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Disease Heritability Inferred from Familial Relationships Reported in Medical Records
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.2009.1758openalex-snapshot
Association Between Carrier Screening and Incidence of Cystic Fibrosis
inferredcites →https://doi.org/10.1001/jama.2015.17703openalex-snapshot
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries
inferredcites →https://doi.org/10.1002/gepi.21855openalex-snapshot
Use of an Electronic Medical Record to Create the Marshfield Clinic Twin/Multiple Birth Cohort
inferredcites →https://doi.org/10.1007/s00125-007-0784-zopenalex-snapshot
Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities
inferredcites →https://doi.org/10.1007/s10519-006-9113-4openalex-snapshot
Genotype by Environment Interaction in Adolescents’ Cognitive Aptitude
inferredcites →https://doi.org/10.1007/s40264-016-0393-1openalex-snapshot
An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval
inferredcites →https://doi.org/10.1016/j.jpeds.2005.06.043openalex-snapshot
Cystic Fibrosis Birth Rates in Canada: A Decreasing Trend since the Onset of Genetic Testing
inferredcites →https://doi.org/10.1037/0033-295x.101.4.568openalex-snapshot
Nature-nurture reconceptualized in developmental perspective: A bioecological model.
inferredcites →https://doi.org/10.1038/nature15816openalex-snapshot
Building the foundation for genomics in precision medicine
inferredcites →https://doi.org/10.1038/ng.3285openalex-snapshot
Meta-analysis of the heritability of human traits based on fifty years of twin studies
inferredcites →https://doi.org/10.1038/nrg.2016.27openalex-snapshot
Developing and evaluating polygenic risk prediction models for stratified disease prevention
inferredcites →https://doi.org/10.1038/nrg2322openalex-snapshot
Heritability in the genomics era — concepts and misconceptions
inferredcites →https://doi.org/10.1038/nrg3377openalex-snapshot
The heritability of human disease: estimation, uses and abuses
inferredcites →https://doi.org/10.1038/oby.2008.675openalex-snapshot
HDL Subspecies in Young Adult Twins: Heritability and Impact of Overweight
inferredcites →https://doi.org/10.1046/j.0956-7976.2003.psci_1475.xopenalex-snapshot
Socioeconomic Status Modifies Heritability of IQ in Young Children
inferredcites →https://doi.org/10.1056/nejmsb042979openalex-snapshot
The Family History — More Important Than Ever
inferredcites →https://doi.org/10.1073/pnas.1510502113openalex-snapshot
Characterizing treatment pathways at scale using the OHDSI network
inferredcites →https://doi.org/10.1086/301844openalex-snapshot
Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees
inferredcites →https://doi.org/10.1086/519795openalex-snapshot
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
inferredcites →https://doi.org/10.1093/jamia/ocv046openalex-snapshot
Birth month affects lifetime disease risk: a phenome-wide method
inferredcites →https://doi.org/10.1109/csie.2009.950openalex-snapshot
The Pilot Way to Grid Resources Using glideinWMS
inferredcites →https://doi.org/10.1111/cts.12178openalex-snapshot
Big Data and Large Sample Size: A Cautionary Note on the Potential for Bias
inferredcites →https://doi.org/10.1126/scitranslmed.3003377openalex-snapshot
Data-Driven Prediction of Drug Effects and Interactions
inferredcites →https://doi.org/10.1136/amiajnl-2011-000681openalex-snapshot
Methods and dimensions of electronic health record data quality assessment: enabling reuse for clinical research
inferredcites →https://doi.org/10.1136/amiajnl-2012-001145openalex-snapshot
Next-generation phenotyping of electronic health records
inferredcites →https://doi.org/10.1146/annurev-publhealth-031914-122747openalex-snapshot
Uses of Electronic Health Records for Public Health Surveillance to Advance Public Health
inferredcites →https://doi.org/10.1161/01.cir.102.18.2300openalex-snapshot
Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms
inferredcites →https://doi.org/10.1161/01.str.31.11.2742openalex-snapshot
Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms
inferredcites →https://doi.org/10.1186/1750-1172-7-14openalex-snapshot
Evidence for decline in the incidence of cystic fibrosis: a 35-year observational study in Brittany, France
inferredcites →https://doi.org/10.1186/s13073-015-0166-yopenalex-snapshot
