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Relationship between the in vitro efficacy, pharmacokinetics and in vivo efficacy of curcumin

https://doi.org/10.1016/j.bcp.2022.115251

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bmc.4267openalex-snapshot

The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice

inferredcites →https://doi.org/10.1002/cncr.21300openalex-snapshot

Liposome‐encapsulated curcumin

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The dark side of curcumin

inferredcites →https://doi.org/10.1002/mnfr.200600283openalex-snapshot

Glucuronidation of curcuminoids by human microsomal and recombinant UDP‐glucuronosyltransferases

inferredcites →https://doi.org/10.1002/mnfr.200900277openalex-snapshot

Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts

inferredcites →https://doi.org/10.1002/pro.4134openalex-snapshot

NF‐κB Rel subunit exchange on a physiological timescale

inferredcites →https://doi.org/10.1002/pros.1074openalex-snapshot

Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo

inferredcites →https://doi.org/10.1007/s002100000260openalex-snapshot

Expression and function of β-glucuronidase in pancreatic cancer: potential role in drug targeting

inferredcites →https://doi.org/10.1007/s00280-011-1749-yopenalex-snapshot

Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice

inferredcites →https://doi.org/10.1007/s00280-018-3654-0openalex-snapshot

A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic cancer

inferredcites →https://doi.org/10.1007/s10016-006-9054-7openalex-snapshot

Oral Administration of Diferuloylmethane (Curcumin) Suppresses Proinflammatory Cytokines and Destructive Connective Tissue Remodeling in Experimental Abdominal Aortic Aneurysms

inferredcites →https://doi.org/10.1007/s11745-999-0453-xopenalex-snapshot

Interaction of curcumin with human serum albumin—A spectroscopic study

inferredcites →https://doi.org/10.1016/j.antiviral.2019.04.011openalex-snapshot

Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity against KSHV replication and pathogenesis

inferredcites →https://doi.org/10.1016/j.bbagen.2006.06.012openalex-snapshot

Transport of liposomal and albumin loaded curcumin to living cells: An absorption and fluorescence spectroscopic study

inferredcites →https://doi.org/10.1016/j.bcp.2004.03.015openalex-snapshot

Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro

inferredcites →https://doi.org/10.1016/j.bgm.2014.06.002openalex-snapshot

Curcumin decreased level of proinflammatory cytokines in monocyte cultures exposed to preeclamptic plasma by affecting the transcription factors NF-κB and PPAR-γ

inferredcites →https://doi.org/10.1016/j.biopha.2017.01.072openalex-snapshot

Combination of arabinogalactan and curcumin induces apoptosis in breast cancer cells in vitro and inhibits tumor growth via overexpression of p53 level in vivo

inferredcites →https://doi.org/10.1016/j.fitote.2013.02.014openalex-snapshot

Curcumin attenuates allergic airway inflammation by regulation of CD4+CD25+ regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized mice

inferredcites →https://doi.org/10.1016/j.foodchem.2011.01.059openalex-snapshot

Optimised nano-formulation on the bioavailability of hydrophobic polyphenol, curcumin, in freely-moving rats

inferredcites →https://doi.org/10.1016/j.intimp.2010.02.011openalex-snapshot

Curcumin attenuates inflammatory response in IL-1β-induced human synovial fibroblasts and collagen-induced arthritis in mouse model

inferredcites →https://doi.org/10.1016/j.intimp.2011.10.013openalex-snapshot

Comparative evaluation of anti-inflammatory properties of thymoquinone and curcumin using an asthmatic murine model

inferredcites →https://doi.org/10.1016/j.intimp.2011.12.009openalex-snapshot

Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): Anti-inflammatory and anti-cancer properties

inferredcites →https://doi.org/10.1016/j.intimp.2013.09.024openalex-snapshot

Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo

inferredcites →https://doi.org/10.1016/j.jchromb.2014.08.009openalex-snapshot

A validated LC-MS/MS method for quantitative analysis of curcumin in mouse plasma and brain tissue and its application in pharmacokinetic and brain distribution studies

inferredcites →https://doi.org/10.1016/j.jprot.2016.01.016openalex-snapshot

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

inferredcites →https://doi.org/10.1016/j.phymed.2009.04.008openalex-snapshot

Curcumin inhibits cell proliferation of MDA-MB-231 and BT-483 breast cancer cells mediated by down-regulation of NFκB, cyclinD and MMP-1 transcription

inferredcites →https://doi.org/10.1016/j.transproceed.2013.09.006openalex-snapshot

Curcumin Treatment Protects Against Renal Ischemia and Reperfusion Injury–Induced Cardiac Dysfunction and Myocardial Injury

inferredcites →https://doi.org/10.1016/s0731-7085(96)02024-9openalex-snapshot

Stability of curcumin in buffer solutions and characterization of its degradation products

inferredcites →https://doi.org/10.1017/s0007114514000567openalex-snapshot

Differential cellular uptake and metabolism of curcuminoids in monocytes/macrophages: regulatory effects on lipid accumulation

