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Molecular pathways mediating mechanical signaling in bone

https://doi.org/10.1016/j.gene.2005.10.028

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Pressure regulates osteoclast formation and MCSF expression in marrow culture

inferredcites →https://doi.org/10.1002/jbmr.5650040519openalex-snapshot

Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo

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Bone mineral loss and recovery after 17 weeks of bed rest

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Integrin expression in human bone

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Stimulation of signal transduction pathways in osteoblasts by mechanical strain potentiated by parathyroid hormone

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ERK activation and αvβ3 integrin signaling through Shc recruitment in response to mechanical stimulation in human osteoblasts

inferredcites →https://doi.org/10.1002/jcb.20363openalex-snapshot

Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue

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Electrophysiological responses of osteoclasts to hormones

inferredcites →https://doi.org/10.1002/jcp.1041420122openalex-snapshot

Effect of a continuously applied compressive pressure on mouse osteoblast‐like cells (MC3T3‐E1) in vitro

inferredcites →https://doi.org/10.1002/jcp.1041430113openalex-snapshot

Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production

inferredcites →https://doi.org/10.1002/jcp.1041570322openalex-snapshot

Effect of stretch on growth and collagen synthesis in cultured rat and lamb pulmonary arterial smooth muscle cells

inferredcites →https://doi.org/10.1002/jor.1100130510openalex-snapshot

Uniformity of resorptive bone loss induced by disuse

inferredcites →https://doi.org/10.1002/jor.1100160414openalex-snapshot

Nonlinear dependence of loading intensity and cycle number in the maintenance of bone mass and morphology

inferredcites →https://doi.org/10.1002/jor.1100170504openalex-snapshot

Osteoclastogenesis is repressed by mechanical strain in an in vitro model

inferredcites →https://doi.org/10.1006/bbrc.1995.2773openalex-snapshot

Sequential Analysis of Gene Expression after an Osteogenic Stimulus - c-fos Expression Is Induced in Osteocytes

inferredcites →https://doi.org/10.1006/bbrc.1996.1824openalex-snapshot

Mechanical Strain-Induced Proliferation of Osteoblastic Cells Parallels Increased TGF-β1 mRNA

inferredcites →https://doi.org/10.1006/bbrc.1998.9270openalex-snapshot

Nitric Oxide Response to Shear Stress by Human Bone Cell Cultures Is Endothelial Nitric Oxide Synthase Dependent

inferredcites →https://doi.org/10.1006/dbio.2000.9633openalex-snapshot

Impaired Bone Formation in Transgenic Mice Resulting from Altered Integrin Function in Osteoblasts

inferredcites →https://doi.org/10.1006/jmcc.1993.1109openalex-snapshot

Stretch-induced Inositol Trisphosphate and Tetrakisphosphate Production in Rat Cardiomyocytes

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Mechanotransduction in Bone Cells: Induction of Nitric Oxide and Prostaglandin Synthesis by Fluid Shear Stress, but Not by Mechanical Strain

inferredcites →https://doi.org/10.1007/bf00301950openalex-snapshot

Mechanically induced periosteal bone formation is paralleled by the upregulation of collagen type one mRNA in osteocytes as measured by In situ reverse transcript-polymerase chain reaction

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Multiple forms of mechanosensitive ion channels in osteoblast-like cells

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Cell membrane stretch in osteoclasts triggers a self-reinforcing Ca2+ entry pathway

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Mechanosensitive ion channels

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Disuse osteoporosis: Physiological aspects

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Regulation of bone mass by mechanical strain magnitude

inferredcites →https://doi.org/10.1007/s00223-004-0213-yopenalex-snapshot

Fluid Shear Stress Induces ?-Catenin Signaling in Osteoblasts

inferredcites →https://doi.org/10.1016/0014-5793(92)80771-8openalex-snapshot

Parathyroid hormone activation of stretch‐activated cation channels in osteosarcoma cells (UMR‐106.01)

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The influence of strain rate on adaptive bone remodelling

inferredcites →https://doi.org/10.1016/0021-9290(82)90246-9openalex-snapshot

Mechanically adaptive bone remodelling

inferredcites →https://doi.org/10.1016/0021-9290(84)90003-4openalex-snapshot

Static vs dynamic loads as an influence on bone remodelling

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A theoretical model for stress-generated fluid flow in the canaliculi-lacunae network in bone tissue

inferredcites →https://doi.org/10.1016/0021-9290(90)90354-6openalex-snapshot

Toward an identification of mechanical parameters initiating periosteal remodeling: A combined experimental and analytic approach

inferredcites →https://doi.org/10.1016/0021-9290(91)90386-2openalex-snapshot

Fluid movement in bone: Theoretical and empirical

inferredcites →https://doi.org/10.1016/0021-9290(93)90048-jopenalex-snapshot

Bone strain sensation via transmembrane potential changes in surface osteoblasts: Loading rate and microstructural implications

inferredcites →https://doi.org/10.1016/0021-9290(94)00157-yopenalex-snapshot

A theoretical model of circulatory interstitial fluid flow and species transport within porous cortical bone

inferredcites →https://doi.org/10.1016/0021-9290(94)90010-8openalex-snapshot

A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses

inferredcites →https://doi.org/10.1016/0021-9290(95)00058-popenalex-snapshot

A case for bone canaliculi as the anatomical site of strain generated potentials

inferredcites →https://doi.org/10.1016/0021-9290(95)00092-5openalex-snapshot

Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: A hypothesis for calcium-dependent and calcium-independent events activated by flow

inferredcites →https://doi.org/10.1016/j.jbiomech.2005.04.032openalex-snapshot

Osteocyte lacunae tissue strain in cortical bone

inferredcites →https://doi.org/10.1016/j.orthres.2004.04.002openalex-snapshot

Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation

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Disruption of Integrin Function in the Murine Myocardium Leads to Perinatal Lethality, Fibrosis, and Abnormal Cardiac Performance

