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Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Cholesterol content in tumor tissues is inversely associated with high-density lipoprotein cholesterol in serum in patients with gastrointestinal cancer
inferredcites →https://doi.org/10.1002/eji.200939842openalex-snapshot
T‐bet, a Th1 transcription factor regulates the expression of Tim‐3
inferredcites →https://doi.org/10.1002/eji.201646875openalex-snapshot
Immune checkpoints and their inhibition in cancer and infectious diseases
inferredcites →https://doi.org/10.1016/j.amjcard.2005.12.010openalex-snapshot
Statin Safety: A Systematic Review
inferredcites →https://doi.org/10.1016/j.ccell.2018.02.005openalex-snapshot
Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation
inferredcites →https://doi.org/10.1016/j.cell.2015.05.025openalex-snapshot
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis
inferredcites →https://doi.org/10.1016/j.cmet.2016.12.018openalex-snapshot
Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments
inferredcites →https://doi.org/10.1016/j.immuni.2016.04.011openalex-snapshot
A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation
inferredcites →https://doi.org/10.1016/j.immuni.2016.04.023openalex-snapshot
Targeting T Cell Co-receptors for Cancer Therapy
inferredcites →https://doi.org/10.1016/j.immuni.2016.12.015openalex-snapshot
SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells
inferredcites →https://doi.org/10.1016/j.molimm.2016.05.014openalex-snapshot
The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter
inferredcites →https://doi.org/10.1038/nature17412openalex-snapshot
Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism
inferredcites →https://doi.org/10.1038/ncb1035openalex-snapshot
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
inferredcites →https://doi.org/10.1038/ni.2046openalex-snapshot
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
inferredcites →https://doi.org/10.1038/ni.3462openalex-snapshot
Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol
inferredcites →https://doi.org/10.1038/s41467-017-00910-zopenalex-snapshot
The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells
inferredcites →https://doi.org/10.1038/s41586-018-0597-xopenalex-snapshot
IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity
inferredcites →https://doi.org/10.1038/s41590-018-0045-yopenalex-snapshot
Metabolic exhaustion in infection, cancer and autoimmunity
inferredcites →https://doi.org/10.1038/s41598-017-00462-8openalex-snapshot
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
inferredcites →https://doi.org/10.1056/nejmc1214827openalex-snapshot
Statin use and reduced cancer-related mortality...N Engl J Med. 2012 Nov 8;367(19): 1792-802
inferredcites →https://doi.org/10.1056/nejmoa1201735openalex-snapshot
Statin Use and Reduced Cancer-Related Mortality
inferredcites →https://doi.org/10.1056/nejmra1514296openalex-snapshot
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
inferredcites →https://doi.org/10.1073/pnas.1317431111openalex-snapshot
Tumor-specific IL-9–producing CD8 + Tc9 cells are superior effector than type-I cytotoxic Tc1 cells for adoptive immunotherapy of cancers
inferredcites →https://doi.org/10.1083/jcb.200502078openalex-snapshot
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor
inferredcites →https://doi.org/10.1084/jem.20100643openalex-snapshot
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
inferredcites →https://doi.org/10.1084/jem.20130208openalex-snapshot
Blimp-1 represses CD8 T cell expression of PD-1 using a feed-forward transcriptional circuit during acute viral infection
inferredcites →https://doi.org/10.1084/jem.20140559openalex-snapshot
VEGF-A modulates expression of inhibitory checkpoints on CD8+ T cells in tumors
inferredcites →https://doi.org/10.1084/jem.20171576openalex-snapshot
Cholesterol negatively regulates IL-9–producing CD8+ T cell differentiation and antitumor activity
inferredcites →https://doi.org/10.1097/coc.0000000000000239openalex-snapshot
CTLA-4 and PD-1 Pathways
inferredcites →https://doi.org/10.1097/qad.0000000000000917openalex-snapshot
Atorvastatin restricts HIV replication in CD4+ T cells by upregulation of p21
inferredcites →https://doi.org/10.1126/science.aar4060openalex-snapshot
Cancer immunotherapy using checkpoint blockade
inferredcites →https://doi.org/10.1126/scisignal.aak9741openalex-snapshot
Foxo1 and Foxp1 play opposing roles in regulating the differentiation and antitumor activity of T H 9 cells programmed by IL-7
inferredcites →https://doi.org/10.1158/0008-5472.can-11-1620openalex-snapshot
Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape
inferredcites →https://doi.org/10.1158/0008-5472.can-12-4100openalex-snapshot
Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-1347openalex-snapshot
TGFβ1-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer
inferredcites →https://doi.org/10.1172/jci73448openalex-snapshot
Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival
inferredcites →https://doi.org/10.1182/blood-2010-08-303099openalex-snapshot
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
inferredcites →https://doi.org/10.1615/forumimmundisther.2015014188openalex-snapshot
Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway
