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Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance

https://doi.org/10.1016/j.cell.2005.02.005

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Erythromycin Resistance Mutations in Ribosomal Proteins L22 and L4 Perturb the Higher Order Structure of 23 S Ribosomal RNA

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Throwing a spanner in the works: antibiotics and the translation apparatus

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Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit

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[20] Processing of X-ray diffraction data collected in oscillation mode

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[25] Ribbons

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Structural Basis of the Ribosomal Machinery for Peptide Bond Formation, Translocation, and Nascent Chain Progression

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A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre

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Gene replacement in Halobacterium halobium and expression of bacteriorhodopsin mutants.

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Databases in Protein Crystallography

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The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution

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Erythromycin resistance by ribosome modification

inferredcites →https://doi.org/10.1128/aac.45.1.1-12.2001openalex-snapshot

Macrolide Resistance Conferred by Base Substitutions in 23S rRNA

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Resistance to Quinupristin-Dalfopristin Due to Mutation of L22 Ribosomal Protein inStaphylococcus aureus

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In Vitro Selection of Resistance in Haemophilus influenzae by Amoxicillin-Clavulanate, Cefpodoxime, Cefprozil, Azithromycin, and Clarithromycin

inferredcites →https://doi.org/10.1128/aac.6.4.474openalex-snapshot

Binding of [ 14 C]Erythromycin to Escherichia coli Ribosomes

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Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coli

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Binding Site of Macrolide Antibiotics on the Ribosome: New Resistance Mutation Identifies a Specific Interaction of Ketolides with rRNA

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Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

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inferred← citeshttps://doi.org/10.1016/j.jmb.2007.06.068openalex-snapshot

Recognition Elements in rRNA for the Tylosin Resistance Methyltransferase RlmAII

inferred← citeshttps://doi.org/10.1016/j.jmb.2008.03.024openalex-snapshot

Interaction of the Tylosin-resistance Methyltransferase RlmAII at its rRNA Target Differs from the Orthologue RlmAI

inferred← citeshttps://doi.org/10.1016/j.jmb.2008.03.075openalex-snapshot

Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant

inferred← citeshttps://doi.org/10.1016/j.jmb.2008.11.042openalex-snapshot

Time-Resolved Binding of Azithromycin to Escherichia coli Ribosomes

inferred← citeshttps://doi.org/10.1016/j.jmb.2008.12.064openalex-snapshot

Recombineering Reveals a Diverse Collection of Ribosomal Proteins L4 and L22 that Confer Resistance to Macrolide Antibiotics

inferred← citeshttps://doi.org/10.1016/j.jmb.2009.01.037openalex-snapshot

Statics of the Ribosomal Exit Tunnel: Implications for Cotranslational Peptide Folding, Elongation Regulation, and Antibiotics Binding

inferred← citeshttps://doi.org/10.1016/j.jmb.2009.04.005openalex-snapshot

U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

inferred← citeshttps://doi.org/10.1016/j.jmb.2012.01.005openalex-snapshot

Non-Stressful Death of 23S rRNA Mutant G2061C Defective in Puromycin Reaction

inferred← citeshttps://doi.org/10.1016/j.jmb.2021.167211openalex-snapshot

Expansion of the Genetic Code Through the Use of Modified Bacterial Ribosomes

inferred← citeshttps://doi.org/10.1016/j.jmgm.2024.108817openalex-snapshot

A computational workflow to determine drug candidates alternative to aminoglycosides targeting the decoding center of E. coli ribosome

inferred← citeshttps://doi.org/10.1016/j.mib.2005.08.004openalex-snapshot

Improving on nature: antibiotics that target the ribosome

inferred← citeshttps://doi.org/10.1016/j.mib.2005.10.012openalex-snapshot

From replication to cultivation: hot news from Haloarchaea

inferred← citeshttps://doi.org/10.1016/j.mib.2008.08.003openalex-snapshot

Macrolide myths

inferred← citeshttps://doi.org/10.1016/j.mib.2011.08.003openalex-snapshot

Combination therapies for combating antimicrobial resistance

inferred← citeshttps://doi.org/10.1016/j.mib.2023.102418openalex-snapshot

The ribosome as a small-molecule sensor

inferred← citeshttps://doi.org/10.1016/j.microb.2025.100617openalex-snapshot

Antimicrobial resistance: Mechanism, causes, prevention and societal impact

inferred← citeshttps://doi.org/10.1016/j.molcel.2006.05.044openalex-snapshot

Capreomycin Binds across the Ribosomal Subunit Interface Using tlyA-Encoded 2′-O-Methylations in 16S and 23S rRNAs