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Patterns of integrin expression in a human mandibular explant model of osteoblast differentiation

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Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin

inferredcites →https://doi.org/10.1016/s0021-9290(02)00058-1openalex-snapshot

Proliferation of human-derived osteoblast-like cells depends on the cycle number and frequency of uniaxial strain

inferredcites →https://doi.org/10.1016/s0021-9290(98)00114-6openalex-snapshot

Differential effect of steady versus oscillating flow on bone cells

inferredcites →https://doi.org/10.1016/s0022-2836(02)01001-xopenalex-snapshot

Identifying Unfolding Intermediates of FN-III10 by Steered Molecular Dynamics

inferredcites →https://doi.org/10.1016/s0022-5193(84)80031-4openalex-snapshot

Dynamic strain similarity in vertebrates; an alternative to allometric limb bone scaling

inferredcites →https://doi.org/10.1016/s0079-6107(98)00052-2openalex-snapshot

Signaling through focal adhesion kinase

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Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts

inferredcites →https://doi.org/10.1016/s0960-9822(01)00582-6openalex-snapshot

Regulating c-Ras function

inferredcites →https://doi.org/10.1016/s8756-3282(00)00245-3openalex-snapshot

Gap junctions and biophysical regulation of bone cell differentiation

inferredcites →https://doi.org/10.1016/s8756-3282(00)00315-xopenalex-snapshot

Osteoblastic networks with deficient coupling: differential effects of magnetic and electric field exposure

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Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players

inferredcites →https://doi.org/10.1016/s8756-3282(02)00797-4openalex-snapshot

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways

inferredcites →https://doi.org/10.1016/s8756-3282(02)00979-1openalex-snapshot

Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways

inferredcites →https://doi.org/10.1016/s8756-3282(03)00025-5openalex-snapshot

Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium

inferredcites →https://doi.org/10.1016/s8756-3282(03)00167-4openalex-snapshot

Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism☆

inferredcites →https://doi.org/10.1016/s8756-3282(03)00242-4openalex-snapshot

Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes

inferredcites →https://doi.org/10.1016/s8756-3282(96)00260-8openalex-snapshot

Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain

inferredcites →https://doi.org/10.1016/s8756-3282(96)00385-7openalex-snapshot

Strain magnitude related changes in whole bone architecture in growing rats

inferredcites →https://doi.org/10.1016/s8756-3282(98)00125-2openalex-snapshot

Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo

inferredcites →https://doi.org/10.1023/b:abme.0000017538.72511.48openalex-snapshot

Integrin-Dependent Signal Cascades in Chondrocyte Mechanotransduction

inferredcites →https://doi.org/10.1038/269080a0openalex-snapshot

Transport mechanism operating between blood supply and osteocytes in long bones

inferredcites →https://doi.org/10.1038/320531a0openalex-snapshot

Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage

inferredcites →https://doi.org/10.1038/35015116openalex-snapshot

Effects of mechanical forces on maintenance and adaptation of form in trabecular bone

inferredcites →https://doi.org/10.1038/35036052openalex-snapshot

Lipid rafts and signal transduction

inferredcites →https://doi.org/10.1038/35088122openalex-snapshot

Low mechanical signals strengthen long bones

inferredcites →https://doi.org/10.1038/378292a0openalex-snapshot

A stomatin-like protein necessary for mechanosensation in C. elegans

inferredcites →https://doi.org/10.1038/424389aopenalex-snapshot

Bone adaptation requires oestrogen receptor-α

inferredcites →https://doi.org/10.1038/ki.1997.144openalex-snapshot

Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells

inferredcites →https://doi.org/10.1046/j.1523-1755.1999.00743.xopenalex-snapshot

Mesangial cell signaling cascades in response to mechanical strain and glucose

inferredcites →https://doi.org/10.1073/pnas.0407429101openalex-snapshot

Mechanotransduction and strain amplification in osteocyte cell processes

inferredcites →https://doi.org/10.1073/pnas.101582198openalex-snapshot

Comparison of the early stages of forced unfolding for fibronectin type III modules

inferredcites →https://doi.org/10.1073/pnas.141199598openalex-snapshot

Mechanical behavior in living cells consistent with the tensegrity model

inferredcites →https://doi.org/10.1073/pnas.93.5.1864openalex-snapshot

Antisense oligodeoxynucleotide inhibition of a swelling-activated cation channel in osteoblast-like osteosarcoma cells.

inferredcites →https://doi.org/10.1073/pnas.94.3.1013openalex-snapshot

Reconstitution of stretch-activated cation channels by expression of the α-subunit of the epithelial sodium channel cloned from osteoblasts

inferredcites →https://doi.org/10.1074/jbc.271.21.12165openalex-snapshot

Gap Junctional Intercellular Communication Contributes to Hormonal Responsiveness in Osteoblastic Networks

inferredcites →https://doi.org/10.1074/jbc.272.10.6525openalex-snapshot

Identification of Peptide and Protein Ligands for the Caveolin-scaffolding Domain

inferredcites →https://doi.org/10.1074/jbc.272.48.30455openalex-snapshot

Fluid Shear Stress Activation of Focal Adhesion Kinase

inferredcites →https://doi.org/10.1074/jbc.273.10.5419openalex-snapshot

Caveolins, a Family of Scaffolding Proteins for Organizing “Preassembled Signaling Complexes” at the Plasma Membrane

