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Role of the Nrf2-ARE pathway in perfluorooctanoic acid (PFOA)-induced hepatotoxicity in Rana nigromaculata
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s00204-010-0572-2openalex-snapshot
Hepatocellular hypertrophy and cell proliferation in Sprague–Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR
inferredcites →https://doi.org/10.1007/s00244-008-9194-6openalex-snapshot
Studies on the Toxicological Effects of PFOA and PFOS on Rats Using Histological Observation and Chemical Analysis
inferredcites →https://doi.org/10.1007/s10646-013-1100-yopenalex-snapshot
Effects of perfluorooctanesulfonate and perfluorobutanesulfonate on the growth and sexual development of Xenopus laevis
inferredcites →https://doi.org/10.1007/s11631-012-0593-zopenalex-snapshot
Immunotoxicity and hepatotoxicity of PFOS and PFOA in tilapia (Oreochromis niloticus)
inferredcites →https://doi.org/10.1016/j.advenzreg.2006.01.007openalex-snapshot
Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
inferredcites →https://doi.org/10.1016/j.aquatox.2007.02.006openalex-snapshot
Induction of oxidative stress and apoptosis by PFOS and PFOA in primary cultured hepatocytes of freshwater tilapia (Oreochromis niloticus)
inferredcites →https://doi.org/10.1016/j.aquatox.2008.07.009openalex-snapshot
Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver
inferredcites →https://doi.org/10.1016/j.aquatox.2014.06.002openalex-snapshot
Endocrine-disrupting effects and reproductive toxicity of low dose MCLR on male frogs (Rana nigromaculata) in vivo
inferredcites →https://doi.org/10.1016/j.chemosphere.2006.11.049openalex-snapshot
Transport of ammonium perfluorooctanoate in environmental media near a fluoropolymer manufacturing facility
inferredcites →https://doi.org/10.1016/j.chemosphere.2007.02.008openalex-snapshot
Perfluorinated compounds in the Pearl River and Yangtze River of China
inferredcites →https://doi.org/10.1016/j.chemosphere.2007.09.022openalex-snapshot
Analysis of perfluorooctanoate (PFOA) and other perfluorinated compounds (PFCs) in the River Po watershed in N-Italy
inferredcites →https://doi.org/10.1016/j.chemosphere.2010.06.028openalex-snapshot
Perfluorooctanoic acid induces peroxisomal fatty acid oxidation and cytokine expression in the liver of male Japanese medaka (Oryzias latipes)
inferredcites →https://doi.org/10.1016/j.chemosphere.2011.01.067openalex-snapshot
Tissue bioaccumulation patterns, xenobiotic biotransformation and steroid hormone levels in Atlantic salmon (Salmo salar) fed a diet containing perfluoroactane sulfonic or perfluorooctane carboxylic acids
inferredcites →https://doi.org/10.1016/j.chemosphere.2013.02.017openalex-snapshot
Perfluorinated compounds in soils from Liaodong Bay with concentrated fluorine industry parks in China
inferredcites →https://doi.org/10.1016/j.envpol.2011.04.036openalex-snapshot
Biomarker responses associated with halogenated organic contaminants in northern fulmars (Fulmarus glacialis) breeding in the Canadian Arctic
inferredcites →https://doi.org/10.1016/j.envpol.2016.05.040openalex-snapshot
Effects of 4-nitrophenol on expression of the ER-α and AhR signaling pathway-associated genes in the small intestine of rats
inferredcites →https://doi.org/10.1016/j.etap.2012.02.004openalex-snapshot
Cytochrome P450 (CYP) in fish
inferredcites →https://doi.org/10.1016/j.etap.2012.06.011openalex-snapshot
In vitro and in vivo studies of the toxic effects of perfluorononanoic acid on rat hepatocytes and Kupffer cells
inferredcites →https://doi.org/10.1016/j.fct.2007.09.099openalex-snapshot
Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2009.12.022openalex-snapshot
Reactive oxygen species, cellular redox systems, and apoptosis
inferredcites →https://doi.org/10.1016/j.jhazmat.2006.04.017openalex-snapshot
Special applications of fluorinated organic compounds
inferredcites →https://doi.org/10.1016/j.jhazmat.2014.08.043openalex-snapshot
The role of interleukin family in perfluorooctanoic acid (PFOA)-induced immunotoxicity
inferredcites →https://doi.org/10.1016/j.marpolbul.2008.11.030openalex-snapshot
Total body burden and tissue distribution of polyfluorinated compounds in harbor seals (Phoca vitulina) from the German Bight
inferredcites →https://doi.org/10.1016/j.reprotox.2008.12.011openalex-snapshot
Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species
inferredcites →https://doi.org/10.1016/j.taap.2007.09.026openalex-snapshot
Lipid homeostasis and oxidative stress in the liver of male rats exposed to perfluorododecanoic acid
inferredcites →https://doi.org/10.1016/j.taap.2010.01.013openalex-snapshot
Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver
inferredcites →https://doi.org/10.1016/j.tox.2005.06.006openalex-snapshot
In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat
inferredcites →https://doi.org/10.1016/s0021-9258(18)99177-5openalex-snapshot
Reactions and significance of cytochrome P-450 enzymes
inferredcites →https://doi.org/10.1016/s0378-4274(01)00466-0openalex-snapshot
Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis
inferredcites →https://doi.org/10.1017/s0030605315001131openalex-snapshot
An alternative framework for responding to the amphibian crisis
inferredcites →https://doi.org/10.1021/es010780ropenalex-snapshot
Quantitative Characterization of Trace Levels of PFOS and PFOA in the Tennessee River
inferredcites →https://doi.org/10.1021/es062811uopenalex-snapshot
Perfluorinated surfactants contaminate German waters | What lurks in cooling towers? | News Briefs: Vehicle life-cycle analysis `Farms and forests could store greenhouse gases ` Wetlands mask methane ` Nanotechnology’s risks ` Plastic pipes could contaminate water ` Recycling cars checks mercury…
inferredcites →https://doi.org/10.1021/es104326wopenalex-snapshot
Monitoring of Perfluorinated Compounds in Aquatic Biota: An Updated Review
inferredcites →https://doi.org/10.1038/35008052openalex-snapshot
Quantitative evidence for global amphibian population declines
inferredcites →https://doi.org/10.1038/labinvest.2008.75openalex-snapshot
The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
inferredcites →https://doi.org/10.1038/nature10650openalex-snapshot
Additive threats from pathogens, climate and land-use change for global amphibian diversity
inferredcites →https://doi.org/10.1039/c0em00373eopenalex-snapshot
Polyfluoroalkyl compounds in the aquatic environment: a review of their occurrence and fate
inferredcites →https://doi.org/10.1081/dct-200039773openalex-snapshot
13‐Week Dietary Toxicity Study of Ammonium Perfluorooctanoate (APFO) in Male Rats
inferredcites →https://doi.org/10.1089/ars.2005.7.385openalex-snapshot
Molecular Mechanisms Activating the Nrf2-Keap1 Pathway of Antioxidant Gene Regulation
inferredcites →https://doi.org/10.1093/toxsci/kfj011openalex-snapshot
Gene Expression Profiles in Rat Liver Treated With Perfluorooctanoic Acid (PFOA)
inferredcites →https://doi.org/10.1093/toxsci/kfj105openalex-snapshot
Effects of Perfluorooctanoic Acid Exposure during Pregnancy in the Mouse
inferredcites →https://doi.org/10.1093/toxsci/kfp142openalex-snapshot
Does Exposure to Perfluoroalkyl Acids Present a Risk to Human Health?
