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Lead induces apoptosis in mouse TM3 Leydig cells through the Fas/FasL death receptor pathway

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00018-010-0285-yopenalex-snapshot
Mitochondrial control of caspase-dependent and -independent cell death
inferredcites →https://doi.org/10.1007/s00204-015-1547-0openalex-snapshot
Mitochondrial permeability transition and its regulatory components are implicated in apoptosis of primary cultures of rat proximal tubular cells exposed to lead
inferredcites →https://doi.org/10.1007/s10495-006-0012-1openalex-snapshot
Up-regulation of CD95 (Apo-1/Fas) is associated with spermatocyte apoptosis during the first round of spermatogenesis in the rat
inferredcites →https://doi.org/10.1007/s10495-012-0703-8openalex-snapshot
N-acetyl-l-cysteine modulates multiple signaling pathways to rescue male germ cells from apoptosis induced by chronic hCG administration to rats
inferredcites →https://doi.org/10.1016/0092-8674(93)90326-lopenalex-snapshot
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
inferredcites →https://doi.org/10.1016/j.bbrc.2009.02.159openalex-snapshot
Deprival of testicular innervation induces apoptosis of Leydig cells via caspase-8-dependent signaling: A novel survival pathway revealed
inferredcites →https://doi.org/10.1016/j.etap.2013.09.006openalex-snapshot
Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: The role of p53, Fas and Caspase-3
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2006.01.012openalex-snapshot
Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress
inferredcites →https://doi.org/10.1016/j.jsbmb.2008.12.022openalex-snapshot
The role of testosterone in the metabolic syndrome: A review
inferredcites →https://doi.org/10.1016/j.jsbmb.2014.07.007openalex-snapshot
Endocrine disruptors and other inhibitors of 11β-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition
inferredcites →https://doi.org/10.1016/j.jtemb.2010.11.003openalex-snapshot
Nickel induced structural and functional alterations in mouse Leydig cells in vitro
inferredcites →https://doi.org/10.1016/j.taap.2007.06.002openalex-snapshot
Exposure to inorganic mercury in vivo attenuates extrinsic apoptotic signaling in Staphylococcal aureus enterotoxin B stimulated T-cells
inferredcites →https://doi.org/10.1016/j.taap.2010.07.016openalex-snapshot
Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium
inferredcites →https://doi.org/10.1016/j.tox.2015.05.003openalex-snapshot
Cytotoxic mechanism related to dihydrolipoamide dehydrogenase in Leydig cells exposed to heavy metals
inferredcites →https://doi.org/10.1038/aja.2010.159openalex-snapshot
Low-dose testosterone treatment decreases oxidative damage in TM3 Leydig cells
inferredcites →https://doi.org/10.1038/s41598-017-00997-wopenalex-snapshot
Beclin-1-mediated Autophagy Protects Against Cadmium-activated Apoptosis via the Fas/FasL Pathway in Primary Rat Proximal Tubular Cell Culture
inferredcites →https://doi.org/10.1038/srep13921openalex-snapshot
Hexavalent chromium induces apoptosis in male somatic and spermatogonial stem cells via redox imbalance
inferredcites →https://doi.org/10.1080/00039896.1984.10545877openalex-snapshot
Endocrine and Reproductive Dysfunction in Men Associated with Occupational Inorganic Lead Intoxication
inferredcites →https://doi.org/10.1080/10715760500308154openalex-snapshot
Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)—induced oxidative damage in Leydig cells
inferredcites →https://doi.org/10.1095/biolreprod23.1.243openalex-snapshot
Establishment and Characterization of Two Distinct Mouse Testicular Epithelial Cell Line
inferredcites →https://doi.org/10.1111/and.12561openalex-snapshot
Protective effects of quercetin against arsenic-induced testicular damage in rats
inferredcites →https://doi.org/10.1126/science.7533326openalex-snapshot
The Fas Death Factor
inferredcites →https://doi.org/10.1530/rep-13-0603openalex-snapshot
Identification of Leydig cell-specific mRNA transcripts in the adult rat testis
inferredcites →https://doi.org/10.3109/01480545.2015.1028068openalex-snapshot
N-acetylcysteine effectively mitigates cadmium-induced oxidative damage and cell death in Leydig cellsin vitro
inferredcites →https://doi.org/10.3967/bes2016.070openalex-snapshot
Cytotoxic Responses and Apoptosis in Rat Kidney Epithelial Cells Exposed to Lead.