inferredcites →https://doi.org/10.1074/jbc.273.41.26323openalex-snapshot

Rapid Mechanotransduction in Situ at the Luminal Cell Surface of Vascular Endothelium and Its Caveolae

inferredcites →https://doi.org/10.1074/jbc.273.48.32304openalex-snapshot

Plasma Membrane Cholesterol Is a Key Molecule in Shear Stress-dependent Activation of Extracellular Signal-regulated Kinase

inferredcites →https://doi.org/10.1074/jbc.274.1.143openalex-snapshot

Fluid Shear Stress Stimulates Big Mitogen-activated Protein Kinase 1 (BMK1) Activity in Endothelial Cells

inferredcites →https://doi.org/10.1074/jbc.274.36.25273openalex-snapshot

Cyclic Strain Stress-induced Mitogen-activated Protein Kinase (MAPK) Phosphatase 1 Expression in Vascular Smooth Muscle Cells Is Regulated by Ras/Rac-MAPK Pathways

inferredcites →https://doi.org/10.1074/jbc.m009846200openalex-snapshot

Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3–E1 Osteoblasts

inferredcites →https://doi.org/10.1074/jbc.m208105200openalex-snapshot

Senescent Phenotype Can Be Reversed by Reduction of Caveolin Status

inferredcites →https://doi.org/10.1074/jbc.m300725200openalex-snapshot

Initiation and Transduction of Stretch-induced RhoA and Rac1 Activation through Caveolae

inferredcites →https://doi.org/10.1074/jbc.m302822200openalex-snapshot

Mechanical Strain Differentially Regulates Endothelial Nitric-oxide Synthase and Receptor Activator of Nuclear κB Ligand Expression via ERK1/2 MAPK

inferredcites →https://doi.org/10.1074/jbc.m313244200openalex-snapshot

Mechanical Strain on Osteoblasts Activates Autophosphorylation of Focal Adhesion Kinase and Proline-rich Tyrosine Kinase 2 Tyrosine Sites Involved in ERK Activation

inferredcites →https://doi.org/10.1074/jbc.m401343200openalex-snapshot

Mechanical Strain Induces Collagenase-3 (MMP-13) Expression in MC3T3-E1 Osteoblastic Cells

inferredcites →https://doi.org/10.1074/jbc.m404096200openalex-snapshot

Transcriptional Induction of FosB/ΔFosB Gene by Mechanical Stress in Osteoblasts

inferredcites →https://doi.org/10.1074/jbc.m500294200openalex-snapshot

Flow Shear Stress Stimulates Gab1 Tyrosine Phosphorylation to Mediate Protein Kinase B and Endothelial Nitric-oxide Synthase Activation in Endothelial Cells

inferredcites →https://doi.org/10.1074/jbc.r300038200openalex-snapshot

Integrins in Mechanotransduction

inferredcites →https://doi.org/10.1080/03008200490278133openalex-snapshot

Bone Anabolic Responses to Mechanical Load In Vitro Involve COX-2 and Constitutive NOS

inferredcites →https://doi.org/10.1083/jcb.200308011openalex-snapshot

Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motility

inferredcites →https://doi.org/10.1091/mbc.e04-10-0912openalex-snapshot

Mechanical Strain Opens Connexin 43 Hemichannels in Osteocytes: A Novel Mechanism for the Release of Prostaglandin

inferredcites →https://doi.org/10.1093/cvr/27.9.1634openalex-snapshot

Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy

inferredcites →https://doi.org/10.1093/rheumatology/36.8.831openalex-snapshot

The Michael Mason Prize Essay 1997. Nitric oxide and bone: what a gas!

inferredcites →https://doi.org/10.1096/fasebj.9.5.7896017openalex-snapshot

Sensitivity of osteocytes to biomechanical stress in vitro

inferredcites →https://doi.org/10.1096/fj.01-0166comopenalex-snapshot

The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low‐magnitude mechanical stimuli

inferredcites →https://doi.org/10.1097/00003086-199401000-00022openalex-snapshot

Promotion of Bony Ingrowth by Frequency-Specific, Low-Amplitude Mechanical Strain

inferredcites →https://doi.org/10.1097/00005768-199610000-00007openalex-snapshot

Musculoskeletal adaptations to weightlessness and development of effective countermeasures

inferredcites →https://doi.org/10.1097/01.moh.0000132240.20671.33openalex-snapshot

Hemolytic disease due to membrane ion channel disorders

inferredcites →https://doi.org/10.1113/jphysiol.1984.sp015317openalex-snapshot

Stretch‐activated single ion channel currents in tissue‐cultured embryonic chick skeletal muscle.

inferredcites →https://doi.org/10.1115/1.1535191openalex-snapshot

Micromechanically Based Poroelastic Modeling of Fluid Flow in Haversian Bone

inferredcites →https://doi.org/10.1126/science.1062688openalex-snapshot

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

inferredcites →https://doi.org/10.1126/science.1086652openalex-snapshot

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

inferredcites →https://doi.org/10.1126/science.1090985openalex-snapshot

Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15

inferredcites →https://doi.org/10.1126/science.278.5339.856openalex-snapshot

Measurement of the Force-Velocity Relation for Growing Microtubules

inferredcites →https://doi.org/10.1126/stke.2192004re4openalex-snapshot

Mechanosensitive Channels: Multiplicity of Families and Gating Paradigms

inferredcites →https://doi.org/10.1128/mcb.17.3.1702openalex-snapshot

Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130 cas , and Nck Adaptor Proteins

