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Endosome-Mediated Epithelial Remodeling Downstream of Hedgehog-Gli Is Required for Tracheoesophageal Separation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/dvdy.23826openalex-snapshot
Rab11 regulates planar polarity and migratory behavior of multiciliated cells in Xenopus embryonic epidermis
inferredcites →https://doi.org/10.1002/dvdy.24180openalex-snapshot
A Molecular atlas of Xenopus respiratory system development
inferredcites →https://doi.org/10.1002/dvdy.24219openalex-snapshot
One shall become two: Separation of the esophagus and trachea from the common foregut tube
inferredcites →https://doi.org/10.1002/dvg.22719openalex-snapshot
Biallelic genome modification in F 0 Xenopus tropicalis embryos using the CRISPR/Cas system
inferredcites →https://doi.org/10.1002/dvg.23329openalex-snapshot
Novel vectors for functional interrogation of Xenopus ORFeome coding sequences
inferredcites →https://doi.org/10.1002/jcb.24811openalex-snapshot
Tissue Crosstalk in Lung Development
inferredcites →https://doi.org/10.1002/wdev.179openalex-snapshot
The initial establishment and epithelial morphogenesis of the esophagus: a new model of tracheal–esophageal separation and transition of simple columnar into stratified squamous epithelium in the developing esophagus
inferredcites →https://doi.org/10.1006/dbio.1999.9234openalex-snapshot
Defects in Tracheoesophageal and Lung Morphogenesis inNkx2.1(−/−) Mouse Embryos
inferredcites →https://doi.org/10.1016/j.celrep.2016.05.060openalex-snapshot
A Retinoic Acid-Hedgehog Cascade Coordinates Mesoderm-Inducing Signals and Endoderm Competence during Lung Specification
inferredcites →https://doi.org/10.1016/j.devcel.2006.04.002openalex-snapshot
Dynasore, a Cell-Permeable Inhibitor of Dynamin
inferredcites →https://doi.org/10.1016/j.devcel.2019.11.002openalex-snapshot
Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation
inferredcites →https://doi.org/10.1016/j.ejmg.2014.05.009openalex-snapshot
Clinical and etiological heterogeneity in patients with tracheo-esophageal malformations and associated anomalies
inferredcites →https://doi.org/10.1016/j.stem.2012.01.019openalex-snapshot
Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells
inferredcites →https://doi.org/10.1016/j.stem.2018.08.008openalex-snapshot
Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification
inferredcites →https://doi.org/10.1016/j.ydbio.2009.11.005openalex-snapshot
Foregut separation and tracheo-oesophageal malformations: The role of tracheal outgrowth, dorso-ventral patterning and programmed cell death
inferredcites →https://doi.org/10.1016/j.ydbio.2010.11.037openalex-snapshot
A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer
inferredcites →https://doi.org/10.1038/1711openalex-snapshot
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
inferredcites →https://doi.org/10.1038/1717openalex-snapshot
Sonic hedgehog is essential to foregut development
inferredcites →https://doi.org/10.1038/nrm3598openalex-snapshot
The mechanisms of Hedgehog signalling and its roles in development and disease
inferredcites →https://doi.org/10.1053/jpsu.2003.50005openalex-snapshot
Role of Sonic hedgehog in the development of the trachea and oesophagus
inferredcites →https://doi.org/10.1073/pnas.1205669109openalex-snapshot
Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi
inferredcites →https://doi.org/10.1086/429346openalex-snapshot
Molecular and Clinical Analyses of Greig Cephalopolysyndactyly and Pallister-Hall Syndromes: Robust Phenotype Prediction from the Type and Position of GLI3 Mutations
inferredcites →https://doi.org/10.1091/mbc.e03-05-0319openalex-snapshot
Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment
inferredcites →https://doi.org/10.1101/gad.1693008openalex-snapshot
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
inferredcites →https://doi.org/10.1101/gad.815400openalex-snapshot
Matrix metalloproteinases: effectors of development and normal physiology
inferredcites →https://doi.org/10.1136/jmg.2005.038158openalex-snapshot
Oesophageal atresia, tracheo-oesophageal fistula, and the VACTERL association: review of genetics and epidemiology
inferredcites →https://doi.org/10.1242/dev.003855openalex-snapshot
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