inferredcites →https://doi.org/10.18632/oncotarget.21003openalex-snapshot
Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling
inferredcites →https://doi.org/10.3109/07357907.2011.616252openalex-snapshot
Reduced Risk of Breast Cancer Recurrence in Patients Using ACE Inhibitors, ARBs, and/or Statins
inferredcites →https://doi.org/10.4049/jimmunol.1302750openalex-snapshot
STAT3, STAT4, NFATc1, and CTCF Regulate PD-1 through Multiple Novel Regulatory Regions in Murine T Cells
inferredcites →https://doi.org/10.4049/jimmunol.1502643openalex-snapshot
Genetic and Epigenetic Regulation of PD-1 Expression
inferredcites →https://doi.org/10.4049/jimmunol.181.8.5433openalex-snapshot
Endoplasmic Reticulum Stress Regulator XBP-1 Contributes to Effector CD8+ T Cell Differentiation during Acute Infection
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy
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Increases in 4‐Acetaminobutyric Acid Generated by Phosphomevalonate Kinase Suppress CD8 + T Cell Activation and Allow Tumor Immune Escape
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PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8 + T Cell Immune Function in Promoting Breast Cancer Lung Metastasis
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High‐Content SRS Imaging Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR‐T Treatment
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NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression
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T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
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T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions
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Biodegradable Nano‐Regulator Reprograms Glioblastoma Immunosuppression: Pyroptosis‐Metabolism‐Immunity Crosstalk for Cascading Immune Activation
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Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment
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Plasma lipid levels are associated with the CD8 + T‐cell infiltration and prognosis of patients with pancreatic cancer
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Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution
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The Role of Cholesterol Metabolism and Its Regulation in Tumor Development
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inferred← citeshttps://doi.org/10.1002/cbf.70215openalex-snapshot
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LPIN3 promotes colorectal cancer growth by dampening intratumoral CD8+ T cell effector function
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Menaquinone-4 protects CD8+ T cells from ferroptosis to enhance anti-tumor immunity
inferred← citeshttps://doi.org/10.1007/s11684-023-1012-zopenalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s11684-023-1025-7openalex-snapshot
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies
inferred← citeshttps://doi.org/10.1007/s11684-026-1228-9openalex-snapshot
CRISPR screening reveals NPC1L1 as a key driver of glioblastoma progression via cholesterol metabolic regulation
inferred← citeshttps://doi.org/10.1007/s11882-025-01199-5openalex-snapshot
T Cell Exhaustion in Allergic Diseases and Allergen Immunotherapy: A Novel Biomarker?
inferred← citeshttps://doi.org/10.1007/s11883-023-01125-yopenalex-snapshot
T-cell Cholesterol Accumulation, Aging, and Atherosclerosis
inferred← citeshttps://doi.org/10.1007/s11906-024-01300-9openalex-snapshot
Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure
inferred← citeshttps://doi.org/10.1007/s11912-025-01718-7openalex-snapshot
Host-related Determinants of Response to Immunotherapy in Non-small Cell Lung Cancer: The Interplay of Body Composition, Metabolism, Sex and Immune Regulation
inferred← citeshttps://doi.org/10.1007/s12020-025-04228-5openalex-snapshot
Predictors of response to lenvatinib in advanced differentiated thyroid cancer: focus on the CONUT score
inferred← citeshttps://doi.org/10.1007/s12026-024-09483-8openalex-snapshot
The immunosuppressive landscape in tumor microenvironment
inferred← citeshttps://doi.org/10.1007/s12032-022-01842-5openalex-snapshot
Reprogramming the tumor microenvironment to improve the efficacy of cancer immunotherapies
inferred← citeshttps://doi.org/10.1007/s12032-024-02435-0openalex-snapshot
The multifaceted role of PCSK9 in cancer pathogenesis, tumor immunity, and immunotherapy
inferred← citeshttps://doi.org/10.1007/s12072-023-10595-wopenalex-snapshot
Distinctly altered lipid components in hepatocellular carcinoma relate to impaired T cell-dependent antitumor immunity
inferred← citeshttps://doi.org/10.1007/s12094-023-03134-4openalex-snapshot
The role of lipid metabolism in cancer radioresistance
inferred← citeshttps://doi.org/10.1007/s12272-023-01473-yopenalex-snapshot
Targeting dysregulated lipid metabolism in the tumor microenvironment
inferred← citeshttps://doi.org/10.1007/s12672-022-00592-0openalex-snapshot
SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1007/s12672-023-00806-zopenalex-snapshot
The genes regulating sensitivity of tumor cells to T cell-mediated killing: could they be potential personalized immunotherapeutic targets in head and neck squamous cell carcinoma?