inferredcites →https://doi.org/10.1128/mcb.18.5.2571openalex-snapshot

Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events

inferredcites →https://doi.org/10.1146/annurev.biochem.67.1.199openalex-snapshot

THE CAVEOLAE MEMBRANE SYSTEM

inferredcites →https://doi.org/10.1146/annurev.physiol.59.1.575openalex-snapshot

TENSEGRITY: THE ARCHITECTURAL BASIS OF CELLULAR MECHANOTRANSDUCTION

inferredcites →https://doi.org/10.1146/annurev.physiol.59.1.633openalex-snapshot

MECHANOSENSITIVE CHANNELS OFESCHERICHIA COLI:The MscL Gene, Protein, and Activities

inferredcites →https://doi.org/10.1146/annurev.physiol.59.1.659openalex-snapshot

MOLECULAR MODELING OF MECHANOTRANSDUCTION IN THE NEMATODE CAENORHABDITIS ELEGANS

inferredcites →https://doi.org/10.1152/ajpcell.00122.2003openalex-snapshot

Flow-dependent regulation of endothelial nitric oxide synthase: role of protein kinases

inferredcites →https://doi.org/10.1152/ajpcell.00131.2004openalex-snapshot

A novel method for assessing effects of hydrostatic fluid pressure on intracellular calcium: a study with bovine articular chondrocytes

inferredcites →https://doi.org/10.1152/ajpcell.00278.2004openalex-snapshot

Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs

inferredcites →https://doi.org/10.1152/ajpcell.1997.273.3.c810openalex-snapshot

Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain

inferredcites →https://doi.org/10.1152/ajpcell.2000.278.5.c989openalex-snapshot

Ca2+regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

inferredcites →https://doi.org/10.1152/ajpcell.2001.281.6.c1917openalex-snapshot

Gap junctions and fluid flow response in MC3T3-E1 cells

inferredcites →https://doi.org/10.1152/ajpendo.1996.270.4.e634openalex-snapshot

Nitric oxide inhibitor L-NAME suppresses mechanically induced bone formation in rats

inferredcites →https://doi.org/10.1152/ajpendo.1997.273.4.e751openalex-snapshot

Induction of NO and prostaglandin E2in osteoblasts by wall-shear stress but not mechanical strain

inferredcites →https://doi.org/10.1152/ajpheart.00302.2003openalex-snapshot

Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells

inferredcites →https://doi.org/10.1152/ajpheart.1997.273.1.h347openalex-snapshot

Role of cytoskeleton in shear stress-induced endothelial nitric oxide production

inferredcites →https://doi.org/10.1152/ajprenal.1994.267.6.f909openalex-snapshot

Chronic, intermittent loading alters mechanosensitive channel characteristics in osteoblast-like cells

inferredcites →https://doi.org/10.1152/jappl.2001.91.2.963openalex-snapshot

Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle

inferredcites →https://doi.org/10.1159/000350077openalex-snapshot

Regulation of Renal Organic Anion Transporter 3 (SLC22A8) Expression and Function by the Integrity of Lipid Raft Domains and their Associated Cytoskeleton

inferredcites →https://doi.org/10.1159/000356667openalex-snapshot

Calcium's Role in Mechanotransduction during Muscle Development

inferredcites →https://doi.org/10.1161/01.atv.0000073314.51987.84openalex-snapshot

Rapid Activation of Ras by Fluid Flow Is Mediated by Gα q and Gβγ Subunits of Heterotrimeric G Proteins in Human Endothelial Cells

inferredcites →https://doi.org/10.1161/01.atv.0000090129.75275.c2openalex-snapshot

Cholesterol Dependence of Vascular ERK1/2 Activation and Growth in Response to Stretch

inferredcites →https://doi.org/10.1161/01.atv.18.2.227openalex-snapshot

Shear Stress Activates p60src-Ras-MAPK Signaling Pathways in Vascular Endothelial Cells

inferredcites →https://doi.org/10.1161/01.hyp.31.1.162openalex-snapshot

Effects of Mechanical Forces on Signal Transduction and Gene Expression in Endothelial Cells

inferredcites →https://doi.org/10.1161/01.res.0000038487.19924.18openalex-snapshot

Role of Integrins in Endothelial Mechanosensing of Shear Stress

inferredcites →https://doi.org/10.1161/01.res.79.2.310openalex-snapshot

MAP Kinase Activation by Flow in Endothelial Cells

inferredcites →https://doi.org/10.1161/01.res.84.7.804openalex-snapshot

Modulation of Ras/Raf/Extracellular Signal–Regulated Kinase Pathway by Reactive Oxygen Species Is Involved in Cyclic Strain–Induced Early Growth Response-1 Gene Expression in Endothelial Cells

inferredcites →https://doi.org/10.1161/hh2301.100806openalex-snapshot

Shear Stress Regulates Endothelial Nitric Oxide Synthase Expression Through c-Src by Divergent Signaling Pathways

inferredcites →https://doi.org/10.1161/hy0202.102699openalex-snapshot

Integrins Play a Critical Role in Mechanical Stress–Induced p38 MAPK Activation

inferredcites →https://doi.org/10.1172/jci5367openalex-snapshot

Distinct roles for the small GTPases Cdc42 and Rho in endothelial responses to shear stress

inferredcites →https://doi.org/10.1210/en.136.2.528openalex-snapshot

Human osteoblast-like cells respond to mechanical strain with increased bone matrix protein production independent of hormonal regulation

inferredcites →https://doi.org/10.1210/en.142.2.760openalex-snapshot

Defective Bone Formation and Anabolic Response to Exogenous Estrogen in Mice with Targeted Disruption of Endothelial Nitric Oxide Synthase

inferredcites →https://doi.org/10.1210/en.2003-0726openalex-snapshot

Nitric Oxide Regulates Receptor Activator of Nuclear Factor-κB Ligand and Osteoprotegerin Expression in Bone Marrow Stromal Cells

inferredcites →https://doi.org/10.1210/en.2003-1225openalex-snapshot

A Physiological Role for the Posttranslational Cleavage of the Thyrotropin Receptor?

