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Microtubule stabilizing agents: Their molecular signaling consequences and the potential for enhancement by drug combination
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1 of the 167 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1074/jbc.m301481200 (notice 2019-12-02).
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ijc.20878openalex-snapshotCyclooxygenase‐2 inhibitor celecoxib augments chemotherapeutic drug‐induced apoptosis by enhancing activation of caspase‐3 and ‐9 in prostate cancer cells
inferredcites →https://doi.org/10.1007/s002620050605openalex-snapshotPaclitaxel up-regulates interleukin-8 synthesis in human lung carcinoma through an NF-κB- and AP-1-dependent mechanism
inferredcites →https://doi.org/10.1016/j.ccr.2005.06.003openalex-snapshotInduction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage
inferredcites →https://doi.org/10.1016/j.lungcan.2004.11.004openalex-snapshotDocetaxel and cyclooxygenase-2 inhibition with celecoxib for advanced non-small cell lung cancer progressing after platinum-based chemotherapy: a multicenter phase II trial
inferredcites →https://doi.org/10.1016/s0026-895x(24)23058-3openalex-snapshotSequence-Dependent Potentiation of Paclitaxel-Mediated Apoptosis in Human Leukemia Cells by Inhibitors of the Mitogen-Activated Protein Kinase Kinase/Mitogen-Activated Protein Kinase Pathway
inferredcites →https://doi.org/10.1016/s0026-895x(24)23261-2openalex-snapshotOverexpression of p21waf1 Decreases G2-M Arrest and Apoptosis Induced by Paclitaxel in Human Sarcoma Cells Lacking Both p53 and Functional Rb Protein
inferredcites →https://doi.org/10.1021/ja00738a045openalex-snapshotPlant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
inferredcites →https://doi.org/10.1023/a:1009652412399openalex-snapshotActivation of MAD 2 checkprotein and persistence of cyclin B1/CDC 2 activity associate with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells
inferredcites →https://doi.org/10.1038/sj.cgt.7700096openalex-snapshotAlteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells
inferredcites →https://doi.org/10.1038/sj.leu.2401449openalex-snapshotMitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/Bcl-2 phosphorylation and apoptosis in leukemia cells
inferredcites →https://doi.org/10.1038/sj.onc.1203768openalex-snapshotPaclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by IκBα super-repressor and parthenolide
inferredcites →https://doi.org/10.1038/sj.onc.1204487openalex-snapshotLow concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity
inferredcites →https://doi.org/10.1038/sj.onc.1206175openalex-snapshotPaclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis
inferredcites →https://doi.org/10.1042/bj20041415openalex-snapshotEssential tension and constructive destruction: the spindle checkpoint and its regulatory links with mitotic exit
inferredcites →https://doi.org/10.1073/pnas.95.7.3896openalex-snapshotTaxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis
inferredcites →https://doi.org/10.1074/jbc.273.43.28253openalex-snapshotPaclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH2-terminal Kinase (JNK/SAPK)
inferredcites →https://doi.org/10.1083/jcb.136.5.1091openalex-snapshotMAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts
inferredcites →https://doi.org/10.1083/jcb.142.6.1533openalex-snapshotActivation of the MKK/ERK Pathway during Somatic Cell Mitosis: Direct Interactions of Active ERK with Kinetochores and Regulation of the Mitotic 3F3/2 Phosphoantigen
inferredcites →https://doi.org/10.1083/jcb.200208092openalex-snapshotThe small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint
inferredcites →https://doi.org/10.1093/carcin/bgh087openalex-snapshotId-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells
inferredcites →https://doi.org/10.1093/jjco/hyi130openalex-snapshotOxaliplatin, a Potent Inhibitor of Survivin, Enhances Paclitaxel-induced Apoptosis and Mitotic Catastrophe in Colon Cancer Cells
inferredcites →https://doi.org/10.1097/00130404-200505000-00007openalex-snapshotThe Combination of the Selective Cyclooxygenase-2 Inhibitor Celecoxib with Weekly Paclitaxel Is a Safe and Active Second-Line Therapy for Non-Small Cell Lung Cancer
inferredcites →https://doi.org/10.1124/mol.52.4.613openalex-snapshotThe Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-04-4391openalex-snapshotEnhancement of the Therapeutic Efficacy of Taxol by the Mitogen-Activated Protein Kinase Kinase Inhibitor CI-1040 in Nude Mice Bearing Human Heterotransplants
inferredcites →https://doi.org/10.1200/jco.2002.12.112openalex-snapshotPaclitaxel Plus Carboplatin Versus Gemcitabine Plus Paclitaxel in Advanced Non–Small-Cell Lung Cancer: A Phase III Randomized Trial
inferredcites →https://doi.org/10.1200/jco.2003.07.127openalex-snapshotCelecoxib, a Selective Cyclo-Oxygenase-2 Inhibitor, Enhances the Response to Preoperative Paclitaxel and Carboplatin in Early-Stage Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1200/jco.2004.01.185openalex-snapshotMulticenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer
inferredcites →https://doi.org/10.1242/jcs.01006openalex-snapshotBub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression
inferredcites →https://doi.org/10.4049/jimmunol.154.8.4113openalex-snapshotTaxol and colchicine increase LPS-induced pro-IL-1 beta production, but do not increase IL-1 beta secretion. A role for microtubules in the regulation of IL-1 beta production.
