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RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/j.1460-2075.1996.tb00602.xopenalex-snapshot
Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation.
inferredcites →https://doi.org/10.1016/j.cell.2006.03.035openalex-snapshot
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
inferredcites →https://doi.org/10.1016/j.cell.2007.03.051openalex-snapshot
Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice
inferredcites →https://doi.org/10.1016/j.cell.2012.06.024openalex-snapshot
A Landscape of Driver Mutations in Melanoma
inferredcites →https://doi.org/10.1016/j.devcel.2011.11.007openalex-snapshot
A Gβγ Effector, ElmoE, Transduces GPCR Signaling to the Actin Network during Chemotaxis
inferredcites →https://doi.org/10.1016/j.molcel.2011.01.026openalex-snapshot
Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism
inferredcites →https://doi.org/10.1016/j.molcel.2012.05.007openalex-snapshot
Cooperative Activation of PI3K by Ras and Rho Family Small GTPases
inferredcites →https://doi.org/10.1016/j.str.2008.06.008openalex-snapshot
The Human Formin FHOD1 Contains a Bipartite Structure of FH3 and GTPase-Binding Domains Required for Activation
inferredcites →https://doi.org/10.1016/s0014-5793(03)00454-xopenalex-snapshot
Phosphoinositide 3‐kinase‐dependent activation of Rac
inferredcites →https://doi.org/10.1016/s0021-9258(17)32226-3openalex-snapshot
Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.
inferredcites →https://doi.org/10.1016/s0092-8674(00)00196-3openalex-snapshot
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
inferredcites →https://doi.org/10.1016/s0092-8674(02)00755-9openalex-snapshot
Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis
inferredcites →https://doi.org/10.1016/s1388-1981(02)00144-0openalex-snapshot
Phosphoinositide 3-kinases in lysophosphatidic acid signaling: regulation and cross-talk with the Ras/mitogen-activated protein kinase pathway
inferredcites →https://doi.org/10.1038/12075openalex-snapshot
Phosphatidylinositol-3-OH kinases are Rab5 effectors
inferredcites →https://doi.org/10.1038/370527a0openalex-snapshot
Phosphatidylinositol-3-OH kinase direct target of Ras
inferredcites →https://doi.org/10.1038/37656openalex-snapshot
Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
inferredcites →https://doi.org/10.1038/nature07091openalex-snapshot
Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
inferredcites →https://doi.org/10.1038/ncb1280openalex-snapshot
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
inferredcites →https://doi.org/10.1038/ncb1493openalex-snapshot
Input from Ras is required for maximal PI(3)K signalling in Drosophila
inferredcites →https://doi.org/10.1038/ncb1494openalex-snapshot
Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils
inferredcites →https://doi.org/10.1038/ncb811openalex-snapshot
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
inferredcites →https://doi.org/10.1038/ng.2359openalex-snapshot
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
inferredcites →https://doi.org/10.1038/nm.2807openalex-snapshot
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
inferredcites →https://doi.org/10.1038/nm1232openalex-snapshot
PI 3-kinase p110β: a new target for antithrombotic therapy
inferredcites →https://doi.org/10.1038/nm1685openalex-snapshot
The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak
inferredcites →https://doi.org/10.1038/nrm2882openalex-snapshot
The emerging mechanisms of isoform-specific PI3K signalling
inferredcites →https://doi.org/10.1042/bj3150775openalex-snapshot
Rac GTPase interacts specifically with phosphatidylinositol 3-kinase
inferredcites →https://doi.org/10.1073/pnas.0510772103openalex-snapshot
Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase
inferredcites →https://doi.org/10.1073/pnas.0607899103openalex-snapshot
The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
inferredcites →https://doi.org/10.1073/pnas.0700373104openalex-snapshot
Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers
inferredcites →https://doi.org/10.1073/pnas.0707761105openalex-snapshot
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
inferredcites →https://doi.org/10.1073/pnas.142193799openalex-snapshot
Rig is a novel Ras-related protein and potential neural tumor suppressor
inferredcites →https://doi.org/10.1073/pnas.94.9.4330openalex-snapshot
p110δ, a novel phosphoinositide 3-kinase in leukocytes
inferredcites →https://doi.org/10.1074/jbc.270.30.17656openalex-snapshot
Rho Family GTPases Bind to Phosphoinositide Kinases
