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Resistance profiles of anaplastic lymphoma kinase tyrosine kinase inhibitors in advanced non–small-cell lung cancer: a multicenter study using targeted next-generation sequencing
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.annonc.2020.04.478openalex-snapshot
Updated overall survival and final progression-free survival data for patients with treatment-naive advanced ALK-positive non-small-cell lung cancer in the ALEX study
inferredcites →https://doi.org/10.1016/j.ccell.2018.06.006openalex-snapshot
Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development
inferredcites →https://doi.org/10.1016/j.ccr.2011.04.004openalex-snapshot
CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant
inferredcites →https://doi.org/10.1016/j.cllc.2016.03.005openalex-snapshot
Anaplastic Lymphoma Kinase (ALK) Kinase Domain Mutation Following ALK Inhibitor(s) Failure in Advanced ALK Positive Non–Small-Cell Lung Cancer: Analysis and Literature Review
inferredcites →https://doi.org/10.1016/j.cllc.2017.04.013openalex-snapshot
Detection of ALK and KRAS Mutations in Circulating Tumor DNA of Patients With Advanced ALK-Positive NSCLC With Disease Progression During Crizotinib Treatment
inferredcites →https://doi.org/10.1016/j.ejca.2008.10.026openalex-snapshot
New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
inferredcites →https://doi.org/10.1016/j.jtho.2016.11.2231openalex-snapshot
Acquired BRAF V600E Mutation as Resistant Mechanism after Treatment with Osimertinib
inferredcites →https://doi.org/10.1016/j.jtho.2019.08.003openalex-snapshot
Monitoring Therapeutic Response and Resistance: Analysis of Circulating Tumor DNA in Patients With ALK+ Lung Cancer
inferredcites →https://doi.org/10.1016/j.jtho.2020.04.019openalex-snapshot
An International Real-World Analysis of the Efficacy and Safety of Lorlatinib Through Early or Expanded Access Programs in Patients With Tyrosine Kinase Inhibitor–Refractory ALK-Positive or ROS1-Positive NSCLC
inferredcites →https://doi.org/10.1016/j.lungcan.2018.07.004openalex-snapshot
Next generation sequencing reveals a novel ALK G1128A mutation resistant to crizotinib in an ALK-Rearranged NSCLC patient
inferredcites →https://doi.org/10.1016/s0140-6736(17)30123-xopenalex-snapshot
First-line ceritinib versus platinum-based chemotherapy in advanced ALK -rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study
inferredcites →https://doi.org/10.1038/srep35249openalex-snapshot
The Role of PIK3CA Mutations among Lung Adenocarcinoma Patients with Primary and Acquired Resistance to EGFR Tyrosine Kinase Inhibition
inferredcites →https://doi.org/10.1056/nejmc1410799openalex-snapshot
Novel Mutations in a Patient with ALK-Rearranged Lung Cancer
inferredcites →https://doi.org/10.1056/nejmoa1007478openalex-snapshot
EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
inferredcites →https://doi.org/10.1056/nejmoa1408440openalex-snapshot
First-Line Crizotinib versus Chemotherapy in ALK -Positive Lung Cancer
inferredcites →https://doi.org/10.1056/nejmoa1810171openalex-snapshot
Brigatinib versus Crizotinib in ALK -Positive Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1056/nejmoa2027187openalex-snapshot
First-Line Lorlatinib or Crizotinib in Advanced ALK -Positive Lung Cancer
inferredcites →https://doi.org/10.1080/15384047.2018.1433496openalex-snapshot
Capture-based ultra-deep sequencing in plasma ctDNA reveals the resistance mechanism of ALK inhibitors in a patient with advanced ALK-positive NSCLC
inferredcites →https://doi.org/10.1093/annonc/mdr626openalex-snapshot
Activating c-KIT mutations in a subset of thymic carcinoma and response to different c-KIT inhibitors
inferredcites →https://doi.org/10.1097/jto.0000000000000358openalex-snapshot
Secondary Mutations at I1171 in the ALK Gene Confer Resistance to Both Crizotinib and Alectinib
inferredcites →https://doi.org/10.1097/jto.0b013e318283dcc0openalex-snapshot
Heterogeneity of Genetic Changes Associated with Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancer
inferredcites →https://doi.org/10.1126/scitranslmed.3003316openalex-snapshot
Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-1648openalex-snapshot
ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-2906openalex-snapshot
Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-3173openalex-snapshot
Characteristics of Lung Cancers Harboring NRAS Mutations
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ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS : An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-3273openalex-snapshot
Acquired MET Y1248H and D1246N Mutations Mediate Resistance to MET Inhibitors in Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-17-2588openalex-snapshot
Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-19-1104openalex-snapshot
Diverse Resistance Mechanisms to the Third-Generation ALK Inhibitor Lorlatinib in ALK-Rearranged Lung Cancer
inferredcites →https://doi.org/10.1158/2159-8290.cd-16-0596openalex-snapshot
Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in ALK -Rearranged Lung Cancer
inferredcites →https://doi.org/10.1158/2159-8290.cd-17-1256openalex-snapshot
Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound ALK Mutations in ALK-Positive Lung Cancer
inferredcites →https://doi.org/10.1200/jco.18.02236openalex-snapshot
ALK Resistance Mutations and Efficacy of Lorlatinib in Advanced Anaplastic Lymphoma Kinase-Positive Non–Small-Cell Lung Cancer
inferredcites →https://doi.org/10.1200/jco.2019.37.15_suppl.9030openalex-snapshot
Acquired resistance to MET inhibition in MET driven NSCLC.