Extracting research-quality phenotypes from electronic health records to support precision medicine
inferredcites →https://doi.org/10.1371/journal.pgen.1006711openalex-snapshot
Phenome-wide heritability analysis of the UK Biobank
inferredcites →https://doi.org/10.1378/chest.128.4.2309openalex-snapshot
Birth Prevalence and Survival in Cystic Fibrosis
inferredcites →https://doi.org/10.1542/13.4.21openalex-snapshot
Health Insurance Portability and Accountability Act of 1996: Potential liability under new fraud and abuse provisions
inferredcites →https://doi.org/10.3389/fgene.2015.00104openalex-snapshot
The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research
inferredcites →https://doi.org/10.4135/9781412952644.n199openalex-snapshot
Health Insurance Portability and Accountability Act
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Polygenic Risk Score-Based Phenome-Wide Association for Glaucoma and its Impact on Disease Susceptibility in Two Large Biobanks
inferred← citeshttps://doi.org/10.1001/jamaophthalmol.2024.3829openalex-snapshot
METTL23 Variants and Patients With Normal-Tension Glaucoma
inferred← citeshttps://doi.org/10.1002/ajh.25421openalex-snapshot
Heritability of fetal hemoglobin, white cell count, and other clinical traits from a sickle cell disease family cohort
inferred← citeshttps://doi.org/10.1002/gepi.22555openalex-snapshot
Breast and bowel cancers diagnosed in people ‘too young to have cancer’: A blueprint for research using family and twin studies
inferred← citeshttps://doi.org/10.1002/sim.70675openalex-snapshot
Multi‐Level Latent Variable Models for Coheritability Analysis in Electronic Health Records
inferred← citeshttps://doi.org/10.1007/978-3-030-42634-7_151openalex-snapshot
The Genetics of Common, Complex Diseases
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Integrating Multimodal Patient Data into Attention-Based Graph Networks for Disease Risk Prediction
inferred← citeshttps://doi.org/10.1007/978-3-319-90495-5_151-1openalex-snapshot
The Genetics of Common, Complex Diseases
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Glaucoma Drug Target Prioritisation Informs Disease-specific Therapeutic Potentials of Targeting SMAD4
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Genetics of depression
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Perspectives for advancing neurotoxicity studies with Drosophila
inferred← citeshttps://doi.org/10.1016/j.bpsgos.2025.100525openalex-snapshot
Mediating Role of Trauma Connecting Psychiatric Family History and Adolescent Mental Health
inferred← citeshttps://doi.org/10.1016/j.cell.2018.05.053openalex-snapshot
Disease Heritability Studies Harness the Healthcare System to Achieve Massive Scale
inferred← citeshttps://doi.org/10.1016/j.cell.2019.02.039openalex-snapshot
Personalized Medicine and the Power of Electronic Health Records
inferred← citeshttps://doi.org/10.1016/j.cell.2023.12.023openalex-snapshot
Making glaucoma genetic studies more diverse
inferred← citeshttps://doi.org/10.1016/j.cgh.2018.06.016openalex-snapshot
Low Rates of Screening for Celiac Disease Among Family Members
inferred← citeshttps://doi.org/10.1016/j.cgh.2019.03.038openalex-snapshot
No Increased Risk of Colorectal Adenomas in Spouses of Patients with Colorectal Neoplasia
inferred← citeshttps://doi.org/10.1016/j.exer.2019.107702openalex-snapshot
Mendelian genes in primary open angle glaucoma
inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e12311openalex-snapshot
Implementation and validation of a probabilistic linkage method for population databases without identification variables
inferred← citeshttps://doi.org/10.1016/j.ijcrp.2026.200612openalex-snapshot
Family history of cardiovascular disease and its modifiable risk factors and association with offspring risk profile
inferred← citeshttps://doi.org/10.1016/j.intell.2023.101737openalex-snapshot
On group differences in the heritability of intelligence: A reply to Giangrande and Turkheimer (2022)
inferred← citeshttps://doi.org/10.1016/j.jacep.2019.03.002openalex-snapshot
My Cousin Also Has Atrial Fibrillation
inferred← citeshttps://doi.org/10.1016/j.jbi.2021.103711openalex-snapshot
Similarity-based health risk prediction using Domain Fusion and electronic health records data