inferredcites →https://doi.org/10.1074/jbc.272.39.24252openalex-snapshot
Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide
inferredcites →https://doi.org/10.1074/jbc.274.41.29311openalex-snapshot
Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ
inferredcites →https://doi.org/10.1074/jbc.m111.274191openalex-snapshot
The Arf Family GTPase Arl4A Complexes with ELMO Proteins to Promote Actin Cytoskeleton Remodeling and Reveals a Versatile Ras-binding Domain in the ELMO Proteins Family
inferredcites →https://doi.org/10.1074/jbc.m202150200openalex-snapshot
Di-Ras, a Distinct Subgroup of Ras Family GTPases with Unique Biochemical Properties
inferredcites →https://doi.org/10.1083/jcb.200208179openalex-snapshot
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
inferredcites →https://doi.org/10.1083/jcb.200505128openalex-snapshot
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
inferredcites →https://doi.org/10.1083/jcb.201006056openalex-snapshot
The class IA phosphatidylinositol 3-kinase p110-β subunit is a positive regulator of autophagy
inferredcites →https://doi.org/10.1091/mbc.e09-08-0744openalex-snapshot
Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a002964openalex-snapshot
Association of Phosphatidylinositol 3-Kinase Composed of p110 -Catalytic and p85-Regulatory Subunits with the Small GTPase Rab5
inferredcites →https://doi.org/10.1101/gad.191973.112openalex-snapshot
The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis
inferredcites →https://doi.org/10.1126/scisignal.1161577openalex-snapshot
Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development
inferredcites →https://doi.org/10.1126/scisignal.2001617openalex-snapshot
PI3Kβ Plays a Critical Role in Neutrophil Activation by Immune Complexes
inferredcites →https://doi.org/10.1126/scisignal.2003264openalex-snapshot
G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness
inferredcites →https://doi.org/10.1128/mcb.24.11.4943-4954.2004openalex-snapshot
Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate
inferredcites →https://doi.org/10.1172/jci35512openalex-snapshot
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
inferredcites →https://doi.org/10.1182/blood-2009-04-217224openalex-snapshot
Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
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Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling
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Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance
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Agonist-stimulated phosphatidylinositol-3,4,5-trisphosphate generation by scaffolded phosphoinositide kinases
inferred← citeshttps://doi.org/10.1038/ncomms15090openalex-snapshot
Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration
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Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling
inferred← citeshttps://doi.org/10.1038/ncomms6937openalex-snapshot
Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization
inferred← citeshttps://doi.org/10.1038/ncomms8400openalex-snapshot
PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
inferred← citeshttps://doi.org/10.1038/ncomms9501openalex-snapshot
A PI3K p110β–Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis
inferred← citeshttps://doi.org/10.1038/ni.3487openalex-snapshot
Control of the innate immune response by the mevalonate pathway
inferred← citeshttps://doi.org/10.1038/ni.3866openalex-snapshot
Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2
inferred← citeshttps://doi.org/10.1038/nrc3860openalex-snapshot
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
inferred← citeshttps://doi.org/10.1038/nrd4204openalex-snapshot
PI3K and cancer: lessons, challenges and opportunities
inferred← citeshttps://doi.org/10.1038/nrd4389openalex-snapshot
Drugging the undruggable RAS: Mission Possible?
inferred← citeshttps://doi.org/10.1038/nri.2016.93openalex-snapshot
PI3Kδ and primary immunodeficiencies
inferred← citeshttps://doi.org/10.1038/onc.2013.593openalex-snapshot
TRIM24 promotes glioma progression and enhances chemoresistance through activation of the PI3K/Akt signaling pathway
inferred← citeshttps://doi.org/10.1038/onc.2014.328openalex-snapshot
P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer
inferred← citeshttps://doi.org/10.1038/onc.2015.394openalex-snapshot
Tumour-suppression function of KLF12 through regulation of anoikis
inferred← citeshttps://doi.org/10.1038/onc.2016.473openalex-snapshot
Rho GTPases: Anti- or pro-neoplastic targets?