inferredcites →https://doi.org/10.1210/endo-118-2-733openalex-snapshot

The Temporal Response of Bone to Unloading*

inferredcites →https://doi.org/10.1210/endo.142.2.7977openalex-snapshot

Defective Bone Formation and Anabolic Response to Exogenous Estrogen in Mice with Targeted Disruption of Endothelial Nitric Oxide Synthase**This study was supported by grants from the Arthritis Research Campaign (UK) and the Medical Research Council (UK).

inferredcites →https://doi.org/10.1242/jcs.113.20.3563openalex-snapshot

Integrin cytoplasmic domain-binding proteins

inferredcites →https://doi.org/10.1302/0301-620x.83b1.0830124openalex-snapshot

Identification of caveolae and detection of caveolin in normal human osteoblasts

inferredcites →https://doi.org/10.1359/jbmr.0301251openalex-snapshot

Prevention of Postmenopausal Bone Loss by a Low-Magnitude, High-Frequency Mechanical Stimuli: A Clinical Trial Assessing Compliance, Efficacy, and Safety

inferredcites →https://doi.org/10.1359/jbmr.040101openalex-snapshot

Genetically Based Influences on the Site-Specific Regulation of Trabecular and Cortical Bone Morphology

inferredcites →https://doi.org/10.1359/jbmr.040129openalex-snapshot

Low Magnitude Mechanical Loading Is Osteogenic in Children With Disabling Conditions

inferredcites →https://doi.org/10.1359/jbmr.040307openalex-snapshot

Cortical and Trabecular Bone Mineral Loss From the Spine and Hip in Long-Duration Spaceflight

inferredcites →https://doi.org/10.1359/jbmr.041004openalex-snapshot

Upregulation of Osteopontin by Osteocytes Deprived of Mechanical Loading or Oxygen

inferredcites →https://doi.org/10.1359/jbmr.041009openalex-snapshot

Fluid Shear-Induced ATP Secretion Mediates Prostaglandin Release in MC3T3-E1 Osteoblasts

inferredcites →https://doi.org/10.1359/jbmr.1997.12.10.1626openalex-snapshot

Signal Transduction of Mechanical Stimuli Is Dependent on Microfilament Integrity: Identification of Osteopontin as a Mechanically Induced Gene in Osteoblasts

inferredcites →https://doi.org/10.1359/jbmr.1997.12.7.1108openalex-snapshot

Expression of Nitric Oxide Synthase Isoforms in Bone and Bone Cell Cultures

inferredcites →https://doi.org/10.1359/jbmr.1997.12.7.1133openalex-snapshot

Electrophysiological Responses of Human Bone Cells to Mechanical Stimulation: Evidence for Specific Integrin Function in Mechanotransduction

inferredcites →https://doi.org/10.1359/jbmr.1998.13.2.218openalex-snapshot

Cyclic Stretch Enhances Gap Junctional Communication Between Osteoblastic Cells

inferredcites →https://doi.org/10.1359/jbmr.1999.14.6.930openalex-snapshot

Steady and Transient Fluid Shear Stress Stimulate NO Release in Osteoblasts Through Distinct Biochemical Pathways

inferredcites →https://doi.org/10.1359/jbmr.1999.14.7.1123openalex-snapshot

Mechanical Strain Stimulates Nitric Oxide Production by Rapid Activation of Endothelial Nitric Oxide Synthase in Osteocytes

inferredcites →https://doi.org/10.1359/jbmr.2000.15.12.2380openalex-snapshot

Caveolin-Enriched Membrane Signaling Complexes in Human and Murine Osteoblasts

inferredcites →https://doi.org/10.1359/jbmr.2000.15.12.2391openalex-snapshot

Caveolae in Human and Murine Osteoblasts

inferredcites →https://doi.org/10.1359/jbmr.2000.15.2.209openalex-snapshot

Functional Gap Junctions Between Osteocytic and Osteoblastic Cells

inferredcites →https://doi.org/10.1359/jbmr.2000.15.8.1501openalex-snapshot

Integrin and Mechanosensitive Ion Channel-Dependent Tyrosine Phosphorylation of Focal Adhesion Proteins and β-Catenin in Human Articular Chondrocytes After Mechanical Stimulation

inferredcites →https://doi.org/10.1359/jbmr.2000.15.9.1731openalex-snapshot

Mechanically Strained Cells of the Osteoblast Lineage Organize Their Extracellular Matrix Through Unique Sites of αVβ3-Integrin Expression

inferredcites →https://doi.org/10.1359/jbmr.2001.16.2.240openalex-snapshot

Parathyroid Hormone Enhances Fluid Shear-Induced [Ca2+]i Signaling in Osteoblastic Cells Through Activation of Mechanosensitive and Voltage-Sensitive Ca2+ Channels

inferredcites →https://doi.org/10.1359/jbmr.2002.17.10.1795openalex-snapshot

L-Type Calcium Channels Mediate Mechanically Induced Bone Formation In Vivo

inferredcites →https://doi.org/10.1359/jbmr.2002.17.12.2281openalex-snapshot

Effect of Long-Term Impact-Loading on Mass, Size, and Estimated Strength of Humerus and Radius of Female Racquet-Sports Players: A Peripheral Quantitative Computed Tomography Study Between Young and Old Starters and Controls

inferredcites →https://doi.org/10.1359/jbmr.2002.17.2.349openalex-snapshot

Quantity and Quality of Trabecular Bone in the Femur Are Enhanced by a Strongly Anabolic, Noninvasive Mechanical Intervention