inferred← citeshttps://doi.org/10.1016/j.molcel.2008.02.026openalex-snapshot

Molecular Mechanism of Drug-Dependent Ribosome Stalling

inferred← citeshttps://doi.org/10.1016/j.molcel.2010.12.031openalex-snapshot

Nascent Peptide in the Ribosome Exit Tunnel Affects Functional Properties of the A-Site of the Peptidyl Transferase Center

inferred← citeshttps://doi.org/10.1016/j.molcel.2014.09.014openalex-snapshot

Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation

inferred← citeshttps://doi.org/10.1016/j.molcel.2015.04.014openalex-snapshot

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

inferred← citeshttps://doi.org/10.1016/j.sbi.2005.05.001openalex-snapshot

Drugs targeting the ribosome

inferred← citeshttps://doi.org/10.1016/j.sbi.2012.07.016openalex-snapshot

Elements of ribosomal drug resistance and specificity

inferred← citeshttps://doi.org/10.1016/j.str.2009.10.013openalex-snapshot

Structure and Mechanism of the Lincosamide Antibiotic Adenylyltransferase LinB

inferred← citeshttps://doi.org/10.1016/j.str.2009.11.001openalex-snapshot

Insights into Resistance against Lincosamide Antibiotics

inferred← citeshttps://doi.org/10.1016/j.str.2017.03.007openalex-snapshot

Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance

inferred← citeshttps://doi.org/10.1016/j.str.2017.06.004openalex-snapshot

The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel

inferred← citeshttps://doi.org/10.1016/j.str.2025.08.017openalex-snapshot

Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD

inferred← citeshttps://doi.org/10.1016/j.tibs.2005.04.006openalex-snapshot

The ribosome revealed

inferred← citeshttps://doi.org/10.1016/j.tibs.2005.11.007openalex-snapshot

Nascent peptide in the ‘birth canal’ of the ribosome

inferred← citeshttps://doi.org/10.1016/j.tibs.2018.06.011openalex-snapshot

How Macrolide Antibiotics Work

inferred← citeshttps://doi.org/10.1016/j.tibtech.2006.02.005openalex-snapshot

The ribosome as a drug target

inferred← citeshttps://doi.org/10.1016/j.tim.2008.05.001openalex-snapshot

Correlating ribosome function with high-resolution structures

inferred← citeshttps://doi.org/10.1016/j.ymben.2013.09.005openalex-snapshot

Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli

inferred← citeshttps://doi.org/10.1016/s0065-7743(05)40023-8openalex-snapshot

Structural Genomics and Drug Discovery

inferred← citeshttps://doi.org/10.1016/s1016-8478(23)13193-1openalex-snapshot

Ribosomal Crystallography: Peptide Bond Formation, Chaperone Assistance and Antibiotics Activity

inferred← citeshttps://doi.org/10.1017/s0033583506004215openalex-snapshot

RNA structural motifs: building blocks of a modular biomolecule

inferred← citeshttps://doi.org/10.1017/s0033583516000056openalex-snapshot

The molecular choreography of protein synthesis: translational control, regulation, and pathways

inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00283openalex-snapshot

Natural Products as Platforms To Overcome Antibiotic Resistance

inferred← citeshttps://doi.org/10.1021/acs.jcim.4c01523openalex-snapshot

Delving into Macrolide Binding Affinities and Associated Structural Modulations in Erythromycin Esterase C: Insights into the Venus Flytrap Mechanism

inferred← citeshttps://doi.org/10.1021/acs.jcim.5b00651openalex-snapshot

Stacking Interactions between 9-Methyladenine and Heterocycles Commonly Found in Pharmaceuticals

