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TLR8 is activated by 5ʹ-methylthioinosine, a Plasmodium falciparum-derived intermediate of the purine salvage pathway

https://doi.org/10.1016/j.celrep.2022.110691

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

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Modulating responsiveness of human TLR7 and 8 to small molecule ligands with T‐rich phosphorothiate oligodeoxynucleotides

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Of inflammasomes and pathogens – sensing of microbes by the inflammasome

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Induction of Apoptosis in Leukemia U937 Cells by 5′-Deoxy-5′-methylthioadenosine, a Potent Inhibitor of Protein Carboxylmethyltransferase

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A Fast Flexible Docking Method using an Incremental Construction Algorithm

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Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen

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Adenosine Deaminase in Malaria Infection: Effect of 2′-Deoxycoformycin in Vivo

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Modeling Primary Human Monocytes with the Trans–Differentiation Cell Line BLaER1

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A consistent description of HYdrogen bond and DEhydration energies in protein–ligand complexes: methods behind the HYDE scoring function

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Mechanism of action of 5'-methylthioadenosine in S49 cells

inferredcites →https://doi.org/10.1016/j.cell.2010.01.022openalex-snapshot

Pattern Recognition Receptors and Inflammation

inferredcites →https://doi.org/10.1016/j.cell.2019.11.001openalex-snapshot

TLR8 Is a Sensor of RNase T2 Degradation Products

inferredcites →https://doi.org/10.1016/j.celrep.2013.03.003openalex-snapshot

C/EBPα Induces Highly Efficient Macrophage Transdifferentiation of B Lymphoma and Leukemia Cell Lines and Impairs Their Tumorigenicity

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Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria

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Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands

inferredcites →https://doi.org/10.1016/j.chembiol.2018.07.004openalex-snapshot

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design

inferredcites →https://doi.org/10.1016/j.chom.2009.01.004openalex-snapshot

Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics

inferredcites →https://doi.org/10.1016/j.coi.2005.11.012openalex-snapshot

How Toll-like receptors signal: what we know and what we don’t know

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Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1

inferredcites →https://doi.org/10.1016/j.immuni.2011.05.016openalex-snapshot

Innate Immune Recognition of an AT-Rich Stem-Loop DNA Motif in the Plasmodium falciparum Genome

inferredcites →https://doi.org/10.1016/j.immuni.2016.09.011openalex-snapshot

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

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Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2

inferredcites →https://doi.org/10.1016/s1093-3263(98)00002-3openalex-snapshot

LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins

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Immucillins in Infectious Diseases

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Methylthioinosine Phosphorylase fromPseudomonas aeruginosa. Structure and Annotation of a Novel Enzyme in Quorum Sensing

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Structural and Metabolic Specificity of Methylthiocoformycin for Malarial Adenosine Deaminases

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Synthesis, Biotransformation, and Pharmacokinetic Studies of 9-(β- d -Arabinofuranosyl)-6-azidopurine: A Prodrug for Ara-A Designed To Utilize the Azide Reduction Pathway

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Small-molecule inhibition of TLR8 through stabilization of its resting state

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Red blood cell as an adaptive optofluidic microlens

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Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

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Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

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Innate sensing of malaria parasites

inferredcites →https://doi.org/10.1038/nsmb.2943openalex-snapshot

Toll-like receptor 8 senses degradation products of single-stranded RNA

inferredcites →https://doi.org/10.1038/s41467-017-02083-1openalex-snapshot

Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors

inferredcites →https://doi.org/10.1038/s41598-019-50038-xopenalex-snapshot

The Bacterial Product Violacein Exerts an Immunostimulatory Effect Via TLR8

inferredcites →https://doi.org/10.1073/pnas.0400937101openalex-snapshot

Recognition of single-stranded RNA viruses by Toll-like receptor 7

inferredcites →https://doi.org/10.1073/pnas.0631696100openalex-snapshot

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

inferredcites →https://doi.org/10.1074/jbc.m412693200openalex-snapshot

Targeting a Novel Plasmodium falciparum Purine Recycling Pathway with Specific Immucillins

inferredcites →https://doi.org/10.1080/08830185.2017.1397656openalex-snapshot

TLRs/NLRs: Shaping the landscape of host immunity

inferredcites →https://doi.org/10.1093/intimm/dxv062openalex-snapshot

Guanosine and its modified derivatives are endogenous ligands for TLR7

inferredcites →https://doi.org/10.1099/mic.0.000670openalex-snapshot

Promiscuity of methionine salvage pathway enzymes in Methanocaldococcus jannaschii

inferredcites →https://doi.org/10.1126/science.1093616openalex-snapshot

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

inferredcites →https://doi.org/10.1126/science.1093620openalex-snapshot

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

inferredcites →https://doi.org/10.1126/science.1229159openalex-snapshot

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

inferredcites →https://doi.org/10.1126/science.781840openalex-snapshot

Human Malaria Parasites in Continuous Culture

inferredcites →https://doi.org/10.1128/iai.00923-13openalex-snapshot

Toll-Like Receptor 7 Mediates Early Innate Immune Responses to Malaria

inferredcites →https://doi.org/10.1128/jvi.01571-13openalex-snapshot

Inosine-Mediated Modulation of RNA Sensing by Toll-Like Receptor 7 (TLR7) and TLR8

inferredcites →https://doi.org/10.1146/annurev-immunol-032414-112240openalex-snapshot

Innate Immune Pattern Recognition: A Cell Biological Perspective

inferredcites →https://doi.org/10.1172/jci.insight.94142openalex-snapshot

cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses

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Open Babel: An open chemical toolbox

inferredcites →https://doi.org/10.1371/journal.pone.0026916openalex-snapshot

Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

inferredcites →https://doi.org/10.1371/journal.pone.0120498openalex-snapshot

A Single Naturally Occurring 2’-O-Methylation Converts a TLR7- and TLR8-Activating RNA into a TLR8-Specific Ligand

inferredcites →https://doi.org/10.1371/journal.ppat.1003885openalex-snapshot

Malaria-Induced NLRP12/NLRP3-Dependent Caspase-1 Activation Mediates Inflammation and Hypersensitivity to Bacterial Superinfection

inferredcites →https://doi.org/10.15252/embr.201540861openalex-snapshot

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

inferredcites →https://doi.org/10.2307/3280287openalex-snapshot

Synchronization of Plasmodium falciparum Erythrocytic Stages in Culture

inferredcites →https://doi.org/10.3389/fimmu.2017.01535openalex-snapshot

The Human-Associated Archaeon Methanosphaera stadtmanae Is Recognized through Its RNA and Induces TLR8-Dependent NLRP3 Inflammasome Activation

inferredcites →https://doi.org/10.3389/fimmu.2019.00371openalex-snapshot

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells

inferredcites →https://doi.org/10.3390/vaccines6010013openalex-snapshot

The Emerging Role of Pattern Recognition Receptors in the Pathogenesis of Malaria

inferredcites →https://doi.org/10.4049/jimmunol.1701048openalex-snapshot

Cyclic GMP–AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria

inferredcites →https://doi.org/10.4049/jimmunol.180.6.3729openalex-snapshot

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Purine and Pyrimidine Pathways as Antimalarial Targets

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