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Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPβ DNA-binding activity
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1098-1128(199603)16:2<181::aid-med3>3.0.co;2-xopenalex-snapshot
Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): Rationale for selective inhibition and progress to date
inferredcites →https://doi.org/10.1006/abio.1987.9999openalex-snapshot
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
inferredcites →https://doi.org/10.1016/0003-2697(82)90118-xopenalex-snapshot
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
inferredcites →https://doi.org/10.1016/0003-2697(87)90021-2openalex-snapshot
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
inferredcites →https://doi.org/10.1016/0005-2760(95)00194-8openalex-snapshot
Prostaglandin synthase 2
inferredcites →https://doi.org/10.1016/s0006-2952(01)00594-9openalex-snapshot
Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide11Abbreviations: NO, nitric oxide; iNOS, inducible nitricoxide synthase; COX-2, cyclooxygenase-2;…
inferredcites →https://doi.org/10.1016/s0024-3205(02)01920-3openalex-snapshot
Hwangryun-Hae-Dok-tang (Huanglian-Jie-Du-Tang) extract and its constituents reduce ischemia-reperfusion brain injury and neutrophil infiltration in rats
inferredcites →https://doi.org/10.1016/s0031-6997(25)06663-3openalex-snapshot
Nitric oxide: physiology, pathophysiology, and pharmacology.
inferredcites →https://doi.org/10.1016/s0165-6147(02)00043-3openalex-snapshot
Cyclooxygenase 2: a molecular target for cancer prevention and treatment
inferredcites →https://doi.org/10.1016/s0304-3835(00)00591-7openalex-snapshot
Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin
inferredcites →https://doi.org/10.1016/s0378-1119(02)00827-2openalex-snapshot
Molecular cloning and characterization of the human budding uninhibited by benomyl (BUB3) promoter
inferredcites →https://doi.org/10.1016/s0898-6568(02)00135-3openalex-snapshot
Induction of cyclooxygenase-2 by lipopolysaccharide in canine tracheal smooth muscle cells: involvement of p42/p44 and p38 mitogen-activated protein kinases and nuclear factor-κB pathways
inferredcites →https://doi.org/10.1021/jf049953xopenalex-snapshot
Potent Inhibitory Effect of Flavonoids inScutellaria baicalensison Amyloid β Protein-Induced Neurotoxicity
inferredcites →https://doi.org/10.1038/sj.onc.1204667openalex-snapshot
Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes
inferredcites →https://doi.org/10.1056/nejm199704103361506openalex-snapshot
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
inferredcites →https://doi.org/10.1073/pnas.93.10.4816openalex-snapshot
Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect.
inferredcites →https://doi.org/10.1073/pnas.95.4.1788openalex-snapshot
Basal expression of cyclooxygenase-2 and nuclear factor–interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet
inferredcites →https://doi.org/10.1074/jbc.270.42.24965openalex-snapshot
Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells
inferredcites →https://doi.org/10.1074/jbc.270.52.31315openalex-snapshot
Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells
inferredcites →https://doi.org/10.1074/jbc.271.17.9906openalex-snapshot
Photolabeling of Prostaglandin Endoperoxide H Synthase-1 with 3-Trifluoro-3-(m-[125I]iodophenyl)diazirine as a Probe of Membrane Association and the Cyclooxygenase Active Site
inferredcites →https://doi.org/10.1074/jbc.271.52.33157openalex-snapshot
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
