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Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors

https://doi.org/10.1016/j.brainres.2009.05.001
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cne.20667openalex-snapshot
Pre- and postsynaptic localization of the 5-HT7 receptor in rat dorsal spinal cord: Immunocytochemical evidence
inferredcites →https://doi.org/10.1002/cne.21665openalex-snapshot
Genetically expressed transneuronal tracer reveals direct and indirect serotonergic descending control circuits
inferredcites →https://doi.org/10.1016/0014-2999(87)90591-7openalex-snapshot
Antinociceptive effect of systemic and intrathecal morphine in spinally transected rats
inferredcites →https://doi.org/10.1016/0031-9384(76)90029-9openalex-snapshot
Chronic catheterization of the spinal subarachnoid space
inferredcites →https://doi.org/10.1016/0143-4179(83)90049-5openalex-snapshot
The rat brain in stereotaxic coordinates
inferredcites →https://doi.org/10.1016/0165-0270(94)90144-9openalex-snapshot
Quantitative assessment of tactile allodynia in the rat paw
inferredcites →https://doi.org/10.1016/0304-3959(92)90041-9openalex-snapshot
An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
inferredcites →https://doi.org/10.1016/0306-4522(95)00329-0openalex-snapshot
5-hydroxytryptamine receptor subtype messenger RNAs in rat peripheral sensory and sympathetic ganglia: A polymerase chain reaction study
inferredcites →https://doi.org/10.1016/b0-443-07287-6/50012-6openalex-snapshot
Central nervous system mechanisms of pain modulation
inferredcites →https://doi.org/10.1016/c2009-0-63235-9openalex-snapshot
The Rat Brain in Stereotaxic Coordinates
inferredcites →https://doi.org/10.1016/j.neulet.2004.06.025openalex-snapshot
Distribution of 5-HT7 receptors in the human brain: a preliminary autoradiographic study using [ ]SB-269970
inferredcites →https://doi.org/10.1016/j.neuroscience.2006.03.016openalex-snapshot
Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization
inferredcites →https://doi.org/10.1016/j.neuroscience.2007.05.004openalex-snapshot
Rostral ventromedial medulla control of spinal sensory processing in normal and pathophysiological states
inferredcites →https://doi.org/10.1016/j.pain.2004.01.030openalex-snapshot
5-HT receptors involved in opioid-activated descending inhibition of spinal withdrawal reflexes in the decerebrated rabbit
inferredcites →https://doi.org/10.1016/j.pain.2004.11.023openalex-snapshot
Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation
inferredcites →https://doi.org/10.1016/j.pain.2005.06.011openalex-snapshot
Pronociceptive role of peripheral and spinal 5-HT7 receptors in the formalin test
inferredcites →https://doi.org/10.1016/j.pain.2008.11.009openalex-snapshot
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice
inferredcites →https://doi.org/10.1016/s0006-8993(01)02652-xopenalex-snapshot
Activation of spinal serotonin2A/2C receptors augments nociceptive responses in the rat
inferredcites →https://doi.org/10.1016/s0022-3565(24)37909-1openalex-snapshot
Multiple Subtypes of Serotonin Receptors Are Expressed in Rat Sensory Neurons in Culture
inferredcites →https://doi.org/10.1016/s0022-3565(25)32351-7openalex-snapshot
Multiplicative interaction between narcotic agonisms expressed at spinal and supraspinal sites of antinociceptive action as revealed by concurrent intrathecal and intracerebroventricular injections of morphine.