inferredcites →https://doi.org/10.4161/cbt.2.6.534openalex-snapshotSequence Dependent Exposure of Mammary Carcinoma Cells to Taxotere® and the MEK1/2 Inhibitor U0126 Causes Enhanced Cell Killing In Vitro
inferredcites →https://doi.org/10.7164/antibiotics.49.560openalex-snapshotEpothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.3919590openalex-extractedThe Effect of the Combined Action of Roscovitine and Paclitaxel on the Apoptotic and Cell Cycle Regulatory Mechanisms in Colon and Anaplastic Thyroid Cancer Cells
inferred← citeshttps://doi.org/10.1002/ijc.23406openalex-snapshotTargeting prostate cancer with HTI‐286, a synthetic analog of the marine sponge product hemiasterlin
inferred← citeshttps://doi.org/10.1002/jso.21870openalex-snapshotDownregulation of stathmin is involved in malignant phenotype reversion and cell apoptosis in esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1002/pmic.201000789openalex-snapshotModulation of septin and molecular motor recruitment in the microtubule environment of the Taxol‐resistant human breast cancer cell line MDA‐MB‐231
inferred← citeshttps://doi.org/10.1002/pros.22624openalex-snapshotNeuroendocrine‐derived peptides promote prostate cancer cell survival through activation of IGF‐1R signaling
inferred← citeshttps://doi.org/10.1002/qsar.200860109openalex-snapshotFragment‐Based QSAR and Molecular Modeling Studies on a Series of Discodermolide Analogs as Microtubule‐Stabilizing Anticancer Agents
inferred← citeshttps://doi.org/10.1007/s11095-010-0079-9openalex-snapshotPhenethyl Isothiocyanate Sensitizes Androgen-Independent Human Prostate Cancer Cells to Docetaxel-Induced Apoptosis In Vitro and In Vivo
inferred← citeshttps://doi.org/10.1007/s12032-014-0079-4openalex-snapshotNuclear survivin expression: a prognostic factor for the response to taxane–platinum chemotherapy in patients with advanced non-small cell lung cancer
inferred← citeshttps://doi.org/10.1016/j.bmc.2014.04.049openalex-snapshotThe design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.08.009openalex-snapshotIn vitro and in vivo pharmacokinetic and pharmacodynamic study of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent
inferred← citeshttps://doi.org/10.1016/j.etp.2013.04.006openalex-snapshotApoptosis induced by paclitaxel via Bcl-2, Bax and caspases 3 and 9 activation in NB4 human leukaemia cells is not modulated by ERK inhibition
inferred← citeshttps://doi.org/10.1016/j.tiv.2017.11.001openalex-snapshotMetformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells
inferred← citeshttps://doi.org/10.1016/s1005-9040(08)60087-2openalex-snapshotBiological Fingerprinting Analysis of Interaction Between Taxoids in Taxus and Microtubule Protein by Microdialysis Coupled with High-performance Liquid Chromatography/Mass Spectrometry for Screening Antimicrotubule Agents
inferred← citeshttps://doi.org/10.1039/b515619jopenalex-snapshotAnticancer drugs from nature—natural products as a unique source of new microtubule-stabilizing agents
inferred← citeshttps://doi.org/10.15407/ubj90.05.005openalex-snapshotBiochemical aspects of the combined use of taxanes, irradiation and other antineoplastic agents for the treatment of anaplastic thyroid carcinoma
inferred← citeshttps://doi.org/10.1593/neo.12728openalex-snapshotInhibition of SIRT2 Potentiates the Anti-motility Activity of Taxanes: Implications for Antineoplastic Combination Therapies
inferred← citeshttps://doi.org/10.3389/fonc.2011.00044openalex-snapshotEvaluation of Activity and Combination Strategies with the Microtubule-Targeting Drug Sagopilone in Breast Cancer Cell Lines
inferred← citeshttps://doi.org/10.82308/25042openalex-snapshotThe diagnostic and therapeutic role of the stromal cell-derived factor (SDF)-1/CXCR4 axis in breast cancer metastasis
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