inferredcites →https://doi.org/10.1074/jbc.273.21.12901openalex-snapshot
Induction of Cyclooxygenase-2 by the Activated MEKK1 → SEK1/MKK4 → p38 Mitogen-activated Protein Kinase Pathway
inferredcites →https://doi.org/10.1074/jbc.273.44.28670openalex-snapshot
Interleukin-1β-induced Cyclooxygenase-2 Expression Requires Activation of Both c-Jun NH2-terminal Kinase and p38 MAPK Signal Pathways in Rat Renal Mesangial Cells
inferredcites →https://doi.org/10.1074/jbc.275.9.6259openalex-snapshot
Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages
inferredcites →https://doi.org/10.1074/jbc.m007386200openalex-snapshot
Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NFκB and Expression of the Inducible Cyclooxygenase
inferredcites →https://doi.org/10.1074/jbc.m106865200openalex-snapshot
The Transcription Factor C/EBPβ Is Essential for Inducible Expression of the cox-2 Gene in Macrophages but Not in Fibroblasts
inferredcites →https://doi.org/10.1074/jbc.m311279200openalex-snapshot
Peptidoglycan Induces Nuclear Factor-κB Activation and Cyclooxygenase-2 Expression via Ras, Raf-1, and ERK in RAW 264.7 Macrophages
inferredcites →https://doi.org/10.1074/jbc.m910237199openalex-snapshot
MAPK Mediation of Hypertonicity-stimulated Cyclooxygenase-2 Expression in Renal Medullary Collecting Duct Cells
inferredcites →https://doi.org/10.1124/mol.62.2.326openalex-snapshot
Transcriptional Regulation of Basal Cyclooxygenase-2 Expression in Murine Lung Tumor-Derived Cell Lines by CCAAT/Enhancer-Binding Protein and Activating Transcription Factor/cAMP Response Element-Binding Protein
inferredcites →https://doi.org/10.1124/mol.63.3.512openalex-snapshot
Potentiation of Lipopolysaccharide-Inducible Cyclooxygenase 2 Expression by C2-Ceramide via c-Jun N-Terminal Kinase-Mediated Activation of CCAAT/Enhancer Binding Protein β in Macrophages
inferredcites →https://doi.org/10.1126/science.1072682openalex-snapshot
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
inferredcites →https://doi.org/10.1142/s0192415x96000050openalex-snapshot
The Anti-inflammatory Activity of Scutellaria rivularis Extracts and Its Active Components, Baicalin, Baicalein and Wogonin
inferredcites →https://doi.org/10.1146/annurev.immunol.15.1.323openalex-snapshot
NITRIC OXIDE AND MACROPHAGE FUNCTION
inferredcites →https://doi.org/10.4049/jimmunol.164.6.3018openalex-snapshot
Role of Mitogen-Activated Protein Kinase Cascades in Mediating Lipopolysaccharide-Stimulated Induction of Cyclooxygenase-2 and IL-1β in RAW264 Macrophages
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Controlled Extraction of Flavonoids From Radix Scutellariae by Subcritical Water
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Inhibition of LPS‐induced C/EBPδ by trichostatin a has a positive effect on LPS‐induced cyclooxygenase 2 expression in RAW264.7 cells
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Differential inhibitory effects of inotilone on inflammatory mediators, inducible nitric oxide synthase and cyclooxygenase‐2, in LPS‐stimulated murine macrophage
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Baicalin Down‐regulates the Expression of Macrophage Migration Inhibitory Factor (MIF) Effectively for Rats with Ulcerative Colitis
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Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy
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Baicalein reduces lipopolysaccharide-induced inflammation via suppressing JAK/STATs activation and ROS production
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Polyphenolic phytochemicals – just antioxidants or much more?