inferredcites →https://doi.org/10.1016/s0024-3205(02)02011-8openalex-snapshot
5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons
inferredcites →https://doi.org/10.1016/s0166-2236(02)02157-4openalex-snapshot
Chronic pain and medullary descending facilitation
inferredcites →https://doi.org/10.1016/s0301-0082(02)00009-6openalex-snapshot
Descending control of pain
inferredcites →https://doi.org/10.1016/s0304-3959(00)00290-6openalex-snapshot
Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat
inferredcites →https://doi.org/10.1016/s0304-3959(00)00480-2openalex-snapshot
Activation of brainstem N-methyl-D-aspartate receptors is required for the analgesic actions of morphine given systemically
inferredcites →https://doi.org/10.1016/s0304-3959(99)00272-9openalex-snapshot
The role of 5-HT1A-receptors in fentanyl-induced bulbospinal inhibition of a spinal withdrawal reflex in the rabbit
inferredcites →https://doi.org/10.1016/s0304-3959(99)00307-3openalex-snapshot
Serotonin receptor subtypes involved in the spinal antinociceptive effect of 5-HT in rats
inferredcites →https://doi.org/10.1016/s0306-4522(02)00038-6openalex-snapshot
Involvement of 5-hydroxytryptamine1A receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation
inferredcites →https://doi.org/10.1021/jm991151jopenalex-snapshot
A Novel, Potent, and Selective 5-HT7Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
inferredcites →https://doi.org/10.1038/nn966openalex-snapshot
Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
inferredcites →https://doi.org/10.1038/sj.bjp.0703357openalex-snapshot
Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist
inferredcites →https://doi.org/10.1038/sj.bjp.0706854openalex-snapshot
Systemic morphine produce antinociception mediated by spinal 5‐HT7, but not 5‐HT1A and 5‐HT2 receptors in the spinal cord
inferredcites →https://doi.org/10.1046/j.1471-4159.2003.01907.xopenalex-snapshot
Systemic morphine‐induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray
inferredcites →https://doi.org/10.1055/b-0034-102574openalex-snapshot
2 Central Nervous System Mechanisms in Pain Modulation
inferredcites →https://doi.org/10.1097/00001756-199412000-00065openalex-snapshot
Spinal serotonin IA and IC/2 receptors mediate supraspinal μ opioidinduced analgesia
inferredcites →https://doi.org/10.1097/00001756-200010200-00020openalex-snapshot
Expression of 5-HT1A receptor mRNA in rat dorsal raphe nucleus and ventrolateral periaqueductal gray neurons after peripheral inflammation
inferredcites →https://doi.org/10.1097/00001813-199204000-00001openalex-snapshot
Review paper
inferredcites →https://doi.org/10.1111/j.1469-7793.1999.0507p.xopenalex-snapshot
Serotonergic modulation of hyperpolarization‐activated current in acutely isolated rat dorsal root ganglion neurons
inferredcites →https://doi.org/10.1124/jpet.302.1.240openalex-snapshot
Reconsideration of 5-Hydroxytryptamine (5-HT)7Receptor Distribution Using [3H]5-Carboxamidotryptamine and [3H]8-Hydroxy-2-(di-n-propylamino)tetraline: Analysis in Brain of 5-HT1A Knockout and 5-HT1A/1B Double-Knockout Mice
inferredcites →https://doi.org/10.1523/jneurosci.4054-04.2005openalex-snapshot
Cholecystokinin in the Rostral Ventromedial Medulla Mediates Opioid-Induced Hyperalgesia and Antinociceptive Tolerance
inferredcites →https://doi.org/10.2174/1568007043482633openalex-snapshot
5-HT7 Receptors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Ondansetron and AS19 Attenuate Morphine Tolerance by Modulating Serotonin 5-HT 3 and 5-HT 7 Receptor Concentrations in Rat Dorsal Root Ganglia
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Neurobiology of Itch (Pruritus)
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Physiology and Pathophysiology of Pain
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Aryl Biphenyl‐3‐ylmethylpiperazines as 5‐HT7 Receptor Antagonists
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Identification and characterization of rostral ventromedial medulla neurons synaptically connected to the urinary bladder afferents in female rats with or without neonatal cystitis
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Blood monoamines as potential biomarkers for conditioned pain modulation efficacy: An exploratory study in paediatrics
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Why mu‐opioid agonists have less analgesic efficacy in neuropathic pain?