inferredcites →https://doi.org/10.1242/dev.01905openalex-snapshot
Cooperative requirement of the Gli proteins in neurogenesis
inferredcites →https://doi.org/10.1242/dev.111161openalex-snapshot
Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation
inferredcites →https://doi.org/10.1242/dev.128.12.2397openalex-snapshot
Haploinsufficiency of the forkhead geneFoxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations
inferredcites →https://doi.org/10.1242/dev.158444openalex-snapshot
aPKC is a key polarity molecule coordinating the function of three distinct cell polarities during collective migration
inferredcites →https://doi.org/10.7554/elife.19153openalex-snapshot
Cilia-mediated Hedgehog signaling controls form and function in the mammalian larynx

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4648583openalex-extracted
inferred← citeshttps://doi.org/10.1002/dvdy.345openalex-snapshot
Molecular crosstalk in tracheal development and its recurrence in adult tissue regeneration
inferred← citeshttps://doi.org/10.1002/dvdy.70006openalex-snapshot
The synergistic link between sonic hedgehog signaling pathway and gut–lung axis: Its influential role toward chronic obstructive pulmonary disease progression
inferred← citeshttps://doi.org/10.1002/dvg.23405openalex-snapshot
Xenopus leads the way: Frogs as a pioneering model to understand the human brain
inferred← citeshttps://doi.org/10.1007/978-3-030-77098-3_1openalex-snapshot
Anatomy and Embryology of the Esophagus
inferred← citeshttps://doi.org/10.1007/978-3-032-26105-2_22openalex-snapshot
Oesophageal Atresia: Upper Pouch Fistula and Recurrent Tracheoesophageal Fistula
inferred← citeshttps://doi.org/10.1016/bs.ctdb.2021.01.001openalex-snapshot
Modeling endoderm development and disease in Xenopus
inferred← citeshttps://doi.org/10.1016/j.ceb.2021.06.007openalex-snapshot
Organogenesis in vitro
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Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110510openalex-snapshot
Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting
inferred← citeshttps://doi.org/10.1016/j.devcel.2019.11.002openalex-snapshot
Isl1 Regulation of Nkx2.1 in the Early Foregut Epithelium Is Required for Trachea-Esophageal Separation and Lung Lobation
inferred← citeshttps://doi.org/10.1016/j.devcel.2025.04.026openalex-snapshot
Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in Xenopus trachea-esophageal morphogenesis
inferred← citeshttps://doi.org/10.1016/j.earlhumdev.2022.105681openalex-snapshot
Management of neonates with oesophageal atresia and tracheoesophageal fistula
inferred← citeshttps://doi.org/10.1016/j.matbio.2020.05.002openalex-snapshot
The elephant in the lung: Integrating lineage-tracing, molecular markers, and single cell sequencing data to identify distinct fibroblast populations during lung development and regeneration
inferred← citeshttps://doi.org/10.1016/j.sempedsurg.2022.151231openalex-snapshot
Anatomy and embryology of tracheo-esophageal fistula
inferred← citeshttps://doi.org/10.1016/j.xhgg.2022.100107openalex-snapshot
Identification and validation of candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas
inferred← citeshttps://doi.org/10.1016/j.ydbio.2021.05.015openalex-snapshot
Developmental basis of trachea-esophageal birth defects
inferred← citeshttps://doi.org/10.1016/j.ydbio.2023.04.007openalex-snapshot
Disruption of BMP4 signaling is associated with laryngeal birth defects in a mouse model
inferred← citeshttps://doi.org/10.1038/s41467-020-17968-xopenalex-snapshot
Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
inferred← citeshttps://doi.org/10.1038/s41467-024-48347-5openalex-snapshot
Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool
inferred← citeshttps://doi.org/10.1038/s41467-025-65644-9openalex-snapshot
Convergent flow-mediated mesenchymal force drives embryonic foregut constriction and splitting
inferred← citeshttps://doi.org/10.1038/s41587-021-01006-2openalex-snapshot
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
inferred← citeshttps://doi.org/10.1089/scd.2020.0075openalex-snapshot
Genetic Mouse Models and Induced Pluripotent Stem Cells for Studying Tracheal-Esophageal Separation and Esophageal Development
inferred← citeshttps://doi.org/10.1101/2022.02.14.480418openalex-snapshot