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Topical herbal medicine combined with pharmacotherapy for psoriasis: a systematic review and meta-analysis
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Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo
inferred← citeshttps://doi.org/10.1007/s10753-009-9172-9openalex-snapshot
Multiple Therapeutic Effects of Adjunctive Baicalin Therapy in Experimental Bacterial Meningitis
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Anti-inflammatory Activity of Baicalein in LPS-Stimulated RAW264.7 Macrophages via Estrogen Receptor and NF-κB-Dependent Pathways
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Baicalin Inhibits NLRP3 Inflammasome Activity Via the AMPK Signaling Pathway to Alleviate Cerebral Ischemia-Reperfusion Injury
inferred← citeshttps://doi.org/10.1007/s10787-023-01206-zopenalex-snapshot
Crosstalk between phytochemicals and inflammatory signaling pathways
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The effect of cytokinins on shoot proliferation, secondary metabolite production and antioxidant potential in shoot cultures of Scutellaria alpina
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Baicalein-Loaded Aspasomal Formulations: Development, Characterization and Evaluation of Antioxidant and Anti-Inflammatory Effects
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The interactions of flavonoids within neuronal signalling pathways
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Polyphenols Suppress and Modulate Inflammation
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Anti-Inflammatory Properties of Botanical Extracts Contribute to Their Protective Effects in Brain Edema in Cerebral Ischemia
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Chinese herbal medicines for the treatment of COVID-19
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Analysis on herbal medicines utilized for treatment of COVID-19
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Baicalein inhibits α-synuclein oligomer formation and prevents progression of α-synuclein accumulation in a rotenone mouse model of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.bcp.2007.10.009openalex-snapshot
Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock
inferred← citeshttps://doi.org/10.1016/j.bcp.2008.04.006openalex-snapshot
CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-κB activation
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Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia
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The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review
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12-HETE is a regulator of PGE2 production via COX-2 expression induced by a snake venom group IIA phospholipase A2 in isolated peritoneal macrophages
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Negative pressure cavitation accelerated processing for extraction of main bioactive flavonoids from Radix Scutellariae
inferred← citeshttps://doi.org/10.1016/j.ejphar.2010.09.023openalex-snapshot
Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen–glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo
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Protective effect of pine (Pinus morrisonicola Hay.) needle on LDL oxidation and its anti-inflammatory action by modulation of iNOS and COX-2 expression in LPS-stimulated RAW 264.7 macrophages
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Dihydro-N-caffeoyltyramine down-regulates cyclooxygenase-2 expression by inhibiting the activities of C/EBP and AP-1 transcription factors
inferred← citeshttps://doi.org/10.1016/j.foodchem.2012.01.055openalex-snapshot
An enhanced preparation and purification of the major antioxidants baicalein and wogonin from Scutellariae radix
inferred← citeshttps://doi.org/10.1016/j.foodchem.2013.06.106openalex-snapshot
Cytoprotective effect of white tea against H2O2-induced oxidative stress in vitro
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Multi-spectroscopic characterization of organic salt components in medicinal plant
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Xiaochaihu Decoction reduces hepatic steatosis and improves D-GalN/LPS-induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)
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The genus Scutellaria an ethnopharmacological and phytochemical review
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Gene expression profiling and pathway network analysis of hepatic metabolic enzymes targeted by baicalein
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Anti-atherosclerotic action of Ger-Gen-Chyn-Lian-Tang and AMPK-dependent lipid lowering effect in hepatocytes
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The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase
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Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells
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The effects of wine-processing on ascending and descending: The distribution of flavonoids in rat tissues after oral administration of crude and wine-processed Radix scutellariae
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Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of Radix Scutellariae
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Identification and quantification of baicalein, wogonin, oroxylin A and their major glucuronide conjugated metabolites in rat plasma after oral administration of Radix scutellariae product
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Yinlai decoction alleviates lipopolysaccharide-induced pneumonia by changing the immune status of juvenile rats: A study based on network pharmacology
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Interactive network pharmacology and electrochemical analysis reveals electron transport-mediating characteristics of Chinese medicine formula Jing Guan Fang
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Comparative chemical profiling and functional analysis of Scutellaria baicalensis: Precision-boiled powder vs. traditional decoction pieces using UHPLC-q-orbitrap MS/MS
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Baicalin administration is effective in positive regulation of twenty-four ischemia/reperfusion-related proteins identified by a proteomic study
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Baicalein suppresses hypoxia-induced HIF-1α protein accumulation and activation through inhibition of reactive oxygen species and PI 3-kinase/Akt pathway in BV2 murine microglial cells
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Inhibition of 12/15 LOX ameliorates cognitive and cholinergic dysfunction in mouse model of hypobaric hypoxia via. attenuation of oxidative/nitrosative stress
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Ginsenoside Rg1 and Re alleviates inflammatory responses and oxidative stress of broiler chicks challenged by lipopolysaccharide
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Baicalin inhibits oxidative injures of mouse uterine tissue induced by acute heat stress through activating the Keap1/Nrf2 signaling pathway
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Secondary metabolites from Scutellaria brevibracteata subsp. subvelutina and their in vitro anti-inflammatory activities
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Development of Novel Therapy for Oral Diseases Using Kampo Medicines
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Adsorption Chromatography Separation of Baicalein and Baicalin Using Collagen Fiber Adsorbent
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Post‐injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury
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Nanoparticle-encapsulated baicalein markedly modulates pro-inflammatory response in gingival epithelial cells
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Effects of Flavonoids and other Polyphenols on Inflammation
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Correlation of antioxidative properties and vaso-relaxation effects of major active constituents of traditional Chinese medicines
inferred← citeshttps://doi.org/10.1080/14786419.2014.939082openalex-snapshot
New phenolics from the root of Scutellariaprostrata JACQ. ex BENTH.