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An investigation into the inhibitory function of serotonin in diffuse noxious inhibitory controls in the neuropathic rat
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Spinal 5‐ HT3 receptors facilitate behavioural hypersensitivity induced by elevated calcium channel alpha‐2‐delta‐1 protein
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Tropisetron alleviate early post‐operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: A randomized, parallel‐group, factorial study
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Irritable Bowel Syndrome and Dysphagia
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Neurophysiology of Orofacial Pain
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Descending Circuitry, Molecular Mechanisms of Activity-Dependent Plasticity
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Descending Facilitation and Inhibition in Neuropathic Pain
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Descending Modulation and Persistent Pain
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Gynecological Pain, Neural Mechanisms
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The 5-HT7 receptor and disorders of the nervous system: an overview
inferred← citeshttps://doi.org/10.1007/s00702-014-1255-6openalex-snapshot
Intracisternal injection of palmitoylethanolamide inhibits the peripheral nociceptive evoked responses of dorsal horn wide dynamic range neurons
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Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System
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The Mechanism of Action of Remote Electrical Neuromodulation (REN) in Treating Migraine and Potentially Other Idiopathic Pain Conditions
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Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives
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Effectiveness of Vortioxetine in Patients with Major Depressive Disorder Associated with Chronic Pain: An Observational Study in a Spanish Population
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Regulation of Nociceptor Signaling by Serotonin
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00037-2openalex-snapshot
Abdominal Pain
inferred← citeshttps://doi.org/10.1016/b978-0-444-64125-0.00017-7openalex-snapshot
Serotonin—pain modulation
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Basic Science of Spinal Receptors
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Zentrales Nervensystem
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Serotonin circuits act cooperatively with pathophysiology of opioid use disorder
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The Neuro-Vascular-Immune (NVI) functional unit: A proposed framework for understanding acupuncture action
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Bidirectional amygdaloid control of neuropathic hypersensitivity mediated by descending serotonergic pathways acting on spinal 5-HT3 and 5-HT1A receptors
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Non-hallucinogenic compounds derived from iboga alkaloids alleviate neuropathic and visceral pain in mice through a mechanism involving 5-HT2A receptor activation
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Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression
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Decrease in the descending inhibitory 5-HT system in rats with spinal nerve ligation
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Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat
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A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: An in vivo electrophysiological study in the rat
inferred← citeshttps://doi.org/10.1016/j.brainres.2013.10.041openalex-snapshot
Functional expression of 5-HT7 receptor on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice
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Hindbrain raphe stimulation boosts cyclic adenosine monophosphate and signaling proteins in the injured spinal cord
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5-HT7 receptor as a potential therapeutic target in irritable bowel syndrome: Current insights and future perspectives
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Role of peripheral versus spinal 5‐HT7 receptors in the modulation of pain undersensitizing conditions
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Systemic cannabinoids produce CB1-mediated antinociception by activation of descending serotonergic pathways that act upon spinal 5-HT7 and 5-HT2A receptors
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Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT7 receptors
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Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline
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Endogenously released 5-HT inhibits A and C fiber-evoked synaptic transmission in the rat spinal cord by the facilitation of GABA/glycine and 5-HT release via 5-HT2A and 5-HT3 receptors
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Multiple roles of serotonin in pain control mechanisms —Implications of 5-HT7 and other 5-HT receptor types
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Contributions of peripheral, spinal, and supraspinal actions to analgesia
