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A physiologically-based nanocarrier biopharmaceutics model to reverse-engineer the in vivo drug release
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Outgoing claims: the papers this work cites, builds on, or argues with.
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The blood volume in cancer
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Correlation of toxicity with pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in metastatic breast carcinoma
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Pharmacokinetics of Monoclonal Antibodies
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Physiological adaptation of maternal plasma volume during pregnancy: a systematic review and meta-analysis
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Comparative pharmacokinetics of doxorubicin given by three different schedules with equal dose intensity in patients with breast cancer
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Ueber die numerische Aufl�sung von Differentialgleichungen
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Pharmacokinetics of liposomal doxorubicin (TLC-D99; Myocet) in patients with solid tumors: an open-label, single-dose study
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An open-label study to evaluate dose and cycle dependence of the pharmacokinetics of pegylated liposomal doxorubicin
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Comparative plasma and tissue distribution of Sun Pharma’s generic doxorubicin HCl liposome injection versus Caelyx® (doxorubicin HCl liposome injection) in syngeneic fibrosarcoma-bearing BALB/c mice and Sprague–Dawley rats
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Two multicenter Phase I randomized trials to compare the bioequivalence and safety of a generic doxorubicin hydrochloride liposome injection with Doxil® or Caelyx® in advanced ovarian cancer
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Potential Influence of Endothelial Adsorption on the Delayed Time to Maximum Concentration of Biopharmaceuticals
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Gelation of liposome interior A novel method for drug encapsulation
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Liposome circulation time and tumor targeting: implications for cancer chemotherapy
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Tumor targeting via EPR: Strategies to enhance patient responses
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Drug delivery to the brain using surfactant-coated poly(lactide-co-glycolide) nanoparticles: Influence of the formulation parameters
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The dispersion releaser technology is an effective method for testing drug release from nanosized drug carriers
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A comparison of two biorelevant in vitro drug release methods for nanotherapeutics based on advanced physiologically-based pharmacokinetic modelling
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Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001
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A dialysis-based in vitro drug release assay to study dynamics of the drug-protein transfer of temoporfin liposomes
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Predicting human pharmacokinetics of liposomal temoporfin using a hybrid in silico model
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In vitro - in vivo relations for the parenteral liposomal formulation of Amphotericin B: A clinically relevant approach with PBPK modeling
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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
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Nanocarriers for intravenous injection—The long hard road to the market
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NMR cryoporometry characterisation studies of the relation between drug release profile and pore structural evolution of polymeric nanoparticles
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Doxorubicin-loaded PLGA nanoparticles for the chemotherapy of glioblastoma: Towards the pharmaceutical development
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Doxil® — The first FDA-approved nano-drug: Lessons learned
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Advanced in silico modeling explains pharmacokinetics and biodistribution of temoporfin nanocrystals in humans
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[186Re]Liposomal doxorubicin (Doxil): in vitro stability, pharmacokinetics, imaging and biodistribution in a head and neck squamous cell carcinoma xenograft model
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Doxorubicin physical state in solution and inside liposomes loaded via a pH gradient
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Accelerated Blood Clearance and Altered Biodistribution of Repeated Injections of Sterically Stabilized Liposomes
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The Prediction of Human Pharmacokinetic Parameters from Preclinical and In Vitro Metabolism Data
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Effect of dose on the biodistribution and pharmacokinetics of PLGA and PLGA–mPEG nanoparticles
inferredcites →https://doi.org/10.1021/acs.molpharmaceut.6b00896openalex-snapshot
Effect of Particle Size on Drug Loading and Release Kinetics of Gefitinib-Loaded PLGA Microspheres
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THE RATE OF SOLUTION OF SOLID SUBSTANCES IN THEIR OWN SOLUTIONS.
