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The biological and pharmacological roles of polyphenol flavonoid tilianin

https://doi.org/10.1016/j.ejphar.2018.10.044

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bmc.4139openalex-snapshot

Simultaneous determination of tilianin and its metabolites in mice using ultra‐high‐performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

inferredcites →https://doi.org/10.1002/jssc.201600645openalex-snapshot

Chemical constituents and quality control of two Dracocephalum species based on high‐performance liquid chromatographic fingerprints coupled with tandem mass spectrometry and chemometrics

inferredcites →https://doi.org/10.1002/ptr.5846openalex-snapshot

Effects of Tilianin on Proliferation, Migration and TGF-β/Smad Signaling in Rat Vascular Smooth Muscle Cells Induced with Angiotensin II

inferredcites →https://doi.org/10.1007/978-0-387-46401-5_3openalex-snapshot

ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN

inferredcites →https://doi.org/10.1007/bf02977797openalex-snapshot

Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-α and IL-1β

inferredcites →https://doi.org/10.1007/s10571-017-0496-yopenalex-snapshot

Neuroprotective Effects of Sigesbeckia pubescens Extract on Glutamate-Induced Oxidative Stress in HT22 Cells via Downregulation of MAPK/caspase-3 Pathways

inferredcites →https://doi.org/10.1007/s11030-013-9490-6openalex-snapshot

Selective MAO-B inhibitors: a lesson from natural products

inferredcites →https://doi.org/10.1007/s12291-014-0446-0openalex-snapshot

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

inferredcites →https://doi.org/10.1016/j.atherosclerosis.2004.11.022openalex-snapshot

Inhibition of cytokine-induced IκB kinase activation as a mechanism contributing to the anti-atherogenic activity of tilianin in hyperlipidemic mice

inferredcites →https://doi.org/10.1016/j.bcp.2009.03.016openalex-snapshot

Antihypertensive and vasorelaxant effects of tilianin isolated from Agastache mexicana are mediated by NO/cGMP pathway and potassium channel opening

inferredcites →https://doi.org/10.1016/j.biopha.2016.07.023openalex-snapshot

Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats

inferredcites →https://doi.org/10.1016/j.biopha.2017.09.031openalex-snapshot

Involvement of MAPK/NF-κB signal transduction pathways: Camellia japonica mitigates inflammation and gastric ulcer

inferredcites →https://doi.org/10.1016/j.bse.2006.04.009openalex-snapshot

Flavonoids from Lygodium japonicum

inferredcites →https://doi.org/10.1016/j.cellsig.2012.01.008openalex-snapshot

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

inferredcites →https://doi.org/10.1016/j.ijbiomac.2017.06.076openalex-snapshot

Potent inhibitions of monoamine oxidase A and B by acacetin and its 7-O-(6-O-malonylglucoside) derivative from Agastache rugosa

inferredcites →https://doi.org/10.1016/j.jep.2005.08.030openalex-snapshot

Protein kinase G-dependent heme oxygenase-1 induction by Agastache rugosa leaf extract protects RAW264.7 cells from hydrogen peroxide-induced injury

inferredcites →https://doi.org/10.1016/j.jep.2011.09.041openalex-snapshot

Validated liquid chromatographic method and analysis of content of tilianin on several extracts obtained from Agastache mexicana and its correlation with vasorelaxant effect

inferredcites →https://doi.org/10.1016/j.jep.2012.05.044openalex-snapshot

Anti-nociceptive and anti-inflammatory activities of the Agastache mexicana extracts by using several experimental models in rodents

inferredcites →https://doi.org/10.1016/j.jep.2012.12.029openalex-snapshot

Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana

inferredcites →https://doi.org/10.1016/j.jep.2016.12.023openalex-snapshot

Spasmogenic and spasmolytic activities of Agastache mexicana ssp. mexicana and A. mexicana ssp. xolocotziana methanolic extracts on the guinea pig ileum