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Toward an Understanding of Pan-Assay Interference Compounds and Promiscuity: A Structural Perspective on Binding Modes

inferredcites →https://doi.org/10.1021/acs.jmedchem.6b00975openalex-snapshot

The Essential Medicinal Chemistry of Curcumin

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Beta-Glucuronidase Catalyzes Deconjugation and Activation of Curcumin-Glucuronide in Bone

inferredcites →https://doi.org/10.1021/jf011601sopenalex-snapshot

Structural Identification of New Curcumin Dimers and Their Contribution to the Antioxidant Mechanism of Curcumin

inferredcites →https://doi.org/10.1021/jf0623283openalex-snapshot

Curcuminoids Form Reactive Glucuronides In Vitro

inferredcites →https://doi.org/10.1021/jm4008714openalex-snapshot

Monitoring Drug Self-Aggregation and Potential for Promiscuity in Off-Target In Vitro Pharmacology Screens by a Practical NMR Strategy

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Induction of β-Glucuronidase Release by Cytostatic Agents in Small Tumors

inferredcites →https://doi.org/10.1038/s41392-020-00312-6openalex-snapshot

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

inferredcites →https://doi.org/10.1038/s41598-018-20179-6openalex-snapshot

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth

inferredcites →https://doi.org/10.1038/sj.bjp.0702803openalex-snapshot

Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin‐12 production in macrophages

inferredcites →https://doi.org/10.1038/sj.leu.2403233openalex-snapshot

Role of curcumin and the inhibition of NF-κB in the onset of chemotherapy-induced mucosal barrier injury

inferredcites →https://doi.org/10.1038/sj.pcan.4500856openalex-snapshot

The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo

inferredcites →https://doi.org/10.1038/srep31695openalex-snapshot

Curcumin suppresses NTHi-induced CXCL5 expression via inhibition of positive IKKβ pathway and up-regulation of negative MKP-1 pathway

inferredcites →https://doi.org/10.1039/c6ra24256aopenalex-snapshot

Effect of pH and temperature on conformational equilibria and aggregation behaviour of curcumin in aqueous binary mixtures of ethanol

inferredcites →https://doi.org/10.1056/nejm199704103361506openalex-snapshot

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

inferredcites →https://doi.org/10.1074/jbc.m111.256180openalex-snapshot

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytes in Vitro

inferredcites →https://doi.org/10.1074/jbc.m414645200openalex-snapshot

Thioredoxin Reductase Is Irreversibly Modified by Curcumin

inferredcites →https://doi.org/10.1074/jbc.ra117.000123openalex-snapshot

The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites

inferredcites →https://doi.org/10.1080/00498254.2016.1183060openalex-snapshot

Impact of curcumin on the pharmacokinetics of rosuvastatin in rats and dogs based on the conjugated metabolites

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Pharmacology of estrogens and progestogens: influence of different routes of administration

inferredcites →https://doi.org/10.1080/13880209.2019.1701042openalex-snapshot

Curcumin inhibited the growth and invasion of human monocytic leukaemia SHI-1 cells in vivo by altering MAPK and MMP signalling

inferredcites →https://doi.org/10.1093/carcin/20.6.1011openalex-snapshot

Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gamma-rays

inferredcites →https://doi.org/10.1093/carcin/bgm123openalex-snapshot

Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism

inferredcites →https://doi.org/10.1093/carcin/bgs312openalex-snapshot

Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2

inferredcites →https://doi.org/10.1096/fasebj.10.7.8635688openalex-snapshot

Antioxidant and redox regulation of gene transcription

inferredcites →https://doi.org/10.1099/jmm.0.016873-0openalex-snapshot

Curcumin alone and in combination with augmentin protects against pulmonaryinflammation and acute lung injury generated during Klebsiella pneumoniae B5055-induced lung infection in BALB/c mice

inferredcites →https://doi.org/10.1111/j.1476-5381.2011.01724.xopenalex-snapshot

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

inferredcites →https://doi.org/10.1124/mol.118.114314openalex-snapshot

Organic Anion Transporting Polypeptides: Emerging Roles in Cancer Pharmacology

inferredcites →https://doi.org/10.1124/pr.110.004044openalex-snapshot

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

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The Liver Partition Coefficient-Corrected Inhibitory Quotient and the Pharmacokinetic-Pharmacodynamic Relationship of Directly Acting Anti-Hepatitis C Virus Agents in Humans

inferredcites →https://doi.org/10.1152/physrev.00025.2013openalex-snapshot

The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

inferredcites →https://doi.org/10.1155/2014/817972openalex-snapshot

Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice

inferredcites →https://doi.org/10.1155/2015/878134openalex-snapshot

Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer

inferredcites →https://doi.org/10.1158/0008-5472.can-05-2708openalex-snapshot

Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice

inferredcites →https://doi.org/10.1158/0008-5472.can-06-3066openalex-snapshot

Curcumin, a Dietary Component, Has Anticancer, Chemosensitization, and Radiosensitization Effects by Down-regulating the MDM2 Oncogene through the PI3K/mTOR/ETS2 Pathway

inferredcites →https://doi.org/10.1158/1055-9965.epi-07-2693openalex-snapshot

Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects

inferredcites →https://doi.org/10.1158/1078-0432.ccr-06-3072openalex-snapshot

Curcumin Inhibits Tumor Growth and Angiogenesis in Ovarian Carcinoma by Targeting the Nuclear Factor-κB Pathway