inferredcites →https://doi.org/10.1023/a:1008202821328openalex-snapshot
Differential Evolution – A Simple and Efficient Heuristic for global Optimization over Continuous Spaces
inferredcites →https://doi.org/10.1023/a:1016243313027openalex-snapshot
Comparative Tissue Distribution and Elimination of Amphotericin B Colloidal Dispersion (Amphocil®) and Fungizone® After Repeated Dosing in Rats
inferredcites →https://doi.org/10.1023/a:1018907715905openalex-snapshot
Prolongation of the Circulation Time of Doxorubicin Encapsulated in Liposomes Containing a Polyethylene Glycol-Derivatized Phospholipid: Pharmacokinetic Studies in Rodents and Dogs
inferredcites →https://doi.org/10.1097/00001813-200303000-00008openalex-snapshot
Pharmacokinetics of doxorubicin administered i.v. as Myocet (TLC D-99; liposome-encapsulated doxorubicin citrate) compared with conventional doxorubicin when given in combination with cyclophosphamide in patients with metastatic breast cancer
inferredcites →https://doi.org/10.1111/j.2042-7158.2011.01429.xopenalex-snapshot
Comparison of in-vivo and in-silico methods used for prediction of tissue: plasma partition coefficients in rat
inferredcites →https://doi.org/10.1111/jphp.12618openalex-snapshot
Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models
inferredcites →https://doi.org/10.1124/dmd.107.016188openalex-snapshot
Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
inferredcites →https://doi.org/10.1124/jpet.103.059535openalex-snapshot
Direct 99mTc Labeling of Pegylated Liposomal Doxorubicin (Doxil) for Pharmacokinetic and Non-Invasive Imaging Studies
inferredcites →https://doi.org/10.1128/aac.36.2.299openalex-snapshot
Relationship of pharmacokinetics and drug distribution in tissue to increased safety of amphotericin B colloidal dispersion in dogs
inferredcites →https://doi.org/10.1128/aac.46.3.828-833.2002openalex-snapshot
Pharmacokinetics, Excretion, and Mass Balance of Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate in Humans
inferredcites →https://doi.org/10.1128/aac.46.3.834-840.2002openalex-snapshot
Plasma Protein Binding of Amphotericin B and Pharmacokinetics of Bound versus Unbound Amphotericin B after Administration of Intravenous Liposomal Amphotericin B (AmBisome) and Amphotericin B Deoxycholate
inferredcites →https://doi.org/10.1145/2330784openalex-snapshot
Proceedings of the 14th annual conference companion on Genetic and evolutionary computation
inferredcites →https://doi.org/10.1155/2011/370308openalex-snapshot
Modeling Drug-Carrier Interaction in the Drug Release from Nanocarriers
inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-1365openalex-snapshot
Effect of Repetitive Administration of Doxorubicin-Containing Liposomes on Plasma Pharmacokinetics and Drug Biodistribution in a Rat Brain Tumor Model
inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-3083openalex-snapshot
Clinically Relevant Concentrations of Anticancer Drugs: A Guide for Nonclinical Studies
inferredcites →https://doi.org/10.1200/jco.2017.35.15_suppl.e13537openalex-snapshot
A phase I study of safety and pharmacokinetics of NanoBB-1-Dox in patients with advanced solid tumors.
