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Omics analysis of human bone to identify genes and molecular networks regulating skeletal remodeling in health and disease

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/art.37753openalex-snapshot
Genome‐wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
inferredcites →https://doi.org/10.1002/jbmr.2175openalex-snapshot
Five Freely Circulating miRNAs and Bone Tissue miRNAs Are Associated With Osteoporotic Fractures
inferredcites →https://doi.org/10.1002/jbmr.2206openalex-snapshot
The C-Terminal Domain of Chondroadherin: A New Regulator of Osteoclast Motility Counteracting Bone Loss
inferredcites →https://doi.org/10.1002/jbmr.2342openalex-snapshot
Methylation of Bone SOST , Its mRNA, and Serum Sclerostin Levels Correlate Strongly With Fracture Risk in Postmenopausal Women
inferredcites →https://doi.org/10.1002/jbmr.2913openalex-snapshot
Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2
inferredcites →https://doi.org/10.1002/jbmr.344openalex-snapshot
Trabecular bone microstructure and local gene expression in iliac crest biopsies of men with idiopathic osteoporosis
inferredcites →https://doi.org/10.1002/jbmr.396openalex-snapshot
Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype
inferredcites →https://doi.org/10.1007/s00198-009-0931-0openalex-snapshot
Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study
inferredcites →https://doi.org/10.1007/s00223-007-9092-3openalex-snapshot
Different Gene Expression Patterns in the Bone Tissue of Aging Postmenopausal Osteoporotic and Non-osteoporotic Women
inferredcites →https://doi.org/10.1007/s00223-013-9749-zopenalex-snapshot
Involvement of WNT/β-catenin Signaling in the Treatment of Osteoporosis
inferredcites →https://doi.org/10.1007/s00223-014-9935-7openalex-snapshot
Analysis of the Bone MicroRNome in Osteoporotic Fractures
inferredcites →https://doi.org/10.1007/s00223-015-0036-zopenalex-snapshot
Serum Circulating MicroRNAs as Biomarkers of Osteoporotic Fracture
inferredcites →https://doi.org/10.1007/s00774-013-0445-xopenalex-snapshot
Triglyceride metabolism in bone tissue is associated with osteoblast and osteoclast differentiation: a gene expression study
inferredcites →https://doi.org/10.1016/j.arcmed.2011.08.005openalex-snapshot
Osteoblastogenesis and Adipogenesis Are Higher in Osteoarthritic than in Osteoporotic Bone Tissue
inferredcites →https://doi.org/10.1016/j.bone.2008.08.120openalex-snapshot
Gene expression profile of the bone microenvironment in human fragility fracture bone
inferredcites →https://doi.org/10.1016/j.bone.2009.11.007openalex-snapshot
Eight genes are highly associated with BMD variation in postmenopausal Caucasian women
inferredcites →https://doi.org/10.1016/j.bone.2012.11.015openalex-snapshot
Identification of transcriptional macromolecular associations in human bone using browser based in silico analysis in a giant correlation matrix
inferredcites →https://doi.org/10.1016/j.bone.2016.08.004openalex-snapshot
Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene
inferredcites →https://doi.org/10.1016/j.canlet.2014.12.032openalex-snapshot
The α2β1 binding domain of chondroadherin inhibits breast cancer-induced bone metastases and impairs primary tumour growth: A preclinical study
inferredcites →https://doi.org/10.1016/j.clim.2009.01.004openalex-snapshot
Transcriptional profiling of immune system-related genes in postmenopausal osteoporotic versus non-osteoporotic human bone tissue
inferredcites →https://doi.org/10.1016/j.exger.2014.05.014openalex-snapshot
Molecular evidence of osteoblast dysfunction in elderly men with osteoporotic hip fractures
inferredcites →https://doi.org/10.1016/j.gene.2013.09.080openalex-snapshot
Contribution of genetic and epigenetic mechanisms to Wnt pathway activity in prevalent skeletal disorders
inferredcites →https://doi.org/10.1016/j.joca.2007.01.003openalex-snapshot
Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritis
inferredcites →https://doi.org/10.1016/j.jprot.2011.04.011openalex-snapshot
Targeted mass spectrometry approaches for protein biomarker verification
inferredcites →https://doi.org/10.1021/pr200522nopenalex-snapshot
Unraveling the Human Bone Microenvironment beyond the Classical Extracellular Matrix Proteins: A Human Bone Protein Library
inferredcites →https://doi.org/10.1021/pr201033wopenalex-snapshot
Unraveling the Human Bone Microenvironment beyond the Classical Extracellular Matrix Proteins: A Human Bone Protein Library
inferredcites →https://doi.org/10.1038/nature14248openalex-snapshot
Integrative analysis of 111 reference human epigenomes
inferredcites →https://doi.org/10.1038/nature14878openalex-snapshot
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
inferredcites →https://doi.org/10.1038/ng.2249openalex-snapshot
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
inferredcites →https://doi.org/10.1080/15592294.2016.1271854openalex-snapshot
Differential analysis of genome-wide methylation and gene expression in mesenchymal stem cells of patients with fractures and osteoarthritis
