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Daphnegiravone D from Daphne giraldii induces cell death by targeting ATR in Hep3B cells

https://doi.org/10.1016/j.bioorg.2021.104802
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cam4.1278openalex-snapshot
Vorinostat enhances the anticancer effect of oxaliplatin on hepatocellular carcinoma cells
inferredcites →https://doi.org/10.1007/978-1-62703-360-2_9openalex-snapshot
iTRAQ-Labeling for Biomarker Discovery
inferredcites →https://doi.org/10.1016/j.biopha.2018.08.141openalex-snapshot
Daphnegiravone D from Daphne giraldii Nitsche induces p38-dependent apoptosis via oxidative and nitrosative stress in hepatocellular carcinoma cells
inferredcites →https://doi.org/10.1016/j.clon.2014.04.031openalex-snapshot
Oxaliplatin-based Chemotherapy: A New Option in Advanced Hepatocellular Carcinoma. A Systematic Review and Pooled Analysis
inferredcites →https://doi.org/10.1016/j.currproblcancer.2017.05.002openalex-snapshot
Targeting ATR in cancer medicine
inferredcites →https://doi.org/10.1016/j.isci.2020.101668openalex-snapshot
Pharmacological Inhibition of ATR Can Block Autophagy through an ATR-Independent Mechanism
inferredcites →https://doi.org/10.1016/j.jhep.2012.09.006openalex-snapshot
Gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma: A large multicenter AGEO study
inferredcites →https://doi.org/10.1016/j.pharmthera.2020.107518openalex-snapshot
Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy
inferredcites →https://doi.org/10.1016/j.radonc.2016.10.023openalex-snapshot
Preclinical testing of an ATR inhibitor demonstrates improved response to standard therapies for esophageal cancer
inferredcites →https://doi.org/10.1016/s0959-8049(16)32607-7openalex-snapshot
Phase I modular study of AZD6738, a novel oral, potent and selective ataxia telangiectasia Rad3-related (ATR) inhibitor in combination (combo) with carboplatin, olaparib or durvalumab in patients (pts) with advanced cancers
inferredcites →https://doi.org/10.1038/nbt.2284openalex-snapshot
Combinatorial drug therapy for cancer in the post-genomic era
inferredcites →https://doi.org/10.1038/nrm2450openalex-snapshot
ATR: an essential regulator of genome integrity
inferredcites →https://doi.org/10.1038/s41419-019-1986-2openalex-snapshot
ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma
inferredcites →https://doi.org/10.1038/s41568-018-0034-3openalex-snapshot
Targeting ATR in cancer
inferredcites →https://doi.org/10.1038/s41598-017-05955-0openalex-snapshot
A new Prenylated Flavonoid induces G0/G1 arrest and apoptosis through p38/JNK MAPK pathways in Human Hepatocellular Carcinoma cells
inferredcites →https://doi.org/10.1038/srep21010openalex-snapshot
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1
inferredcites →https://doi.org/10.1038/srep21230openalex-snapshot
Correction: Corrigendum: The Serum Profile of Hypercytokinemia Factors Identified in H7N9-Infected Patients can Predict Fatal Outcomes
inferredcites →https://doi.org/10.1039/c9ra10089jopenalex-snapshot
iTRAQ-based proteomic and physiological analyses of mustard sprouts in response to heat stress
inferredcites →https://doi.org/10.1042/bsr20202603openalex-snapshot
Identification of prognostic biomarkers and correlations with immune infiltrates among cGAS-STING in hepatocellular carcinoma
inferredcites →https://doi.org/10.1080/09723757.2013.11886194openalex-snapshot
iTRAQ, a New Prospect of Toxicogenomics
inferredcites →https://doi.org/10.1093/nar/gkt833openalex-snapshot
ATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage
inferredcites →https://doi.org/10.1126/science.1233606openalex-snapshot
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
inferredcites →https://doi.org/10.1136/jitc-2019-000340openalex-snapshot