inferredcites →https://doi.org/10.1016/j.phymed.2017.08.007openalex-snapshot

Tilianin pretreatment prevents myocardial ischemia-reperfusion injury via preservation of mitochondrial function in rat heart

inferredcites →https://doi.org/10.1016/s0014-5793(01)02379-1openalex-snapshot

Inhibition of cytokine‐induced vascular cell adhesion molecule‐1 expression; possible mechanism for anti‐atherogenic effect of Agastache rugosa

inferredcites →https://doi.org/10.1016/s0896-6273(03)00568-3openalex-snapshot

Parkinson's Disease

inferredcites →https://doi.org/10.1016/s1995-7645(14)60312-6openalex-snapshot

Depressant effects of Agastache mexicana methanol extract and one of major metabolites tilianin

inferredcites →https://doi.org/10.1021/jf300833mopenalex-snapshot

Accumulation of Tilianin and Rosmarinic Acid and Expression of Phenylpropanoid Biosynthetic Genes in Agastache rugosa

inferredcites →https://doi.org/10.1038/emm.2006.52openalex-snapshot

Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

inferredcites →https://doi.org/10.1038/nrn1883openalex-snapshot

The therapeutic potential of monoamine oxidase inhibitors

inferredcites →https://doi.org/10.1038/srep22135openalex-snapshot

Neuroprotective Effects of A Standardized Flavonoid Extract of Safflower Against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease

inferredcites →https://doi.org/10.1083/jcb.201102095openalex-snapshot

Signal transduction by reactive oxygen species

inferredcites →https://doi.org/10.1089/jmf.2005.8.281openalex-snapshot

Flavonols, Flavones, Flavanones, and Human Health: Epidemiological Evidence

inferredcites →https://doi.org/10.1097/00001573-200009000-00008openalex-snapshot

Low density lipoprotein oxidation, antioxidants, and atherosclerosis

inferredcites →https://doi.org/10.1097/01.pap.0000249915.12185.58openalex-snapshot

The Future of Antihypertensive Treatment

inferredcites →https://doi.org/10.1097/mca.0000000000000187openalex-snapshot

Antioxidants and coronary artery disease

inferredcites →https://doi.org/10.1111/j.1541-4337.2011.00156.xopenalex-snapshot

Natural Antioxidants: Sources, Compounds, Mechanisms of Action, and Potential Applications

inferredcites →https://doi.org/10.1128/mmbr.53.2.210-230.1989openalex-snapshot

Common themes in microbial pathogenicity

inferredcites →https://doi.org/10.1146/annurev-clinpsy-032210-104518openalex-snapshot

Gene-Environment Interaction in Psychological Traits and Disorders

inferredcites →https://doi.org/10.1155/2017/6596241openalex-snapshot

Therapeutic Effects of Phytochemicals and Medicinal Herbs on Depression

inferredcites →https://doi.org/10.1155/2017/8137627openalex-snapshot

In Vivo and In Vitro Hepatoprotective Effects of Geranium koreanum Methanolic Extract via Downregulation of MAPK/Caspase‐3 Pathway

inferredcites →https://doi.org/10.1167/iovs.15-16595openalex-snapshot

Quercetin and Resveratrol Decrease the Inflammatory and Oxidative Responses in Human Ocular Surface Epithelial Cells

inferredcites →https://doi.org/10.1186/1471-2261-5-33openalex-snapshot

Cardiovascular disease, risk factors and heart rate variability in the elderly general population: Design and objectives of the CARdiovascular disease, Living and Ageing in Halle (CARLA) Study

inferredcites →https://doi.org/10.1186/s12906-017-1592-8openalex-snapshot

Chemical constituents and coagulation activity of Agastache rugosa

inferredcites →https://doi.org/10.1186/s13065-016-0223-7openalex-snapshot

Analysis of tilianin and acacetin in Agastache rugosa by high-performance liquid chromatography with ionic liquids-ultrasound based extraction

inferredcites →https://doi.org/10.1186/s40662-015-0026-2openalex-snapshot

Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss

inferredcites →https://doi.org/10.1186/s40842-016-0039-3openalex-snapshot

Diabetes and its drivers: the largest epidemic in human history?