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Inhibition of CCAAT/enhancer binding protein δ expression by chrysin in microglial cells results in anti‐inflammatory and neuroprotective effects
inferred← citeshttps://doi.org/10.1111/j.1476-5381.2009.00139.xopenalex-snapshot
Baicalin attenuates air embolism‐induced acute lung injury in rat isolated lungs
inferred← citeshttps://doi.org/10.1111/j.1745-7254.2008.00850.xopenalex-snapshot
Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers1
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Reciprocal cooperation of phytochemicals and micronutrients against typical and atypical forms ofBorreliasp.
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Scutellariae Radix enhances but Scutellariae Radix-containing Kampo formulas, Orengedokuto and San'oshashinto, prevent intestinal bleeding associated with indomethacin-induced enteropathy in mice
inferred← citeshttps://doi.org/10.11339/jtm.25.55openalex-snapshot
Scutellariae Radix augments ulceration but attenuates proinflammatory cytokine and chemokine gene induction in the small intestine during indomethacin-induced enteropathy in mice
inferred← citeshttps://doi.org/10.11339/jtm.25.81openalex-snapshot
Scutellariae Radix aggravates diclofenac sodium-induced enteropathy in mice
inferred← citeshttps://doi.org/10.1139/y11-025openalex-snapshot
Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen
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Aqueous Extract of Clerodendranthus spicatus Exerts Protective Effect on UV‐Induced Photoaged Mice Skin
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Medicinal Plants of the Family Lamiaceae in Pain Therapy: A Review
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Systematic Study on a Quantitative Analysis of Multicomponents by Single Marker (QAMS) Method for Simultaneous Determination of Eight Constituents in Pneumonia Mixture by UPLC-MS/MS
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Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1β-activated human mast cells were inhibited by Baicalein via regulation of the NF-κB pathway
inferred← citeshttps://doi.org/10.1186/1476-7961-5-5openalex-snapshot
Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway
inferred← citeshttps://doi.org/10.1186/s13223-023-00792-5openalex-snapshot
Immunomodulatory effects of modified Liu-Wei-Di-Huang-Wan Traditional Chinese medicine on allergic asthmatic mice
inferred← citeshttps://doi.org/10.1208/s12248-011-9310-9openalex-snapshot
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Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts
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Synthesis and Anti-influenza Activities of Novel Baicalein Analogs
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Synergism and Rules from Combination of Baicalin, Jasminoidin and Desoxycholic acid in Refined Qing Kai Ling for Treat Ischemic Stroke Mice Model
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Baicalein Selectively Induces Apoptosis in Activated Lymphocytes and Ameliorates Concanavalin A-Induced Hepatitis in Mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0094466openalex-snapshot
Therapeutic Effect of Jinzhen Oral Liquid for Hand Foot and Mouth Disease: A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Trial
inferred← citeshttps://doi.org/10.1515/hepo-2016-0013openalex-snapshot
Chemical variability of common skullcap (Scutellaria galericulataL.) wild growing in the area of eastern Poland
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Intracellular Signaling Pathways Modulated by Phenolic Compounds: Application for New Anti-Inflammatory Drugs Discovery
inferred← citeshttps://doi.org/10.2174/138945011794815347openalex-snapshot
