On the public citation graph

Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated osteoclastogenesis

https://doi.org/10.1016/j.cyto.2018.03.005
0 signed · 103 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/art.20218openalex-snapshot
Expression of interleukin‐21 receptor, but not interleukin‐21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis
inferredcites →https://doi.org/10.1002/art.30504openalex-snapshot
Cytosolic phospholipase A2induction and prostaglandin E2release by interleukin-1β via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-κB activity in human rheumatoid arthritis synovial fibroblasts
inferredcites →https://doi.org/10.1002/art.33390openalex-snapshot
Interleukin‐21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen‐induced arthritis
inferredcites →https://doi.org/10.1002/jcb.24156openalex-snapshot
Norisoboldine inhibits the production of interleukin‐6 in fibroblast‐like synoviocytes from adjuvant arthritis rats through PKC/MAPK/NF‐κB‐p65/CREB pathways
inferredcites →https://doi.org/10.1002/jcp.26158openalex-snapshot
Multifaceted role of IL‐21 in rheumatoid arthritis: Current understanding and future perspectives
inferredcites →https://doi.org/10.1007/s00281-017-0631-3openalex-snapshot
Synovial cellular and molecular markers in rheumatoid arthritis
inferredcites →https://doi.org/10.1007/s00281-017-0633-1openalex-snapshot
Cellular and molecular perspectives in rheumatoid arthritis
inferredcites →https://doi.org/10.1007/s00281-017-0634-0openalex-snapshot
Cellular and molecular pathways of structural damage in rheumatoid arthritis
inferredcites →https://doi.org/10.1007/s10495-017-1387-xopenalex-snapshot
Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1β-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition
inferredcites →https://doi.org/10.1007/s10753-014-9909-yopenalex-snapshot
Berberine Ameliorates Collagen-Induced Arthritis in Rats Associated with Anti-inflammatory and Anti-angiogenic Effects
inferredcites →https://doi.org/10.1007/s10753-015-0219-9openalex-snapshot
Apoptotic Effect of Geniposide on Fibroblast-Like Synoviocytes in Rats with Adjuvant-Induced Arthritis via Inhibiting ERK Signal Pathway In Vitro
inferredcites →https://doi.org/10.1016/j.ajpath.2015.07.017openalex-snapshot
Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis
inferredcites →https://doi.org/10.1016/j.biopha.2017.02.099openalex-snapshot
Anti-arthritic effect of berberine on adjuvant-induced rheumatoid arthritis in rats
inferredcites →https://doi.org/10.1016/j.blre.2014.02.001openalex-snapshot
The pathogenesis and treatment of large granular lymphocyte leukemia
inferredcites →https://doi.org/10.1016/j.bone.2015.02.017openalex-snapshot
Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways
inferredcites →https://doi.org/10.1016/j.cellsig.2016.11.007openalex-snapshot
Docosahexaenoic acid signaling attenuates the proliferation and differentiation of bone marrow-derived osteoclast precursors and promotes apoptosis in mature osteoclasts
inferredcites →https://doi.org/10.1016/j.clim.2015.02.010openalex-snapshot
Cyr61 participates in the pathogenesis of rheumatoid arthritis by promoting proIL-1β production by fibroblast-like synoviocytes through an AKT-dependent NF-κB signaling pathway
inferredcites →https://doi.org/10.1016/j.intimp.2015.08.026openalex-snapshot
Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways
inferredcites →https://doi.org/10.1016/j.jaut.2012.12.011openalex-snapshot
Cytopenia and autoimmune diseases: A vicious cycle fueled by mTOR dysregulation in hematopoietic stem cells
inferredcites →https://doi.org/10.1016/j.jbspin.2013.02.009openalex-snapshot
A role for benzo[a]pyrene and Slug in invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis: A potential molecular link between smoking and radiographic progression
inferredcites →https://doi.org/10.1016/j.semarthrit.2017.03.008openalex-snapshot
Second-line biologic therapy optimization in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
inferredcites →https://doi.org/10.1016/j.semcancer.2017.04.015openalex-snapshot
PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux
inferredcites →https://doi.org/10.1016/j.taap.2015.11.005openalex-snapshot
Oleanolic acid acetate inhibits rheumatoid arthritis by modulating T cell immune responses and matrix-degrading enzymes
inferredcites →https://doi.org/10.1016/s0140-6736(17)31472-1openalex-snapshot
Pathogenetic insights from the treatment of rheumatoid arthritis
inferredcites →https://doi.org/10.1016/s0140-6736(17)31491-5openalex-snapshot