inferredcites →https://doi.org/10.1208/s12248-011-9272-yopenalex-snapshot
Dissolution Testing for Generic Drugs: An FDA Perspective
inferredcites →https://doi.org/10.1208/s12248-016-9969-zopenalex-snapshot
A Quality by Design Approach to Developing and Manufacturing Polymeric Nanoparticle Drug Products
inferredcites →https://doi.org/10.1517/14656566.3.12.1739openalex-snapshot
Myocet (liposome-encapsulated doxorubicin citrate): a new approach in breast cancer therapy
inferredcites →https://doi.org/10.18433/j3d59topenalex-snapshot
Kinetic Analysis of Drug Release From Nanoparticles
inferredcites →https://doi.org/10.18433/j3jg61openalex-snapshot
Reciprocal Powered Time model for Release Kinetic Analysis of Ibuprofen Solid Dispersions in Oleaster Powder, Microcrystalline Cellulose and Crospovidone
inferredcites →https://doi.org/10.2165/00003088-200342050-00002openalex-snapshot
Pharmacokinetics of Pegylated Liposomal Doxorubicin
inferredcites →https://doi.org/10.2174/187231207780363606openalex-snapshot
Application of Simple Mathematical Expressions to Relate Half-Lives of Drugs in Mice to Those in Humans
inferredcites →https://doi.org/10.3390/pharmaceutics11030110openalex-snapshot
Pharmacokinetics and Pharmacodynamics Modeling and Simulation Systems to Support the Development and Regulation of Liposomal Drugs
inferredcites →https://doi.org/10.3390/pharmaceutics11100489openalex-snapshot
Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances
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Challenging Traditional ADME Assumptions for Physiologically Based Pharmacokinetic Models for Intravenous Administration of Iron–Carbohydrate Nanomedicines: Potential Utility of Gold Nanoparticle Models as a Roadmap
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Liposomal encapsulation redirects the in vivo disposition of paclitaxel: a comparative pharmacokinetic, tissue distribution, and excretion study in rats
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Putting square pegs in round holes: Why traditional pharmacokinetic principles cannot universally be applied to iron-carbohydrate complexes
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Prediction of in vivo behavior of nanoparticles using physiologically based pharmacokinetic model: The modeling approach and issues
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Injectable drug delivery systems of doxorubicin revisited: In vitro-in vivo relationships using human clinical data
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Understanding the In Vitro-In Vivo Nexus: Advanced correlation models predict clinical performance of liposomal doxorubicin
inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.06.029openalex-snapshot
Revisiting the in-vitro and in-vivo considerations for in-silico modelling of complex injectable drug products
inferred← citeshttps://doi.org/10.1016/j.jconrel.2024.07.069openalex-snapshot
A bio-predictive release assay for liposomal prednisolone phosphate
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Revisiting nanomedicine design strategies for follow-on products: A model-informed approach to optimize performance
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Targeted therapies against breast cancer: Clinical perspectives, obstacles and new opportunities
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In vitro and in vivo correlation of injectable lipid-based nanomedicines: From dissolution to protein coronas
inferred← citeshttps://doi.org/10.1021/acsnano.3c08290openalex-snapshot
A Design-Conversed Strategy Establishes the Performance Safe Space for Doxorubicin Nanosimilars
inferred← citeshttps://doi.org/10.1021/acsnano.6c05350openalex-snapshot
Shear Stress Modeling and Machine Learning for Nanomedicine Development: A Mechanistic Pathway to Pharmacokinetic Prediction
inferred← citeshttps://doi.org/10.1039/d2bm01252aopenalex-snapshot
Pharmaceutical liposomal delivery—specific considerations of innovation and challenges
inferred← citeshttps://doi.org/10.1080/17425247.2022.2081682openalex-snapshot
Biopredictive tools for the development of injectable drug products
inferred← citeshttps://doi.org/10.1111/php.13730openalex-snapshot
The Photosensitizer Temoporfin ( m THPC ) – Chemical, Pre‐clinical and Clinical Developments in the Last Decade † ‡
inferred← citeshttps://doi.org/10.2147/ijn.s440598openalex-snapshot
Blood-Nanoparticle Interactions Create a Brain Delivery Superhighway for Doxorubicin
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Liposomal Drug Delivery: Progress, Clinical Outlook, and Ongoing Challenges
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Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence
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Exploring the Interplay between Drug Release and Targeting of Lipid-Like Polymer Nanoparticles Loaded with Doxorubicin
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Application of Computing as a High-Practicability and -Efficiency Auxiliary Tool in Nanodrugs Discovery
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Comparison of Compartmental and Non-Compartmental Analysis to Detect Biopharmaceutical Similarity of Intravenous Nanomaterial-Based Rifabutin Formulations
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Need for Expansion of Pharmacy Education Globally for the Growing Field of Nanomedicine
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The Hemodynamic Landscape: an interactive three-dimensional atlas of wall shear stress for nanomedicine research
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PBPK modeling of doxorubicin-loaded polymeric nanoparticles : potential for clinical translation
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