Natural Products Triggering Biological Targets- A Review of the Anti-Inflammatory Phytochemicals Targeting the Arachidonic Acid Pathway in Allergy Asthma and Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.2174/1573412915666190522083850openalex-snapshot
Investigation on the Metabolism of Curcumin and Baicalein in Zebrafish by Liquid Chromatography-tandem Mass Spectrometry Analysis
inferred← citeshttps://doi.org/10.2485/jhtb.19.43openalex-snapshot
Preventive Effects of a Kampo Medicine, Hangeshashinto on Inflammatory Responses in Lipopolysaccharide-Treated Human Gingival Fibroblasts
inferred← citeshttps://doi.org/10.3109/13880209.2013.834366openalex-snapshot
Influence of mefenamic acid on the intestinal absorption and metabolism of three bioactive flavones inRadix Scutellariaeand potential pharmacological impact
inferred← citeshttps://doi.org/10.31219/osf.io/2w8ynopenalex-snapshot
Therapeutic Properties of Baicalin - A Literature Review
inferred← citeshttps://doi.org/10.3389/fphar.2018.00793openalex-snapshot
Semi-Mechanism-Based Pharmacodynamic Model for the Anti-Inflammatory Effect of Baicalein in LPS-Stimulated RAW264.7 Macrophages
inferred← citeshttps://doi.org/10.3389/fphar.2021.583279openalex-snapshot
Fever and Antipyretic Supported by Traditional Chinese Medicine: A Multi-Pathway Regulation
inferred← citeshttps://doi.org/10.3389/fphar.2022.1104280openalex-snapshot
Wine-processed radix scutellariae alleviates ARDS by regulating tryptophan metabolism through gut microbiota
inferred← citeshttps://doi.org/10.3390/medicines5040122openalex-snapshot
The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region
inferred← citeshttps://doi.org/10.3390/metabo13030461openalex-snapshot
Microbial and Host Metabolites at the Backstage of Fever: Current Knowledge about the Co-Ordinate Action of Receptors and Molecules Underlying Pathophysiology and Clinical Implications
inferred← citeshttps://doi.org/10.3390/molecules24112143openalex-snapshot
Inhibitory Effects of Scutellaria baicalensis Root Extract on Linoleic Acid Hydroperoxide-induced Lung Mitochondrial Lipid Peroxidation and Antioxidant Activities
inferred← citeshttps://doi.org/10.3390/nu13113953openalex-snapshot
Understanding the Functional Activity of Polyphenols Using Omics-Based Approaches
inferred← citeshttps://doi.org/10.3923/ijp.2010.81.88openalex-snapshot
Protective Effect of Baicalein Extracted from Scutellaria baicalensis against Lipopolysaccharide-Induced Glomerulonephritis in Mice
inferred← citeshttps://doi.org/10.4028/www.scientific.net/amr.662.293openalex-snapshot
Study on Subcritical Water Extraction of Flavonoids from Scutellaria baicalenses
inferred← citeshttps://doi.org/10.4103/wjtcm.wjtcm_68_20openalex-snapshot
Progress of Traditional Chinese Medicine Treating COVID-19
inferred← citeshttps://doi.org/10.4172/2329-9509.1000191openalex-snapshot
Why Age Matters: Inflammation, Cancer and Hormones in the Development of Sarcopenia
inferred← citeshttps://doi.org/10.4236/cm.2011.21004openalex-snapshot
Development and Validation of an HPLC Method for Simultaneous Determination of Nine Active Components in ‘Da-Chai-Hu-Tang’
inferred← citeshttps://doi.org/10.5772/20055openalex-snapshot
Therapeutic Potential of Polyphenols in Parkinson’s Disease
inferred← citeshttps://doi.org/10.5772/954openalex-snapshot
Towards New Therapies for Parkinson's Disease
inferred← citeshttps://doi.org/10.6116/kjh.2013.28.2.93openalex-snapshot
Effects of Baicalein on Neuroinflammation in Lipopolysaccharide-treated Mice
inferred← citeshttps://doi.org/10.7282/t3c24w5qopenalex-snapshot
Effects of inotilone on inflammation and inflammation-associated tumorigenesis
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