Novel treatment strategies in rheumatoid arthritis
inferredcites →https://doi.org/10.1038/cddis.2016.490openalex-snapshot
IL-17-mediated mitochondrial dysfunction impairs apoptosis in rheumatoid arthritis synovial fibroblasts through activation of autophagy
inferredcites →https://doi.org/10.1038/nrrheum.2016.69openalex-snapshot
Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis
inferredcites →https://doi.org/10.1038/nrrheum.2016.92openalex-snapshot
Autophagy: controlling cell fate in rheumatic diseases
inferredcites →https://doi.org/10.1038/nrrheum.2017.107openalex-snapshot
Antigen-specific immunotherapies in rheumatic diseases
inferredcites →https://doi.org/10.1038/nrrheum.2017.125openalex-snapshot
The complement system as a potential therapeutic target in rheumatic disease
inferredcites →https://doi.org/10.1038/nrrheum.2017.132openalex-snapshot
The case for periodontitis in the pathogenesis of rheumatoid arthritis
inferredcites →https://doi.org/10.1038/nrrheum.2017.49openalex-snapshot
Immunometabolism in early and late stages of rheumatoid arthritis
inferredcites →https://doi.org/10.1038/nrrheum.2017.81openalex-snapshot
Biologics registers in RA: methodological aspects, current role and future applications
inferredcites →https://doi.org/10.1038/srep14405openalex-snapshot
Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats
inferredcites →https://doi.org/10.1074/jbc.m111.259549openalex-snapshot
Akt Fine-tunes NF-κB-dependent Gene Expression during T Cell Activation
inferredcites →https://doi.org/10.1111/all.12878openalex-snapshot
T follicular helper (Tfh) cells in normal immune responses and in allergic disorders
inferredcites →https://doi.org/10.1111/cei.12751openalex-snapshot
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis
inferredcites →https://doi.org/10.1111/sji.12396openalex-snapshot
Interleukin‐21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast‐like Synoviocytes of Patients with Rheumatoid Arthritis
inferredcites →https://doi.org/10.1126/science.aaj2155openalex-snapshot
mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation
inferredcites →https://doi.org/10.1136/annrheumdis-2013-203486openalex-snapshot
Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells
inferredcites →https://doi.org/10.1136/annrheumdis-2017-211555openalex-snapshot
Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?
inferredcites →https://doi.org/10.1158/1078-0432.ccr-13-0279openalex-snapshot
Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors
inferredcites →https://doi.org/10.1186/s13075-015-0892-yopenalex-snapshot
Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1
inferredcites →https://doi.org/10.1186/s13075-017-1248-6openalex-snapshot
Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts
inferredcites →https://doi.org/10.1186/s13075-017-1303-3openalex-snapshot
Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis
inferredcites →https://doi.org/10.1186/s13075-017-1308-yopenalex-snapshot
Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis
inferredcites →https://doi.org/10.1189/jlb.2a0414-206rropenalex-snapshot
Mammalian target of rapamycin complex 2 (mTORC2) regulates LPS-induced expression of IL-12 and IL-23 in human dendritic cells
inferredcites →https://doi.org/10.1258/ebm.2011.010366openalex-snapshot
Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytes
inferredcites →https://doi.org/10.2119/molmed.2010.00049openalex-snapshot
mTOR Regulates the Invasive Properties of Synovial Fibroblasts in Rheumatoid Arthritis
inferredcites →https://doi.org/10.3390/ijms18030484openalex-snapshot
Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis
inferredcites →https://doi.org/10.3892/ijmm.2016.2722openalex-snapshot
Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL
inferredcites →https://doi.org/10.3892/mmr.2017.7459openalex-snapshot
Gambogic acid suppresses inflammation in rheumatoid arthritis rats via PI3K/Akt/mTOR signaling pathway
inferredcites →https://doi.org/10.4049/jimmunol.1101254openalex-snapshot
Akt Induces Osteoclast Differentiation through Regulating the GSK3β/NFATc1 Signaling Cascade
inferredcites →https://doi.org/10.4049/jimmunol.1402551openalex-snapshot
mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo
inferredcites →https://doi.org/10.4049/jimmunol.1501541openalex-snapshot
mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production
inferredcites →https://doi.org/10.4155/fmc.15.55openalex-snapshot
The PI3K/Akt/PTEN/mTOR Pathway: A Fruitful Target for Inducing Cell Death in Rheumatoid Arthritis?