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The inhibitory effect of granisetron on ventrolateral medulla neuron responses to colorectal distension in rats
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The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia
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Changes in opioid receptors, opioid peptides and morphine antinociception in mice subjected to early life stress
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Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission
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Lentiviral vector-driven inhibition of 5-HT synthesis in B3 bulbo-spinal serotonergic projections – Consequences on nociception, inflammatory and neuropathic pain in rats
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Enhanced descending pain facilitation in acute traumatic brain injury
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Loss of diffuse noxious inhibitory control after traumatic brain injury in rats: A chronic issue
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Voluntary wheel running alleviates and prevents long-lasting mechanical hyperalgesia induced by short-term vertical chronic restraint stress
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Recent Approaches on Signal Transduction and Transmission in Acupuncture: A Biophysical Overview for Medical Sciences
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Characterisation of peripheral and central components of the rat monoiodoacetate model of Osteoarthritis
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Progesterone Prevents Allodynia After Experimental Spinal Cord Injury
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Central Sensitization and Neuropathic Features of Ongoing Pain in a Rat Model of Advanced Osteoarthritis
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Antidepressant Drugs
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Ondansetron and AS19 attenuate morphine tolerance by modulating serotonin 5-HT3 and 5-HT7 receptor expressions in rat dorsal root ganglia
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N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception
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Changes in serotoninergic and noradrenergic descending pain pathways during painful diabetic neuropathy: The preventive action of IGF1
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Pain modulation from the brain during diabetic neuropathy: Uncovering the role of the rostroventromedial medulla
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Thalamus: The ‘promoter’ of endogenous modulation of pain and potential therapeutic target in pathological pain
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Absence of morphine analgesia and its underlying descending serotonergic activation in an experimental mouse model of fibromyalgia
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Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain
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Intrathecal nefopam-induced antinociception through activation of descending serotonergic projections involving spinal 5-HT7 but not 5-HT3 receptors
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Serotonin enhances urinary bladder nociceptive processing via a 5-HT3 receptor mechanism
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Ropivacaine-induced seizures evoked pain sensitization in rats: Participation of 5-HT/5-HT3R
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Placebo Analgesia: A Predictive Coding Perspective
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A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins
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Beneficios potenciales de vortioxetina en el tratamiento del dolor crónico
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GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain
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Modality selective roles of pro-nociceptive spinal 5-HT2A and 5-HT3 receptors in normal and neuropathic states
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Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT4, 5-HT6 and 5-HT7 receptors
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2013.06.057openalex-snapshot
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2013.07.035openalex-snapshot
Neural processing of itch
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2013.12.030openalex-snapshot
Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2014.08.063openalex-snapshot
Cholestasis induced antinociception and decreased gene expression of MOR1 in rat brain
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Circuitry and plasticity of the dorsal horn – Toward a better understanding of neuropathic pain
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RETRACTED: Inhibition of spinal 5-HT3R reverted diabetes-induced mechanical hypersensitivity in a GABAAR-mediated neurotransmission-dependent manner
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Opioid-induced hyperalgesia: Cellular and molecular mechanisms
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Chronic Increases in Daily Neuromuscular Activity Promote Changes in Gene Expression in Small and Large Dorsal Root Ganglion Neurons in Rat