inferredcites →https://doi.org/10.1093/nar/gkv007openalex-snapshot
limma powers differential expression analyses for RNA-sequencing and microarray studies
inferredcites →https://doi.org/10.1093/schbul/sbv074openalex-snapshot
Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research
inferredcites →https://doi.org/10.1096/fj.09-148908openalex-snapshot
Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes
inferredcites →https://doi.org/10.1097/gme.0b013e318188b260openalex-snapshot
Effect of menopause on gene expression pattern in bone tissue of nonosteoporotic women
inferredcites →https://doi.org/10.1097/psy.0000000000000048openalex-snapshot
Association Between Methylation of the SLC6A4 Promoter Region in Peripheral Blood Leukocytes and Methylation in Amygdala Tissue
inferredcites →https://doi.org/10.1152/ajpendo.00487.2006openalex-snapshot
Abnormal muscle and hematopoietic gene expression may be important for clinical morbidity in primary hyperparathyroidism
inferredcites →https://doi.org/10.1161/hypertensionaha.113.02077openalex-snapshot
Identifying Common Genetic Variants in Blood Pressure Due to Polygenic Pleiotropy With Associated Phenotypes
inferredcites →https://doi.org/10.1186/1423-0127-19-28openalex-snapshot
The relationship between osteoclastogenic and anti-osteoclastogenic pro-inflammatory cytokines differs in human osteoporotic and osteoarthritic bone tissues
inferredcites →https://doi.org/10.1186/1471-2350-8-75openalex-snapshot
CD209 in inflammatory bowel disease: a case-control study in the Spanish population
inferredcites →https://doi.org/10.1186/1471-2474-14-41openalex-snapshot
Differences in osteogenic and apoptotic genes between osteoporotic and osteoarthritic patients
inferredcites →https://doi.org/10.1186/ar2301openalex-snapshot
Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling
inferredcites →https://doi.org/10.1186/ar4380openalex-snapshot
Genome-wide expression profiles of subchondral bone in osteoarthritis
inferredcites →https://doi.org/10.1186/s12859-016-1210-7openalex-snapshot
Tilting the lasso by knowledge-based post-processing
inferredcites →https://doi.org/10.1186/s12920-015-0149-2openalex-snapshot
MiRNA profiling of whole trabecular bone: identification of osteoporosis-related changes in MiRNAs in human hip bones
inferredcites →https://doi.org/10.1196/annals.1402.018openalex-snapshot
Osteocytes as Dynamic Multifunctional Cells
inferredcites →https://doi.org/10.1210/jc.2009-0595openalex-snapshot
The Glucocorticoid-Induced Leucine Zipper Gene (GILZ) Expression Decreases after Successful Treatment of Patients with Endogenous Cushing’s Syndrome and May Play a Role in Glucocorticoid-Induced Osteoporosis
inferredcites →https://doi.org/10.1242/jcs.003855openalex-snapshot
Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice
inferredcites →https://doi.org/10.1258/ebm.2012.011374openalex-snapshot
A proteomic study of protein variation between osteopenic and age-matched control bone tissue
inferredcites →https://doi.org/10.1261/rna.049148.114openalex-snapshot
Global miRNA expression and correlation with mRNA levels in primary human bone cells
inferredcites →https://doi.org/10.1359/jbmr.1999.14.12.1993openalex-snapshot
Suggestive Linkage of the Parathyroid Receptor Type 1 to Osteoporosis
inferredcites →https://doi.org/10.1359/jbmr.2000.15.2.332openalex-snapshot
Enhanced Expression of Osteocalcin mRNA in Human Osteoarthritic Trabecular Bone of the Proximal Femur Is Associated with Decreased Expression of Interleukin-6 and Interleukin-11 mRNA
inferredcites →https://doi.org/10.1371/journal.pgen.1000977openalex-snapshot
An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits
inferredcites →https://doi.org/10.1371/journal.pgen.1002718openalex-snapshot
Meta-Analysis of Genome-Wide Scans for Total Body BMD in Children and Adults Reveals Allelic Heterogeneity and Age-Specific Effects at the WNT16 Locus
inferredcites →https://doi.org/10.1371/journal.pgen.1004423openalex-snapshot
Phenotypic Dissection of Bone Mineral Density Reveals Skeletal Site Specificity and Facilitates the Identification of Novel Loci in the Genetic Regulation of Bone Mass Attainment
inferredcites →https://doi.org/10.1371/journal.pone.0010692openalex-snapshot
Skeletal Site-Related Variation in Human Trabecular Bone Transcriptome and Signaling
inferredcites →https://doi.org/10.1371/journal.pone.0138347openalex-snapshot
Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing
inferredcites →https://doi.org/10.1371/journal.pone.0138524openalex-snapshot
Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation
inferredcites →https://doi.org/10.1371/journal.pone.0144531openalex-snapshot
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci
inferredcites →https://doi.org/10.1530/eje-11-1082openalex-snapshot
TXNIP is highly regulated in bone biopsies from patients with endogenous Cushing's syndrome and related to bone turnover
inferredcites →https://doi.org/10.25405/ncl.34227405openalex-snapshot