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4446918openalex-extracted
Study on the Material Basis and Potential Mechanisms of Action of Huamoyan Granules in the Treatment of Synovitis
inferred← citeshttps://doi.org/10.1002/bmc.5520openalex-snapshot
Anti‐rheumatoid arthritis effects of Xanthii Fructus by affecting the PI3K‐AKT signaling pathway based on TMT‐labeled quantitative proteomics
inferred← citeshttps://doi.org/10.1002/cbf.3924openalex-snapshot
Chitosan/alginate scaffold enhanced with Berberis vulgaris extract for osteocyte differentiation of ovine fetal stem cells
inferred← citeshttps://doi.org/10.1002/mco2.70209openalex-snapshot
Inhibition Peroxiredoxin‐2 by Capsaicin Ameliorates Rheumatoid Arthritis via ROS‐Mediated Apoptosis in Fibroblast‐Like Synoviocytes
inferred← citeshttps://doi.org/10.1002/med.21703openalex-snapshot
Biologically active isoquinoline alkaloids covering 2014–2018
inferred← citeshttps://doi.org/10.1007/s10495-019-01548-6openalex-snapshot
Berberine mitigates IL-21/IL-21R mediated autophagic influx in fibroblast-like synoviocytes and regulates Th17/Treg imbalance in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1007/s11033-025-10769-9openalex-snapshot
Deciphering the role of ERK and PI3K/Akt as crosstalk pathways between fibroblast-like synoviocytes and osteoclasts; novel therapeutic approach for rheumatoid arthritis
inferred← citeshttps://doi.org/10.1007/s11626-023-00827-6openalex-snapshot
Myricetin ameliorates the IL-21-induced tumorigenic phenotype of adjuvant-induced arthritis FLS by modulating the choline kinase signaling cascade
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11202-4openalex-snapshot
Role of Interleukins on Physiological and Pathological Bone Resorption and Bone Formation: Effects by Cytokines in The IL-1 and IL-2 Families
inferred← citeshttps://doi.org/10.1016/j.ajt.2023.01.019openalex-snapshot
Complement inhibition alleviates donor brain death-induced liver injury and posttransplant cascade injury by regulating phosphoinositide 3-kinase signaling
inferred← citeshttps://doi.org/10.1016/j.bcp.2025.117405openalex-snapshot
ACOD1/Itaconate regulates trophoblast function through the PI3K/Akt/FOLR1 axis to participate in the pathogenesis of recurrent spontaneous abortion
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112562openalex-snapshot
Lack of berberine effect on bone mechanical properties in rats with experimentally induced diabetes
inferred← citeshttps://doi.org/10.1016/j.cbi.2021.109730openalex-snapshot
Hormesis and bone marrow stem cells: Enhancing cell proliferation, differentiation and resilience to inflammatory stress
inferred← citeshttps://doi.org/10.1016/j.cyto.2019.154952openalex-snapshot
Effects of daphnetin on the autophagy signaling pathway of fibroblast-like synoviocytes in rats with collagen-induced arthritis (CIA) induced by TNF-α
inferred← citeshttps://doi.org/10.1016/j.cytox.2019.100015openalex-snapshot
WITHDRAWN: Effects of daphnetin on the autophagy signaling pathway of fibroblast-like synoviocytes in rats with collagen-induced arthritis (CIA) induced by TNF-α
inferred← citeshttps://doi.org/10.1016/j.ejphar.2019.02.026openalex-snapshot
Berberine promotes osteogenic differentiation of mesenchymal stem cells with therapeutic potential in periodontal regeneration
inferred← citeshttps://doi.org/10.1016/j.fitote.2025.106534openalex-snapshot
The key active ingredients identification and pharmacological mechanism investigation of extract of ethyl acetate from Er Miao San aganist rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.121591openalex-snapshot
An updated review of isoquinoline alkaloids: Biological activity and mode of action, structural modifications, and agricultural applications
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112422openalex-snapshot
Berberine, a natural alkaloid: Advances in its pharmacological effects and mechanisms in the treatment of autoimmune diseases
inferred← citeshttps://doi.org/10.1016/j.jep.2021.114249openalex-snapshot
Berberine for bone regeneration: Therapeutic potential and molecular mechanisms
inferred← citeshttps://doi.org/10.1016/j.jep.2023.116250openalex-snapshot
Panlongqi tablet suppresses adjuvant-induced rheumatoid arthritis by inhibiting the inflammatory reponse in vivo and in vitro
inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2025.113334openalex-snapshot
Femtosecond laser and bee venom as promising anti-arthritic treatments: Modulation of JAK/STAT and PI3K/AKT/mTOR signaling pathways in vivo
inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122766openalex-snapshot
A glimpse on the role of IL-21 in psoriatic arthritis pathogenesis
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105667openalex-snapshot
Efficacy of berberine in treatment of rheumatoid arthritis: From multiple targets to therapeutic potential
inferred← citeshttps://doi.org/10.1038/s41392-023-01331-9openalex-snapshot
Signaling pathways in rheumatoid arthritis: implications for targeted therapy
inferred← citeshttps://doi.org/10.1038/s41598-023-48248-5openalex-snapshot
Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics
inferred← citeshttps://doi.org/10.1093/bbb/zbad103openalex-snapshot
Interleukin-21 knockout reduces bone loss in ovariectomized mice by inhibiting osteoclastogenesis
inferred← citeshttps://doi.org/10.1097/md.0000000000036287openalex-snapshot
Mechanisms of action underlying Shentong Zhuyu decoction based treatment of rheumatoid arthritis using systems biology and computer-aided drug design
inferred← citeshttps://doi.org/10.1111/jcmm.15803openalex-snapshot
Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management
inferred← citeshttps://doi.org/10.1111/sji.13169openalex-snapshot
γ‐Secretase inhibitors suppress IL‐20‐mediated osteoclastogenesis via Notch signalling and are affected by Notch2 in vitro
inferred← citeshttps://doi.org/10.1186/s12906-020-2825-9openalex-snapshot
Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract
inferred← citeshttps://doi.org/10.12659/msm.916977openalex-snapshot
Anti-Inflammatory Effects of Different Elution Fractions of Er-Miao-San on Acute Inflammation Induced by Carrageenan in Rat Paw Tissue
inferred← citeshttps://doi.org/10.14712/fb2025071010008openalex-snapshot
The Potential Inflammatory Role of IL-6 Signalling in Perturbing the Energy Metabolism Function by Stimulating the Akt-mTOR Pathway in Jurkat T Cells
inferred← citeshttps://doi.org/10.18388/abp.2020_5948openalex-snapshot
Immunomodulatory effects of berberine on Staphylococcus aureus-induced septic arthritis through down-regulation of Th17 and Treg signaling pathways
inferred← citeshttps://doi.org/10.2174/0113894501276093231206064243openalex-snapshot
An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.2174/0115680266346339250328153358openalex-snapshot
Rheumatoid Arthritis: Pathogenesis, Therapeutic Strategies, Advances, and Structural Activity Relationships of Synthesized Agents
inferred← citeshttps://doi.org/10.26420/austinjsurg.2022.1288openalex-snapshot
Panlongqi Tablet (PLQT) Inhibits LPS-Induced Abnormal Proliferation of RA-HFLS by Regulating PI3K/ AKT and MAPK Signaling Pathways
inferred← citeshttps://doi.org/10.3389/fbinf.2026.1891543openalex-snapshot
Integrating transcriptomic analysis to explore biomarkers and therapeutic targets for rheumatoid arthritis: a case-control and systems biology approach
inferred← citeshttps://doi.org/10.3389/fbioe.2022.851561openalex-snapshot
Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration
inferred← citeshttps://doi.org/10.3389/fendo.2025.1541714openalex-snapshot
Research on the role and mechanism of the PI3K/Akt/mTOR signalling pathway in osteoporosis
inferred← citeshttps://doi.org/10.3389/fmolb.2026.1834429openalex-snapshot
Integrating multi-omics, machine learning, and molecular dynamics simulations to identify glutamate metabolism-related biomarkers and drug candidates in rheumatoid arthritis
inferred← citeshttps://doi.org/10.3389/fphar.2020.561962openalex-snapshot
Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.3389/fphar.2022.938915openalex-snapshot
Traditional Tibetan medicine: therapeutic potential in rheumatoid arthritis
inferred← citeshttps://doi.org/10.3389/fphar.2022.973587openalex-snapshot
Cytokine storm-calming property of the isoquinoline alkaloids in Coptis chinensis Franch
inferred← citeshttps://doi.org/10.3390/molecules27165080openalex-snapshot
Anti-Alphaviral Alkaloids: Focus on Some Isoquinolines, Indoles and Quinolizidines
inferred← citeshttps://doi.org/10.3390/ph17111504openalex-snapshot
Levamisole Ameliorates Rheumatoid Arthritis by Downregulating the PI3K/Akt Pathway in SD Rats
inferred← citeshttps://doi.org/10.70675/a6eb1b46zd562z4ef1zb8dez266eecd56eeaopenalex-snapshot
Activités antivirales et immunomodulatrices d’alcaloïdes contre l’infection par l’alphavirus arthritogénique O’nyong-nyong
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.