Directed differentiation of EA/TEF patient-derived induced pluripotent stem cells into esophageal epithelial organoids reveal SOX2 dysregulation at the anterior foregut stage
inferred← citeshttps://doi.org/10.1101/2023.10.11.561909openalex-snapshot
Disrupted Endosomal Trafficking of the Vangl-Celsr Polarity Complex Underlies Congenital Anomalies in Trachea-Esophageal Morphogenesis
inferred← citeshttps://doi.org/10.1111/dgd.12807openalex-snapshot
The homeodomain transcription factor Ventx2 regulates respiratory progenitor cell number and differentiation timing during Xenopus lung development
inferred← citeshttps://doi.org/10.1172/jci123597openalex-snapshot
Noggin regulates foregut progenitor cell programming and mis-expression leads to esophageal atresia
inferred← citeshttps://doi.org/10.1177/01926233251365601openalex-snapshot
Histology Atlas of the Developing Mouse Digestive System With Emphasis From Prenatal Day 7.5 Through Early Postnatal Development
inferred← citeshttps://doi.org/10.1183/2312508x.10008720openalex-snapshot
Lung development
inferred← citeshttps://doi.org/10.1201/9781003050230-21openalex-snapshot
Modeling Digestive and Respiratory System Development and Disease in Xenopus
inferred← citeshttps://doi.org/10.1242/dev.193839openalex-snapshot
The development and stem cells of the esophagus
inferred← citeshttps://doi.org/10.1242/dev.198192openalex-snapshot
Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies
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Deep learning is widely applicable to phenotyping embryonic development and disease
inferred← citeshttps://doi.org/10.1242/dev.200356openalex-snapshot
Normal Table of Xenopus development: a new graphical resource
inferred← citeshttps://doi.org/10.1242/dev.202820openalex-snapshot
The dynamics of tubulogenesis in development and disease
inferred← citeshttps://doi.org/10.1242/dev.205236openalex-snapshot
SMAD6 is required for normal foregut development in humans and frogs
inferred← citeshttps://doi.org/10.1242/dmm.046573openalex-snapshot
Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads to tracheomalacia and a loss of Sox9+ tracheal chondrocytes
inferred← citeshttps://doi.org/10.1242/dmm.049541openalex-snapshot
iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage
inferred← citeshttps://doi.org/10.3389/fcell.2022.1022457openalex-snapshot
Lung epithelium development and airway regeneration
inferred← citeshttps://doi.org/10.3389/fcell.2022.887107openalex-snapshot
Won’t You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity
inferred← citeshttps://doi.org/10.3389/fcell.2023.1092753openalex-snapshot
Development of the foregut and the formation of the trachea and esophagus in rat embryos. A symphony of confusion
inferred← citeshttps://doi.org/10.3390/cells15050448openalex-snapshot
Induced Pluripotent Stem Cells as a Tool to Decipher the Normal and Abnormal Development of the Esophagus and Trachea from Normal Morphogenesis to Esophageal Atresia, Tracheomalacia, and Laryngo–Tracheal Clefts
inferred← citeshttps://doi.org/10.3390/genes12101595openalex-snapshot
Heritability and De Novo Mutations in Oesophageal Atresia and Tracheoesophageal Fistula Aetiology
inferred← citeshttps://doi.org/10.37811/cl_rcm.v8i1.9888openalex-snapshot
Experiencia en el Manejo de Pacientes Diagnosticados con Atresia Esofágica y sus Complicaciones Postquirúrgicas en la Unidad de Cuidados Intensivos Neonatales
inferred← citeshttps://doi.org/10.55204/pmea.27.c85openalex-snapshot
Atresia esofágica. Caso clínico
inferred← citeshttps://doi.org/10.55981/tridam.2025.14349openalex-snapshot
Dose Analysis of Esophageal Cancer Therapy with Boron Neutron Capture Therapy (BNCT) Using PHITS Version 3.33
inferred← citeshttps://doi.org/10.64898/2026.09.17.752534openalex-snapshot
Human foregut morphogenesis exhibits murine-like molecular patterning but avian-like epithelial architecture
inferred← citeshttps://doi.org/10.7554/elife.60234openalex-snapshot
Sonic hedgehog signaling directs patterned cell remodeling during cranial neural tube closure
inferred← citeshttps://doi.org/10.7554/elife.77055openalex-snapshot
Hedgehog regulation of epithelial cell state and morphogenesis in the larynx
inferred← citeshttps://doi.org/10.7759/cureus.80419openalex-snapshot
A Narrative Review of the Evolving Role of Robotic Surgery in Pediatrics: Innovations and Future Prospects
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