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2023.06.007openalex-snapshot
Descending Facilitation of Nociceptive Transmission From the Rostral Ventromedial Medulla Contributes to Hyperalgesia in Mice with Sickle Cell Disease
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Negative allosteric modulator of Group Ⅰ mGluRs: Recent advances and therapeutic perspective for neuropathic pain
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5-HT7 receptor activation: A novel target for treatment of opioid-induced hyperalgesia – A hypothesis and mini review
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Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity
inferred← citeshttps://doi.org/10.1016/j.pain.2010.10.004openalex-snapshot
Mu-opioid and noradrenergic α2-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats
inferred← citeshttps://doi.org/10.1016/j.pain.2010.11.031openalex-snapshot
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat
inferred← citeshttps://doi.org/10.1016/j.pain.2010.12.020openalex-snapshot
Role of peripheral 5-HT4, 5-HT6, and 5-HT7 receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia
inferred← citeshttps://doi.org/10.1016/j.pain.2011.03.012openalex-snapshot
Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy
inferred← citeshttps://doi.org/10.1016/j.pbb.2011.06.005openalex-snapshot
Blockade of 5-HT7 receptors reduces tactile allodynia in the rat
inferred← citeshttps://doi.org/10.1016/j.pbb.2012.05.006openalex-snapshot
5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice
inferred← citeshttps://doi.org/10.1016/j.pbb.2014.02.001openalex-snapshot
Spinal 5-HT5A receptors mediate 5-HT-induced antinociception in several pain models in rats
inferred← citeshttps://doi.org/10.1016/j.pbb.2014.10.007openalex-snapshot
Antihyperalgesic effect of 5-HT7 receptor activation on the midbrain periaqueductal gray in a rat model of neuropathic pain
inferred← citeshttps://doi.org/10.1016/j.pharep.2017.09.007openalex-snapshot
Antinociceptive and pronociceptive effect of levetiracetam in tonic pain model
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2010.08.013openalex-snapshot
Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.104949openalex-snapshot
Role of 5-HT receptors in neuropathic pain: potential therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2012.01.004openalex-snapshot
Unmasking the mysteries of the habenula in pain and analgesia
inferred← citeshttps://doi.org/10.1016/j.pneurobio.2012.06.010openalex-snapshot
The serotonergic system in ageing and Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.pnpbp.2012.01.007openalex-snapshot
Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception
inferred← citeshttps://doi.org/10.1016/j.redar.2021.04.001openalex-snapshot
Papel de vortioxetina en el tratamiento del dolor neuropático
inferred← citeshttps://doi.org/10.1016/j.redare.2022.09.003openalex-snapshot
Role of vortioxetine in the treatment of neuropathic pain
inferred← citeshttps://doi.org/10.1016/j.tvjl.2018.05.004openalex-snapshot
The neurobiology of acute pain
inferred← citeshttps://doi.org/10.1016/j.tvjl.2018.05.005openalex-snapshot
Gainfully employing descending controls in acute and chronic pain management
inferred← citeshttps://doi.org/10.1016/j.ynpai.2018.01.004openalex-snapshot
Involvement of 5-HT1A/1B receptors in the antinociceptive effect of paracetamol in the rat formalin test
inferred← citeshttps://doi.org/10.1016/s1073-5437(09)79341-6openalex-snapshot
Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors
inferred← citeshttps://doi.org/10.1021/acschemneuro.8b00283openalex-snapshot
Pharmacology and Therapeutic Potential of the 5-HT7Receptor
inferred← citeshttps://doi.org/10.1038/s41390-021-01638-9openalex-snapshot
The development of descending serotonergic modulation of the spinal nociceptive network: a life span perspective
inferred← citeshttps://doi.org/10.1038/s41467-026-71289-zopenalex-snapshot
Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon
inferred← citeshttps://doi.org/10.1038/s41575-024-01017-9openalex-snapshot
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract
inferred← citeshttps://doi.org/10.1038/s41593-023-01268-wopenalex-snapshot
Neurons in the caudal ventrolateral medulla mediate descending pain control
inferred← citeshttps://doi.org/10.1038/s41598-017-02509-2openalex-snapshot
The developmental emergence of differential brainstem serotonergic control of the sensory spinal cord
inferred← citeshttps://doi.org/10.1038/s41598-022-20292-7openalex-snapshot
Monoamine control of descending pain modulation after mild traumatic brain injury
inferred← citeshttps://doi.org/10.1055/s-0038-1677358openalex-snapshot
Serotonerge Modulation der Schmerzwahrnehmung
inferred← citeshttps://doi.org/10.1080/14737175.2024.2307490openalex-snapshot
An update on the pharmacotherapeutic options for complex regional pain syndrome
inferred← citeshttps://doi.org/10.1089/neu.2021.0485openalex-snapshot
Activation of the Locus Coeruleus Mediated by Designer Receptor Exclusively Activated by Designer Drug Restores Descending Nociceptive Inhibition after Traumatic Brain Injury in Rats
inferred← citeshttps://doi.org/10.1089/neu.2024.0031openalex-snapshot
Designer Receptor Exclusively Activated by Designer Drug (DREADD)-Mediated Activation of the Periaqueductal Gray Restores Nociceptive Descending Inhibition After Traumatic Brain Injury in Rats