inferred← citeshttps://doi.org/10.1007/s12672-024-01658-xopenalex-snapshot
Analysis of transcriptomic data reveals the landscape of cholesterol metabolism in prostate cancer and impact of related signature on survival
inferred← citeshttps://doi.org/10.1007/s12672-025-01890-zopenalex-snapshot
Unveiling tumor-infiltrating immune cell-driven immune-mediated drug resistance in clear cell renal cell carcinoma: prognostic insights and therapeutic strategies
inferred← citeshttps://doi.org/10.1007/s12672-025-02430-5openalex-snapshot
Research progress on cholesterol metabolism and tumor therapy
inferred← citeshttps://doi.org/10.1007/s12672-025-03033-wopenalex-snapshot
The multi-omics analysis identifies a novel endoplasmic reticulum stress and immune related genes signature in lung adenocarcinoma
inferred← citeshttps://doi.org/10.1007/s12672-026-04787-7openalex-snapshot
The controversial role of metabolic reprogramming in anti-tumor therapy resistance
inferred← citeshttps://doi.org/10.1007/s12672-026-05070-5openalex-snapshot
Cuproptosis as a novel predictor of immunotherapy response and shapes the immune landscape in pan-cancer analysis
inferred← citeshttps://doi.org/10.1007/s12672-026-05112-yopenalex-snapshot
Single-cell transcriptomics reveals ADRB1 as a key immune checkpoint regulating T cell exhaustion in lung cancer and its prognostic value in lung cancer
inferred← citeshttps://doi.org/10.1007/s12672-026-05340-2openalex-snapshot
An integrated machine learning and mendelian randomization approach identifies SERPING1 as a prognostic biomarker associated with CD8 + T-cell infiltration in DLBCL
inferred← citeshttps://doi.org/10.1007/s12672-026-05445-8openalex-snapshot
Steroidogenesis is associated with bladder cancer progression via reprogramming the metabolic landscape of the tumor immune microenvironment
inferred← citeshttps://doi.org/10.1007/s12672-026-05474-3openalex-snapshot
Multi-omics and metabolic flux modeling reveal that macrophage CYP27A1-derived 26-hydroxycholesterol drives immunosuppression and cancer malignancy
inferred← citeshttps://doi.org/10.1007/s13105-026-01144-8openalex-snapshot
Advances and challenges of ferroptosis in tumor immunity
inferred← citeshttps://doi.org/10.1007/s13105-026-01171-5openalex-snapshot
Exploring the role of metabolic disorders and gut microbiome in immune checkpoint regulation in cancer: PI3K/AKT/mTOR focus
inferred← citeshttps://doi.org/10.1007/s13346-025-01886-wopenalex-snapshot
D-mannose augments targeted radioligand-immunotherapy of prostate cancer by enhancing radiosensitivity and reshaping immune microenvironment
inferred← citeshttps://doi.org/10.1007/s13402-026-01171-zopenalex-snapshot
Pan-cancer analysis of cholesterol metabolism reveals the uptake as a modulator of tumor immune features and of the KRAS pathway
inferred← citeshttps://doi.org/10.1007/s13402-026-01209-2openalex-snapshot
METTL7A inhibits progression of colorectal cancer through the SREBP1 / FDFT1 / SQLE / CYP51A1 / cholesterol metabolic pathway
inferred← citeshttps://doi.org/10.1007/s13668-024-00542-yopenalex-snapshot
Cholesterol and Immune Microenvironment: Path Towards Tumorigenesis
inferred← citeshttps://doi.org/10.1007/s13679-026-00750-3openalex-snapshot
Remodeling the Immune Landscape: How Obesity-Induced SASPs Create a Pro-Tumorigenic Niche
inferred← citeshttps://doi.org/10.1007/s40843-025-3348-1openalex-snapshot
Nanotherapeutic platform-mediated cholesterol metabolism regulation for boosting antitumor chemo-immunotherapy
inferred← citeshttps://doi.org/10.1007/s44178-024-00096-7openalex-snapshot
Oncometabolites in cancer: from cancer cells to the tumor microenvironment
inferred← citeshttps://doi.org/10.1016/b978-0-12-823397-9.00006-5openalex-snapshot
Metabolic reprogramming and immunity in cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-824043-4.00007-5openalex-snapshot
The role of fatty acids metabolism on cancer progression and therapeutics development
inferred← citeshttps://doi.org/10.1016/b978-0-12-824465-4.00275-1openalex-snapshot
Immunometabolism Governs T Cell Immunity
inferred← citeshttps://doi.org/10.1016/b978-0-323-90528-2.00007-2openalex-snapshot
Cholesterol metabolism in prostate cancer
inferred← citeshttps://doi.org/10.1016/b978-0-443-13827-0.00006-8openalex-snapshot
T cell metabolism and cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/b978-0-443-13827-0.00008-1openalex-snapshot
Modulating T cell metabolism to improve T cell therapy
inferred← citeshttps://doi.org/10.1016/b978-0-443-13827-0.00018-4openalex-snapshot
Targeting immunometabolism to improve cancer therapies
inferred← citeshttps://doi.org/10.1016/b978-0-443-14064-8.00028-xopenalex-snapshot