inferred← citeshttps://doi.org/10.1038/onc.2017.400openalex-snapshot
Suppression of RAC1-driven malignant melanoma by group A PAK inhibitors
inferred← citeshttps://doi.org/10.1038/s41386-019-0457-xopenalex-snapshot
Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function
inferred← citeshttps://doi.org/10.1038/s41388-022-02431-6openalex-snapshot
PACT promotes the metastasis of basal-like breast cancer through Rac1 SUMOylation and activation
inferred← citeshttps://doi.org/10.1038/s41392-025-02473-8openalex-snapshot
Targeting KRAS mutations: orchestrating cancer evolution and therapeutic challenges
inferred← citeshttps://doi.org/10.1038/s41419-022-05184-yopenalex-snapshot
CDC42 governs normal oviduct multiciliogenesis through activating AKT to ensure timely embryo transport
inferred← citeshttps://doi.org/10.1038/s41467-018-06897-5openalex-snapshot
Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion
inferred← citeshttps://doi.org/10.1038/s41467-018-07698-6openalex-snapshot
Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis
inferred← citeshttps://doi.org/10.1038/s41467-020-15308-7openalex-snapshot
Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
inferred← citeshttps://doi.org/10.1038/s41467-024-55766-xopenalex-snapshot
Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation
inferred← citeshttps://doi.org/10.1038/s41577-022-00701-8openalex-snapshot
The role of PI3Kγ in the immune system: new insights and translational implications
inferred← citeshttps://doi.org/10.1038/s41580-019-0129-zopenalex-snapshot
PI3K isoforms in cell signalling and vesicle trafficking
inferred← citeshttps://doi.org/10.1038/s41580-023-00682-zopenalex-snapshot
Patterning of the cell cortex by Rho GTPases
inferred← citeshttps://doi.org/10.1038/s41586-022-04584-6openalex-snapshot
Anatomic position determines oncogenic specificity in melanoma
inferred← citeshttps://doi.org/10.1038/s41598-017-16029-6openalex-snapshot
Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase
inferred← citeshttps://doi.org/10.1038/s41598-021-04736-0openalex-snapshot
Mutated RAS-associating proteins and ERK activation in relapse/refractory diffuse large B cell lymphoma
inferred← citeshttps://doi.org/10.1038/s41598-021-93484-2openalex-snapshot
SPP1 overexpression is associated with poor outcomes in ALK fusion lung cancer patients without receiving targeted therapy
inferred← citeshttps://doi.org/10.1038/s41598-023-28756-0openalex-snapshot
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α
inferred← citeshttps://doi.org/10.1038/s41698-024-00496-yopenalex-snapshot
Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
inferred← citeshttps://doi.org/10.1038/s44318-025-00390-8openalex-snapshot
Different Ras isoforms regulate synaptic plasticity in opposite directions
inferred← citeshttps://doi.org/10.1038/s44319-024-00203-9openalex-snapshot
Complex interplay between RAS GTPases and RASSF effectors regulates subcellular localization of YAP
inferred← citeshttps://doi.org/10.1042/bcj20170279openalex-snapshot
Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ
inferred← citeshttps://doi.org/10.1042/bcj20200442openalex-snapshot
The molecular functions of RIT1 and its contribution to human disease
inferred← citeshttps://doi.org/10.1042/bcj20210004openalex-snapshot
Organismal roles for the PI3Kα and β isoforms: their specificity, redundancy or cooperation is context-dependent
inferred← citeshttps://doi.org/10.1042/bcj20210584openalex-snapshot
Macropinocytosis: mechanisms and regulation
inferred← citeshttps://doi.org/10.1042/bcj20250142openalex-snapshot
Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass
inferred← citeshttps://doi.org/10.1042/bj20150099openalex-snapshot
Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity
inferred← citeshttps://doi.org/10.1042/bsr20130133openalex-snapshot
Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells
inferred← citeshttps://doi.org/10.1042/bst20130255openalex-snapshot
Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme
inferred← citeshttps://doi.org/10.1042/bst20170531openalex-snapshot
RHO GTPases in cancer: known facts, open questions, and therapeutic challenges
inferred← citeshttps://doi.org/10.1042/cs20160026openalex-snapshot
Prostate cancer, PI3K, PTEN and prognosis
inferred← citeshttps://doi.org/10.1042/cs20257631openalex-snapshot
Physiological roles of phosphoinositides and inositol phosphates: Implications for metabolic dysfunction-associated steatotic liver disease
