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Cell lineage-specific mitochondrial resilience during mammalian organogenesis

https://doi.org/10.1016/j.cell.2023.01.034
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease
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MELAS: Clinical features, biochemistry, and molecular genetics
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Formation of the node of Ranvier by Schwann cells is under control of transcription factor Sox10
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The Foxa family of transcription factors in development and metabolism
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Sequence and gene organization of mouse mitochondrial DNA
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Construction of improved M13 vectors using oligodeoxynucleotide-directed mutagenesis
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SoxE factors as multifunctional neural crest regulatory factors
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GATA transcription factors in the developing and adult heart
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HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
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MTERF3 Is a Negative Regulator of Mammalian mtDNA Transcription
inferredcites →https://doi.org/10.1016/j.cell.2008.06.016openalex-snapshot
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
inferredcites →https://doi.org/10.1016/j.cell.2019.10.032openalex-snapshot
A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering
inferredcites →https://doi.org/10.1016/j.cell.2021.04.004openalex-snapshot
A single-embryo, single-cell time-resolved model for mouse gastrulation
inferredcites →https://doi.org/10.1016/j.celrep.2016.08.037openalex-snapshot
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease
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mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
inferredcites →https://doi.org/10.1016/j.cmet.2017.07.007openalex-snapshot
mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression
inferredcites →https://doi.org/10.1016/j.cmet.2019.08.019openalex-snapshot
Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions
inferredcites →https://doi.org/10.1016/j.febslet.2012.07.043openalex-snapshot
MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins
inferredcites →https://doi.org/10.1016/j.mito.2010.09.011openalex-snapshot
Tissue-specific differences in mitochondrial activity and biogenesis
inferredcites →https://doi.org/10.1016/j.phrs.2020.105385openalex-snapshot
Mitochondrial dysfunction interferes with neural crest specification through the FoxD3 transcription factor
inferredcites →https://doi.org/10.1016/j.semcdb.2005.06.007openalex-snapshot
Specification of neural crest cell formation and migration in mouse embryos
inferredcites →https://doi.org/10.1016/s0092-8674(03)00926-7openalex-snapshot
Integrated Analysis of Protein Composition, Tissue Diversity, and Gene Regulation in Mouse Mitochondria
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Respiratory function in cybrid cell lines carrying European mtDNA haplogroups: implications for Leber's hereditary optic neuropathy
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MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes
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MSnbase, Efficient and Elegant R-Based Processing and Visualization of Raw Mass Spectrometry Data
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Comparison of Extraction Methods for the Comprehensive Analysis of Mouse Brain Proteome using Shotgun-based Mass Spectrometry
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Mitochondrial DNA Mutations and Pathogenesis
inferredcites →https://doi.org/10.1038/nature02517openalex-snapshot
Premature ageing in mice expressing defective mitochondrial DNA polymerase
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Mitochondrial disorders as windows into an ancient organelle
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The selective tRNA aminoacylation mechanism based on a single G•U pair
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The Perseus computational platform for comprehensive analysis of (prote)omics data
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SCENIC: single-cell regulatory network inference and clustering
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Mitochondrial diseases
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The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease
inferredcites →https://doi.org/10.1038/nrm.2017.66openalex-snapshot
Mitochondrial diseases: the contribution of organelle stress responses to pathology
inferredcites →https://doi.org/10.1038/s41419-021-04099-4openalex-snapshot
SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells
inferredcites →https://doi.org/10.1038/s41422-022-00615-zopenalex-snapshot
Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals
inferredcites →https://doi.org/10.1038/s41556-017-0013-zopenalex-snapshot
Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation
inferredcites →https://doi.org/10.1038/s41576-020-00284-xopenalex-snapshot
Extreme heterogeneity of human mitochondrial DNA from organelles to populations
inferredcites →https://doi.org/10.1038/s41586-019-0933-9openalex-snapshot
A single-cell molecular map of mouse gastrulation and early organogenesis
inferredcites →https://doi.org/10.1038/s41586-019-1825-8openalex-snapshot
Multi-omics profiling of mouse gastrulation at single-cell resolution
inferredcites →https://doi.org/10.1038/s41586-020-03048-zopenalex-snapshot
Small-molecule inhibitors of human mitochondrial DNA transcription
inferredcites →https://doi.org/10.1038/s41586-020-2496-1openalex-snapshot