inferredcites →https://doi.org/10.7150/ijbs.4499openalex-snapshot
The Role of α-synuclein and Tau Hyperphosphorylation-Mediated Autophagy and Apoptosis in Lead-induced Learning and Memory Injury
inferredcites →https://doi.org/10.7555/jbr.29.20130037openalex-snapshot
Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Optimal Dietary Isalo Scorpion Cytotoxic Peptide (Isct) Promotes Gill Health Through Enhancing Gill Structure Integrity and Immune Function in Grass Carp (Ctenopharyngodon Idella) Infected with Flavobacterium Columnare
inferred← citeshttps://doi.org/10.1002/tox.23654openalex-snapshot
RETRACTED: Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of sperm, and blunting the downregulation of enzymes involved in the steroidogenesis
inferred← citeshttps://doi.org/10.1007/s10495-024-02038-0openalex-snapshot
Advancements in programmed cell death research in antitumor therapy: a comprehensive overview
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inferred← citeshttps://doi.org/10.1007/s12011-018-1508-6openalex-snapshot
Chlorogenic Acid Ameliorates Lead-Induced Renal Damage in Mice
inferred← citeshttps://doi.org/10.1007/s12011-021-02818-8openalex-snapshot
Wild Garlic Allium triquetrum L. Alleviates Lead Acetate-Induced Testicular Injuries in Rats
inferred← citeshttps://doi.org/10.1007/s12011-023-03721-0openalex-snapshot
Zinc Inhibits Lead-Induced Oxidative Stress and Apoptosis of ST Cells Through ROS/PTEN/PI3K/AKT Axis
inferred← citeshttps://doi.org/10.1007/s12011-025-04795-8openalex-snapshot
Lead and Cadmium in Orange Juices Marketed in Morocco: A Comprehensive Survey and Human Health Risk Assessment
inferred← citeshttps://doi.org/10.1007/s12640-021-00348-8openalex-snapshot
Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex
inferred← citeshttps://doi.org/10.1007/s43032-022-01140-5openalex-snapshot
Taurine Improves Sperm Mitochondrial Indices, Blunts Oxidative Stress Parameters, and Enhances Steroidogenesis and Kinematics of Sperm in Lead-Exposed Mice
inferred← citeshttps://doi.org/10.1016/j.aquatox.2026.107831openalex-snapshot
Acidification exacerbates lead-induced toxicity in crabs: Oxidative stress, microbiota disruption, and dietary intervention
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112359openalex-snapshot
Glyphaeaside C- enriched extract of Glyphaea brevis restored the antioxidant and reproductive integrity of 1,4-Dinitrobenzene-intoxicated rats
inferred← citeshttps://doi.org/10.1016/j.cbpc.2018.03.007openalex-snapshot
Effects of short term lead exposure on gut microbiota and hepatic metabolism in adult zebrafish
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2019.125794openalex-snapshot
Antagonistic effect of selenium on lead-induced neutrophil apoptosis in chickens via miR-16-5p targeting of PiK3R1 and IGF1R
inferred← citeshttps://doi.org/10.1016/j.cotox.2019.09.005openalex-snapshot
Cadmium, arsenic, and lead: elements affecting male reproductive health
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.109827openalex-snapshot
Subcellular partitioning of cadmium and lead in Eisenia fetida and their effects to sperm count, morphology and apoptosis
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2020.110266openalex-snapshot
Selenium ameliorates cadmium-induced mouse leydig TM3 cell apoptosis via inhibiting the ROS/JNK /c-jun signaling pathway
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115612openalex-snapshot
Exposure to 4-nonylphenol compromises Leydig cell development in pubertal male mice
inferred← citeshttps://doi.org/10.1016/j.fsi.2020.02.015openalex-snapshot
Cadmium exposure induces apoptosis, inflammation and immunosuppression through CYPs activation and antioxidant dysfunction in common carp neutrophils
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e21847openalex-snapshot