Transcriptome Profiling Reveals that Postmenopausal Osteoporosis and Bone Density Correlate with Fat Metabolism but not Adiposity
inferredcites →https://doi.org/10.3109/17435390.2015.1078852openalex-snapshot
Alterations in DNA methylation corresponding with lung inflammation and as a biomarker for disease development after MWCNT exposure
inferredcites →https://doi.org/10.3892/ol.2013.1543openalex-snapshot
Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/ar.24339openalex-snapshot
Osteoarthritis from evolutionary and mechanistic perspectives
inferred← citeshttps://doi.org/10.1002/jbm4.10213openalex-snapshot
microRNA‐Mediated Regulation of Bone Remodeling: A Brief Review
inferred← citeshttps://doi.org/10.1002/jbmr.3698openalex-snapshot
Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry
inferred← citeshttps://doi.org/10.1002/prca.201900084openalex-snapshot
Proteomic and Transcriptomic Approaches for Studying Bone Regeneration in Health and Systemically Compromised Conditions
inferred← citeshttps://doi.org/10.1002/prca.202100049openalex-snapshot
Proteomic profiling of human bone from different anatomical sites – A pilot study
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Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research
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Structure, Function, and Relationship of Estrogens
inferred← citeshttps://doi.org/10.1016/b978-0-12-813259-3.00009-9openalex-snapshot
Skeletal Genetics
inferred← citeshttps://doi.org/10.1016/b978-0-12-814841-9.00008-7openalex-snapshot
Wnt signaling and bone cell activity
inferred← citeshttps://doi.org/10.1016/b978-0-12-814841-9.00068-3openalex-snapshot
Genetic determinants of bone mass and osteoporotic fracture
inferred← citeshttps://doi.org/10.1016/j.bonr.2020.100287openalex-snapshot
The effect of age on the microarchitecture and profile of gene expression in femoral head and neck bone from patients with osteoarthritis
inferred← citeshttps://doi.org/10.1016/j.bonr.2022.101624openalex-snapshot
Isolating mineralized bone and bone marrow mRNA from transiliac bone biopsies stored in a stabilizing solution: A comparative study
inferred← citeshttps://doi.org/10.1016/j.carbpol.2024.122232openalex-snapshot
Engineering biomimetic scaffolds for bone regeneration: Chitosan/alginate/polyvinyl alcohol-based double-network hydrogels with carbon nanomaterials
inferred← citeshttps://doi.org/10.1016/j.gene.2026.150319openalex-snapshot
Integrative analysis of transcriptomics and metabolomics reveals mitochondria function genes and associated metabolite pathways in endometritis
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.109844openalex-snapshot
CircRNA hsa_circ_0006859 inhibits the osteogenic differentiation of BMSCs and aggravates osteoporosis by targeting miR-642b-5p/miR-483-3p and upregulating EFNA2/DOCK3
inferred← citeshttps://doi.org/10.1016/j.jprot.2018.01.017openalex-snapshot
The use of omics profiling to improve outcomes of bone regeneration and osseointegration. How far are we from personalized medicine in dentistry?
inferred← citeshttps://doi.org/10.1038/s41598-021-81731-5openalex-snapshot
Molecular characterisation of osteoblasts from bone obtained from people of Polynesian and European ancestry undergoing joint replacement surgery
inferred← citeshttps://doi.org/10.1039/c9tb01494bopenalex-snapshot
Direct 3D printing of a tough hydrogel incorporated with carbon nanotubes for bone regeneration
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Triblock Copolymer Bioinks in Hydrogel Three-Dimensional Printing for Regenerative Medicine: A Focus on Pluronic F127
inferred← citeshttps://doi.org/10.1111/acel.12764openalex-snapshot
Advanced oxidation protein products induce pre‐osteoblast apoptosis through a nicotinamide adenine dinucleotide phosphate oxidase‐dependent, mitogen‐activated protein kinases‐mediated intrinsic apoptosis pathway
inferred← citeshttps://doi.org/10.1111/cpr.13095openalex-snapshot
Scara3 regulates bone marrow mesenchymal stem cell fate switch between osteoblasts and adipocytes by promoting Foxo1
inferred← citeshttps://doi.org/10.1111/jre.12498openalex-snapshot
Protein expression during early stages of bone regeneration under hydrophobic and hydrophilic titanium domes. A pilot study
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Assessment of Reference Genes Stability in Cortical Bone of Obese and Diabetic Mice
inferred← citeshttps://doi.org/10.3389/fbioe.2021.703725openalex-snapshot
Towards in silico Models of the Inflammatory Response in Bone Fracture Healing
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Proteomic Insights into Osteoporosis: Unraveling Diagnostic Markers of and Therapeutic Targets for the Metabolic Bone Disease
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From Genomics to Metabolomics: Molecular Insights into Osteoporosis for Enhanced Diagnostic and Therapeutic Approaches
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“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era
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