inferred← citeshttps://doi.org/10.1016/j.neubiorev.2019.12.012openalex-snapshot
Obesity and eating behavior from the perspective of twin and genetic research
inferred← citeshttps://doi.org/10.1016/j.ogla.2025.03.011openalex-snapshot
Gonioscopy-Assisted Transluminal Trabeculotomy for Myocilin-Associated Juvenile Open-Angle Glaucoma
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2022.101066openalex-snapshot
The genetic basis for adult onset glaucoma: Recent advances and future directions
inferred← citeshttps://doi.org/10.1016/j.tig.2018.09.007openalex-snapshot
Genomic and Phenomic Research in the 21st Century
inferred← citeshttps://doi.org/10.1016/j.xgen.2022.100142openalex-snapshot
Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma
inferred← citeshttps://doi.org/10.1016/j.ypmed.2022.107016openalex-snapshot
Expanding adverse child experiences to inequality and racial discrimination
inferred← citeshttps://doi.org/10.1017/s0033291721000441openalex-snapshot
The genetic basis of major depression
inferred← citeshttps://doi.org/10.1017/thg.2019.35openalex-snapshot
The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins
inferred← citeshttps://doi.org/10.1038/s41380-021-01231-wopenalex-snapshot
Exploring the genetic heterogeneity in major depression across diagnostic criteria
inferred← citeshttps://doi.org/10.1038/s41380-024-02878-xopenalex-snapshot
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
inferred← citeshttps://doi.org/10.1038/s41467-018-07460-yopenalex-snapshot
Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
inferred← citeshttps://doi.org/10.1038/s41467-019-13455-0openalex-snapshot
Estimating heritability and genetic correlations from large health datasets in the absence of genetic data
inferred← citeshttps://doi.org/10.1038/s41467-023-44250-7openalex-snapshot
Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity
inferred← citeshttps://doi.org/10.1038/s41467-024-49566-6openalex-snapshot
Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan
inferred← citeshttps://doi.org/10.1038/s41467-024-51795-8openalex-snapshot
Uncovering the heritable components of multimorbidities and disease trajectories using a nationwide cohort
inferred← citeshttps://doi.org/10.1038/s41467-025-60502-0openalex-snapshot
BIGFAM - variance components analysis from relatives without genotype
inferred← citeshttps://doi.org/10.1038/s41467-026-69991-zopenalex-snapshot
Mapping the heritability of disease: a nationwide study
inferred← citeshttps://doi.org/10.1038/s41576-018-0021-2openalex-snapshot
Estimating heritability without genetic testing
inferred← citeshttps://doi.org/10.1038/s41576-020-0224-1openalex-snapshot
Electronic health records and polygenic risk scores for predicting disease risk
inferred← citeshttps://doi.org/10.1038/s41586-022-04769-zopenalex-snapshot
ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs
inferred← citeshttps://doi.org/10.1038/s41586-024-08264-5openalex-snapshot
Haematological setpoints are a stable and patient-specific deep phenotype
inferred← citeshttps://doi.org/10.1038/s41588-018-0313-7openalex-snapshot
Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes
inferred← citeshttps://doi.org/10.1038/s41591-021-01468-6openalex-snapshot
Personalized lab test models to quantify disease potentials in healthy individuals
inferred← citeshttps://doi.org/10.1038/s41746-021-00428-1openalex-snapshot
Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies
inferred← citeshttps://doi.org/10.1038/s42003-025-08180-yopenalex-snapshot
Computationally efficient methods for estimating phenome—wide coheritability of multi-type phenotypes using biobank data
inferred← citeshttps://doi.org/10.1038/s43856-021-00058-4openalex-snapshot
Estimating heritability of glycaemic response to metformin using nationwide electronic health records and population-sized pedigree
inferred← citeshttps://doi.org/10.1073/pnas.1806901116openalex-snapshot
Effects of the peer metagenomic environment on smoking behavior
inferred← citeshttps://doi.org/10.1080/09286586.2021.1992784openalex-snapshot
Development and Evaluation of a Rules-based Algorithm for Primary Open-Angle Glaucoma in the VA Million Veteran Program
inferred← citeshttps://doi.org/10.1089/jop.2021.0057openalex-snapshot
Chimeric Helper-Dependent Adenoviruses Transduce Retinal Ganglion Cells and Müller Cells in Human Retinal Explants