inferredcites →https://doi.org/10.12659/msm.903259openalex-snapshot

Tilianin Post-Conditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondrial Protection and Inhibition of Apoptosis

inferredcites →https://doi.org/10.1371/journal.pone.0193845openalex-snapshot

Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway

inferredcites →https://doi.org/10.14336/ad.2015.0803openalex-snapshot

Chronic Inflammatory Diseases and Endothelial Dysfunction

inferredcites →https://doi.org/10.2174/138161212798919002openalex-snapshot

Herbal Medicines for the Prevention and Treatment of Alzheimer's Disease

inferredcites →https://doi.org/10.2174/156802612805219978openalex-snapshot

Monoamine Oxidases: The Biochemistry of the Proteins As Targets in Medicinal Chemistry and Drug Discovery

inferredcites →https://doi.org/10.2174/1871524914666140826111930openalex-snapshot

Plant Secondary Metabolites- Potent Inhibitors of Monoamine Oxidase Isoforms

inferredcites →https://doi.org/10.3233/rnn-140486openalex-snapshot

Involvement of the GABAergic system in the neuroprotective and sedative effects of acacetin 7-O-glucoside in rodents

inferredcites →https://doi.org/10.3389/fncel.2014.00167openalex-snapshot

GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer’s disease

inferredcites →https://doi.org/10.3390/ijms18071482openalex-snapshot

Hepatoprotective Role of Hydrangea macrophylla against Sodium Arsenite-Induced Mitochondrial-Dependent Oxidative Stress via the Inhibition of MAPK/Caspase-3 Pathways

inferredcites →https://doi.org/10.3892/mmr.2014.2954openalex-snapshot

Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury

inferredcites →https://doi.org/10.4014/jmb.1610.10012openalex-snapshot

Tilianin Inhibits MUC5AC Expression Mediated Via Down-Regulation of EGFR-MEK-ERK-Sp1 Signaling Pathway in NCI-H292 Human Airway Cells

inferredcites →https://doi.org/10.4061/2011/514623openalex-snapshot

Oxidative Stress and Inflammation in Heart Disease: Do Antioxidants Have a Role in Treatment and/or Prevention?

inferredcites →https://doi.org/10.4103/0973-7847.70902openalex-snapshot

Free radicals, antioxidants and functional foods: Impact on human health

inferredcites →https://doi.org/10.4103/0973-7847.79097openalex-snapshot

Role of natural herbs in the treatment of hypertension

inferredcites →https://doi.org/10.4103/0974-8520.100295openalex-snapshot

Drug discovery from plant sources: An integrated approach

inferredcites →https://doi.org/10.4161/oxim.2.5.9498openalex-snapshot

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

inferredcites →https://doi.org/10.4239/wjd.v6.i13.1246openalex-snapshot

Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research

inferredcites →https://doi.org/10.4268/cjcmm20101117openalex-snapshot

Chemical constituents of Discocleidion rufescens

inferredcites →https://doi.org/10.4268/cjcmm20151001openalex-snapshot

Separation and authentication of tilianin and quality standards of semen of Dracocephalum moldavia

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Anchor Peptide‐Based Immobilization Strategy Promote the Applications of Pickering Emulsion System in Natural Products Glycosylation

inferred← citeshttps://doi.org/10.1002/ddr.22062openalex-snapshot

Tilianin alleviates lipid deposition and fibrosis in mice with nonalcoholic steatohepatitis by activating the PPARα/Nnat axis

inferred← citeshttps://doi.org/10.1002/jbt.23761openalex-snapshot

Tilianin enhances the antitumor effect of sufentanil on non‐small cell lung cancer

inferred← citeshttps://doi.org/10.1007/s00425-025-04816-9openalex-snapshot

Floral development and phenolic compounds production in Agastache rugosa through light regulation