inferred← citeshttps://doi.org/10.1042/cs20260571openalex-snapshot
FGF2 in the regulation of regenerative repair and fibrosis: TGF-β cross-talk and therapeutic advances
inferred← citeshttps://doi.org/10.1053/j.seminoncol.2016.11.011openalex-snapshot
PI3K signaling pathway in normal B cells and indolent B-cell malignancies
inferred← citeshttps://doi.org/10.1073/pnas.1213773111openalex-snapshot
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis
inferred← citeshttps://doi.org/10.1073/pnas.1323004111openalex-snapshot
PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
inferred← citeshttps://doi.org/10.1073/pnas.1513801113openalex-snapshot
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
inferred← citeshttps://doi.org/10.1073/pnas.1604450113openalex-snapshot
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor
inferred← citeshttps://doi.org/10.1073/pnas.1803446115openalex-snapshot
Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors
inferred← citeshttps://doi.org/10.1073/pnas.1813012116openalex-snapshot
p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity
inferred← citeshttps://doi.org/10.1074/jbc.m114.616680openalex-snapshot
ClipR-59 Interacts with Elmo2 and Modulates Myoblast Fusion
inferred← citeshttps://doi.org/10.1074/jbc.m114.633701openalex-snapshot
The Bipartite Rac1 Guanine Nucleotide Exchange Factor Engulfment and Cell Motility 1/Dedicator of Cytokinesis 180 (Elmo1/Dock180) Protects Endothelial Cells from Apoptosis in Blood Vessel Development
inferred← citeshttps://doi.org/10.1074/jbc.m115.668244openalex-snapshot
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase
inferred← citeshttps://doi.org/10.1074/jbc.m115.681544openalex-snapshot
Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans
inferred← citeshttps://doi.org/10.1074/jbc.m115.689604openalex-snapshot
Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer
inferred← citeshttps://doi.org/10.1074/jbc.m115.695940openalex-snapshot
Rapid Remodeling of Invadosomes by Gi-coupled Receptors
inferred← citeshttps://doi.org/10.1074/jbc.m115.700088openalex-snapshot
The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells
inferred← citeshttps://doi.org/10.1074/jbc.m116.731521openalex-snapshot
Elmo2 Is a Regulator of Insulin-dependent Glut4 Membrane Translocation
inferred← citeshttps://doi.org/10.1074/jbc.m117.789263openalex-snapshot
Molecular mechanism of activation of class IA phosphoinositide 3-kinases (PI3Ks) by membrane-localized HRas
inferred← citeshttps://doi.org/10.1074/jbc.ra118.006032openalex-snapshot
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion
inferred← citeshttps://doi.org/10.1080/07391102.2015.1127774openalex-snapshot
Biophysical aspect of phosphatidylinositol 3-kinase and role of oncogenic mutants (E542K & E545K)
inferred← citeshttps://doi.org/10.1080/15384101.2018.1560205openalex-snapshot
Ras signals principally via Erk in G1 but cooperates with PI3K/Akt for Cyclin D induction and S-phase entry
inferred← citeshttps://doi.org/10.1080/17460441.2022.2029842openalex-snapshot
Novel approaches for the development of direct KRAS inhibitors: structural insights and drug design
inferred← citeshttps://doi.org/10.1080/21541248.2016.1178366openalex-snapshot
Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma
inferred← citeshttps://doi.org/10.1080/21541248.2016.1232583openalex-snapshot
Rho GTPases: Regulation and roles in cancer cell biology
inferred← citeshttps://doi.org/10.1080/21541248.2017.1304855openalex-snapshot
Cross-talk between Rho GTPases and PI3K in the neutrophil
inferred← citeshttps://doi.org/10.1080/21541248.2023.2202612openalex-snapshot
PI3K Functions Downstream of Cdc42 to Drive Cancer phenotypes in a Melanoma Cell Line
inferred← citeshttps://doi.org/10.1080/23723556.2014.996016openalex-snapshot
The PREX1/Rac signaling axis: Potential as a biomarker and therapeutic target in breast cancer
inferred← citeshttps://doi.org/10.1091/mbc.e15-11-0796openalex-snapshot
The novel RacE-binding protein GflB sharpens Ras activity at the leading edge of migrating cells
inferred← citeshttps://doi.org/10.1091/mbc.e19-03-0182openalex-snapshot
PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation
inferred← citeshttps://doi.org/10.1093/ecco-jcc/jjy133openalex-snapshot
Engulfment and Cell Motility Protein 1 Protects Against DSS-induced Colonic Injury in Mice via Rac1 Activation