inferred← citeshttps://doi.org/10.1093/bioinformatics/btab419openalex-snapshot
E-Pedigrees: a large-scale automatic family pedigree prediction application
inferred← citeshttps://doi.org/10.1093/bioinformatics/btag308openalex-snapshot
PEStimate : predicting offspring disease risk after polygenic embryo screening
inferred← citeshttps://doi.org/10.1093/genetics/iyaf238openalex-snapshot
Kinship estimation bias carries over to heritability estimation bias using variance components
inferred← citeshttps://doi.org/10.1093/jamia/ocad028openalex-snapshot
Using electronic health record data to link families: an illustrative example using intergenerational patterns of obesity
inferred← citeshttps://doi.org/10.1093/jamia/ocad154openalex-snapshot
The value of parental medical records for the prediction of diabetes and cardiovascular disease: a novel method for generating and incorporating family histories
inferred← citeshttps://doi.org/10.1093/jamia/ocae297openalex-snapshot
Enhancing patient representation learning with inferred family pedigrees improves disease risk prediction
inferred← citeshttps://doi.org/10.1093/jamia/ocaf102openalex-snapshot
Identifying family structures from obituaries and matching them to patients in an electronic heath record
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Prevalence of Open-angle Glaucoma in the Faroese Population
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Glaucoma Cascade Screening in a High Risk Afro-Caribbean Haitian Population: A Pilot Study
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Integrating Genetics in Glaucoma Screening
inferred← citeshttps://doi.org/10.1097/mop.0000000000001415openalex-snapshot
Linking household members and defining relational networks using routine health data
inferred← citeshttps://doi.org/10.1101/2020.07.16.206219openalex-snapshot
An ancient deletion in the ABO gene affects the composition of the porcine microbiome by altering intestinal N-acetyl-galactosamine concentrations
inferred← citeshttps://doi.org/10.1101/2022.05.23.22275364openalex-snapshot
A Monte Carlo Estimation of the Narrow-Sense Heritability of COVID-19 Infection and Severity from AncestryDNA Survey Data
inferred← citeshttps://doi.org/10.1101/2023.02.08.23285642openalex-snapshot
Uncovering the Heritable Components of Multimorbidities and Disease Trajectories: A Nationwide Cohort Study
inferred← citeshttps://doi.org/10.1101/2023.09.26.23296146openalex-snapshot
Hematologic setpoints are a stable and patient-specific deep phenotype
inferred← citeshttps://doi.org/10.1101/2024.03.12.24304163openalex-snapshot
Enhancing patient representation learning from electronic health records through predicted family relations
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Integrated cell type-specific analysis of blood and gut identifies matching eQTL for 140 IBD risk loci and entrectinib as possible repurposing candidate
inferred← citeshttps://doi.org/10.1101/2025.05.16.25327749openalex-snapshot
Automatic detection of n-degree family members
inferred← citeshttps://doi.org/10.1101/731976openalex-snapshot
Familial relationships in electronic health records (EHR) v2
inferred← citeshttps://doi.org/10.1101/770396openalex-snapshot
Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective
inferred← citeshttps://doi.org/10.1111/gbb.12660openalex-snapshot
Using the tools of genetic epidemiology to understand sex differences in neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1142/9789811270611_0038openalex-snapshot
Diversity is key for cross-ancestry transferability of glaucoma genetic risk scores in Hispanic Veterans in the Million Veteran Program
inferred← citeshttps://doi.org/10.1158/1055-9965.epi-19-0912openalex-snapshot
Family Study Designs Informed by Tumor Heterogeneity and Multi-Cancer Pleiotropies: The Power of the Utah Population Database
inferred← citeshttps://doi.org/10.1159/000514536openalex-snapshot
Dermatologic Research Potential of the Observational Health Data Sciences and Informatics (OHDSI) Network
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Developing and Optimizing Innovative Tools to Address Familial Hypercholesterolemia Underdiagnosis: Identification Methods, Patient Activation, and Cascade Testing for Familial Hypercholesterolemia.