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-4722openalex-snapshot

Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to γ-Radiation by Targeting Nuclear Factor-κB–Regulated Gene Products

inferredcites →https://doi.org/10.1158/1535-7163.mct-10-0172openalex-snapshot

Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer

inferredcites →https://doi.org/10.1158/1940-6207.capr-13-0248openalex-snapshot

Curcumin Implants, Not Curcumin Diet, Inhibit Estrogen-Induced Mammary Carcinogenesis in ACI Rats

inferredcites →https://doi.org/10.1159/000099202openalex-snapshot

The Chemopreventive Polyphenol Curcumin Prevents Hematogenous Breast Cancer Metastases in Immunodeficient Mice

inferredcites →https://doi.org/10.1159/000500355openalex-snapshot

Plasma Beta-Glucuronidase Activity: A Novel Tool to Distinguish Type 1 from Type 2 Amiodarone-Induced Thyrotoxicosis?

inferredcites →https://doi.org/10.1166/jbn.2015.2073openalex-snapshot

Improving Anti-Tumor Activity of Curcumin by Polymeric Micelles in Thermosensitive Hydrogel System in Colorectal Peritoneal Carcinomatosis Model

inferredcites →https://doi.org/10.1177/1758834016687482openalex-snapshot

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inferredcites →https://doi.org/10.1186/s12885-020-07256-8openalex-snapshot

Clinical effects of curcumin in enhancing cancer therapy: A systematic review

inferredcites →https://doi.org/10.1186/s13578-015-0056-4openalex-snapshot

NF-κB in inflammation and renal diseases

inferredcites →https://doi.org/10.1248/bpb.b17-00339openalex-snapshot

Curcumin β-D-Glucuronide Plays an Important Role to Keep High Levels of Free-Form Curcumin in the Blood

inferredcites →https://doi.org/10.1371/journal.pone.0032813openalex-snapshot

Epithelial Proinflammatory Response and Curcumin-Mediated Protection from Staphylococcal Toxic Shock Syndrome Toxin-1

inferredcites →https://doi.org/10.1371/journal.pone.0144462openalex-snapshot

Curcumin Inhibits Non-Small Cell Lung Cancer Cells Metastasis through the Adiponectin/NF-κb/MMPs Signaling Pathway

inferredcites →https://doi.org/10.1517/17425255.1.3.429openalex-snapshot

Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination

inferredcites →https://doi.org/10.1590/1678-457x.6515openalex-snapshot

Production, solubility and antioxidant activity of curcumin nanosuspension

inferredcites →https://doi.org/10.18632/oncotarget.19164openalex-snapshot

Nanoformulations of curcumin: an emerging paradigm for improved remedial application

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Curcumin alleviates rheumatoid arthritis-induced inflammation and synovial hyperplasia by targeting mTOR pathway in rats

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Distribution and Metabolism of Lipocurc™ (Liposomal Curcumin) in Dog and Human Blood Cells: Species Selectivity and Pharmacokinetic Relevance

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Intense Uptake of Liposomal Curcumin by Multiple Myeloma Cell Lines: Comparison to Normal Lymphocytes, Red Blood Cells and Chronic Lymphocytic Leukemia Cells

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Investigating the anti-tumoral effect of curcumin on the mice in which Ehrlich ascites and solid tumor is created.

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Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces

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NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini Review

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Nanocurcumin: A Promising Candidate for Therapeutic Applications

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An Update on the Exploratory Use of Curcumin in Neuropsychiatric Disorders

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Synergistic Antitumorigenic Activity of Calcitriol with Curcumin or Resveratrol is Mediated by Angiogenesis Inhibition in Triple Negative Breast Cancer Xenografts

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Uptake Transporters of the SLC21, SLC22A, and SLC15A Families in Anticancer Therapy—Modulators of Cellular Entry or Pharmacokinetics?

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A Review of Curcumin and Its Derivatives as Anticancer Agents

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The Chemistry of Curcumin: From Extraction to Therapeutic Agent

inferredcites →https://doi.org/10.3748/wjg.14.2003openalex-snapshot

Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice

inferredcites →https://doi.org/10.3892/ijmm.2016.2524openalex-snapshot

Determining whether curcumin degradation/condensation is actually bioactivation (Review)

inferredcites →https://doi.org/10.3892/ijo.2012.1734openalex-snapshot

Oral or parenteral administration of curcumin does not prevent the growth of high-risk t(4;11) acute lymphoblastic leukemia cells engrafted into a NOD/SCID mouse model

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Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation

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Organic anion‑transporting polypeptides contribute to the uptake of curcumin and its main metabolites by human breast cancer cells: Impact on antitumor activity

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Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity

inferredcites →https://doi.org/10.4111/kju.2015.56.9.656openalex-snapshot

Effect of curcumin on the interaction between androgen receptor and Wnt/β-catenin in LNCaP xenografts

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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