Dietary alterations to induce antitumor immunity
inferred← citeshttps://doi.org/10.1016/bs.apha.2026.05.001openalex-snapshot
Engineering T cell metabolism to enhance therapeutic efficacy
inferred← citeshttps://doi.org/10.1016/j.actbio.2026.01.011openalex-snapshot
Restoring antitumor immunity by reprogramming abnormal lipid metabolism in the tumor microenvironment using irisin-manganese co-loaded nanoparticles
inferred← citeshttps://doi.org/10.1016/j.adcanc.2022.100065openalex-snapshot
Repurposing of metabolic drugs and mitochondrial modulators as an emerging class of cancer therapeutics with a special focus on breast cancer
inferred← citeshttps://doi.org/10.1016/j.adcanc.2023.100110openalex-snapshot
Therapeutic influence of simvastatin on MCF-7 and MDA-MB-231 breast cancer cells via mitochondrial depletion and improvement in chemosensitivity of cytotoxic drugs
inferred← citeshttps://doi.org/10.1016/j.addr.2023.115122openalex-snapshot
Engineering metabolism to modulate immunity
inferred← citeshttps://doi.org/10.1016/j.apsb.2021.03.027openalex-snapshot
Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.apsb.2022.10.027openalex-snapshot
The impact of lipids on the cancer–immunity cycle and strategies for modulating lipid metabolism to improve cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.apsb.2023.04.002openalex-snapshot
Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA
inferred← citeshttps://doi.org/10.1016/j.apsb.2024.07.021openalex-snapshot
Precise targeting of lipid metabolism in the era of immuno-oncology and the latest advances in nano-based drug delivery systems for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2021.736631openalex-snapshot
Role of dietary Schizochytrium sp. in improving disease resistance of zebrafish through metabolic and microbial analysis
inferred← citeshttps://doi.org/10.1016/j.autrev.2024.103579openalex-snapshot
Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy
inferred← citeshttps://doi.org/10.1016/j.autrev.2026.103989openalex-snapshot
Metabolic traits of T cells and the implications in autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.bbadis.2024.167646openalex-snapshot
Follicular cytotoxic T cells is dysfunctional in chronic hepatitis B patients with non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.167962openalex-snapshot
Unraveling the protective role of m6A methylation in SLC22A3 expression for breast Cancer intervention
inferred← citeshttps://doi.org/10.1016/j.bbalip.2019.158518openalex-snapshot
Low profile high value target: The role of OxLDL in cancer
inferred← citeshttps://doi.org/10.1016/j.bbalip.2021.158964openalex-snapshot
Regulation of macrophage functions by FABP-mediated inflammatory and metabolic pathways
inferred← citeshttps://doi.org/10.1016/j.bbalip.2021.159066openalex-snapshot
Lipid scavenging macrophages and inflammation
inferred← citeshttps://doi.org/10.1016/j.bbalip.2026.159745openalex-snapshot
Metabolic interaction between catecholamines and cholesterol derivatives is a potential mechanism for immune homeostasis of chicken adipose tissue
inferred← citeshttps://doi.org/10.1016/j.bbcan.2020.188394openalex-snapshot
Cholesterol metabolism: New functions and therapeutic approaches in cancer
inferred← citeshttps://doi.org/10.1016/j.bbcan.2024.189162openalex-snapshot
T cell exhaustion in human cancers
inferred← citeshttps://doi.org/10.1016/j.bbcan.2024.189183openalex-snapshot
Pancreatic ductal adenocarcinoma cells reshape the immune microenvironment: Molecular mechanisms and therapeutic targets
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189416openalex-snapshot
Targeting lipid metabolism to enhance cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189422openalex-snapshot
Targeting cholesterol metabolism in tumor and its immune microenvironment: opportunities and challenges
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189518openalex-snapshot
Astrocytes in glioblastoma tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189536openalex-snapshot
Precision cytokine modulation to overcome tumor microenvironment-driven resistance to immune checkpoint blockade
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189637openalex-snapshot
Current status, prospects, and challenges of cell therapy for urological tumors
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189671openalex-snapshot
Temporal and spatial molecular heterogeneity of gastric cancer: Roles of post-translational modifications
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189680openalex-snapshot