inferredcites →https://doi.org/10.1093/toxsci/kfq066openalex-snapshot
The Role of Nrf2 and MAPK Pathways in PFOS-Induced Oxidative Stress in Zebrafish Embryos
inferredcites →https://doi.org/10.1126/science.253.5022.860openalex-snapshot
Declining Amphibian Populations
inferredcites →https://doi.org/10.1146/annurev.ecolsys.35.112202.130132openalex-snapshot
Application of Ecological Indicators
inferredcites →https://doi.org/10.11588/heidok.00014550openalex-snapshot
Long-term effects and chemosensitizing potential of perfluorinated chemicals (PFCs) in zebrafish (Danio rerio)
inferredcites →https://doi.org/10.1177/0192623308318216openalex-snapshot
Comparative Hepatic Effects of Perfluorooctanoic Acid and WY 14,643 in PPAR-α Knockout and Wild-type Mice
inferredcites →https://doi.org/10.1242/jeb.040865openalex-snapshot
The cause of global amphibian declines: a developmental endocrinologist's perspective
inferredcites →https://doi.org/10.1890/1051-0761(2003)013[0829:ioaiha]2.0.co;2openalex-snapshot
INTERACTIONS OF AN INSECTICIDE, HERBICIDE, AND NATURAL STRESSORS IN AMPHIBIAN COMMUNITY MESOCOSMS
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4750932openalex-extracted
The Impact of Imidacloprid on the Liver-Intestinal Axis in Rana Nigromaculata
inferred← citeshttps://doi.org/10.1002/etc.5723openalex-snapshot
The Use of Multiple Biomarkers to Assess the Health of Anuran Amphibians in the Brazilian Cerrado Savanna: An Ecotoxicological Approach
inferred← citeshttps://doi.org/10.1007/398_2020_57openalex-snapshot
Fluorotelomer Alcohols’ Toxicology Correlates with Oxidative Stress and Metabolism
inferred← citeshttps://doi.org/10.1007/s10653-025-02766-5openalex-snapshot
Emerging contaminants of perfluoroalkyl carboxylic acids (PFCAs): a review of sources, occurrence, and accumulation in plants
inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.106907openalex-snapshot
Poly- and perfluoroalkyl substances (PFASs) in amphibians and reptiles – exposure and health effects
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2021.112081openalex-snapshot
Integrated analysis of physiological, transcriptomics and metabolomics provides insights into detoxication disruption of PFOA exposure in Mytilus edulis
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117098openalex-snapshot
Perfluorooctanoic acid (PFOA) induces cardiotoxicity by activating the Keap1/Nrf2 pathway in zebrafish (Danio rerio) embryos
inferred← citeshttps://doi.org/10.1016/j.envint.2022.107413openalex-snapshot
Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.envint.2026.110076openalex-snapshot
PFOA and co-exposure with PFOS induce AMPK-dependent hypoglycemia in mice: integrated evidence from physiology, multi-omics, and molecular docking
inferred← citeshttps://doi.org/10.1016/j.envpol.2019.01.035openalex-snapshot
Perfluorooctanoic acid exposure induces apoptosis in SMMC-7721 hepatocellular cancer cells
inferred← citeshttps://doi.org/10.1016/j.envpol.2020.114182openalex-snapshot
Combined effects and toxicological interactions of perfluoroalkyl and polyfluoroalkyl substances mixtures in human liver cells (HepG2)
inferred← citeshttps://doi.org/10.1016/j.envpol.2020.114341openalex-snapshot
Perfluorooctanoic acid exposure impact a trade-off between self-maintenance and reproduction in lizards (Eremias argus) in a gender-dependent manner
inferred← citeshttps://doi.org/10.1016/j.envpol.2020.114928openalex-snapshot
Comparative toxicometabolomics of perfluorooctanoic acid (PFOA) and next-generation perfluoroalkyl substances
inferred← citeshttps://doi.org/10.1016/j.envpol.2020.115655openalex-snapshot
Autophagy mediates perfluorooctanoic acid-induced lipid metabolism disorder and NLRP3 inflammasome activation in hepatocytes
inferred← citeshttps://doi.org/10.1016/j.envpol.2021.118112openalex-snapshot
Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha
inferred← citeshttps://doi.org/10.1016/j.envpol.2022.118791openalex-snapshot