inferredcites →https://doi.org/10.1200/jco.2019.37.15_suppl.e20532openalex-snapshot
EGFR extracellular domain mutation in patients with lung cancer.
inferredcites →https://doi.org/10.18632/oncotarget.2834openalex-snapshot
PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies
inferredcites →https://doi.org/10.3389/fonc.2019.01088openalex-snapshot
A Comparative Analysis of Individual RAS Mutations in Cancer Biology
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/cac2.12524openalex-snapshot
Updated overall survival and circulating tumor DNA analysis of ensartinib for crizotinib‐refractory ALK ‐positive NSCLC from a phase II study
inferred← citeshttps://doi.org/10.1002/mco2.694openalex-snapshot
Mechanisms of resistance to tyrosine kinase inhibitor‐targeted therapy and overcoming strategies
inferred← citeshttps://doi.org/10.1007/978-3-031-93894-8_8openalex-snapshot
Molecular Mechanisms of Acquired Therapeutic Resistance to Tyrosine Kinase Targeted Therapy
inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118521openalex-snapshot
Novel PROTACs with polyhedral alkanes as linkers for enhanced ALK degradation in drug-resistant NSCLC
inferred← citeshttps://doi.org/10.1016/j.chphi.2025.100984openalex-snapshot
Application of chemoinformatics and molecular simulations in lead optimization targeting A549 cell proliferation for lung cancer therapy
inferred← citeshttps://doi.org/10.1016/j.ctarc.2025.101023openalex-snapshot
Artificial intelligence-based pharmacological approach in non-small cell lung cancer in the precision medicine era
inferred← citeshttps://doi.org/10.1016/j.drup.2022.100863openalex-snapshot
Genetic alterations shaping tumor response to anti-EGFR therapies
inferred← citeshttps://doi.org/10.1016/j.jtho.2023.01.004openalex-snapshot
Response to: Efficacy of Brigatinib After Progression on Alectinib or Ceritinib: Does One Drug Work in a Pretreated Heterogeneous ALK-Positive NSCLC Population?
inferred← citeshttps://doi.org/10.1016/j.jtho.2025.03.045openalex-snapshot
Activating Mutations in the MET Kinase Domain Co-Occur With Other Driver Oncogenes and Mediate Resistance to Targeted Therapy in NSCLC
inferred← citeshttps://doi.org/10.1016/j.neo.2025.101133openalex-snapshot
An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors
inferred← citeshttps://doi.org/10.1038/s41392-022-01168-8openalex-snapshot
Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective
inferred← citeshttps://doi.org/10.1038/s41401-025-01511-zopenalex-snapshot
Anti-EGFR therapy can overcome acquired resistance to the third-generation ALK-tyrosine kinase inhibitor lorlatinib mediated by activation of EGFR
inferred← citeshttps://doi.org/10.1038/s41467-023-38195-0openalex-snapshot
Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma
inferred← citeshttps://doi.org/10.1038/s41598-023-34397-0openalex-snapshot
A retrospective study of postoperative targeted therapy in ALK-positive lung cancer
inferred← citeshttps://doi.org/10.1038/s44321-025-00354-9openalex-snapshot
NOTCH1 intracellular domain stabilization by MDM2 plays a major role in NSCLC response to platinum
inferred← citeshttps://doi.org/10.1080/14737140.2023.2265566openalex-snapshot
Treatment of advanced ALK-rearranged NSCLC following second-generation ALK–TKI failure
inferred← citeshttps://doi.org/10.1101/2024.04.29.591624openalex-snapshot
MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy
inferred← citeshttps://doi.org/10.1111/1759-7714.14656openalex-snapshot
MET gene amplification is a mechanism of resistance to entrectinib in ROS1 + NSCLC
inferred← citeshttps://doi.org/10.1111/1759-7714.14980openalex-snapshot
Dynamic monitoring of circulating tumor DNA to analyze genetic characteristics and resistance profile of lorlatinib in ALK positive previously treated NSCLC
inferred← citeshttps://doi.org/10.1177/17588359261480332openalex-snapshot
Lorlatinib-specific outcomes by timing of lorlatinib initiation in advanced ALK-positive non-small cell lung cancer: A retrospective cohort study