Antagonistic effects of N-acetylcysteine on lead-induced apoptosis and oxidative stress in chicken embryo fibroblast cells
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.02.010openalex-snapshot
FAS/FAS-L-mediated apoptosis and autophagy of SPC-A-1 cells induced by water-soluble polysaccharide from Polygala tenuifolia
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.05.016openalex-snapshot
A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.07.098openalex-snapshot
A cold-water polysaccharide-protein complex from Grifola frondosa exhibited antiproliferative activity via mitochondrial apoptotic and Fas/FasL pathways in HepG2 cells
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.04.020openalex-snapshot
Protective effect of diallyl sulfide against lead-mediated oxidative damage, apoptosis and down-regulation of CYP19 gene expression in rat testes
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.05.067openalex-snapshot
Thymoquinone attenuates testicular and spermotoxicity following subchronic lead exposure in male rats: Possible mechanisms are involved
inferred← citeshttps://doi.org/10.1016/j.taap.2019.02.012openalex-snapshot
Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells
inferred← citeshttps://doi.org/10.1038/s41598-023-36835-5openalex-snapshot
Lead induces mouse skin fibroblast apoptosis by disrupting intracellular homeostasis
inferred← citeshttps://doi.org/10.1039/c8fo01122bopenalex-snapshot
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model
inferred← citeshttps://doi.org/10.1080/09603123.2019.1625034openalex-snapshot
Lead acetate induces apoptosis in Leydig cells by activating PPARγ/caspase-3/PARP pathway
inferred← citeshttps://doi.org/10.1093/mtomcs/mfab042openalex-snapshot
Induction of mitochondrial apoptosis pathway mediated through caspase-8 and c-Jun N-terminal kinase by cadmium-activated Fas in rat cortical neurons
inferred← citeshttps://doi.org/10.1155/2024/8059770openalex-snapshot
Exploring the Potential of Isalo Scorpion Cytotoxic Peptide in Enhancing Gill Barrier Function and Immunity in Grass Carp (Ctenopharyngodon idella) Infected with Flavobacterium columnare
inferred← citeshttps://doi.org/10.1186/s13148-021-01198-zopenalex-snapshot
Prenatal metal exposure, cord blood DNA methylation and persistence in childhood: an epigenome-wide association study of 12 metals
inferred← citeshttps://doi.org/10.21037/atm.2019.12.28openalex-snapshot
Toll-like receptor 4 (TLR4) deficiency aggravates dextran sulfate sodium (DSS)-induced intestinal injury by down-regulating IL6, CCL2 and CSF3
inferred← citeshttps://doi.org/10.22038/ajp.2019.13513openalex-snapshot
Carob (Ceratonia siliqua L.) fruit hydro-alcoholic extract alleviates reproductive toxicity of lead in male mice: Evidence on sperm parameters, sex hormones, oxidative stress biomarkers and expression of Nrf2 and iNOS.
inferred← citeshttps://doi.org/10.24275/uami.sx61dm341openalex-snapshot
Efecto de la exposición perinatal a plomo sobre la concentración de testosterona, la conducta sexual masculina y la inmunorreactividad de los receptores para andrógenos y estrógenos en el área preóptica medial y la amígdala medial de la rata
inferred← citeshttps://doi.org/10.3389/fnut.2022.911838openalex-snapshot
Structural Characterization and Anti-breast Cancer Activity in vitro of a Novel Polysaccharide From Cymbopogon citratus
inferred← citeshttps://doi.org/10.3389/fphys.2021.574913openalex-snapshot
Pb Toxicity on Gut Physiology and Microbiota
inferred← citeshttps://doi.org/10.3390/ijms24076083openalex-snapshot
Insights into Canine Infertility: Apoptosis in Chronic Asymptomatic Orchitis
inferred← citeshttps://doi.org/10.3390/ijms26031050openalex-snapshot
Persistent Metabolic Changes Are Induced by 24 h Low-Dose Lead (Pb) Exposure in Zebrafish Embryos
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