inferred← citeshttps://doi.org/10.1093/bja/aes136openalex-snapshot
Electroacupuncture inhibition of hyperalgesia in an inflammatory pain rat model: involvement of distinct spinal serotonin and norepinephrine receptor subtypes
inferred← citeshttps://doi.org/10.1093/bja/aet336openalex-snapshot
Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models
inferred← citeshttps://doi.org/10.1093/oxfordhb/9780190860509.013.23openalex-snapshot
Dorsal Horn Pain Mechanisms
inferred← citeshttps://doi.org/10.1097/ajp.0b013e318243ede4openalex-snapshot
Diffuse Noxious Inhibitory Control Function in Women With Provoked Vestibulodynia
inferred← citeshttps://doi.org/10.1097/aln.0000000000000324openalex-snapshot
Peripheral Nerve Injury Reduces Analgesic Effectsof Systemic Morphine via Spinal 5-Hydroxytryptamine 3 Receptors
inferred← citeshttps://doi.org/10.1097/aln.0b013e31820efb19openalex-snapshot
5-Hydroxytryptamine Type 3 Receptor Modulates Opioid-induced Hyperalgesia and Tolerance in Mice
inferred← citeshttps://doi.org/10.1097/aln.0b013e318260d381openalex-snapshot
Ondansetron Reverses Antihypersensitivity from Clonidine in Rats after Peripheral Nerve Injury
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000000240openalex-snapshot
Diffuse noxious inhibitory controls and nerve injury
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000000372openalex-snapshot
Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000000568openalex-snapshot
What the brain tells the spinal cord
inferred← citeshttps://doi.org/10.1097/j.pain.0000000000002806openalex-snapshot
Monoaminergic mediation of hyperalgesic and analgesic descending control of nociception in mice
inferred← citeshttps://doi.org/10.1097/pr9.0000000000000872openalex-snapshot
Neonatal complete Freund's adjuvant-induced inflammation does not induce or alter hyperalgesic priming or alter adult distributions of C-fibre dorsal horn innervation
inferred← citeshttps://doi.org/10.1097/spc.0000000000000055openalex-snapshot
Descending pain modulation and chronification of pain
inferred← citeshttps://doi.org/10.1101/2023.09.11.557127openalex-snapshot
Discovery of a functionally selective serotonin 5-HT 1A receptor agonist for the treatment of pain
inferred← citeshttps://doi.org/10.1111/bcp.14412openalex-snapshot
Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans
inferred← citeshttps://doi.org/10.1111/bph.14911openalex-snapshot
Mu and delta opioid receptors play opposite nociceptive and behavioural roles on nerve‐injured mice
inferred← citeshttps://doi.org/10.1111/bph.15710openalex-snapshot
5‐hydroxytryptamine in migraine: The puzzling role of ionotropic 5‐HT 3 receptor in the context of established therapeutic effect of metabotropic 5‐HT 1 subtypes
inferred← citeshttps://doi.org/10.1111/ejn.14614openalex-snapshot
Serotoninergic pain modulation from the rostral ventromedial medulla (RVM) in chemotherapy‐induced neuropathy: The role of spinal 5‐HT3 receptors
inferred← citeshttps://doi.org/10.1111/nmo.12790openalex-snapshot
Anticipation of thermal pain in diverticular disease
inferred← citeshttps://doi.org/10.1113/jphysiol.2013.266494openalex-snapshot
The degree of acute descending control of spinal nociception in an area of primary hyperalgesia is dependent on the peripheral domain of afferent input
inferred← citeshttps://doi.org/10.1124/pr.118.015552openalex-snapshot
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function
inferred← citeshttps://doi.org/10.1126/sciadv.adv9267openalex-snapshot
Discovery of a functionally selective serotonin receptor (5-HT 1A R) agonist for the treatment of pain
inferred← citeshttps://doi.org/10.1134/s1819712411020085openalex-snapshot
The role of serotonin receptors in migraine headaches
inferred← citeshttps://doi.org/10.1136/bmjopen-2024-093633openalex-snapshot
Effects of ondansetron applied before the induction of anaesthesia on postoperative nausea and vomiting in high-risk patients: protocol for a randomised controlled trial
inferred← citeshttps://doi.org/10.1136/gutjnl-2011-300253openalex-snapshot
The balancing act: endogenous modulation of pain in functional gastrointestinal disorders
inferred← citeshttps://doi.org/10.1139/cjpp-2017-0567openalex-snapshot
Contribution of spinal 5-HT5A receptors to the antinociceptive effects of systemically administered cannabinoid agonist WIN 55,212-2 and morphine
inferred← citeshttps://doi.org/10.1152/jn.00613.2018openalex-snapshot
An investigation into the noradrenergic and serotonergic contributions of diffuse noxious inhibitory controls in a monoiodoacetate model of osteoarthritis
inferred← citeshttps://doi.org/10.1155/2012/312041openalex-snapshot
Assessment of 5-HT7Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice
inferred← citeshttps://doi.org/10.1155/2015/686424openalex-snapshot
Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms
inferred← citeshttps://doi.org/10.1155/2019/1389296openalex-snapshot
The Role of Descending Pain Modulation in Chronic Primary Pain: Potential Application of Drugs Targeting Serotonergic System
inferred← citeshttps://doi.org/10.11575/prism/28333openalex-snapshot
The Role of Microglial P2X7 Receptor Phosphorylation in Neuropathic Pain
inferred← citeshttps://doi.org/10.11606/t.42.2019.tde-16102018-120421openalex-snapshot
Efeitos do enriquecimento ambiental na neuropatia periférica induzida em ratos.