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00446openalex-snapshot

The Role of Allylic Strain for Conformational Control in Medicinal Chemistry

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01357openalex-snapshot

Halogenated Rocaglate Derivatives: Pan-antiviral Agents against Hepatitis E Virus and Emerging Viruses

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00329openalex-snapshot

Halogen Bonding in Nucleic Acid Complexes

inferred← citeshttps://doi.org/10.1021/acs.joc.7b01702openalex-snapshot

Wittig Cyclization of ω-Hydroxy Hemiacetals: Synthesis of (+)-Aspicilin

inferred← citeshttps://doi.org/10.1021/acs.orglett.6b01151openalex-snapshot

Direct Entry to 4,10-Didesmethyl (9S)-Dihydroerythronolide A via Catalytic Allene Osmylation

inferred← citeshttps://doi.org/10.1021/bi7015266openalex-snapshot

Crystal Structure and Mechanism of the Staphylococcus cohnii Virginiamycin B Lyase (Vgb)

inferred← citeshttps://doi.org/10.1021/cb200418fopenalex-snapshot

The Chemistry of Peptidyltransferase Center-Targeted Antibiotics: Enzymatic Resistance and Approaches to Countering Resistance

inferred← citeshttps://doi.org/10.1021/cb5003224openalex-snapshot

Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome

inferred← citeshttps://doi.org/10.1021/ci8003495openalex-snapshot

Molecular Insights into 14-Membered Macrolides Using the MM-PBSA Method

inferred← citeshttps://doi.org/10.1021/ja207496popenalex-snapshot

Direct Entry to Erythronolides via a Cyclic Bis[Allene]

inferred← citeshttps://doi.org/10.1021/ja304682qopenalex-snapshot

Precursor Directed Biosynthesis of an Orthogonally Functional Erythromycin Analogue: Selectivity in the Ribosome Macrolide Binding Pocket

inferred← citeshttps://doi.org/10.1021/ja909118aopenalex-snapshot

Natural Products Version 2.0: Connecting Genes to Molecules

inferred← citeshttps://doi.org/10.1021/ja909317nopenalex-snapshot

Molecular Determinants of Microbial Resistance to Thiopeptide Antibiotics

inferred← citeshttps://doi.org/10.1021/jacs.1c03529openalex-snapshot

Practical Gram-Scale Synthesis of Iboxamycin, a Potent Antibiotic Candidate

inferred← citeshttps://doi.org/10.1021/jacs.1c03536openalex-snapshot

A Practical, Component-Based Synthetic Route to Methylthiolincosamine Permitting Facile Northern-Half Diversification of Lincosamide Antibiotics

inferred← citeshttps://doi.org/10.1021/jacs.9b02109openalex-snapshot

Expanding the Scope of Protein Synthesis Using Modified Ribosomes

inferred← citeshttps://doi.org/10.1021/jo201319bopenalex-snapshot

Total Synthesis of (−)-4,8,10-Tridesmethyl Telithromycin

inferred← citeshttps://doi.org/10.1021/ml1002184openalex-snapshot

Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Telithromycin

inferred← citeshttps://doi.org/10.1021/ml200254hopenalex-snapshot

Desmethyl Macrolides: Synthesis and Evaluation of 4,10-Didesmethyl Telithromycin

inferred← citeshttps://doi.org/10.1021/ml300230hopenalex-snapshot

Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin

inferred← citeshttps://doi.org/10.1021/ml400337topenalex-snapshot

Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Cethromycin

inferred← citeshttps://doi.org/10.1021/ml5002097openalex-snapshot

Desmethyl Macrolides: Synthesis and Evaluation of 4-Desmethyl Telithromycin

inferred← citeshttps://doi.org/10.1038/emboj.2009.17openalex-snapshot

Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency

inferred← citeshttps://doi.org/10.1038/emboj.2009.280openalex-snapshot

A ribosome–nascent chain sensor of membrane protein biogenesis in Bacillus subtilis