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inferred← citeshttps://doi.org/10.1016/b978-0-443-49142-9.00014-7openalex-snapshot

Valerian flavonoids in neuropharmacology: Insights and advances

inferred← citeshttps://doi.org/10.1016/j.arabjc.2022.103961openalex-snapshot

Tilianin alleviates airway inflammation in ovalbumin-induced allergic asthma in mice through the regulation of Th2 cytokines and TGF-β1/Smad markers

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A shear-responsive nanosystem engineered from fucoidan targets endothelial for atherosclerosis therapy

inferred← citeshttps://doi.org/10.1016/j.chroma.2024.465031openalex-snapshot

Rapid purification and scale-up of tilianin using counter-current chromatography with rectangular horizontal tubing

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Effectiveness of silver nitrate application on plant growth and bioactive compounds in Agastache rugosa (Fisch. & C.A.Mey.) kuntze

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Karafsin, a unique mono-acylated flavonoid apiofurnoside from the leaves of Apium graveolens var. secalinum Alef: In vitro and in vivo anti-inflammatory assessment

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Renoprotective effects of Tilianin in diabetic rats through modulation of oxidative stress via Nrf2-Keap1 pathway and inflammation via TLR4/MAPK/NF-κB pathways

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Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF-κB/NLRP3 and PGC1a/SIRT3 pathways

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Tilianin regulates the proliferation, invasion and tumor immune microenvironment of thyroid cancer cells through the TLR4/NF-κB axis

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Euryops arabicus displays anti-inflammatory activities in experimental models

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Metabolites identification for major active components of Agastache rugosa in rat by UPLC-Orbitap-MS: Comparison of the difference between metabolism as a single component and as a component in a multi-component extract

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Bioactivity and molecular docking of lactones isolated from Centaurea pseudosinaica Czerep

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Tilianin attenuates HDM-induced allergic asthma by suppressing Th2-immune responses via downregulation of IRF4 in dendritic cells

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Tilianin improves lipid profile and alleviates atherosclerosis in ApoE−/− mice through up-regulation of SREBP2-mediated LDLR expression

inferred← citeshttps://doi.org/10.1016/j.phymed.2023.154768openalex-snapshot

Therapeutic application of natural products: NAD+ metabolism as potential target

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An efficient flavonoid glycosyltransferase NjUGT73B1 from Nardostachys jatamansi of alpine Himalayas discovered by structure-based protein clustering

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Managing cancer in autoimmune patients: Overcoming therapeutic challenges and expanding treatment options

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Tilianin inhibits the human ovarian cancer (PA-1) cell proliferation via blocking cell cycle, inducing apoptosis and inhibiting JAK2/STAT3 signaling pathway

inferred← citeshttps://doi.org/10.1038/s41598-025-34712-xopenalex-snapshot

Effect of short-duration microwave treatments on flower development and secondary metabolite production in Agastache rugosa

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Preparation and characterization of PLGA-PEG-PLGA polymeric nanoparticles for co-delivery of 5-Fluorouracil and Chrysin

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An Identification and a Quantitative Assessment of Phenolic Compounds in a Butanol Fraction of Extract from Cosmary Flowers (Tanacetum vulgare)

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Tilianin Ameliorates Cognitive Dysfunction and Neuronal Damage in Rats with Vascular Dementia via p‐CaMKII/ERK/CREB and ox‐CaMKII‐Dependent MAPK/NF‐κB Pathways

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Tilianin Protects against Nonalcoholic Fatty Liver Disease in Early Obesity Mice

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Tilianin attenuates MPP+‑induced oxidative stress and apoptosis of dopaminergic neurons in a cellular model of Parkinson's disease

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