inferredcites →https://doi.org/10.1359/jbmr.2002.17.3.493openalex-snapshot

Noninvasive Loading of the Murine Tibia: An In Vivo Model for the Study of Mechanotransduction

inferredcites →https://doi.org/10.1359/jbmr.2002.17.8.1452openalex-snapshot

Activation of Extracellular Signal–Regulated Kinase Is Involved in Mechanical Strain Inhibition of RANKL Expression in Bone Stromal Cells

inferredcites →https://doi.org/10.1359/jbmr.2002.17.9.1613openalex-snapshot

Low‐Magnitude Mechanical Loading Becomes Osteogenic When Rest Is Inserted Between Each Load Cycle

inferredcites →https://doi.org/10.1359/jbmr.2003.18.10.1863openalex-snapshot

Focal Adhesion Kinase pp125FAK Interacts With the Large Conductance Calcium-Activated hSlo Potassium Channel in Human Osteoblasts: Potential Role in Mechanotransduction

inferredcites →https://doi.org/10.1359/jbmr.2003.18.2.352openalex-snapshot

inferredcites →https://doi.org/10.1359/jbmr.2003.18.5.807openalex-snapshot

Mechanical Loading Stimulates Dentin Matrix Protein 1 (DMP1) Expression in Osteocytes In Vivo

inferredcites →https://doi.org/10.1529/biophysj.104.040436openalex-snapshot

Estimating the Sensitivity of Mechanosensitive Ion Channels to Membrane Strain and Tension

inferredcites →https://doi.org/10.1542/peds.112.6.e447openalex-snapshot

A School-Based Exercise Intervention Elicits Substantial Bone Health Benefits: A 2-Year Randomized Controlled Trial in Girls

inferredcites →https://doi.org/10.1615/critreveukargeneexpr.v11.i1-3.70openalex-snapshot

Space Flight: A Challenge for Normal Bone Homeostasis

inferredcites →https://doi.org/10.1677/joe.0.1500001openalex-snapshot

The focal adhesion kinase

inferredcites →https://doi.org/10.2106/00004623-197759020-00012openalex-snapshot

Humeral hypertrophy in response to exercise

inferredcites →https://doi.org/10.2106/00004623-198466030-00012openalex-snapshot

Regulation of bone formation by applied dynamic loads.

inferredcites →https://doi.org/10.2106/00004623-199610000-00010openalex-snapshot

Differentiation of the Bone-Tissue Remodeling Response to Axial and Torsional Loading in the Turkey Ulna*†

inferredcites →https://doi.org/10.2741/1239openalex-snapshot

Regulation of endothelial cell function BY FAK and PYK2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.addr.2014.08.009openalex-snapshot

Biomechanical forces in the skeleton and their relevance to bone metastasis: Biology and engineering considerations

inferred← citeshttps://doi.org/10.1016/j.apsusc.2012.03.067openalex-snapshot

The enhanced characteristics of osteoblast adhesion to porous Zinc–TiO2 coating prepared by plasma electrolytic oxidation

inferred← citeshttps://doi.org/10.1016/j.archoralbio.2012.04.010openalex-snapshot

Effects of mechanical vibration on proliferation and osteogenic differentiation of human periodontal ligament stem cells

inferred← citeshttps://doi.org/10.1016/j.archoralbio.2012.11.003openalex-snapshot

Compressive stress induced the up-regulation of M-CSF, RANKL, TNF-α expression and the down-regulation of OPG expression in PDL cells via the integrin-FAK pathway

inferred← citeshttps://doi.org/10.1016/j.archoralbio.2014.07.015openalex-snapshot

Nitric oxide in human gingival crevicular fluid after orthodontic force application

inferred← citeshttps://doi.org/10.1016/j.bbamem.2011.09.018openalex-snapshot

Gap junctions and hemichannels in signal transmission, function and development of bone

inferred← citeshttps://doi.org/10.1016/j.bbrc.2006.06.090openalex-snapshot

The cytoskeleton of osteoblastic cell line UMR-106 displays reversible changes exposed to two different mechanical strains at physiological level☆

inferred← citeshttps://doi.org/10.1016/j.bbrc.2007.03.121openalex-snapshot

Lysophosphatidic acid induces osteocyte dendrite outgrowth

inferred← citeshttps://doi.org/10.1016/j.bbrc.2008.05.066openalex-snapshot

P2X7 receptor as sensitive flow sensor for ERK activation in osteoblasts

inferred← citeshttps://doi.org/10.1016/j.bbrc.2010.09.044openalex-snapshot

ERK1/2 is involved in cyclic compressive force-induced IL-6 secretion in MLO-Y4 cells

inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.04.044openalex-snapshot

A multishear microfluidic device for quantitative analysis of calcium dynamics in osteoblasts

inferred← citeshttps://doi.org/10.1016/j.bej.2022.108685openalex-snapshot

Fluid shear stress promotes osteogenesis of bone mesenchymal stem cells at early matrix maturity phase through Lamin A/ METTL3 signal axis

inferred← citeshttps://doi.org/10.1016/j.bihy.2009.04.009openalex-snapshot

Polycystin-1 may play an important role in mechanical modulation of bone growth and healing

inferred← citeshttps://doi.org/10.1016/j.bioactmat.2016.09.001openalex-snapshot

The modulation of stem cell behaviors by functionalized nanoceramic coatings on Ti-based implants

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2011.08.023openalex-snapshot

Promotion of osteoblast differentiation in 3D biomaterial micro-chip arrays comprising fibronectin-coated poly(methyl methacrylate) polycarbonate