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
inferredcites →https://doi.org/10.1038/s41588-018-0264-zopenalex-snapshot
Mitochondrial genetic medicine
inferredcites →https://doi.org/10.1038/s41591-018-0165-9openalex-snapshot
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo
inferredcites →https://doi.org/10.1038/sj.emboj.7600465openalex-snapshot
The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells
inferredcites →https://doi.org/10.1042/bj20140291openalex-snapshot
Complex IV-deficient Surf1−/− mice initiate mitochondrial stress responses
inferredcites →https://doi.org/10.1074/jbc.274.47.33426openalex-snapshot
Threshold Effect and Tissue Specificity
inferredcites →https://doi.org/10.1074/jbc.m113.471649openalex-snapshot
The Leucine-rich Pentatricopeptide Repeat-containing Protein (LRPPRC) Does Not Activate Transcription in Mammalian Mitochondria
inferredcites →https://doi.org/10.1083/jcb.201702058openalex-snapshot
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
inferredcites →https://doi.org/10.1089/omi.2011.0118openalex-snapshot
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
inferredcites →https://doi.org/10.1093/bioinformatics/btr645openalex-snapshot
MSnbase-an R/Bioconductor package for isobaric tagged mass spectrometry data visualization, processing and quantitation
inferredcites →https://doi.org/10.1093/bioinformatics/bts635openalex-snapshot
STAR: ultrafast universal RNA-seq aligner
inferredcites →https://doi.org/10.1093/cercor/bhx185openalex-snapshot
The Transcription Factors COUP-TFI and COUP-TFII have Distinct Roles in Arealisation and GABAergic Interneuron Specification in the Early Human Fetal Telencephalon
inferredcites →https://doi.org/10.1093/hmg/ddq246openalex-snapshot
Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups
inferredcites →https://doi.org/10.1093/nar/gkaa1011openalex-snapshot
MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations
inferredcites →https://doi.org/10.1093/nar/gkt1397openalex-snapshot
The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation
inferredcites →https://doi.org/10.1093/nar/gkv1003openalex-snapshot
MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins
inferredcites →https://doi.org/10.1093/nar/gkv105openalex-snapshot
TEFM is a potent stimulator of mitochondrial transcription elongation in vitro
inferredcites →https://doi.org/10.1093/nar/gky1131openalex-snapshot
STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
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Different Metabolic Properties of Mitochondrial Oxidative Phosphorylation in Different Cell Types ‐ Important Implications for Mitochondrial Cytopathies
inferredcites →https://doi.org/10.1126/sciadv.aav9824openalex-snapshot
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
inferredcites →https://doi.org/10.1126/sciadv.abi5657openalex-snapshot
Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission
inferredcites →https://doi.org/10.1152/ajpcell.00108.2006openalex-snapshot
Tissue heterogeneity of the mammalian mitochondrial proteome
inferredcites →https://doi.org/10.1152/ajpcell.00109.2006openalex-snapshot
Functional consequences of mitochondrial proteome heterogeneity
inferredcites →https://doi.org/10.1152/ajpcell.00195.2006openalex-snapshot
Physiological diversity of mitochondrial oxidative phosphorylation
inferredcites →https://doi.org/10.1152/physrev.00025.2007openalex-snapshot
Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function
inferredcites →https://doi.org/10.1161/circresaha.119.316075openalex-snapshot
Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression
inferredcites →https://doi.org/10.1172/jci136055openalex-snapshot
Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity
inferredcites →https://doi.org/10.1186/1471-2105-14-128openalex-snapshot
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
inferredcites →https://doi.org/10.1186/s13059-017-1382-0openalex-snapshot
SCANPY: large-scale single-cell gene expression data analysis
inferredcites →https://doi.org/10.1242/dev.105445openalex-snapshot
Establishing neural crest identity: a gene regulatory recipe
inferredcites →https://doi.org/10.1242/dev.150664openalex-snapshot
Coup-TF1 and Coup-TF2 control subtype and laminar identity of MGE-derived neocortical interneurons
inferredcites →https://doi.org/10.1242/jeb.201.24.3377openalex-snapshot
Inter-Tissue Differences In Mitochondrial Enzyme Activity, Rna And Dna In Rainbow Trout (Oncorhynchus Mykiss)
inferredcites →https://doi.org/10.15252/embr.201642077openalex-snapshot
Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt
inferredcites →https://doi.org/10.15252/embr.202153054openalex-snapshot
Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen
inferredcites →https://doi.org/10.32614/cran.package.umapopenalex-snapshot
umap: Uniform Manifold Approximation and Projection
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Calcium handling precedes cardiac differentiation to initiate the first heartbeat
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Maturation of selected human mitochondrial tRNAs requires deadenylation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Mitochondrial replacement techniques to resolve mitochondrial dysfunction and ooplasmic deficiencies: where are we now?
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LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation
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Targeted deletions in human mitochondrial DNA engineered by Type V CRISPR–Cas12a system
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An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
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Single‐cell mitochondrial sequencing reveals low‐frequency mitochondrial mutations in naturally aging mice
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