TBBPA and its alternative TCBPA induced ROS-dependent mitochondria-mediated apoptosis in the liver of Rana nigromaculata
inferred← citeshttps://doi.org/10.1016/j.envpol.2022.120022openalex-snapshot
Perfluorooctanoic acid-induced developmental cardiotoxicity in chicken embryo: Roles of miR-490-5p
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.125595openalex-snapshot
Perfluorodecanoic acid (PFDA) increases oxidative stress through inhibition of mitochondrial β-oxidation
inferred← citeshttps://doi.org/10.1016/j.envpol.2026.127967openalex-snapshot
Integrated transcriptomic and metabolomic analysis reveals the molecular mechanisms underlying perfluorooctanoic acid (PFOA)-induced developmental toxicity during the early life stages of Paralichthys olivaceus
inferred← citeshttps://doi.org/10.1016/j.envres.2019.05.008openalex-snapshot
PFOA and PFOS interact with superoxide dismutase and induce cytotoxicity in mouse primary hepatocytes: A combined cellular and molecular methods
inferred← citeshttps://doi.org/10.1016/j.envres.2025.121683openalex-snapshot
The toxicological effects of perfluorooctanoic acid (PFOA) exposure in large yellow croaker (Larimichthys crocea): exploring the relationship between liver damage and gut microbiota dysbiosis
inferred← citeshttps://doi.org/10.1016/j.fsi.2023.108729openalex-snapshot
The role of Nrf2 signaling pathway in the mud crab (Scylla paramamosain) in response to Vibrio parahaemolyticus infection
inferred← citeshttps://doi.org/10.1016/j.fsi.2025.110908openalex-snapshot
Perfluorooctanoic acid (PFOA) exposure induced ferroptosis through the PPARα/FABP7 signaling pathway in the liver of spotted sea bass (Lateolabrax maculatus)
inferred← citeshttps://doi.org/10.1016/j.jclepro.2022.135478openalex-snapshot
Insights into the per- and polyfluoroalkyl substances-contaminated paper mill processing discharge: Detection, phytotoxicity, bioaccumulative profiling, and health risk verification
inferred← citeshttps://doi.org/10.1016/j.jes.2025.10.001openalex-snapshot
Co-exposure to polystyrene microplastics and perfluorooctanoic acid can exacerbate lipid metabolism disorders and liver damage in adult zebrafish
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2021.126827openalex-snapshot
Combined effects of mixed per- and polyfluoroalkyl substances on the Nrf2-ARE pathway in ARE reporter-HepG2 cells
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2022.128863openalex-snapshot
Evaluation of the ecological impacts of short- and long-chain perfluoroalkyl acids on constructed wetland systems: Perfluorobutyric acid and perfluorooctanoic acid
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2023.132552openalex-snapshot
Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS)
inferred← citeshttps://doi.org/10.1016/j.marpolbul.2026.119851openalex-snapshot
Increasing salinity exacerbates the bioaccumulation and toxicity of perfluorooctanoic acid (PFOA) in Manila clams (Ruditapes philippinarum)
inferred← citeshttps://doi.org/10.1016/j.neuro.2026.103533openalex-snapshot
Mechanisms underlying perfluorooctanoic acid-induced neuronal loss and cognitive deficits: Disruption of mitochondrial dynamics, impaired mitophagy, and blood-brain barrier dysfunction
inferred← citeshttps://doi.org/10.1016/j.reprotox.2024.108745openalex-snapshot
Role of Rab proteins in PFOA-induced changes in boar sperm motility and capacitation
inferred← citeshttps://doi.org/10.1016/j.reprotox.2024.108829openalex-snapshot
Mixed exposure to PFOA and PFOS induces oocyte apoptosis and subfertility in mice by activating the Hippo signaling pathway
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2019.02.418openalex-snapshot
Antioxidant defence system is responsible for the toxicological interactions of mixtures: A case study on PFOS and PFOA in Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2019.135334openalex-snapshot
Adverse effects of perfluoroalkyl acids on fish and other aquatic organisms: A review
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2021.152732openalex-snapshot
