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RETRACTED: R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling

https://doi.org/10.1016/j.ebiom.2019.03.076
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jcp.22924openalex-snapshot
Rspo2/Int7 regulates invasiveness and tumorigenic properties of mammary epithelial cells
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High bat (Chiroptera) diversity in the Early Eocene of India
inferredcites →https://doi.org/10.1007/s00418-008-0464-1openalex-snapshot
Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front
inferredcites →https://doi.org/10.1007/s10555-007-9082-yopenalex-snapshot
Metastasis of squamous cell carcinoma of the oral tongue
inferredcites →https://doi.org/10.1007/s11864-017-0484-yopenalex-snapshot
Overview of the 8th Edition TNM Classification for Head and Neck Cancer
inferredcites →https://doi.org/10.1016/j.canlet.2017.05.024openalex-snapshot
RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway
inferredcites →https://doi.org/10.1016/j.cell.2009.11.007openalex-snapshot
Epithelial-Mesenchymal Transitions in Development and Disease
inferredcites →https://doi.org/10.1016/j.cell.2015.05.001openalex-snapshot
Integrative Clinical Genomics of Advanced Prostate Cancer
inferredcites →https://doi.org/10.1016/j.cellsig.2011.09.023openalex-snapshot
Cellular signaling and biological functions of R-spondins
inferredcites →https://doi.org/10.1016/j.celrep.2017.11.096openalex-snapshot
PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression
inferredcites →https://doi.org/10.1016/j.devcel.2004.07.019openalex-snapshot
R-Spondin2 Is a Secreted Activator of Wnt/β-Catenin Signaling and Is Required for Xenopus Myogenesis
inferredcites →https://doi.org/10.1016/j.devcel.2008.05.009openalex-snapshot
Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
inferredcites →https://doi.org/10.1016/j.ebiom.2018.12.044openalex-snapshot
Targeting cancer stem cell signature gene SMOC-2 Overcomes chemoresistance and inhibits cell proliferation of endometrial carcinoma
inferredcites →https://doi.org/10.1016/j.oraloncology.2008.06.002openalex-snapshot
Global epidemiology of oral and oropharyngeal cancer
inferredcites →https://doi.org/10.1016/j.oraloncology.2014.09.010openalex-snapshot
Reviewing and reconsidering invasion assays in head and neck cancer
inferredcites →https://doi.org/10.1016/j.oraloncology.2015.04.006openalex-snapshot
Cancer stem cells and field cancerization of Oral squamous cell carcinoma
inferredcites →https://doi.org/10.1038/nature11282openalex-snapshot
Recurrent R-spondin fusions in colon cancer
inferredcites →https://doi.org/10.1038/nature15748openalex-snapshot
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
inferredcites →https://doi.org/10.1038/nature16064openalex-snapshot
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
inferredcites →https://doi.org/10.1038/ncomms10180openalex-snapshot
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
inferredcites →https://doi.org/10.1038/ncomms4149openalex-snapshot
RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer
inferredcites →https://doi.org/10.1038/ng1907openalex-snapshot
R-spondin1 is essential in sex determination, skin differentiation and malignancy
inferredcites →https://doi.org/10.1038/nm.1951openalex-snapshot
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
inferredcites →https://doi.org/10.1038/nrc2131openalex-snapshot
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
inferredcites →https://doi.org/10.1038/onc.2014.417openalex-snapshot
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness
inferredcites →https://doi.org/10.1038/s41388-019-0729-2openalex-snapshot
An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells
inferredcites →https://doi.org/10.1053/j.seminoncol.2015.01.001openalex-snapshot
Cancer Stem Cells: The Promise and the Potential
inferredcites →https://doi.org/10.1073/pnas.1106083108openalex-snapshot
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
inferredcites →https://doi.org/10.1074/jbc.274.27.19465openalex-snapshot
Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling
inferredcites →https://doi.org/10.1126/science.1137065openalex-snapshot
Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
inferredcites →https://doi.org/10.1126/science.1163040openalex-snapshot
A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer
inferredcites →https://doi.org/10.1126/science.1228522openalex-snapshot
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
inferredcites →https://doi.org/10.1158/0008-5472.can-05-0699openalex-snapshot
The Fallacy of Epithelial Mesenchymal Transition in Neoplasia
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2161openalex-snapshot
FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor Growth
inferredcites →https://doi.org/10.1158/0008-5472.can-14-1327openalex-snapshot
RSPO2 Enhances Canonical Wnt Signaling to Confer Stemness-Associated Traits to Susceptible Pancreatic Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-15-0561openalex-snapshot
Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types
inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0081openalex-snapshot
Canonical Wnt/β-catenin Signaling Drives Human Schwann Cell Transformation, Progression, and Tumor Maintenance
inferredcites →https://doi.org/10.1172/jci39104openalex-snapshot
The basics of epithelial-mesenchymal transition
inferredcites →https://doi.org/10.1242/dev.027284openalex-snapshot
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
inferredcites →https://doi.org/10.1371/journal.pone.0078144openalex-snapshot
Analysis of LGR4 Receptor Distribution in Human and Mouse Tissues
inferredcites →https://doi.org/10.18632/oncotarget.11341openalex-snapshot
ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer
inferredcites →https://doi.org/10.3389/fendo.2015.00131openalex-snapshot
LGR4 and Its Role in Intestinal Protection and Energy Metabolism
inferredcites →https://doi.org/10.4161/cc.5.1.2305openalex-snapshot
R-Spondin Proteins: A Novel Link to β-catenin Activation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4597996openalex-extracted
Inhibition of IFITM1 Transcription a New Mechanism for FoxO3a Suppressing Stemness in NSCLC
inferred← citeshttps://doi.org/10.1002/cam4.5604openalex-snapshot
LINC00669 promotes lung adenocarcinoma growth by stimulating the Wnt/β‐catenin signaling pathway
inferred← citeshttps://doi.org/10.1007/s10735-025-10628-8openalex-snapshot
ETV5 transcriptionally activates LGR4 and promotes cancer cell invasion and migration of nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1007/s12033-021-00330-xopenalex-snapshot
Ubiquitin-Specific Peptidase 5 is Involved in the Proliferation of Trophoblast Cells by Regulating Wnt/β-Catenin Signaling
inferred← citeshttps://doi.org/10.1007/s12672-026-05249-wopenalex-snapshot
Regulatory mechanisms of LGR4 on cancer and cancer stem cell properties
inferred← citeshttps://doi.org/10.1007/s13577-020-00427-6openalex-snapshot
Diversity in cancer invasion phenotypes indicates specific stroma regulated programs
inferred← citeshttps://doi.org/10.1016/j.archoralbio.2023.105625openalex-snapshot
Immunity-related long noncoding RNA WDFY3-AS2 inhibited cell proliferation and metastasis through Wnt/β-catenin signaling in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.cellsig.2023.110814openalex-snapshot
LGR4 promotes tumorigenesis by activating TGF-β1/Smad signaling pathway in multiple myeloma
inferred← citeshttps://doi.org/10.1016/j.cyto.2023.156185openalex-snapshot
Effect of LGR4/EGFR signaling on cell growth and cancer stem cell-like characteristics in liver cancer
inferred← citeshttps://doi.org/10.1016/j.dci.2024.105297openalex-snapshot
Molecular dynamics and spatial response of proliferation and apoptosis in wound healing and early intestinal regeneration of sea cucumber Apostichopus japonicus
inferred← citeshttps://doi.org/10.1016/j.ebiom.2019.05.033openalex-snapshot
Understanding the role of the R-spondin 2-LGR4 system in tongue squamous cell carcinoma progression
inferred← citeshttps://doi.org/10.1016/j.gastre.2023.05.018openalex-snapshot
Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway
inferred← citeshttps://doi.org/10.1016/j.gastrohep.2023.05.016openalex-snapshot
Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105184openalex-snapshot
RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118737openalex-snapshot
Ablation of LGR4 signaling enhances radiation sensitivity of prostate cancer cells
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101600openalex-snapshot
Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.tranon.2020.100919openalex-snapshot
HPV+ve/−ve oral-tongue cancer stem cells: A potential target for relapse-free therapy
inferred← citeshttps://doi.org/10.1038/s41419-021-03941-zopenalex-snapshot
DNA methylation mediated RSPO2 to promote follicular development in mammals
inferred← citeshttps://doi.org/10.1080/07853890.2023.2166981openalex-snapshot
R-spondin family biology and emerging linkages to cancer
inferred← citeshttps://doi.org/10.1093/cvr/cvab050openalex-snapshot
Arterial lymphangiogenesis ReSPONDINg 2 a new cue: the R-spondin2/LRG4 axis limits VEGFR3-mediated lymphangiogenesis and reverse cholesterol transport
inferred← citeshttps://doi.org/10.1096/fj.202002566ropenalex-snapshot
Role of TCF‐1 in differentiation, exhaustion, and memory of CD8 + T cells: A review
inferred← citeshttps://doi.org/10.1111/jcmm.17243openalex-snapshot
Hsa_circ_0003945 promotes progression of hepatocellular carcinoma by mediating miR‐34c‐5p/LGR4/β‐catenin axis activity
inferred← citeshttps://doi.org/10.1172/jci144579openalex-snapshot
RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis
inferred← citeshttps://doi.org/10.11817/j.issn.1672-7347.2023.220316openalex-snapshot
Expression and effect of heterogeneous nuclear ribonucleoprotein A2/B1 in tongue squamous cell carcinoma.
