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Combination therapy with benznidazole and doxycycline shows no additive effect to monotherapy with benznidazole in mice infected with the VL-10 strain of the Trypanosoma cruzi

https://doi.org/10.1016/j.ijcard.2019.07.047

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.1969.03160170045010openalex-snapshot

Evaluation of a New Antibacterial Agent

inferredcites →https://doi.org/10.1007/s00436-008-0992-6openalex-snapshot

Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions

inferredcites →https://doi.org/10.1016/j.actatropica.2017.07.005openalex-snapshot

The immunomodulatory effects of the Enalapril in combination with Benznidazole during acute and chronic phases of the experimental infection with Trypanosoma cruzi

inferredcites →https://doi.org/10.1016/j.ahj.2008.04.001openalex-snapshot

Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)

inferredcites →https://doi.org/10.1016/j.amjmed.2015.04.036openalex-snapshot

Chagas Heart Disease: An Update

inferredcites →https://doi.org/10.1016/j.ijcard.2007.06.012openalex-snapshot

Right ventricular dysfunction is an independent predictor of survival in patients with dilated chronic Chagas' cardiomyopathy

inferredcites →https://doi.org/10.1016/s0008-6363(03)00361-4openalex-snapshot

Pathophysiology of the heart in Chagas' disease: current status and new developments

inferredcites →https://doi.org/10.1016/s0300-8932(10)70181-0openalex-snapshot

Factores predictivos de la mortalidad en pacientes con miocardiopatía dilatada: importancia de la enfermedad de Chagas como etiología

inferredcites →https://doi.org/10.1016/s1473-3099(01)00065-2openalex-snapshot

Clinical and epidemiological aspects of Chagas disease

inferredcites →https://doi.org/10.1016/s1885-5857(10)70163-8openalex-snapshot

Predictors of Mortality in Patients With Dilated Cardiomyopathy: Relevance of Chagas Disease as an Etiological Factor

inferredcites →https://doi.org/10.1086/381892openalex-snapshot

Elevated Concentrations of CCL2 and Tumor Necrosis Factor–α in Chagasic Cardiomyopathy

inferredcites →https://doi.org/10.1086/587487openalex-snapshot

Increased Activities of Cardiac Matrix Metalloproteinases Matrix Metalloproteinase (MMP)–2 and MMP‐9 Are Associated with Mortality during the Acute Phase of ExperimentalTrypanosoma cruziInfection

inferredcites →https://doi.org/10.1111/j.1540-8175.2009.01081.xopenalex-snapshot

Left Ventricular Diastolic Function and Exercise Capacity in Patients with Chagas Cardiomyopathy

inferredcites →https://doi.org/10.1111/j.1582-4934.2010.01007.xopenalex-snapshot

Chagas’ disease: an update on immune mechanisms and therapeutic strategies

inferredcites →https://doi.org/10.1111/j.1742-4658.2012.08622.xopenalex-snapshot

Ischemia/reperfusion‐induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

inferredcites →https://doi.org/10.1111/jeu.12184openalex-snapshot

Recent Clinical Trials for the Etiological Treatment of Chronic Chagas Disease: Advances, Challenges and Perspectives

inferredcites →https://doi.org/10.1111/tmi.12002openalex-snapshot

Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with Benznidazole

inferredcites →https://doi.org/10.1128/iai.71.3.1185-1193.2003openalex-snapshot

Evidence that Development of Severe Cardiomyopathy in Human Chagas' Disease Is Due to a Th1-Specific Immune Response

inferredcites →https://doi.org/10.1155/2015/329418openalex-snapshot

Anti‐Inflammatory Properties of Low and High Doxycycline Doses: An In Vitro Study

inferredcites →https://doi.org/10.1155/2016/3694714openalex-snapshot

Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi -Infected Dogs

inferredcites →https://doi.org/10.1161/01.cir.101.15.1833openalex-snapshot

Matrix Metalloproteinase-2 Contributes to Ischemia-Reperfusion Injury in the Heart

inferredcites →https://doi.org/10.1161/circulationaha.106.627265openalex-snapshot

Predictors of Mortality in Chronic Chagas Disease

inferredcites →https://doi.org/10.1586/14787210.5.4.717openalex-snapshot

Etiological treatment of chronic Chagas disease: neglected ‘evidence’ by evidence-based medicine

inferredcites →https://doi.org/10.1590/0037-8682-0536-2016openalex-snapshot

Influence of environmental enrichment on the behavior and physiology of mice infected by Trypanosoma cruzi

inferredcites →https://doi.org/10.1590/0074-02760180271openalex-snapshot

The β-blocker carvedilol and the benznidazole modulate the cardiac immune response in the acute infection induced by Colombian strain of the Trypanosoma cruzi

inferredcites →https://doi.org/10.1590/s0074-02762009000900022openalex-snapshot

Morbidity and prognostic factors in chronic chagasic cardiopathy

inferredcites →https://doi.org/10.1590/s0074-02762012000400012openalex-snapshot

Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease

inferredcites →https://doi.org/10.2174/138955712798868977openalex-snapshot

Tetracyclines: Drugs with Huge Therapeutic Potential

inferredcites →https://doi.org/10.4269/ajtmh.17-0657openalex-snapshot

Parasite–Vector Interaction of Chagas Disease: A Mini-Review

inferredcites →https://doi.org/10.4269/ajtmh.2011.10-0285openalex-snapshot

Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4746016openalex-extracted

Chagas Disease: History, Pathophysiology and Therapeutic Treatment

inferred← citeshttps://doi.org/10.1002/cbdv.202100362openalex-snapshot

γ‐Lactones from Persea americana and Persea fulva – in Vitro and in Silico Evaluation of Trypanosoma cruzi Activity

inferred← citeshttps://doi.org/10.1002/cmdc.202500408openalex-snapshot

Sertraline as a Scaffold for Antitrypanosoma Cruzi Drug Development: Design of Novel Derivatives and Computational Target Screening

inferred← citeshttps://doi.org/10.1016/j.actatropica.2021.106210openalex-snapshot

Drug associations as alternative and complementary therapy for neglected tropical diseases

inferred← citeshttps://doi.org/10.1016/j.actatropica.2025.107887openalex-snapshot

Nitazoxanide modulates inflammation but fails to control parasitemia in experimental Trypanosoma cruzi infection

inferred← citeshttps://doi.org/10.1016/j.phrs.2020.104907openalex-snapshot

Could phenothiazine-benznidazole combined chemotherapy be effective in controlling heart parasitism and acute infectious myocarditis?

inferred← citeshttps://doi.org/10.1590/0074-02760240183openalex-snapshot

Looking for approved-medicines to be repositioned as anti-Trypanosoma cruzi agents. Identification of new chemotypes with good individual- or in combination-biological behaviours

inferred← citeshttps://doi.org/10.1590/s1678-9946202163061openalex-snapshot

Prospective study of ventricular function and myocardial deformation related to survival in acute Chagas disease: an experimental animal model

inferred← citeshttps://doi.org/10.32776/revbiomed.v32i1.786openalex-snapshot

Aplicaciones y potencial de las técnicas de diagnóstico por imagen en la investigación biomédica de la enfermedad de Chagas

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