inferred← citeshttps://doi.org/10.1172/jci154588openalex-snapshot
Molecular identification of bulbospinal ON neurons by GPER, which drives pain and morphine tolerance
inferred← citeshttps://doi.org/10.1172/jci43766openalex-snapshot
Central modulation of pain
inferred← citeshttps://doi.org/10.1177/0269881120936467openalex-snapshot
Attenuation of stress-induced behavioral changes by activation of serotonin type 7 receptors in the median raphe nucleus of rats
inferred← citeshttps://doi.org/10.1177/08977151251413263openalex-snapshot
The Impact of Sex on the Dysfunction of Endogenous Pain Control after Traumatic Brain Injury
inferred← citeshttps://doi.org/10.1177/10738584261463492openalex-snapshot
Cortical and Subcortical Stimulation for Pain: Network Mechanisms and Therapeutic Implications
inferred← citeshttps://doi.org/10.1177/1744806918808987openalex-snapshot
Multimodal antidepressant vortioxetine causes analgesia in a mouse model of chronic neuropathic pain
inferred← citeshttps://doi.org/10.1177/1744806919859723openalex-snapshot
Spinal 5-HT 3 receptor contributes to somatic hyperalgesia induced by sub-chronic stress
inferred← citeshttps://doi.org/10.1177/17448069211043965openalex-snapshot
A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation
inferred← citeshttps://doi.org/10.1179/174329111x13045147380537openalex-snapshot
Opioid tolerance and hyperalgesia: basic mechanisms and management in review
inferred← citeshttps://doi.org/10.1186/1744-8069-10-35openalex-snapshot
Spinal 5-HT 3 Receptors Mediate Descending Facilitation and Contribute to Behavioral Hypersensitivity via a Reciprocal Neuron-Glial Signaling Cascade
inferred← citeshttps://doi.org/10.1186/1744-8069-5-45openalex-snapshot
Descending Serotonergic Facilitation and the Antinociceptive Effects of Pregabalin in a Rat Model of Osteoarthritic Pain
inferred← citeshttps://doi.org/10.1186/1744-8069-6-54openalex-snapshot
Injury Induced Activation of Extracellular Signal-Regulated Kinase (ERK) in the Rat Rostral Ventromedial Medulla (RVM) is Age Dependant and Requires the Lamina I Projection Pathway
inferred← citeshttps://doi.org/10.1186/1744-8069-8-58openalex-snapshot
Identification of 5-HT Receptor Subtypes Enhancing Inhibitory Transmission in the Rat Spinal Dorsal Horn in vitro
inferred← citeshttps://doi.org/10.1186/1744-8069-8-78openalex-snapshot
Trigeminal-Rostral Ventromedial Medulla Circuitry is Involved in Orofacial Hyperalgesia Contralateral to Tissue Injury
inferred← citeshttps://doi.org/10.1186/s13000-015-0397-7openalex-snapshot
RETRACTED ARTICLE: Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg2+-ATPase imbalances in spinal cord-injured male rats
inferred← citeshttps://doi.org/10.1186/s13000-016-0563-6openalex-snapshot
Retraction note: Serotonin 5-HT7 receptor agonist, LP-211, exacerbates Na+, K+-ATPase/Mg2+ ATPase imbalances in spinal cord-injured male rats
inferred← citeshttps://doi.org/10.1186/s13041-020-00645-xopenalex-snapshot
Contribution of central sensitization to stress-induced spreading hyperalgesia in rats with orofacial inflammation
inferred← citeshttps://doi.org/10.1213/ane.0000000000006505openalex-snapshot
Mild Traumatic Brain Injury–Induced Augmented Postsurgical Pain Is Driven by Central Serotonergic Pain-Facilitatory Signaling
inferred← citeshttps://doi.org/10.1248/bpb.b15-01035openalex-snapshot
Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia
inferred← citeshttps://doi.org/10.1254/jphs.11039scopenalex-snapshot
Potentiation of Morphine Analgesia by Adjuvant Activation of 5-HT7 Receptors