inferred← citeshttps://doi.org/10.1038/emboj.2010.180openalex-snapshot

The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide

inferred← citeshttps://doi.org/10.1038/ja.2013.27openalex-snapshot

Speculative strategies for new antibacterials: all roads should not lead to Rome

inferred← citeshttps://doi.org/10.1038/ja.2015.119openalex-snapshot

Synthesis and structure–activity relationships of novel lincomycin derivatives. Part 1. Newly generated antibacterial activities against Gram-positive bacteria with erm gene by C-7 modification

inferred← citeshttps://doi.org/10.1038/ja.2015.125openalex-snapshot

Synthesis and structure–activity relationships of novel lincomycin derivatives. Part 2. Synthesis of 7(S)-7-deoxy-7-(4-morpholinocarbonylphenylthio)lincomycin and its 3-dimensional analysis with rRNA

inferred← citeshttps://doi.org/10.1038/ja.2016.114openalex-snapshot

Synthesis and structure–activity relationships of novel lincomycin derivatives part 3: discovery of the 4-(pyrimidin-5-yl)phenyl group in synthesis of 7(S)-thiolincomycin analogs

inferred← citeshttps://doi.org/10.1038/nature13895openalex-snapshot

The complete structure of the large subunit of the mammalian mitochondrial ribosome

inferred← citeshttps://doi.org/10.1038/nature17967openalex-snapshot

A platform for the discovery of new macrolide antibiotics

inferred← citeshttps://doi.org/10.1038/nbt1266openalex-snapshot

New antibiotics from bacterial natural products

inferred← citeshttps://doi.org/10.1038/nchembio.1998openalex-snapshot

Nascent peptide assists the ribosome in recognizing chemically distinct small molecules

inferred← citeshttps://doi.org/10.1038/nchembio.326openalex-snapshot

Garbled messages and corrupted translations

inferred← citeshttps://doi.org/10.1038/ncomms4501openalex-snapshot

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

inferred← citeshttps://doi.org/10.1038/nrd2202openalex-snapshot

Multi-targeting by monotherapeutic antibacterials

inferred← citeshttps://doi.org/10.1038/nrmicro1265openalex-snapshot

The bacterial ribosome as a target for antibiotics

inferred← citeshttps://doi.org/10.1038/nrmicro1458openalex-snapshot

Aptamers come of age – at last

inferred← citeshttps://doi.org/10.1038/nrmicro3155openalex-snapshot

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

inferred← citeshttps://doi.org/10.1038/nsmb.1571openalex-snapshot

Tertiary interactions within the ribosomal exit tunnel

inferred← citeshttps://doi.org/10.1038/nsmb.2313openalex-snapshot

One core, two shells: bacterial and eukaryotic ribosomes

inferred← citeshttps://doi.org/10.1038/s41429-019-0156-1openalex-snapshot

Glycosylation of an allenic erythronolide

inferred← citeshttps://doi.org/10.1038/s41429-026-00939-7openalex-snapshot

Macrolide antibiotic action, resistance, and tolerance, and approaches to improve their activity against Gram-negative bacteria

inferred← citeshttps://doi.org/10.1038/s41467-017-02680-0openalex-snapshot

The evolution of substrate discrimination in macrolide antibiotic resistance enzymes

inferred← citeshttps://doi.org/10.1038/s41467-021-22016-3openalex-snapshot

Structural and functional insights into esterase-mediated macrolide resistance

inferred← citeshttps://doi.org/10.1038/s41467-021-23068-1openalex-snapshot

Context-specific action of macrolide antibiotics on the eukaryotic ribosome

inferred← citeshttps://doi.org/10.1038/s41467-021-23753-1openalex-snapshot

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens

inferred← citeshttps://doi.org/10.1038/s41467-023-39653-5openalex-snapshot

Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A

inferred← citeshttps://doi.org/10.1038/s41467-024-46762-2openalex-snapshot

The SecM arrest peptide traps a pre-peptide bond formation state of the ribosome

inferred← citeshttps://doi.org/10.1038/s41579-020-0386-zopenalex-snapshot

Target protection as a key antibiotic resistance mechanism

inferred← citeshttps://doi.org/10.1038/s41586-020-2761-3openalex-snapshot

Synthetic group A streptogramin antibiotics that overcome Vat resistance

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