inferred← citeshttps://doi.org/10.1176/appi.ajp.2018.18070789openalex-snapshot
Population-Based Estimates of Heritability Shed New Light on Clinical Features of Major Depression
inferred← citeshttps://doi.org/10.1186/s12859-020-3456-3openalex-snapshot
Toxo: a library for calculating penetrance tables of high-order epistasis models
inferred← citeshttps://doi.org/10.1186/s12967-024-05152-4openalex-snapshot
Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks
inferred← citeshttps://doi.org/10.1186/s13040-020-00230-xopenalex-snapshot
Comparative analysis, applications, and interpretation of electronic health record-based stroke phenotyping methods
inferred← citeshttps://doi.org/10.1186/s13040-022-00301-1openalex-snapshot
Novel digital approaches to the assessment of problematic opioid use
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Identification of Individuals With Hereditary Cancer Risk Through Multiple Data Sources: A Population-Based Method Using the GARDE Platform and The Utah Population Database
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Utilizing a Biology-Driven Approach to Map the Exposome in Health and Disease: An Essential Investment to Drive the Next Generation of Environmental Discovery
inferred← citeshttps://doi.org/10.1371/journal.pdig.0000685openalex-snapshot
Evaluating Large Language Models in extracting cognitive exam dates and scores
inferred← citeshttps://doi.org/10.1371/journal.pgen.1008124openalex-snapshot
Estimating variance components in population scale family trees
inferred← citeshttps://doi.org/10.15406/ijfcm.2018.02.00070openalex-snapshot
Genetic and medical advising information and education tools for the patient and his family
inferred← citeshttps://doi.org/10.18653/v1/w19-32openalex-snapshot
Proceedings of the Fourth Social Media Mining for Health Applications (#SMM4H) Workshop & Shared Task
inferred← citeshttps://doi.org/10.18653/v1/w19-3201openalex-snapshot
Extracting Kinship from Obituary to Enhance Electronic Health Records for Genetic Research
inferred← citeshttps://doi.org/10.21037/aes-20-124openalex-snapshot
Association between the M98K variant of the OPTN gene and the risk for primary open angle glaucoma: an updated meta-analysis
inferred← citeshttps://doi.org/10.2147/dmso.s288419openalex-snapshot
Identifying Diabetic Macular Edema and Other Retinal Diseases by Optical Coherence Tomography Image and Multiscale Deep Learning
inferred← citeshttps://doi.org/10.2196/25670openalex-snapshot
Construction of Genealogical Knowledge Graphs From Obituaries: Multitask Neural Network Extraction System
inferred← citeshttps://doi.org/10.23889/ijpds.v6i1.1686openalex-snapshot
Multigenerational Health Research using Population-Based Linked Databases: An International Review
inferred← citeshttps://doi.org/10.33631/duzcesbed.679732openalex-snapshot
Kalıtım Derecesinin Tahmini ve İnsan Hastalıklarının/Özelliklerinin Kalıtsallığı
inferred← citeshttps://doi.org/10.3389/fcogn.2024.1505549openalex-snapshot
Expanded taxonomies of human memory
inferred← citeshttps://doi.org/10.3389/fgene.2025.1708315openalex-snapshot
Automatic detection of n-degree family members
inferred← citeshttps://doi.org/10.3390/genes11121408openalex-snapshot
‘There and Back Again’—Forward Genetics and Reverse Phenotyping in Pulmonary Arterial Hypertension
inferred← citeshttps://doi.org/10.3390/genes12101509openalex-snapshot
Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees
inferred← citeshttps://doi.org/10.3390/genes13040646openalex-snapshot
Major Depressive Disorder: Existing Hypotheses about Pathophysiological Mechanisms and New Genetic Findings
inferred← citeshttps://doi.org/10.3390/ijms20205013openalex-snapshot
Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective
inferred← citeshttps://doi.org/10.3390/microorganisms14030662openalex-snapshot
Handling Missing Race and Ethnicity in an EHR-Based Study Through Integration of Individual Measures and Neighborhood Sociodemographic and Socioeconomic Measures
inferred← citeshttps://doi.org/10.6084/m9.figshare.13346962openalex-snapshot
Additional file 1 of Comparative analysis, applications, and interpretation of electronic health record-based stroke phenotyping methods
inferred← citeshttps://doi.org/10.6084/m9.figshare.26707065openalex-snapshot
Additional file 1 of Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks
inferred← citeshttps://doi.org/10.6084/m9.figshare.26707068openalex-snapshot
Additional file 2 of Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks
inferred← citeshttps://doi.org/10.64898/2026.09.18.26363428openalex-snapshot
Identifying Family Relationships from Electronic Health Records: A Machine Learning Approach
inferred← citeshttps://doi.org/10.7326/m18-0425openalex-snapshot
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