ATR inhibitor AZD6738 enhances the antitumor activity of radiotherapy and immune checkpoint inhibitors by potentiating the tumor immune microenvironment in hepatocellular carcinoma
inferredcites →https://doi.org/10.1158/0008-5472.can-18-1733openalex-snapshot
Temozolomide Induces Senescence and Repression of DNA Repair Pathways in Glioblastoma Cells via Activation of ATR–CHK1, p21, and NF-κB
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-3748openalex-snapshot
Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776
inferredcites →https://doi.org/10.1158/1541-7786.mcr-19-0585openalex-snapshot
Inhibition of the ATR–CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2
inferredcites →https://doi.org/10.1159/000511001openalex-snapshot
Recent Advances in Systemic Therapy for Hepatocellular Carcinoma in an Aging Society: 2020 Update
inferredcites →https://doi.org/10.1172/jci96519openalex-snapshot
ATR kinase inhibitor AZD6738 potentiates CD8+ T cell–dependent antitumor activity following radiation
inferredcites →https://doi.org/10.1186/s13578-020-0376-xopenalex-snapshot
ATM, ATR and DNA-PKcs kinases—the lessons from the mouse models: inhibition ≠ deletion
inferredcites →https://doi.org/10.1200/jco.2012.44.5643openalex-snapshot
Randomized, Multicenter, Open-Label Study of Oxaliplatin Plus Fluorouracil/Leucovorin Versus Doxorubicin As Palliative Chemotherapy in Patients With Advanced Hepatocellular Carcinoma From Asia
inferredcites →https://doi.org/10.18632/oncotarget.6247openalex-snapshot
The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancerin vivo
inferredcites →https://doi.org/10.3389/fonc.2020.00001openalex-snapshot
Clinical Applications and Future Directions of Minimal Residual Disease Testing in Multiple Myeloma
inferredcites →https://doi.org/10.3389/fonc.2020.597464openalex-snapshot
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/β-Catenin Signaling
inferredcites →https://doi.org/10.3390/cancers9010001openalex-snapshot
Retroareolar Carcinomas in Breast Ultrasound: Pearls and Pitfalls
inferredcites →https://doi.org/10.3390/cancers9050041openalex-snapshot
Targeting the ATR-CHK1 Axis in Cancer Therapy
inferredcites →https://doi.org/10.3892/ol.2020.11932openalex-snapshot
Digitoxin inhibits proliferation of multidrug‑resistant HepG2 cells through G2/M cell cycle arrest and apoptosis
inferredcites →https://doi.org/10.4161/cbt.21093openalex-snapshot
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4530290openalex-extracted
Daphnegiravone D, a Potential Atr Inhibitor, Synergistically Inhibits Hepatocellular Carcinoma Cells with Oxaliplatin
inferred← citeshttps://doi.org/10.1002/ptr.7654openalex-snapshot
Deoxyelephantopin, a germacrane‐type sesquiterpene lactone from Elephantopus scaber, induces mitochondrial apoptosis of hepatocarcinoma cells by targeting Hsp90α in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.154862openalex-snapshot
CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products
inferred← citeshttps://doi.org/10.1039/d5nj03258jopenalex-snapshot
Discovery of prenylated flavonoids from Daphne giraldii Nitsche that inhibit the growth of hepatocellular carcinoma cells based on ion identity molecular networking
inferred← citeshttps://doi.org/10.1097/hm9.0000000000000201openalex-snapshot
Daphnegiravone D synergistically inhibits liver cancer in combination with oxaliplatin in vitro and in vivo
inferred← citeshttps://doi.org/10.1248/cpb.c24-00462openalex-snapshot
Guided Isolation of Isopentenyl Flavonoids from Daphne giraldii Based on the Combination of GNPS and SMART
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1100876/v1openalex-snapshot
Significance of HMMR Overexpression in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.25135/rnp.475.2405.3230openalex-snapshot
Phytochemistry, Pharmacology and Clinical Applications of Cortex Daphnes：A Review
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.