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2018.05.027openalex-snapshot

Gold and gold-silver alloy nanoparticles enhance the myogenic differentiation of myoblasts through p38 MAPK signaling pathway and promote in vivo skeletal muscle regeneration

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121989openalex-snapshot

SAXS imaging reveals optimized osseointegration properties of bioengineered oriented 3D-PLGA/aCaP scaffolds in a critical size bone defect model

inferred← citeshttps://doi.org/10.1016/j.bone.2006.09.018openalex-snapshot

Knee loading dynamically alters intramedullary pressure in mouse femora

inferred← citeshttps://doi.org/10.1016/j.bone.2007.01.018openalex-snapshot

Effects of surgical holes in mouse tibiae on bone formation induced by knee loading

inferred← citeshttps://doi.org/10.1016/j.bone.2007.04.192openalex-snapshot

Biphasic change and disuse-mediated regression of canal network structure in cortical bone of growing rats

inferred← citeshttps://doi.org/10.1016/j.bone.2007.08.020openalex-snapshot

Transgenic over-expression of plasminogen activator inhibitor-1 results in age-dependent and gender-specific increases in bone strength and mineralization

inferred← citeshttps://doi.org/10.1016/j.bone.2008.04.012openalex-snapshot

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice

inferred← citeshttps://doi.org/10.1016/j.bone.2008.05.018openalex-snapshot

NMDA enhances stretching-induced differentiation of osteobalsts through the ERK1/2 signaling pathway

inferred← citeshttps://doi.org/10.1016/j.bone.2008.07.253openalex-snapshot

The effects of frequency-dependent dynamic muscle stimulation on inhibition of trabecular bone loss in a disuse model

inferred← citeshttps://doi.org/10.1016/j.bone.2008.10.058openalex-snapshot

Body mass influences cortical bone mass independent of leptin signaling

inferred← citeshttps://doi.org/10.1016/j.bone.2008.12.027openalex-snapshot

Use of rapidly mineralising osteoblasts and short periods of mechanical loading to accelerate matrix maturation in 3D scaffolds

inferred← citeshttps://doi.org/10.1016/j.bone.2009.01.367openalex-snapshot

Joint loading-driven bone formation and signaling pathways predicted from genome-wide expression profiles

inferred← citeshttps://doi.org/10.1016/j.bone.2009.07.088openalex-snapshot

A 246-km continuous running race causes significant changes in bone metabolism

inferred← citeshttps://doi.org/10.1016/j.bone.2009.09.014openalex-snapshot

Nmp4/CIZ: Road block at the intersection of PTH and load

inferred← citeshttps://doi.org/10.1016/j.bone.2010.01.382openalex-snapshot

Evidence for pleiotropic factors in genetics of the musculoskeletal system

inferred← citeshttps://doi.org/10.1016/j.bone.2010.09.138openalex-snapshot

Bone tissue engineering bioreactors: Dynamic culture and the influence of shear stress

inferred← citeshttps://doi.org/10.1016/j.bone.2010.12.019openalex-snapshot

Midkine-deficiency increases the anabolic response of cortical bone to mechanical loading

inferred← citeshttps://doi.org/10.1016/j.bone.2011.04.023openalex-snapshot

Attenuated anabolic response to exercise in lamin A/C haploinsufficient mice

inferred← citeshttps://doi.org/10.1016/j.bone.2012.06.030openalex-snapshot

Dynamic hydraulic flow stimulation on mitigation of trabecular bone loss in a rat functional disuse model

inferred← citeshttps://doi.org/10.1016/j.bone.2012.12.002openalex-snapshot

Ex vivo real-time observation of Ca2+ signaling in living bone in response to shear stress applied on the bone surface

inferred← citeshttps://doi.org/10.1016/j.bone.2015.03.019openalex-snapshot

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

inferred← citeshttps://doi.org/10.1016/j.bone.2015.09.010openalex-snapshot

Sclerostin antibody and interval treadmill training effects in a rodent model of glucocorticoid-induced osteopenia

inferred← citeshttps://doi.org/10.1016/j.bone.2016.02.001openalex-snapshot

Combined exposure to big endothelin-1 and mechanical loading in bovine sternal cores promotes osteogenesis

inferred← citeshttps://doi.org/10.1016/j.bone.2021.115998openalex-snapshot

Suppression of cancer-associated bone loss through dynamic mechanical loading

inferred← citeshttps://doi.org/10.1016/j.bone.2026.117784openalex-snapshot

Alterations in osteocyte mechanostimulation within trabecular-lacunar cavities of human bone from intact to implanted cases: a multiscale model elucidating the role of osteocyte mechanosensors

inferred← citeshttps://doi.org/10.1016/j.bpc.2017.07.010openalex-snapshot

Controlled single-cell cyclic compression and transcription analysis: A pilot study

inferred← citeshttps://doi.org/10.1016/j.bpj.2015.03.008openalex-snapshot

Seeing the Unseen: Cell Strain and Mechanosensing

inferred← citeshttps://doi.org/10.1016/j.cbpa.2008.11.020openalex-snapshot

Calcium transport in strongly calcifying laying birds: Mechanisms and regulation

inferred← citeshttps://doi.org/10.1016/j.ceca.2009.12.005openalex-snapshot

An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation

inferred← citeshttps://doi.org/10.1016/j.cellbi.2006.05.002openalex-snapshot

Effects of fluid shear stress on mRNA expression of carbonic anhydrase II in polarized rat osteoclasts

inferred← citeshttps://doi.org/10.1016/j.cellsig.2007.01.004openalex-snapshot

Mechanical stress-initiated signal transduction in vascular smooth muscle cells in vitro and in vivo