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Optimizing treatment and sequencing strategies for maximal survival and net health benefits in ALK-positive NSCLC: a systematic review and reconstructed individual patient data meta-analysis
inferred← citeshttps://doi.org/10.1186/s12916-022-02646-0openalex-snapshot
Conteltinib (CT-707) in patients with advanced ALK-positive non-small cell lung cancer: a multicenter, open-label, first-in-human phase 1 study
inferred← citeshttps://doi.org/10.1200/jco-25-02822openalex-snapshot
Therapy for Stage IV Non–Small Cell Lung Cancer With Driver Alterations: ASCO Living Guideline, 2026.3.0
inferred← citeshttps://doi.org/10.20517/cdr.2024.25openalex-snapshot
ALK inhibitors in cancer: mechanisms of resistance and therapeutic management strategies
inferred← citeshttps://doi.org/10.21037/tlcr-23-482openalex-snapshot
Primary resistance to ALK inhibitors in KLC1/ALK-rearranged pleural metastatic lung adenocarcinoma: a case report
inferred← citeshttps://doi.org/10.2217/fon-2022-0184openalex-snapshot
Lorlatinib as a treatment for ALK-positive lung cancer
inferred← citeshttps://doi.org/10.3389/fonc.2022.1027664openalex-snapshot
Circulating tumor DNA detection in MRD assessment and diagnosis and treatment of non-small cell lung cancer
inferred← citeshttps://doi.org/10.3389/fonc.2023.1227980openalex-snapshot
Two case reports: EML4-ALK rearrangement large cell neuroendocrine carcinoma and literature review
inferred← citeshttps://doi.org/10.3389/fonc.2026.1779992openalex-snapshot
Acquired EGFR L858R mutation following ALK-TKI resistance in lung adenocarcinoma: a case report
inferred← citeshttps://doi.org/10.3389/fphar.2023.1125547openalex-snapshot
Recent progress in targeted therapy for non-small cell lung cancer
inferred← citeshttps://doi.org/10.3390/biomedicines12020297openalex-snapshot
Unraveling the Potential of ALK-Targeted Therapies in Non-Small Cell Lung Cancer: Comprehensive Insights and Future Directions
inferred← citeshttps://doi.org/10.3390/cancers13236003openalex-snapshot
Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL
inferred← citeshttps://doi.org/10.3390/cancers14071751openalex-snapshot
Brigatinib for Pretreated, ALK-Positive, Advanced Non-Small-Cell Lung Cancers: Long-Term Follow-Up and Focus on Post-Brigatinib Lorlatinib Efficacy in the Multicenter, Real-World BrigALK2 Study
inferred← citeshttps://doi.org/10.3390/cancers14194954openalex-snapshot
Prognostic Value of Circulating Tumor DNA (ctDNA) in Oncogene-Driven NSCLC: Current Knowledge and Future Perspectives
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Phase II Trial of the Combination of Alectinib with Bevacizumab in Alectinib Refractory ALK-Positive Nonsquamous Non-Small-Cell Lung Cancer (NLCTG1501)
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Medullary Thyroid Cancer: Molecular Drivers and Immune Cellular Milieu of the Tumour Microenvironment—Implications for Systemic Treatment
inferred← citeshttps://doi.org/10.3390/cells11182871openalex-snapshot
Liquid Biopsy Analysis as a Tool for TKI-Based Treatment in Non-Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.3390/curroncol29100618openalex-snapshot
Therapeutic Advances of Rare ALK Fusions in Non-Small Cell Lung Cancer
inferred← citeshttps://doi.org/10.3390/diagnostics12030682openalex-snapshot
Multiple Genetic Alterations as Resistance Mechanism during Second-Line Lorlatinib for Advanced ALK-Rearranged Lung Adenocarcinoma: A Case Report
inferred← citeshttps://doi.org/10.3390/ijms23137037openalex-snapshot
State-of-the-Art Molecular Oncology of Lung Cancer in Taiwan
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Additional file 1 of Conteltinib (CT-707) in patients with advanced ALK-positive non-small cell lung cancer: a multicenter, open-label, first-in-human phase 1 study
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