Single PFAS and PFAS mixtures affect nuclear receptor- and oxidative stress-related pathways in precision-cut liver slices of Atlantic cod (Gadus morhua)
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.157313openalex-snapshot
Perfluorooctanoic acid alternatives hexafluoropropylene oxides exert male reproductive toxicity by disrupting blood-testis barrier
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.166421openalex-snapshot
Tetrabromobisphenol a and its alternative tetrachlorobisphenol a induce oxidative stress, lipometabolism disturbance, and autophagy in the liver of male Pelophylax nigromaculatus
inferred← citeshttps://doi.org/10.1016/j.tox.2020.152521openalex-snapshot
Regulation of Hox and ParaHox genes by perfluorochemicals in mouse liver
inferred← citeshttps://doi.org/10.1016/j.tox.2026.154530openalex-snapshot
Perfluorooctanoic acid induces mitochondrial dysfunction–driven apoptosis and PINK1/Parkin-mediated mitophagy in testicular cells
inferred← citeshttps://doi.org/10.1016/j.toxrep.2019.12.010openalex-snapshot
Acute PFOA exposure promotes epigenomic alterations in mouse kidney tissues
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.5c03097openalex-snapshot
Highly Sensitive Turn-On Detection of Perfluorooctanoic Acid by a Tb(III)-Based Coordination Polymer
inferred← citeshttps://doi.org/10.1039/c8sm02301hopenalex-snapshot
Destabilizing effect of perfluorodecanoic acid on simple membrane models
inferred← citeshttps://doi.org/10.1039/d1ra04097aopenalex-snapshot
Antioxidant defense system responses, lysosomal membrane stability and DNA damage in earthworms ( Eisenia fetida ) exposed to perfluorooctanoic acid: an integrated biomarker approach to evaluating toxicity
inferred← citeshttps://doi.org/10.1093/toxres/tfaf129openalex-snapshot
Counteracting effects of Ethanolic extract of allium Sativum on Perfluorooctanoic acid-induced cardiotoxicity: insights into Keap1-Nrf2/PPARα pathways
inferred← citeshttps://doi.org/10.1093/toxsci/kfab043openalex-snapshot
Perfluorooctanesulfonic Acid (PFOS) Thwarts the Beneficial Effects of Calorie Restriction and Metformin
inferred← citeshttps://doi.org/10.1098/rspb.2024.1536openalex-snapshot
The impact of chemical pollution across major life transitions: a meta-analysis on oxidative stress in amphibians
inferred← citeshttps://doi.org/10.1177/10915818211010490openalex-snapshot
Exploring Potential Carcinogenic Activity of Per- and Polyfluorinated Alkyl Substances Utilizing High-Throughput Toxicity Screening Data
inferred← citeshttps://doi.org/10.1210/endocr/bqab194openalex-snapshot
PFAS and Potential Adverse Effects on Bone and Adipose Tissue Through Interactions With PPARγ
inferred← citeshttps://doi.org/10.2139/ssrn.5168087openalex-snapshot
The Toxicological Effects of Perfluorooctanoic Acid (Pfoa) Exposure in Large Yellow Croaker (Larimichthys Crocea): Linking Liver Damage to Gut Microbiota Dysbiosis
inferred← citeshttps://doi.org/10.22038/ijbms.2023.64318.14149openalex-snapshot
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
inferred← citeshttps://doi.org/10.2478/aiht-2022-73-3629openalex-snapshot
Perfluorooctanoic acid affects mouse brain and liver tissue through oxidative stress
inferred← citeshttps://doi.org/10.3390/ijerph18073332openalex-snapshot
Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food
inferred← citeshttps://doi.org/10.3390/oceans5040049openalex-snapshot
The Impact of Perfluorooctanoic Acid (PFOA) on the Mussel Mytilus galloprovincialis: A Multi-Biomarker Evaluation
inferred← citeshttps://doi.org/10.3390/toxics11060543openalex-snapshot
Poly- and Perfluoroalkyl Substances (PFAS): Do They Matter to Aquatic Ecosystems?
inferred← citeshttps://doi.org/10.3390/toxics13020111openalex-snapshot
Protective Effects of Resveratrol Against Perfluorooctanoic Acid-Induced Testicular and Epididymal Toxicity in Adult Rats Exposed During Their Prepubertal Period
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