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Injectable cell-encapsulating composite alginate-collagen platform with inducible termination switch for safer ocular drug delivery

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A study of the influence of polysaccharides on collagen self‐assembly: Nanostructure and kinetics
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Biomimetic injectable HUVEC‐adipocytes/collagen/alginate microsphere co‐cultures for adipose tissue engineering
inferredcites →https://doi.org/10.1002/bit.260440916openalex-snapshot
Induction of apoptosis in nutrient‐deprived cultures of hybridoma and myeloma cells
inferredcites →https://doi.org/10.1006/mthe.2001.0308openalex-snapshot
Recombinant AAV-Mediated Delivery of a Tet-Inducible Reporter Gene to the Rat Retina
inferredcites →https://doi.org/10.1007/s10856-012-4575-9openalex-snapshot
Stability of alginate microbead properties in vitro
inferredcites →https://doi.org/10.1016/0167-7799(90)90139-oopenalex-snapshot
Alginate as immobilization matrix for cells
inferredcites →https://doi.org/10.1016/j.addr.2008.12.016openalex-snapshot
In vivo gene regulation using tetracycline-regulatable systems
inferredcites →https://doi.org/10.1016/j.addr.2013.11.005openalex-snapshot
Polymers in cell encapsulation from an enveloped cell perspective
inferredcites →https://doi.org/10.1016/j.biomaterials.2007.04.028openalex-snapshot
Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix
inferredcites →https://doi.org/10.1016/j.biomaterials.2007.08.016openalex-snapshot
A 3D collagen microsphere culture system for GDNF-secreting HEK293 cells with enhanced protein productivity
inferredcites →https://doi.org/10.1016/j.biomaterials.2008.11.017openalex-snapshot
Drug carrier systems based on collagen–alginate composite structures for improving the performance of GDNF-secreting HEK293 cells
inferredcites →https://doi.org/10.1016/j.biomaterials.2012.10.076openalex-snapshot
Inactivation of encapsulated cells and their therapeutic effects by means of TGL triple-fusion reporter/biosafety gene
inferredcites →https://doi.org/10.1016/j.biomaterials.2014.02.039openalex-snapshot
Neural differentiation of pluripotent cells in 3D alginate-based cultures
inferredcites →https://doi.org/10.1016/j.biomaterials.2014.06.047openalex-snapshot
Influence of the stiffness of three-dimensional alginate/collagen-I interpenetrating networks on fibroblast biology
inferredcites →https://doi.org/10.1016/j.carbpol.2010.07.005openalex-snapshot
Assembly of collagen fibrillar networks in the presence of alginate
inferredcites →https://doi.org/10.1016/j.jneumeth.2008.06.004openalex-snapshot
Adeno-associated virus-mediated ILK gene silencing in the rat NAc core
inferredcites →https://doi.org/10.1016/j.msec.2010.09.008openalex-snapshot
Fabrication and evaluation of biomimetic scaffolds by using collagen–alginate fibrillar gels for potential tissue engineering applications
inferredcites →https://doi.org/10.1016/j.msec.2016.04.015openalex-snapshot
A scaffold-filter model for studying the chondrogenic differentiation of stem cells in vitro
inferredcites →https://doi.org/10.1016/j.nurt.2008.02.006openalex-snapshot
Spheramine for Treatment of Parkinson’s Disease
inferredcites →https://doi.org/10.1016/j.progpolymsci.2011.06.003openalex-snapshot
Alginate: Properties and biomedical applications
inferredcites →https://doi.org/10.1016/j.survophthal.2013.09.004openalex-snapshot
Trophic factors in the pathogenesis and therapy for retinal degenerative diseases
inferredcites →https://doi.org/10.1016/j.tips.2015.05.003openalex-snapshot
Cell encapsulation: technical and clinical advances
inferredcites →https://doi.org/10.1016/s1525-0016(03)00144-8openalex-snapshot
AAV-Mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa
inferredcites →https://doi.org/10.1038/gt.2011.154openalex-snapshot
Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose
inferredcites →https://doi.org/10.1038/sj.cgt.7700825openalex-snapshot
Development of an inducible suicide gene system based on human caspase 8
inferredcites →https://doi.org/10.1038/sj.gt.3302460openalex-snapshot
Long-term preservation of retinal function in the RCS rat model of retinitis pigmentosa following lentivirus-mediated gene therapy
inferredcites →https://doi.org/10.1039/c2sm06869aopenalex-snapshot
Biomimetic interpenetrating polymer network hydrogels based on methacrylated alginate and collagen for 3D pre-osteoblast spreading and osteogenic differentiation
inferredcites →https://doi.org/10.1074/jbc.m709604200openalex-snapshot
FoxM1c Counteracts Oxidative Stress-induced Senescence and Stimulates Bmi-1 Expression
inferredcites →https://doi.org/10.1080/02713683.2016.1179333openalex-snapshot
Evaluation of Retinal Function and Morphology of the Pink-Eyed Royal College of Surgeons (RCS) Rat: A Comparative Study of in Vivo and in Vitro Methods
inferredcites →https://doi.org/10.1080/13543776.2016.1211640openalex-snapshot
Cancer suicide gene therapy: a patent review
inferredcites →https://doi.org/10.1089/104303404772679968openalex-snapshot
A Single Lentivirus Vector Mediates Doxycycline-Regulated Expression of Transgenes in the Brain
inferredcites →https://doi.org/10.1089/ten.tea.2012.0197openalex-snapshot
Calcium-Alginate Hydrogel-Encapsulated Fibroblasts Provide Sustained Release of Vascular Endothelial Growth Factor
inferredcites →https://doi.org/10.1093/emboj/17.6.1675openalex-snapshot
Two CD95 (APO‐1/Fas) signaling pathways
inferredcites →https://doi.org/10.1093/emboj/cdg414openalex-snapshot
Interdimer processing mechanism of procaspase‐8 activation
inferredcites →https://doi.org/10.1101/gad.10.9.1054openalex-snapshot
p53: puzzle and paradigm.