inferred← citeshttps://doi.org/10.1016/j.cellsig.2020.109877openalex-snapshot

The functions of mechanosensitive ion channels in tooth and bone tissues

inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114043openalex-snapshot

A mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteolytic effects of breast cancer cells

inferred← citeshttps://doi.org/10.1016/j.colsurfb.2021.112227openalex-snapshot

Anisotropic magneto-mechanical stimulation on collagen coatings to accelerate osteogenesis

inferred← citeshttps://doi.org/10.1016/j.diff.2013.07.003openalex-snapshot

One load to rule them all: Mechanical control of the musculoskeletal system in development and aging

inferred← citeshttps://doi.org/10.1016/j.ejcb.2007.06.004openalex-snapshot

Mechanotransduction of keratinocytes in culture and in the epidermis

inferred← citeshttps://doi.org/10.1016/j.isci.2021.102486openalex-snapshot

Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear

inferred← citeshttps://doi.org/10.1016/j.jbiomech.2007.11.024openalex-snapshot

Compressive forces induce osteogenic gene expression in calvarial osteoblasts

inferred← citeshttps://doi.org/10.1016/j.jbiomech.2009.09.016openalex-snapshot

Boning up on Wolff's Law: Mechanical regulation of the cells that make and maintain bone

inferred← citeshttps://doi.org/10.1016/j.jbiomech.2010.01.030openalex-snapshot

Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow

inferred← citeshttps://doi.org/10.1016/j.jbiomech.2014.12.009openalex-snapshot

Strain energy density gradients in bone marrow predict osteoblast and osteoclast activity: A finite element study

inferred← citeshttps://doi.org/10.1016/j.jbiomech.2016.11.051openalex-snapshot

Novel multi-functional fluid flow device for studying cellular mechanotransduction

inferred← citeshttps://doi.org/10.1016/j.jbiosc.2015.02.006openalex-snapshot

MiR-494-3p induced by compressive force inhibits cell proliferation in MC3T3-E1 cells

inferred← citeshttps://doi.org/10.1016/j.joca.2008.09.007openalex-snapshot

Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts

inferred← citeshttps://doi.org/10.1016/j.joms.2012.10.017openalex-snapshot

Guided Implant Surgery: What Is the Influence of This New Technique on Bone Cell Viability?

inferred← citeshttps://doi.org/10.1016/j.jot.2023.07.004openalex-snapshot

Discovery of multipotent progenitor cells from human induced membrane: Equivalent to periosteum-derived stem cells in bone regeneration

inferred← citeshttps://doi.org/10.1016/j.jtbi.2008.10.013openalex-snapshot

Mathematical modelling of fibre-enhanced perfusion inside a tissue-engineering bioreactor

inferred← citeshttps://doi.org/10.1016/j.jtbi.2012.03.001openalex-snapshot

Do calcium fluxes within cortical bone affect osteocyte mechanosensitivity?

inferred← citeshttps://doi.org/10.1016/j.lfs.2013.05.015openalex-snapshot

Co-regulation of LPS and tensile strain downregulating osteogenicity via c-fos expression

inferred← citeshttps://doi.org/10.1016/j.lfs.2018.03.038openalex-snapshot

Continuous application of compressive force induces fusion of osteoclast-like RAW264.7 cells via upregulation of RANK and downregulation of LGR4

inferred← citeshttps://doi.org/10.1016/j.matbio.2008.05.003openalex-snapshot

Role for β1 integrins in cortical osteocytes during acute musculoskeletal disuse

inferred← citeshttps://doi.org/10.1016/j.mbm.2025.100137openalex-snapshot

Causal association analysis between blood metabolomes and osteopenia and therapeutic target prediction for mechanomedicine

inferred← citeshttps://doi.org/10.1016/j.medengphy.2012.06.005openalex-snapshot

Primary cilia act as mechanosensors during bone healing around an implant

inferred← citeshttps://doi.org/10.1016/j.mee.2012.07.050openalex-snapshot

Methodology for investigating the duration of intracellular calcium expression in response to mechanical stimulation in a single cell

inferred← citeshttps://doi.org/10.1016/j.mehy.2008.10.023openalex-snapshot

Low-magnitude mechanical vibration may be applied clinically to promote dental implant osseointegration

inferred← citeshttps://doi.org/10.1016/j.micron.2014.01.003openalex-snapshot

Characterization of calcium carbonate crystals in pigeon yolk sacs with different incubation times

inferred← citeshttps://doi.org/10.1016/j.mporth.2009.12.004openalex-snapshot

(ii) An update on fracture healing and non-union

inferred← citeshttps://doi.org/10.1016/j.mporth.2015.07.004openalex-snapshot

(ii) An update on fracture healing and non-union

inferred← citeshttps://doi.org/10.1016/j.msec.2021.112433openalex-snapshot

Insights into oxidative stress in bone tissue and novel challenges for biomaterials

inferred← citeshttps://doi.org/10.1016/j.ocl.2023.09.005openalex-snapshot

Sequestration and Involucrum

inferred← citeshttps://doi.org/10.1016/j.odw.2008.11.003openalex-snapshot

Induction of osteoclast differentiation by NOC-18, a long-acting nitric oxide donor

inferred← citeshttps://doi.org/10.1016/j.odw.2012.12.001openalex-snapshot

Facilitation of experimental tooth movement by NOC-18, a long-acting nitric oxide donor

inferred← citeshttps://doi.org/10.1016/j.ohx.2024.e00535openalex-snapshot

EnduroBone: A 3D printed bioreactor for extended bone tissue culture

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2015.11.005openalex-snapshot

The roles of exercise in bone remodeling and in prevention and treatment of osteoporosis

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