inferred← citeshttps://doi.org/10.1093/humrep/deae246openalex-snapshot
CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure
inferred← citeshttps://doi.org/10.1093/jbmr/zjae102openalex-snapshot
Direct activation of PI3K in osteoblasts and osteocytes strengthens murine bone through sex-specific actions on cortical surfaces
inferred← citeshttps://doi.org/10.1096/fj.202100554ropenalex-snapshot
FGD5 regulates endothelial cell PI3 kinase‐β to promote neo‐angiogenesis
inferred← citeshttps://doi.org/10.1096/fj.202603316rropenalex-snapshot
Dynamic Remodeling of Oocyte‐Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta‐Analyses
inferred← citeshttps://doi.org/10.1101/2022.07.19.500601openalex-snapshot
Epinephrine inhibits PI3K alpha via the Hippo kinases
inferred← citeshttps://doi.org/10.1101/2023.05.01.538969openalex-snapshot
Molecular dissection of PI3Kβ synergistic activation by receptor tyrosine kinases, GβGγ, and Rho-family GTPases
inferred← citeshttps://doi.org/10.1101/2024.10.27.620536openalex-snapshot
Ribosomal Biogenesis Hyperactivation and ErbB signalling Mediated Network Rewiring Causes Adaptive Resistance to FGFR2 Inhibition
inferred← citeshttps://doi.org/10.1101/2025.05.13.653657openalex-snapshot
PI3Kδ Bridges Microbial Surveillance with Antigen Presentation to Reinforce Intestinal Immunity
inferred← citeshttps://doi.org/10.1101/cshperspect.a031435openalex-snapshot
KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer
inferred← citeshttps://doi.org/10.1101/cshperspect.a031450openalex-snapshot
PI3K: A Crucial Piece in the RAS Signaling Puzzle
inferred← citeshttps://doi.org/10.1101/gad.249409.114openalex-snapshot
Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α
inferred← citeshttps://doi.org/10.1111/cbdd.12895openalex-snapshot
Microsecond molecular dynamics simulations provide insight into the ATP‐competitive inhibitor‐induced allosteric protection of Akt kinase phosphorylation
inferred← citeshttps://doi.org/10.1111/cge.12908openalex-snapshot
Emerging roles of RAC1 in treating lung cancer patients
inferred← citeshttps://doi.org/10.1111/exd.14489openalex-snapshot
The role of PI3'‐lipid signalling in melanoma initiation, progression and maintenance
inferred← citeshttps://doi.org/10.1111/gtc.12097openalex-snapshot
Longest neurite‐specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI 3‐kinase
inferred← citeshttps://doi.org/10.1111/pcmr.12586openalex-snapshot
PIK3CA ‐mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation
inferred← citeshttps://doi.org/10.1111/pcmr.12889openalex-snapshot
RAC1mutation is not a predictive biomarker for PI3’‐kinase‐β‐selective pathway‐targeted therapy
inferred← citeshttps://doi.org/10.1124/mol.116.105338openalex-snapshot
Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment
inferred← citeshttps://doi.org/10.1126/science.adz4117openalex-snapshot
Harnessing insulin biology to treat diabetes and cancer
inferred← citeshttps://doi.org/10.1126/scisignal.aae0453openalex-snapshot
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
inferred← citeshttps://doi.org/10.1126/scisignal.aba8627openalex-snapshot
A PI3K- and GTPase-independent Rac1-mTOR mechanism mediates MET-driven anchorage-independent cell growth but not migration
inferred← citeshttps://doi.org/10.1134/s0006297916070051openalex-snapshot
Better understanding of phosphoinositide 3-kinase (PI3K) pathways in vasculature: Towards precision therapy targeting angiogenesis and tumor blood supply
inferred← citeshttps://doi.org/10.1155/2013/986320openalex-snapshot
Signalling in Neutrophils: A Retro Look
inferred← citeshttps://doi.org/10.11575/prism/24934openalex-snapshot
Anti-Cryptococcal Signaling in NK Cells
inferred← citeshttps://doi.org/10.1158/0008-5472.can-15-1675openalex-snapshot
GPCR Signaling Mediates Tumor Metastasis via PI3Kβ
inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-0448openalex-snapshot
KRASQ61H Preferentially Signals through MAPK in a RAF Dimer-Dependent Manner in Non–Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.can-23-2814openalex-snapshot
Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-15-2764openalex-snapshot
Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-17-0676openalex-snapshot
Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-20-2077openalex-snapshot
Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C–Mutant Non–Small Cell Lung Cancer
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