inferred← citeshttps://doi.org/10.1254/jphs.13223fpopenalex-snapshot
Preventive and Alleviative Effect of Tramadol on Neuropathic Pain in Rats: Roles of α2-Adrenoceptors and Spinal Astrocytes
inferred← citeshttps://doi.org/10.1371/journal.pone.0026107openalex-snapshot
Treatment of Rat Spinal Cord Injury with the Neurotrophic Factor Albumin-Oleic Acid: Translational Application for Paralysis, Spasticity and Pain
inferred← citeshttps://doi.org/10.1371/journal.pone.0074891openalex-snapshot
Relative Contributions of Norepinephrine and Serotonin Transporters to Antinociceptive Synergy between Monoamine Reuptake Inhibitors and Morphine in the Rat Formalin Model
inferred← citeshttps://doi.org/10.1371/journal.pone.0078889openalex-snapshot
Polymorphism in Serotonin Receptor 3B Is Associated with Pain Catastrophizing
inferred← citeshttps://doi.org/10.14232/phd.4155openalex-snapshot
Characterization of new antinociceptive ligands in rat model: preclinical studies
inferred← citeshttps://doi.org/10.1515/revneuro-2020-0121openalex-snapshot
The cellular mechanism by which the rostral ventromedial medulla acts on the spinal cord during chronic pain
inferred← citeshttps://doi.org/10.1523/jneurosci.1268-11.2011openalex-snapshot
Neuronal Loss in the Rostral Ventromedial Medulla in a Rat Model of Neuropathic Pain
inferred← citeshttps://doi.org/10.1523/jneurosci.1564-11.2011openalex-snapshot
Spinal 5-HT3Receptor Activation Induces Behavioral Hypersensitivity via a Neuronal-Glial-Neuronal Signaling Cascade
inferred← citeshttps://doi.org/10.1523/jneurosci.2038-21.2022openalex-snapshot
Postsurgical Latent Pain Sensitization Is Driven by Descending Serotonergic Facilitation and Masked by µ-Opioid Receptor Constitutive Activity in the Rostral Ventromedial Medulla
inferred← citeshttps://doi.org/10.1523/jneurosci.5389-09.2010openalex-snapshot
Molecular Depletion of Descending Serotonin Unmasks Its Novel Facilitatory Role in the Development of Persistent Pain
inferred← citeshttps://doi.org/10.2147/jpr.s443915openalex-snapshot
Pain Comorbidities with Attention Deficit: A Narrative Review of Clinical and Preclinical Research
inferred← citeshttps://doi.org/10.2174/1570159x15666170911121027openalex-snapshot
Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System
inferred← citeshttps://doi.org/10.22038/ajp.2016.6956openalex-snapshot
Antinociceptive action of Vanillosmopsis arborea in male mice.
inferred← citeshttps://doi.org/10.2217/ijr.13.57openalex-snapshot
The important role of CNS facilitation and inhibition for chronic pain
inferred← citeshttps://doi.org/10.2217/pmt.15.63openalex-snapshot
Cortical and Subcortical Modulation of Pain
inferred← citeshttps://doi.org/10.24275/uami.3484zg93gopenalex-snapshot
Efecto del levetiracetam en la respuesta nociceptiva sobre los receptores 5-HT1A y 5-HT7 en tálamo y su participación en la modulación del dolor
inferred← citeshttps://doi.org/10.33425/2639-846x.1032openalex-snapshot
Effects of 5-HydroxyTryptamine (5-HT) on Pain Modulation: A Brief Review
inferred← citeshttps://doi.org/10.3389/fcell.2023.1072629openalex-snapshot
Neuropathic pain: Mechanisms and therapeutic strategies
inferred← citeshttps://doi.org/10.3389/fmed.2024.1355262openalex-snapshot
The efficacy of silver needle therapy for treating low back pain: a protocol for meta-analysis of randomized controlled trials
inferred← citeshttps://doi.org/10.3389/fneur.2025.1535136openalex-snapshot
The “brain-gut” mechanism of postherpetic neuralgia: a mini-review
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