inferredcites →https://doi.org/10.1126/science.281.5381.1312openalex-snapshot
Caspases: Enemies Within
inferredcites →https://doi.org/10.1155/2016/5062706openalex-snapshot
Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase
inferredcites →https://doi.org/10.1155/s0962935195000020openalex-snapshot
Apoptosis and inflammation
inferredcites →https://doi.org/10.1167/iovs.06-1340openalex-snapshot
Caspase-8–Mediated Apoptosis in Human RPE Cells
inferredcites →https://doi.org/10.1167/iovs.12-9970openalex-snapshot
Two-Year Intraocular Delivery of Ciliary Neurotrophic Factor by Encapsulated Cell Technology Implants in Patients with Chronic Retinal Degenerative Diseases
inferredcites →https://doi.org/10.1271/bbb.80576openalex-snapshot
Control of Collagen Molecular Assembly with Anionic Polysaccharides
inferredcites →https://doi.org/10.1371/journal.pone.0062032openalex-snapshot
Impact of Alginate Composition: From Bead Mechanical Properties to Encapsulated HepG2/C3A Cell Activities for In Vivo Implantation
inferredcites →https://doi.org/10.1371/journal.pone.0128739openalex-snapshot
Cytotoxicity of TSP in 3D Agarose Gel Cultured Cell
inferredcites →https://doi.org/10.1371/journal.pone.0159342openalex-snapshot
Sustained Delivery of Bioactive GDNF from Collagen and Alginate-Based Cell-Encapsulating Gel Promoted Photoreceptor Survival in an Inherited Retinal Degeneration Model
inferredcites →https://doi.org/10.1523/jneurosci.1903-07.2007openalex-snapshot
Transient Growth Factor Delivery Sustains Regenerated Axons after Spinal Cord Injury
inferredcites →https://doi.org/10.1523/jneurosci.23-10-04164.2003openalex-snapshot
Increased Expression of Brain-Derived Neurotrophic Factor Preserves Retinal Function and Slows Cell Death from Rhodopsin Mutation or Oxidative Damage
inferredcites →https://doi.org/10.3390/ijms150610669openalex-snapshot
Carriers in Cell-Based Therapies for Neurological Disorders
inferredcites →https://doi.org/10.4103/1673-5374.205093openalex-snapshot
Delivery of therapeutics to posterior eye segment: cell-encapsulating systems
inferredcites →https://doi.org/10.5301/jabfm.2012.9340openalex-snapshot
Comparative Study of Collagen Hydrogels Modified in Two Ways Using the Model of Ectopic Cartilage Construction with Diffusion-chamber in Immunocompetent Host

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4496211openalex-extracted
Impact of Sio2 Nanoparticles on the Structure and Property of Type I Collagen in Three Different Forms
inferred← citeshttps://doi.org/10.1002/9783527845583.ch7openalex-snapshot
Sources, Structures, and Properties of Collagen
inferred← citeshttps://doi.org/10.1002/adhm.202202114openalex-snapshot
Acellularized Uvea Hydrogel as Novel Injectable Platform for Cell‐Based Delivering Treatment of Retinal Degeneration and Optimizing Retinal Organoids Inducible System
inferred← citeshttps://doi.org/10.1002/adma.202305828openalex-snapshot
Exploring the Application and Prospects of Synthetic Biology in Engineered Living Materials
inferred← citeshttps://doi.org/10.1002/admi.202100809openalex-snapshot
An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications
inferred← citeshttps://doi.org/10.1002/jbm.b.35348openalex-snapshot
Review of electrospun microtube array membrane ( MTAM )‐a novel new class of hollow fiber for encapsulated cell therapy ( ECT ) in clinical applications
inferred← citeshttps://doi.org/10.1002/mabi.202400049openalex-snapshot
Injectable Hydrogels: A Paradigm Tailored with Design, Characterization, and Multifaceted Approaches
inferred← citeshttps://doi.org/10.1002/term.3154openalex-snapshot
Plasma polymer surface modified expanded polytetrafluoroethylene promotes epithelial monolayer formation in vitro and can be transplanted into the dystrophic rat subretinal space
inferred← citeshttps://doi.org/10.1016/b978-0-12-824011-3.00007-2openalex-snapshot
Encapsulation devices to enhance graft survival: The latest in the development of micro and macro encapsulation devices to improve clinical, xeno, and stem cell transplantation outcomes