Lipid metabolism remodeling the immunological landscape of hepatocellular carcinoma: From mechanisms to therapeutics
inferred← citeshttps://doi.org/10.1016/j.bbcan.2026.189730openalex-snapshot
Beyond the membrane: lipid rafts and oxysterols establish cholesterol as a dynamic signaling hub while underlying the cholesterol paradox in cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.154385openalex-snapshot
Single-cell transcriptomics reveals CD8 + T-cell heterogeneity linked to immunotherapy response in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.154533openalex-snapshot
Activation of lipid synthesis following glycolysis is required for CD8+ T cells to acquire antitumor immune activity
inferred← citeshttps://doi.org/10.1016/j.bcp.2025.116802openalex-snapshot
Cholesterol metabolism in tumor immunity: Mechanisms and therapeutic opportunities for cancer
inferred← citeshttps://doi.org/10.1016/j.bict.2025.100021openalex-snapshot
Statin therapy with CD19-directed CAR-T therapy improves outcomes in relapsed or refractory large B-cell lymphoma
inferred← citeshttps://doi.org/10.1016/j.biochi.2022.01.017openalex-snapshot
The unfolded protein response and the biology of uveal melanoma
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122609openalex-snapshot
Mitochondria targeted drug delivery system overcoming drug resistance in intrahepatic cholangiocarcinoma by reprogramming lipid metabolism
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.123022openalex-snapshot
Targeting lipid metabolism via nanomedicine: A prospective strategy for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2025.123760openalex-snapshot
A multifunctional manganese-based nanozyme platform for synergistic hypoxia alleviation and cholesterol depletion to potentiate STING-mediated cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2026.124346openalex-snapshot
Multifunctional immunomodulator with cascade catalytic activities to reprogram endoplasmic reticulum stress-mediated immunosuppression for enhancing anti-tumor immunotherapy
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112277openalex-snapshot
Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113665openalex-snapshot
Single-intraosseous simvastatin injection suppresses cancers via activating CD8+ T cells
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113741openalex-snapshot
Endoplasmic reticulum stress in melanoma pathogenesis and resistance
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115131openalex-snapshot
State of CD8+ T cells in progression from nonalcoholic steatohepatitis to hepatocellular carcinoma: From pathogenesis to immunotherapy
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.116030openalex-snapshot
Effect of metabolic reprogramming on the immune microenvironment in gastric cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2020.05.033openalex-snapshot
Resolving the HIF paradox in pancreatic cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2021.02.013openalex-snapshot
The tumor microenvironment shapes the molecular characteristics of exhausted CD8+ T cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216208openalex-snapshot
Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216267openalex-snapshot
Lipid metabolism reprogramming of CD8+ T cell and therapeutic implications in cancer
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216336openalex-snapshot
BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216396openalex-snapshot
Targeting cancer metabolic pathways for improving chemotherapy and immunotherapy
inferred← citeshttps://doi.org/10.1016/j.canlet.2023.216511openalex-snapshot
PA suppresses antitumor immunity of T cells by disturbing mitochondrial activity through Akt/mTOR-mediated Ca2+ flux
inferred← citeshttps://doi.org/10.1016/j.canlet.2025.217613openalex-snapshot
Unraveling UPR-mediated intercellular crosstalk: Implications for immunotherapy resistance mechanisms
inferred← citeshttps://doi.org/10.1016/j.canlet.2026.218338openalex-snapshot
Unraveling the potential of targeting methionine metabolism in cancer
inferred← citeshttps://doi.org/10.1016/j.ccell.2022.02.003openalex-snapshot
CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
inferred← citeshttps://doi.org/10.1016/j.ccell.2023.01.009openalex-snapshot
Metabolic programming and immune suppression in the tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.ccell.2023.03.002openalex-snapshot
Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
inferred← citeshttps://doi.org/10.1016/j.ccell.2023.04.016openalex-snapshot
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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