inferred← citeshttps://doi.org/10.1186/s12935-021-02202-5openalex-snapshot
Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs
inferred← citeshttps://doi.org/10.1186/s13075-023-03198-1openalex-snapshot
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway
inferred← citeshttps://doi.org/10.21037/atm-20-5586openalex-snapshot
Vitexin attenuates epithelial ovarian cancer cell viability and motility in vitro and carcinogenesis in vivo via p38 and ERK1/2 pathways related VEGFA
inferred← citeshttps://doi.org/10.21037/atm-20-8027openalex-snapshot
MicroRNA-377-3p targeting MMP-16 inhibits ovarian cancer cell growth, invasion, and interstitial transition
inferred← citeshttps://doi.org/10.21203/rs.3.rs-4178896/v1openalex-snapshot
FERMT1 contributes to the progression of prostate cancer through the p53 pathway
inferred← citeshttps://doi.org/10.2147/cmar.s274171openalex-snapshot
miR-196b-5p Promotes Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells via Targeting RSPO2
inferred← citeshttps://doi.org/10.2147/ott.s251806openalex-snapshot
Wogonoside Attenuates Cutaneous Squamous Cell Carcinoma by Reducing Epithelial–Mesenchymal Transition/Invasion and Cancer Stem-Like Cell Property
inferred← citeshttps://doi.org/10.3389/fendo.2022.867001openalex-snapshot
LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation
inferred← citeshttps://doi.org/10.3389/fgene.2021.728827openalex-snapshot
Emerging Roles for LGR4 in Organ Development, Energy Metabolism and Carcinogenesis
inferred← citeshttps://doi.org/10.3389/fonc.2023.1323744openalex-snapshot
RETRACTED: The biological functions and related signaling pathways of SPON2
inferred← citeshttps://doi.org/10.3390/biomedicines13030607openalex-snapshot
LGR4 (GPR48): The Emerging Inter-Bridge in Osteoimmunology
inferred← citeshttps://doi.org/10.3390/ijms22094690openalex-snapshot
The Role of LGR4 (GPR48) in Normal and Cancer Processes
inferred← citeshttps://doi.org/10.3390/ijms222313097openalex-snapshot
A Review of Prostate Organogenesis and a Role for iPSC-Derived Prostate Organoids to Study Prostate Development and Disease
inferred← citeshttps://doi.org/10.3390/neuroglia4010006openalex-snapshot
Targeting Bioinformatics Predicted Biomarkers Associated with Cell Proliferation and Migration for Treating Gliomas: Preclinical Studies in a GL261 Mouse Model
inferred← citeshttps://doi.org/10.3390/neuroglia5040028openalex-snapshot
R-Spondin 1 Suppresses Inflammatory Cytokine Production in Human Cortical Astrocytes
inferred← citeshttps://doi.org/10.4103/ijpm.ijpm_452_23openalex-snapshot
Prognostic prediction and diagnostic role of Rspondin 1 expression in esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.6084/m9.figshare.24540613openalex-snapshot
Additional file 1 of Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway
inferred← citeshttps://doi.org/10.7150/jca.93585openalex-snapshot
Knockdown of LRP5 Promotes Proliferation and Invasion of Tongue Squamous Cell Carcinoma through Compensatory Activation of Akt Signaling
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