inferred← citeshttps://doi.org/10.1016/b978-0-443-15564-2.00008-1openalex-snapshot
Hybrid polymeric systems for potential applications in ocular drug delivery
inferred← citeshttps://doi.org/10.1016/j.apsb.2023.05.009openalex-snapshot
Wearable patches for transdermal drug delivery
inferred← citeshttps://doi.org/10.1016/j.bioadv.2023.213422openalex-snapshot
Engineering a material-genetic interface as safety switch for embedded therapeutic cells
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2023.122123openalex-snapshot
An electrospun macrodevice for durable encapsulation of human cells with consistent secretion of therapeutic antibodies
inferred← citeshttps://doi.org/10.1016/j.carbpol.2024.123164openalex-snapshot
Alginate-functionalized nanoceria as ion-responsive eye drop formulation to treat corneal abrasion
inferred← citeshttps://doi.org/10.1016/j.carres.2026.110077openalex-snapshot
From molecular architecture to clinical translation: Structure–property–performance relationships in alginate-based nanostructured hydrogels
inferred← citeshttps://doi.org/10.1016/j.cej.2022.134583openalex-snapshot
Nano SIM@ZIF-8 modified injectable High-intensity biohydrogel with bidirectional regulation of osteogenesis and Anti-adipogenesis for bone repair
inferred← citeshttps://doi.org/10.1016/j.cis.2025.103456openalex-snapshot
Collagen-based hydrogel sol-gel phase transition mechanism and their applications
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2019.06.023openalex-snapshot
Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy
inferred← citeshttps://doi.org/10.1016/j.fhfh.2022.100071openalex-snapshot
Recent progress in alginate-based carriers for ocular targeting of therapeutics
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.123538openalex-snapshot
Facile preparation of pH-sensitive biocompatible alginate beads havening layered double hydroxide supported metal-organic framework for controlled release from doxorubicin to breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.125048openalex-snapshot
Alginate: Microbial production, functionalization, and biomedical applications
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.132086openalex-snapshot
Injectable hydrogels based on biopolymers for the treatment of ocular diseases
inferred← citeshttps://doi.org/10.1016/j.ipha.2024.09.008openalex-snapshot
Advancements in transdermal drug delivery systems: Enhancing medicine with pain-free and controlled drug release
inferred← citeshttps://doi.org/10.1016/j.jconrel.2021.06.006openalex-snapshot
Cell microencapsulation technologies for sustained drug delivery: Latest advances in efficacy and biosafety
inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.08.041openalex-snapshot
An insight on ophthalmic drug delivery systems: Focus on polymeric biomaterials-based carriers
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.01.063openalex-snapshot
Next generation therapeutics for retinal neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102889openalex-snapshot
Alginate nanoparticles as ocular drug delivery carriers
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107159openalex-snapshot
Encapsulated cell technology: Delivering cytokines to treat posterior ocular diseases
inferred← citeshttps://doi.org/10.1016/j.saa.2023.123520openalex-snapshot
Impact of SiO2 nanoparticles on the structure and property of type I collagen in three different forms
inferred← citeshttps://doi.org/10.1021/acs.chemrev.2c00179openalex-snapshot
Self-Healing Injectable Hydrogels for Tissue Regeneration
inferred← citeshttps://doi.org/10.1021/acsbiomaterials.0c00457openalex-snapshot
Alginate Microencapsulation for Three-Dimensional In Vitro Cell Culture
inferred← citeshttps://doi.org/10.1038/s41419-022-04924-4openalex-snapshot
Involvement of FSP1-CoQ10-NADH and GSH-GPx-4 pathways in retinal pigment epithelium ferroptosis
inferred← citeshttps://doi.org/10.1039/9781839163975-00077openalex-snapshot
Naturally Occurring and Nature-derived Polymers as Injectable Hydrogels
