The Molecular Landscape and Biological Alterations Induced by PRAS40-Knockout in Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/fonc.2021.614332openalex-snapshot
Precision Medicine Approaches to Overcome Resistance to Therapy in Head and Neck Cancers
inferred← citeshttps://doi.org/10.3389/fonc.2021.730412openalex-snapshot
Targeted Therapy as a Potential De-Escalation Strategy in Locally Advanced HPV-Associated Oropharyngeal Cancer: A Literature Review
inferred← citeshttps://doi.org/10.3389/fonc.2022.837835openalex-snapshot
Rational Combinations of Targeted Therapy and Immune Checkpoint Inhibitors in Head and Neck Cancers
inferred← citeshttps://doi.org/10.3389/fonc.2022.943064openalex-snapshot
Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models
inferred← citeshttps://doi.org/10.3389/fonc.2022.960340openalex-snapshot
In vitro models for head and neck cancer: Current status and future perspective
inferred← citeshttps://doi.org/10.3389/fonc.2023.1140133openalex-snapshot
Mutual connected IL-6, EGFR and LIN28/Let7-related mechanisms modulate PD-L1 and IGF upregulation in HNSCC using immunotherapy
inferred← citeshttps://doi.org/10.3389/fonc.2026.1745024openalex-snapshot
The mechanism of the PI3K-AKT-mTOR signaling pathway in renal cell carcinoma: current developments and future prospects
inferred← citeshttps://doi.org/10.3389/fphar.2021.699044openalex-snapshot
Phytochemicals as Potential Chemopreventive and Chemotherapeutic Agents for Emerging Human Papillomavirus–Driven Head and Neck Cancer: Current Evidence and Future Prospects
inferred← citeshttps://doi.org/10.3389/fphar.2021.770667openalex-snapshot
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells
inferred← citeshttps://doi.org/10.3389/fphar.2023.1174330openalex-snapshot
Pharmacological impact of microRNAs in head and neck squamous cell carcinoma: Prevailing insights on molecular pathways, diagnosis, and nanomedicine treatment
inferred← citeshttps://doi.org/10.3389/fphar.2023.1272546openalex-snapshot
A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid
inferred← citeshttps://doi.org/10.3389/fphar.2024.1434994openalex-snapshot
Nanomedicine in HNSCC therapy-a challenge to conventional therapy
inferred← citeshttps://doi.org/10.3389/fpls.2024.1423678openalex-snapshot
A multidimensional strategy for uncovering comprehensive quality markers of Scutellariae Radix based on UPLC-Q-TOF-MS analysis, artificial neural network, network pharmacology analysis, and molecular simulation
inferred← citeshttps://doi.org/10.3389/froh.2021.647980openalex-snapshot
At the Crossroads of Molecular Biology and Immunology: Molecular Pathways for Immunological Targeting of Head and Neck Squamous Cell Carcinoma
inferred← citeshttps://doi.org/10.3389/froh.2023.1246873openalex-snapshot
Exploring the potential of dietary factors and plant extracts as chemopreventive agents in oral squamous cell carcinoma treatment
inferred← citeshttps://doi.org/10.3389/fsurg.2022.1011845openalex-snapshot
PTEN is recognized as a prognostic-related biomarker and inhibits proliferation and invasiveness of skull base chordoma cells
inferred← citeshttps://doi.org/10.3390/app132413293openalex-snapshot
Recent Advances in the Targeting of Head and Neck Cancer Stem Cells
inferred← citeshttps://doi.org/10.3390/biology12050672openalex-snapshot
PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications
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