inferred← citeshttps://doi.org/10.1039/d2bm01413kopenalex-snapshot
Injectable composite hydrogels encapsulating gelatin methacryloyl/chitosan microspheres as ARPE-19 cell transplantation carriers
inferred← citeshttps://doi.org/10.1039/d3bm01352aopenalex-snapshot
Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications
inferred← citeshttps://doi.org/10.1039/d5tb01575hopenalex-snapshot
Hydrogel-based ocular drug delivery systems
inferred← citeshttps://doi.org/10.1080/09205063.2020.1744246openalex-snapshot
Crosslinked nanogel-based porous hydrogel as a functional scaffold for tongue muscle regeneration
inferred← citeshttps://doi.org/10.1124/jpet.119.256933openalex-snapshot
Ocular Drug Delivery: Present Innovations and Future Challenges
inferred← citeshttps://doi.org/10.1186/s42825-023-00127-5openalex-snapshot
Structure, extraction, processing, and applications of collagen as an ideal component for biomaterials - a review
inferred← citeshttps://doi.org/10.2174/0118756298373915250404093922openalex-snapshot
An Expository Review on the Multifaceted Applications of Sodium Alginate as a Scaffold in Metal-Organic Frameworks
inferred← citeshttps://doi.org/10.29328/journal.abse.1001024openalex-snapshot
Hydrogel-Based Formulations for Drug Delivery to the Posterior Segment of the Eye
inferred← citeshttps://doi.org/10.3389/fmed.2021.787644openalex-snapshot
Considerations for Polymers Used in Ocular Drug Delivery
inferred← citeshttps://doi.org/10.3390/app15126472openalex-snapshot
Diversity of Collagen Proteins and Their Biomedical Applications in Drug Delivery
inferred← citeshttps://doi.org/10.3390/bioengineering7040163openalex-snapshot
Engineered Collagen Matrices
inferred← citeshttps://doi.org/10.3390/brainsci12121620openalex-snapshot
Hydrogels to Support Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells
inferred← citeshttps://doi.org/10.3390/coatings11020121openalex-snapshot
Sustainable Coated Nanostructures Based on Alginate and Electrospun Collagen Loaded with Antimicrobial Agents
inferred← citeshttps://doi.org/10.3390/ijms23169035openalex-snapshot
Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art
inferred← citeshttps://doi.org/10.3390/ma13245641openalex-snapshot
Blended Natural Support Materials—Collagen Based Hydrogels Used in Biomedicine
inferred← citeshttps://doi.org/10.3390/ma14154290openalex-snapshot
Recent Advances in the Excipients Used for Modified Ocular Drug Delivery
inferred← citeshttps://doi.org/10.3390/ma17010086openalex-snapshot
Hydrogels in Ophthalmology: Novel Strategies for Overcoming Therapeutic Challenges
inferred← citeshttps://doi.org/10.3390/md22090394openalex-snapshot
Bioactive Glial-Derived Neurotrophic Factor from a Safe Injectable Collagen–Alginate Composite Gel Rescues Retinal Photoreceptors from Retinal Degeneration in Rabbits
inferred← citeshttps://doi.org/10.3390/molecules30122542openalex-snapshot
Biodegradable Contact Lenses for Targeted Ocular Drug Delivery: Recent Advances, Clinical Applications, and Translational Perspectives
inferred← citeshttps://doi.org/10.3390/pharmaceutics15041094openalex-snapshot
Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems
inferred← citeshttps://doi.org/10.3390/pharmaceutics15051330openalex-snapshot
Maillard Reaction Crosslinked Alginate-Albumin Scaffolds for Enhanced Fenofibrate Delivery to the Retina: A Promising Strategy to Treat RPE-Related Dysfunction
inferred← citeshttps://doi.org/10.3390/polym13111852openalex-snapshot
Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
inferred← citeshttps://doi.org/10.3390/polym14122359openalex-snapshot
Intravitreal Injectable Hydrogels for Sustained Drug Delivery in Glaucoma Treatment and Therapy
inferred← citeshttps://doi.org/10.3390/polym15061373openalex-snapshot
Breaking Barriers in Eye Treatment: Polymeric Nano-Based Drug-Delivery System for Anterior Segment Diseases and Glaucoma
inferred← citeshttps://doi.org/10.5772/intechopen.103063openalex-snapshot
Collagen-Based Biomaterial as Drug Delivery Module
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